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Painful Issues in Pain Prediction

Li Hu, Gian Domenico Iannetti
2016 Trends in Neurosciences  
Trends Predicting perceived pain from brain activity has enormous implications: "pain signatures" from brain imaging data are increasingly used as evidence for pain perception in minimally conscious patients  ...  of human brain activity distinguish painful from non-painful thermal 24 stimulation.  ... 
doi:10.1016/j.tins.2016.01.004 pmid:26898163 fatcat:p5pmj2a2zbcblkcn37m2kkorzm

Baseline brain activity fluctuations predict somatosensory perception in humans

M. Boly, E. Balteau, C. Schnakers, C. Degueldre, G. Moonen, A. Luxen, C. Phillips, P. Peigneux, P. Maquet, S. Laureys
2007 Proceedings of the National Academy of Sciences of the United States of America  
brain activity.  ...  We performed two distinct analyses by using a voxel-by-voxel statistical approach. A first analysis identified differences in brain activity in response to perceived-vs.  ...  A standard head coil was used in the data acquisition.  ... 
doi:10.1073/pnas.0611404104 pmid:17616583 pmcid:PMC1924544 fatcat:pxr54khd3bhjlnu46vdz7qi7di

A Dual-Brain Approach for Understanding the Neural Mechanisms that Underlie the Comforting Effects of Social Touch

Adi Korisky, Naomi I. Eisenberger, Michael Nevat, Irit Weissman-Fogel, Simone G. Shamay-Tsoory
2020 Cortex  
Here we adopt a dual-brain approach with fMRI to examine whether social touch involves similar activations between the suffering 'target' and the empathizer in brain regions related to emotional sharing  ...  The brain-to-brain analysis further revealed a positive correlation of IPL activation levels between the target and the empathizer.  ...  The authors thank Amitay Ron and Bar Izkovich for assisting in running the study, Daniela Cohen, Naama Mayseless and Lee Bareket-Kisler for assisting in data analysis and Nir Adi who created the illustrations  ... 
doi:10.1016/j.cortex.2020.01.028 pmid:32259669 fatcat:e4pjlwxhxfcczkc6fvxis3akvy

Linking Neural Activity to Mental Processes

Shihui Han, Fang Fang
2008 Brain Imaging and Behavior  
Researchers have developed sophisticated methods of experimental design and data analysis in order to link observed neural activity to mental processes.  ...  Brain imaging research has developed for more than two decades and has enriched our knowledge about human brain functions.  ...  Conclusion The purpose of functional neuroimaging studies is to link neural activities to specific cognitive processes in the human brain and to employ certain patterns of neural activity to predict human  ... 
doi:10.1007/s11682-008-9030-7 fatcat:aukt3e4hvrdyrngri6hc3jhmj4

Importance of the Habenula for Avoidance Learning Including Contextual Cues in the Human Brain: A Preliminary fMRI Study

Atsuo Yoshino, Yasumasa Okamoto, Yuki Sumiya, Go Okada, Masahiro Takamura, Naho Ichikawa, Takashi Nakano, Chiyo Shibasaki, Hidenori Aizawa, Yosuke Yamawaki, Kyoko Kawakami, Satoshi Yokoyama (+2 others)
2020 Frontiers in Human Neuroscience  
Human habenula studies are gradually advancing, primarily through the use of functional magnetic resonance imaging (fMRI) analysis of passive (Pavlovian) conditioning tasks as well as probabilistic reinforcement  ...  The left and right habenula were activated during aversive outcomes and the activation was associated with aversive prediction errors.  ...  We also wish to thank all the staff and therapists in the Department of Psychiatry at Hiroshima University Hospital.  ... 
doi:10.3389/fnhum.2020.00165 pmid:32477084 pmcid:PMC7235292 fatcat:zftjg6lyujda7cmfptcdewfdmy

Dissociable Learning Processes Underlie Human Pain Conditioning

Suyi Zhang, Hiroaki Mano, Gowrishankar Ganesh, Trevor Robbins, Ben Seymour
2016 Current Biology  
We thank the imaging team at the Center for Information and Neural Networks for their assistance in performing the study.  ...  learning signals to probe brain activity [7, 8, 33] .  ...  We recorded activity in the 1-s CS-US interval and compared it to pre-CS baseline activity.  ... 
doi:10.1016/j.cub.2015.10.066 pmid:26711494 pmcid:PMC4712170 fatcat:mkp6z33znvhchiq7iufjvvdhay

Decoding an Individual's Sensitivity to Pain from the Multivariate Analysis of EEG Data

E. Schulz, A. Zherdin, L. Tiemann, C. Plant, M. Ploner
2011 Cerebral Cortex  
We repeatedly applied identical painful stimuli to healthy human subjects and recorded brain activity by using electroencephalography (EEG).  ...  Here, we aimed to predict the individual pain sensitivity from brain activity.  ...  To this end, an MVPA technique was trained on the single-trial EEG data of healthy human subjects to investigate whether it is possible to predict another individual's pain sensitivity from brain activity  ... 
doi:10.1093/cercor/bhr186 pmid:21765182 fatcat:ejrmwjeq3vc3bfhagdwvta2qmu

Consciousness and cerebral baseline activity fluctuations

Melanie Boly, Christophe Phillips, Evelyne Balteau, Caroline Schnakers, Christian Degueldre, Gustave Moonen, Andre Luxen, Philippe Peigneux, Marie-Elisabeth Faymonville, Pierre Maquet, Steven Laureys
2008 Human Brain Mapping  
We here review evidence that baseline brain activity in the areas involved in sensory perception predict subsequent variations in sensory awareness.  ...  We place these findings in light of recent findings on the architecture of spontaneous BOLD fluctuations in the awake human brain, and discuss the possible origins of the observed baseline brain activity  ...  In parallel, recent functional magnetic resonance imaging (fMRI) studies have identified spontaneous fluctuations in neural activity in the resting human brain. Slow blood oxy- Figure 1.  ... 
doi:10.1002/hbm.20602 pmid:18465800 fatcat:mcwwwwkzabe3dpbvwqkngyjgfi

Brain Signature Predicts Negative Emotion in Individuals

Janelle Weaver
2015 PLoS Biology  
But there has been a pressing need to identify neural signatures that predict emotional experiences in individuals in order to translate brain-imaging data into clinical applications.  ...  The researchers then used machine-learning algorithms to find global patterns of brain activity that best predicted participants' ratings.  ...  Comparison of the two signatures revealed that the experiences of negative emotion and pain are predicted by distinct patterns of neural activity.  ... 
doi:10.1371/journal.pbio.1002179 pmid:26098828 pmcid:PMC4476724 fatcat:lnvgyfnca5aghiymix4cxshdri

Page 4102 of The Journal of Neuroscience Vol. 14, Issue 7 [page]

1994 The Journal of Neuroscience  
Our findings of SI activation during painful stimulation were less predictable. Early human lesion and stimulation data had suggested a minimal role of SI cortex in pain processing.  ...  4102 Coghill et al. » Processing of Pain and Vibration by the Human Brain Figure 6. (34°C) control, whereas our previous study and that of Jones et al. (1991) used a warm (41-42°C) control; thus, the present  ... 

Maturation of Pain Empathy from Child to Adult Shifts from Single to Multiple Neural Rhythms to Support Interoceptive Representations

Jonathan Levy, Abraham Goldstein, Maayan Pratt, Ruth Feldman
2018 Scientific Reports  
of updating sensory predictions and activating affective empathy in viceromotor cortex via higher-level representations involving beta-and gamma-band activity.  ...  Using magnetoencephalography, we monitored the brain response of children, adolescents, and adults (n = 209) to others' pain, testing the shift from childhood to adult functioning.  ...  We would like to particularly thank Galit Schneider and Shahar Aberbach for invaluable help in MEG acquisition. We would also like to thank Yuval Harpaz for technical support.  ... 
doi:10.1038/s41598-018-19810-3 pmid:29379042 pmcid:PMC5788915 fatcat:ea2seci2tngqtfpej2emc4bfti

Identifying biological markers of activity in human nociceptive pathways to facilitate analgesic drug development

Boris A. Chizh, Joel D. Greenspan, Kenneth L. Casey, Michael I. Nemenov, Rolf-Detlef Treede
2008 Pain  
Acknowledgments We are grateful to the participants of the workshop 'Sensory Evaluation for Pain and Analgesia Research', St.  ...  Boris Chizh is an employee of GlaxoSmithKline, and the compound described in Ref. [10] , SB-705498, is GSK's development compound.  ...  humans the pharmacology predicted from preclinical data.  ... 
doi:10.1016/j.pain.2008.09.024 pmid:18950938 pmcid:PMC4711771 fatcat:c5nib5juhfhrfdqympyynuhdhm

Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children

Laurens F M Verscheijden, Carlijn H C Litjens, Jan B Koenderink, Ron H J Mathijssen, Marcel M Verbeek, Saskia N de Wildt, Frans G M Russel
2021 PLoS Computational Biology  
Incorporation of active Pgp-mediated BBB transport into the PB-PK/PD model resulted in a 1.3-fold reduced brain exposure in adults, indicating only a modest contribution on brain disposition.  ...  In summary, an age-appropriate morphine PB-PK/PD model was developed for the prediction of brain pharmacokinetics and analgesic effects.  ...  Fraction of unbound morphine in brain was derived from primate data because of the good correlation with human data [78, 84] .  ... 
doi:10.1371/journal.pcbi.1008786 pmid:33661919 pmcid:PMC7963108 fatcat:isugkfwphfecflzuevlnzter7q

Studying the Brain-Gut Axis with Pharmacological Imaging

Kirsten Tillisch, Zhuo Wang, Lisa Kilpatrick, Daniel P. Holschneider, Emeran A. Mayer
2008 Annals of the New York Academy of Sciences  
This chapter reviews the state of the art in pharmacological imaging studies, both in human subjects and in animal models of brain-gut interactions.  ...  By combining evaluation of symptoms, behavior, and brain responses to relevant stimuli, use of neuroimaging is able to move the study of brain-gut disorders away from more subjective outcomes and emphasize  ...  Early work suggests that imaging may be a useful tool for preclinical evaluation of candidate drugs, 41, 49 the results of which may predict similar changes in humans.  ... 
doi:10.1196/annals.1418.025 pmid:19076383 pmcid:PMC3817712 fatcat:bloa2xk6ynakllrlw7jq7n73f4

Common brain activations for painful and non-painful aversive stimuli

Dave J Hayes, Georg Northoff
2012 BMC Neuroscience  
To help clarify this issue, this report used a cross-species translational approach in humans (i.e. meta-analysis) and rodents (i.e. systematic review of functional neuroanatomy).  ...  Results: Animal and human data combined to show a core aversion-related network, consisting of similar cortical (i.e.  ...  In addition, we would like to thank Niall W. Duncan, Aaron Kucyi, and the reviewers for their critical reading of the manuscript. G.  ... 
doi:10.1186/1471-2202-13-60 pmid:22676259 pmcid:PMC3464596 fatcat:vlgld7kyzfawnko3nr753bf4k4
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