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In-vitro AND In-silico CORRELATION STUDIES OF NATURAL AChE INHIBITORS: AN APPROACH TOWARDS ALZHEIMER'S DISEASE

Vasudev Pai, K. S. Chandrashekar, Aravind Pai, Anuraag Muralidharan, M. Manjunath Setty
2021 RASAYAN Journal of Chemistry  
Pengas, K. Dawson, L.A. Brown and P. Clatworthy, British Medical Journal, 338, b2023(2009), https://doi.org/10.1136/bmj.b2030 3. J.E. Graham, K. Rockwood, B.L. Beattie, R. Eastwood, S.  ...  Manjunath Setty1,  1 Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104  ... 
doi:10.31788/rjc.2021.1456602 fatcat:y74776yjv5an3eu36w4y3jz2pa

Unicystic ameloblastoma of the mandible - an unusual case report and review of literature

Rakesh S Ramesh, Suraj Manjunath, Tanveer H Ustad, Saira Pais, K Shivakumar
2010 Head & Neck Oncology  
Ameloblastoma is a true neoplasm of odontogenic epithelial origin. It is the second most common odontogenic neoplasm, and only odontoma outnumbers it in reported frequency of occurrence. Its incidence, combined with its clinical behavior, makes ameloblastoma the most significant odontogenic neoplasm. Unicystic ameloblastoma (UA) refers to those cystic lesions that show clinical, radiographic, or gross features of a mandibular cyst, but on histologic examination show a typical ameloblastomatous
more » ... pithelium lining part of the cyst cavity, with or without luminal and/or mural tumor growth. It accounts for 5-15% of all intraosseous ameloblastomas. We report a case of unicystic ameloblastoma in a 30-year-old female, and review the literature.
doi:10.1186/1758-3284-2-1 pmid:20157425 pmcid:PMC2821325 fatcat:zdvwgzd5brc7bmgfqzti6w3j7u

In-vitro AND In-silico STUDIES OF AYURVEDIC MEDICINAL PLANTS PIPALI AND JYOTISHMATI FOR AChE INHIBITION: APPROACH FOR TREATMENT OF MEMORY DISORDER

Vasudev Pai, M. Manjunath Setty, Aravind Pai, Anuraag Muralidharan, K. S. Chandrashekar
2022 RASAYAN Journal of Chemistry  
Alzheimer's is the typical type of dementia that affects Senior people and is an irrevocable, progressive neurodegenerative disorder. The characteristic symptoms are loss of memory, behavioral disturbances, mood and personality swing, followed by diminished cognitive performance. There is no permanent remedy for AD and the existing drugs in the treatment of disease have minimal effectiveness. Medicinal plants used Ayurveda have been found more productive source for lead development of drugs,
more » ... many advanced herbal products are being evaluated are in the developmental stage in a clinical trial. In fact, several studies have reported the use of various Ayurvedic medicinal plant extracts and their most active chemical constituents for the management of Alzheimer's disease. Although the accurate molecular mechanism is unknown. Pipali and Jyotishmati are extensively used in Ayurveda for various diseases and for the enhancement of memory. An attempt has been made in the current study to acknowledge the activity of extracts of Piper longum and Celastrus paniculatus, and marker compounds like Piperine on acetylcholinesterase inhibition by in-vitro and Rivastigmin as standard. In-silico AChE inhibition studies were carried out on various active constituents like Piperine, Paniculatine, Malkanguinine and Donepezil as standard. Both the enhanced extracts and the standard marker have promising AChE inhibitory action, indicating that they could be used to treat memory problems.
doi:10.31788/rjc.2022.1516746 fatcat:6goyb5bpujdw5gvmyqcakcgxxy

Breast cancer presenting as parotid tumour — first reported case in literature

Rakesh S. Ramesh, Suraj Manjunath, Tanveer Hussain Ustad, Saira Pais, K. Shivakumar
2010 Indian Journal of Surgical Oncology  
Breast cancer presenting as parotid tumour is very rare. This is the first reported case in which parotid tumour was the presenting complaint of the patient. Since the patient was estrogen and progesterone receptor positivewas put on hormone therapy and responded well.
doi:10.1007/s13193-010-0015-9 pmid:22930622 pmcid:PMC3420998 fatcat:4nc7n3mozbhw3guyny7z76fjki

Exploration of antioxidant and antimicrobial potential of methanolic extract of root stock of Premna herbacea

Isha Dhamija, Nitesh Kumar, K.S.R. Pai, M. Manjunath Setty, Sandeep Kumar, Asim K. Jana
2014 Bangladesh Journal of Pharmacology  
doi:10.3329/bjp.v9i4.21165 fatcat:hnahhfmsqffd3pmn5rvgkfl62a

Modified Active Surveillance System (MASS); a novel clinicopathological evaluation of PB leprosy patients after RFT, in Mangalore, India

R. MANJUNATH, K. NARENDRA KAMATH, GANESH S. PAI, JEROME PINTO, VIMALA VINOD
2001 Leprosy Review  
The current recommendations for leprosy control programmes inc1ude stopping active surveillance in view of the very 10w relapse rates and a phased integration of leprosy services with the general health services. Passive surveillance may not be adequate, more so because of the introduction of newer, shorter drug regimens. This study is an effort to evolve a modified active surveillance, which is cost-effective, simple and also a novel substitute for the increased workload caused by the
more » ... number of PMWS. One thousand one hundred RFT-PB leprosy patients were recalled for a review under the Modified Active Surveillance System (MASS), carried out over two phases. Patients were divided into groups as per the mode of response to the mailed postcards; Responders (patients who reported to the OPD in person), Untraceables (patients whose postcards returned back) and non responders (patients who did not report to the OPD after receiving the mail). At the end of phase I, we had 120 Responders, 480 Untraceables and 500 Non-responders. ln phase II, which began 2 months later, the 500 non-responders were dispatched rerninders. ln this phase, there were 31 responders, 60 untraceables and 409 non responders. Thus, at the completion of phases I and II, there were 151 responders, 540 untraceables and 409 non-responders. Of the 151 patients examined, 71 had no complaints (category 1), 41 had fresh leprosy-related complaints (category lIA), 14 had fresh leprosy-unrelated complaints (category IIB) and 25 had persistence of old complaints (category III). Cumulative PYR of the 151 patients was 1155-42. Forty one patients had fresh leprosy-related complaints. Skin biopsy was done in the 17 patients with fresh skin patches, of whom four showed histopathological evidence of relapse. Relapse rate in our study was 0·35/100 PYR. Mean duration after RFT at relapse was 4·9 years. Our scepticism towards passive surveillance systems is justified by these 41 patients with fresh leprosy-related complaints, who voluntarily reported only after receiving the postcards. We recommend the introduction of a phase III, wherein the services of PMW s may be used to contact the 409 patients who remained unresponsive at the completion of phases I and II. We also recommend the introduction of a universal format for recording addresses of all new patients,
doi:10.5935/0305-7518.20010008 fatcat:iqbju3cawjhxvedzcnekyqtxse

Validation of intraosseous delivery of valproic acid in a swine model of polytrauma

Ben E Biesterveld, Rachel O'Connell, Michael T Kemp, Glenn K Wakam, Aaron M Williams, Manjunath P Pai, Hasan B Alam
2021 Trauma Surgery & Acute Care Open  
BackgroundIntraosseous (IO) drug delivery may be necessary in emergency situations when intravenous access is unattainable. Valproic acid (VPA) is a histone deacetylase inhibitor that has previously been shown to improve survival in preclinical models of lethal polytrauma. In this study, we sought to compare serum levels of intravenously and IO-delivered VPA, and to analyze the effect of IO-delivered VPA.MethodsSwine were subjected to 40% blood volume hemorrhage, brain injury, femur fracture,
more » ... ctus crush injury and liver laceration. After 1 hour of shock, animals were randomized (n=3/group) to receive normal saline resuscitation (control), normal saline+intravenous VPA 150 mg/kg (intravenous group) or normal saline +IO VPA 150 mg/kg (IO group). Serum levels of VPA were assessed between groups, and proteomics analyses were performed on IO and control groups on heart, lung and liver samples.ResultsIntravenous and IO serum VPA levels were similar at 1, 3, 5 and 7 hours after starting the infusion (p>0.05). IO-delivered VPA induced significant proteomics changes in the heart, lung and liver, which were most pronounced in the lung. Biologic processes affected included inflammation, metabolism and transcriptional & translational machinery. The control group had 0% survival, and the intravenous and IO group both had 100% survival to the end of the experiment (p<0.05).DiscussionIO-delivered VPA is noninferior to intravenous administration and is a viable option in emergent situations when intravenous access is unattainable.Level of evidenceNot applicable (animal study).
doi:10.1136/tsaco-2021-000683 pmid:33791436 pmcid:PMC7978107 fatcat:ufdowez6lrghhlrwbryd23iewi

IN VITRO ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF AQUEOUS AND ETHANOLIC LEAF EXTRACTS OF ACACIA AURICULIFORMIS

Amita Shobha Rao, Shobha Kl, Manjunath S Shetty, Sreedhara R Pai K
2018 Asian Journal of Pharmaceutical and Clinical Research  
Ethanolic extract of A. auriculiformis exhibited antibacterial activity against all the strains including MDR strains of K. pneumoniae and E. coli.  ...  Antifungal activity was exhibited by both aqueous and ethanol leaf extracts of A. auriculiformis.Conclusion: Ethanol extract could be used against MDR K. pneumoniae and MDR E. coli.  ...  It is now the requirement of developing the alternative drug line to treat infectious diseases caused by MDR organisms such as Staphylococcus aureus, K. pneumoniae, and E. coli.  ... 
doi:10.22159/ajpcr.2018.v11i12.28853 fatcat:6w5hxugjr5dcvglkl3brsne3bm

Assessment of the in vitro cytotoxicity and in vivo anti-tumor activity of the alcoholic stem bark extract/fractions of Mimusops elengi Linn

Harish Kumar, Mihir Savaliya, Subhankar Biswas, Pawan G. Nayak, Naseer Maliyakkal, M. Manjunath Setty, Karthik Gourishetti, K. Sreedhara Ranganath Pai
2015 Cytotechnology (Dordrecht)  
Various parts of Mimusops elengi Linn. (Sapotaceae) have been used widely in traditional Indian medicine for the treatment of pain, inflammation and wounds. The study was conducted to explore the use of stem bark of M. elengi on pharmacological grounds and to evaluate the scientific basis of cytotoxic and anti-tumor activity. Extract/fractions were prepared and in vitro cytotoxicity was assessed using SRB assay. Most effective fractions were subjected to fluorescence microscopy based acridine
more » ... ange/ethidium bromide (AO/EB) and Hoechst 33342 staining to determine apoptosis induction and DNA fragmentation assay. Comet and micronuclei assay were performed to assess genotoxicity. Cell cycle analysis was also performed. In vivo anti-tumor potential was evaluated by Ehrlich ascites carcinoma (EAC) model in mice. The alcoholic stem bark extract of M. elengi along with four fractions showed potential in vitro cytotoxicity in SRB assay. Of these, dichloromethane and ethyl acetate fractions were selected for further studies. The fractions revealed apoptosis inducing potential in AO/EB and Hoechst 33342 staining, which was further confirmed by DNA fragmentation assay. Genotoxic potential was revealed by comet and micronuclei assay. Fractions also exhibited specific cell cycle inhibition in G 0 /G 1 phase. In EAC model, ethyl acetate fraction along with the standard (cisplatin) effectively reduced the increase in body weight compared to control and improved mean survival time. Both fractions were able to restore the altered hematological and biochemical parameters. Hence, M. elengi stem bark may be a possible therapeutic candidate having cytotoxic and anti-tumor potential.
doi:10.1007/s10616-014-9839-4 pmid:25701190 pmcid:PMC4960137 fatcat:ouygtg625jglvj74727qqijm3q

Everolimus improves the efficacy of dasatinib in the treatment of PDGFRA-driven glioma [article]

Zachary Miklja, Vivek Nand Yadav, Rodrigo Cartaxo, Ruby Siada, Brendan Mullan, Stefanie Stallard, Alyssa Paul, Amy K. Bruzek, Kyle Wierzbicki, Tao Yang, Taylor Garcia, Ian Wolfe (+12 others)
2020 medRxiv   pre-print
Stallard S, Savelieff MG, Wierzbicki K, et al. CSF H3F3A K27M circulating tumor DNA copy number quantifies tumor growth and in vitro treatment response. Acta 2015;17(7):992-998.  ... 
doi:10.1101/2019.12.28.19015974 fatcat:2ojdgazxx5hqlhtr6dpla5vxfy

Page 2 of Pharmacotherapy Vol. 24, Issue 5 [page]

2004 Pharmacotherapy  
Pharmacy Education: Beyond the Basics Manjunath P. Pai, Pharm.D. Acetaminophen Intoxication and Length of Treatment: How Long Is Long Enough?—A Comment Simone E. Taylor, Pharm.D.  ...  Effect of Age on International Normalized Ratio at the Time of Major Bleeding in Patients Treated with Warfarin Ann K. Wittkowsky, Pharm.D., Kelly S.  ... 

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2018 2018 2nd International Conference on Trends in Electronics and Informatics (ICOEI)  
K. A.  ...  Amogh Santosh Pai Raiturkar, Prof. Ms. Sonia Fernandes, Prof. Mrs. Anusha Pai 157 31 Wearable smart health monitoring system for animals Prathamesh Khatate, Anagha Savkar, Dr.C.Y.  ... 
doi:10.1109/icoei.2018.8553968 fatcat:uqolpdol2fbybbzydezrx2gxpa

Table of Contents

2021 2021 IEEE International Conference on Computation System and Information Technology for Sustainable Solutions (CSITSS)  
CSITSS-2021-047 Guru Prasad and Nagaraj G Cholli. 109-116 DRUNKENESS FACE DETECTION USING GNN Vighnesh Kamath, Sagar Pai, Shwetha Poojary, Ananth 22.  ...  CSITSS-2021-107 Computer 282-286 2021-108 DDoS Attack Detection and Mitigation using Anomaly Detection and Machine Learning Models Sakshi Vattikuti, Manjunath R Hedge, Manish M, Vineeth Bodduvaram and  ... 
doi:10.1109/csitss54238.2021.9683345 fatcat:7fv4augs7zhurocf6euogwcmty

Table of Contents

2021 IEEE Communications Magazine  
Millefiori, Stefano Marano, Peter K. Willett, and Krishna R.  ...  IEEE COMMUNICATIONS MAGAZINE SEPTEMBER 2021, vol. 59, no. 9 www.comsoc.org/commag Pai Chet Ng, Petros Spachos, Stefano Gregori, and Konstantinos N.  ... 
doi:10.1109/mcom.2021.9566519 fatcat:ni7s54mxerfdhlugovii7jf6fi

POTENCIAL SIMBIOTICO Y EFECTIVIDAD DE HONGOS MICORRIZO ARBUSCULARES DE TRES SUELOS SOMETIDOS A DIFERENTES USOS MYCORRHIZAL SYMBIOTIC POTENTIAL AND EFFECTIVENESS OF THREE SOILS UNDER DIFFERENT USES

Sandra Patricia Jaramillo Padilla, Jhon Mauricio Silva Benjumea, Nelson Walter Osorio Vega
2004 Revista Facultad Nacional de Agronomía  
A pesar de la sencillez y utilidad de la técnica del pinulo este método, no ha sido empleado en los estudios de la asociación micorrizal en el país.  ...  En este trabajo tales síntomas fueron similares a los reportados por Habte y Manjunath (1987) y Smith et al. (1992) .  ... 
doaj:ede096f7f480428b81c90bdf823849f7 fatcat:eok3662oebh65fhmuqxly32o4m
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