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The integration of artificial intelligence models to augment imaging modalities in pancreatic cancer

Xianze Wang, Wen Yuan Chung, Elon Correa, Yi Zhu, Eyad Issa, Ashley R. Dennison
2020 Journal of Pancreatology  
The integration of AI models to augment imaging modalities in PDAC has made great progression in the past 5 years, especially in organ segmentation, AI-aided diagnosis, and radiomics based individualized  ...  Shimizu et al presented one of the earliest studies of pancreas segmentation in 2007 and demonstrated a 35% JI by using the atlas guided segmentation incorporating with an extended EM algorithm.  ...  Roth et al achieved a performance of 68% in DSC and revealed the potential of CNN in pancreas segmentation and a similar approach has been used by Farag et al.  ... 
doi:10.1097/jp9.0000000000000056 fatcat:tbrhf4adszau7jecay4dnjc7my

Using Quantitative Imaging for Personalized Medicine in Pancreatic Cancer: A Review of Radiomics and Deep Learning Applications

Kiersten Preuss, Nate Thach, Xiaoying Liang, Michael Baine, Justin Chen, Chi Zhang, Huijing Du, Hongfeng Yu, Chi Lin, Michael A. Hollingsworth, Dandan Zheng
2022 Cancers  
patients in order to characterize unique imaging phenotypes.  ...  These two methods aim to mine hidden information in medical images that is missed by conventional radiology and gain insights by systematically comparing the quantitative image information across different  ...  McGovern et al. [124] CT Unknown Predicting the ALT phenotype in PNET patients Manual (2) 121 <20 Univariate (p < 0.05) and multivariate features (p = 0.006) found.  ... 
doi:10.3390/cancers14071654 pmid:35406426 pmcid:PMC8997008 fatcat:bcqcgcpbbvdq3o43ig24m2yz3m

CT texture analysis of Abdominal Lesions – Part II.: Tumors of the Kidney and Pancreas

Veronica Frank, Sonaz Shariati, Bettina Katalin Budai, Bence Fejér, Ambrus Tóth, Vince Orbán, Viktor Bérczi, Pál Novák Kaposi
2021 Imaging  
We review studies in which CTTA was used for the classification of histology grades in pancreas and kidney tumors.  ...  We also review the role of radiogenomics in the prediction of the molecular and genetic subtypes of pancreatic tumors.  ...  Slice-wise manual segmentation of the area of the whole pancreas on the axial view of arterial phase CT scans (A).  ... 
doi:10.1556/1647.2021.00020 fatcat:2k64hv46b5f77fk7gzpwkwpmam

Impact of a novel 14 bp MEN1 deletion in a patient with hyperparathyroidism and gastrinoma

Shweta Birla, Viveka P Jyotsna, Rajiv Singla, Madhavi Tripathi, Arundhati Sharma
2015 Endocrinology, Diabetes & Metabolism Case Reports  
Four months later, radiofrequency ablation (RFA) of segment 4 of the liver was done followed by three and a half parathyroidectomy.  ...  Evaluation for pathogenicity and protein structure prediction showed that the mutation led to a frameshift thereby causing premature termination resulting in a truncated protein.  ...  This is in concordance with the results of the in-silico analysis which predicted the sequence change to be pathogenic resulting in the disease phenotype.  ... 
doi:10.1530/edm-15-0011 pmid:26191410 pmcid:PMC4482156 fatcat:r2qg3s2mknhzndusowkh35kv6m

CT-Based Radiomics Analysis to Predict Malignancy in Patients with Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas

David Tobaly, Joao Santinha, Riccardo Sartoris, Marco Dioguardi Burgio, Celso Matos, Jérôme Cros, Anne Couvelard, Vinciane Rebours, Alain Sauvanet, Maxime Ronot, Nikolaos Papanikolaou, Valérie Vilgrain
2020 Cancers  
To assess the performance of CT-based radiomics analysis in differentiating benign from malignant intraductal papillary mucinous neoplasms of the pancreas (IPMN), preoperative scans of 408 resected patients  ...  After semi-automatic tumor segmentation, PyRadiomics was used to extract radiomics features. A multivariate model was developed using a logistic regression approach.  ...  Segmentation Image segmentation was performed by one reader with five years of abdominal imaging experience.  ... 
doi:10.3390/cancers12113089 pmid:33114028 fatcat:k2yqmgvfdnexddjfjaqezxtmkq

Heterogeneity of the Clinical Presentation of the MEN1 LRG_509 c.781C>T (p.Leu261Phe) Variant Within a Three-Generation Family

Aleksandra Gilis-Januszewska, Anna Bogusławska, Kornelia Hasse-Lazar, Beata Jurecka-Lubieniecka, Barbara Jarząb, Anna Sowa-Staszczak, Marta Opalińska, Magdalena Godlewska, Anna Grochowska, Anna Skalniak, Alicja Hubalewska-Dydejczyk
2021 Genes  
We describe a heterogenic phenotype of the MEN1 variant c.781C>T (LRG_509t1), which was previously reported only once in a family with isolated hyperparathyroidism.  ...  The phenotype of MEN1 syndrome varies between patients in terms of tumor localization, age of onset, and clinical aggressiveness, even between affected members within the same family.  ...  Transverse CT image of pancreas with calcifications (a) and lung metastasis in axial (b) and transverse (c) CT (arrows).  ... 
doi:10.3390/genes12040512 pmid:33807230 fatcat:pr2gahf3nbg3rp5edjovhswzti

PDX1 -MODY and dorsal pancreatic agenesis: New phenotype of a rare disease

L.A. Caetano, L.S. Santana, A.D. Costa-Riquetto, A.M. Lerario, M. Nery, G.F. Nogueira, C.D. Ortega, M.S. Rocha, A.A.L. Jorge, M.G. Teles
2017 Clinical Genetics  
Abdominal computed tomography (CT) scan of these two patients harboring the heterozygous PDX1 variant showed agenesis of the caudal pancreas and no sign of the main pancreatic duct of this segment.  ...  The proband's brother had a normal pancreas on CT scan (Fig. 1c) . The proband had reduced fecal elastase (< 100 mcg/g), which characterizes exocrine pancreatic insufficiency.  ... 
doi:10.1111/cge.13044 pmid:28436541 fatcat:nl4phl7j7rgc5ohkbly4lfqwqi

Artificial Intelligence for the Management of Pancreatic Diseases

Myrte Gorris, Sanne A. Hoogenboom, Michael B. Wallace, Jeanin E. Hooft
2020 Digestive Endoscopy  
model to detect and segment pancreatic cancer lesions on CT.  ...  Another study reported their results on a ML-based model distinguishing cancerous from normal pancreatic tissue using segmented pancreas CT images. 43 Interestingly, the model classified all PDACs as  ... 
doi:10.1111/den.13875 pmid:33065754 fatcat:epgv7svszfejblnurh6mfnyzj4

Comprehensive Validation of Automated Whole Body Skeletal Muscle, Adipose Tissue, and Bone Segmentation from 3D CT images for Body Composition Analysis: Towards Extended Body Composition [article]

Da Ma, Vincent Chow, Karteek Popuri, Mirza Faisal Beg
2021 arXiv   pre-print
population-wide models that are useful to discover aggregate patterns that hold for group-based analysis to patient-specific models that can drive patient-specific decisions with regard to treatment choices, and predictions  ...  recognized as an important driver and risk factor for a wide variety of diseases, as well as a predictor of individual patient-specific clinical outcomes to treatment choices or surgical interventions. 3D CT  ...  by the proposed 3D whole-body tissue segmentation on a subset of the population.  ... 
arXiv:2106.00652v3 fatcat:i3gcwk6suvedvcvzyym3rxsusq

Homozygous Mutations in NEUROD1 Are Responsible for a Novel Syndrome of Permanent Neonatal Diabetes and Neurological Abnormalities

O. Rubio-Cabezas, J. A. L. Minton, I. Kantor, D. Williams, S. Ellard, A. T. Hattersley
2010 Diabetes  
Both mutations introduced a frameshift that would be predicted to generate a truncated protein completely lacking the activating domain.  ...  This syndrome highlights the critical role of NEUROD1 in both the development of the endocrine pancreas and the central nervous system in humans.  ...  The mutation-containing homozygous segment was the largest homozygous segment (46.6-Mb long) and spanned 2q31.1-2q36.1 delimited by the SNPs rs726032 to rs724149.  ... 
doi:10.2337/db10-0011 pmid:20573748 pmcid:PMC2927956 fatcat:nwpilraf5rdrlmrqnzdsigojkq

Minimally Invasive Treatment for Severe Acute Pancreatitis With Superior Mesenteric Vein and Common Bile Duct Stenosis

Zhe Wan, Bo Shen, Dong Cen, Hong Yu, Xiujun Cai
2019 Pancreas  
This study was supported by Natural Science Foundation of Zhejiang Province (grant number: LY18H030003). Z.W., B.S., and D.C. contributed equally to this work.  ...  Abdominal enhanced computed tomography (CT) revealed swollen pancreas with extensive effusion around epigastrium (Fig. 1A) .  ...  Furthermore, GM-CSF is produced by T cells and has been used to predict survival in patients with resectable pancreatic adenocarcinoma, as high plasma levels of this cytokine were significantly associated  ... 
doi:10.1097/mpa.0000000000001379 pmid:31425486 pmcid:PMC6750144 fatcat:rqviyki4nzdbblyoz6ucz2bi7e

A primary retroperitoneal anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with tumor thrombosis

Jisong Li, Xiaodong Tian, Mangju Wang, Wei Liu, Xiaochao Guo, Ke Wang, Lin Nong, Wei Wang, Yinmo Yang
2018 OncoTargets and Therapy  
Contrast-enhanced computed tomography (CT) showed a retroperitoneal mass with involvement of pancreas and duodenum and formation of splenic venous tumor thrombus.  ...  The patient was able to tolerate oral intake after two cycles of chemotherapy and showed no sign of lymphoma by positron emission tomography (PET)-CT after the fourth cycle of chemotherapy.  ...  Acknowledgment This study was supported in part by grants from the National Natural Science Foundation of China (nos. 81372605, 81672353, and 81572339).  ... 
doi:10.2147/ott.s183298 pmid:30588013 pmcid:PMC6296199 fatcat:dlx6o3jfsjh3hprf7aw7lkjeba

Predictive Modeling for Voxel-Based Quantification of Imaging-Based Subtypes of Pancreatic Ductal Adenocarcinoma (PDAC): A Multi-Institutional Study

Mohamed Zaid, Lauren Widmann, Annie Dai, Kevin Sun, Jie Zhang, Jun Zhao, Mark W. Hurd, Gauri R. Varadhachary, Robert A. Wolff, Anirban Maitra, Matthew H. G. Katz, Joseph M. Herman (+6 others)
2020 Cancers  
Previously, we characterized qualitative imaging-based subtypes of pancreatic ductal adenocarcinoma (PDAC) on computed tomography (CT) scans.  ...  Analyses revealed that PDAC quantitative enhancement values are predictive of the qualitative delta scoring and were used to build a classification model (q-delta).  ...  Acknowledgments: Data used in this publication were generated by the National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC).  ... 
doi:10.3390/cancers12123656 pmid:33291471 fatcat:i3jqgrqlirhvdp2ekcbes4ouxe

A family with hydrocephalus as a complication of cerebellar hemangioblastoma: identification of Pro157Leu mutation in the VHL gene

K. Fukino, A. Teramoto, K. Adachi, H. Takahashi, M. Emi
2000 Journal of Human Genetics  
Direct sequencing and restriction fragment length polymorphism analysis identified a germline missense mutation, Proline-to-Leucine, caused by a C-to-T transition at the second nucleotide of codon 157.  ...  Acknowledgements Supported by special Grants-in-Aid for Cancer Research and "Genome Science" from the Ministry of Education, Science, and Culture of Japan; and by a Research Grant for Cancer Research from  ...  At the time of the third surgery she was suffering visual loss caused by retinal angiomas of the left eye, and an abdominal CT scan revealed that she also had a cystic lesion in the pancreas.  ... 
doi:10.1007/s100380050009 pmid:10697963 fatcat:66ocqgkjrvgnliognc7anqsrsm

Front Matter: Volume 11596

Bennett A. Landman, Ivana Išgum
2021 Medical Imaging 2021: Image Processing  
Papers were selected and subject to review by the editors and conference program committee. Some conference presentations may not be available for publication.  ...  and partial volume correction for percutaneous ablation [11596-39] 11596 1B Automatic pancreas segmentation in abdominal CT image with contrast enhancement block [11596-40] 11596 1C Automation  ...  11596 0G A pairwise approach for fMRI group studies using the BrainSync transform [11596-9] 11596 0H Association and prediction of phenotypic traits from neuroimaging data using a multi- component  ... 
doi:10.1117/12.2595437 fatcat:7x4u3yicqvev5n3gmo54gqr2am
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