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On the selection of appropriate distances for gene expression data clustering

Pablo A Jaskowiak, Ricardo JGB Campello, Ivan G Costa
2014 BMC Bioinformatics  
Given different settings of microarray experiments, clustering proves itself as a versatile exploratory tool.  ...  It can help to unveil new cancer subtypes or to identify groups of genes that respond similarly to a specific experimental condition.  ...  BMC Bioinformatics 2014, 15(Suppl 2):S2 http://www.biomedcentral.com/1471-2105/15/S2/S2 Page 7 of 17 Jaskowiak et al.  ... 
doi:10.1186/1471-2105-15-s2-s2 pmid:24564555 pmcid:PMC4072854 fatcat:2fgtl2rqunertlqeyzqj4kgpza

Density-Based Clustering Validation [chapter]

Davoud Moulavi, Pablo A. Jaskowiak, Ricardo J. G. B. Campello, Arthur Zimek, Jörg Sander
2014 Proceedings of the 2014 SIAM International Conference on Data Mining  
In this paper we propose a relative validation index for density-based, arbitrarily shaped clusters.  ...  A number of different relative validity criteria have been proposed for the validation of globular, clusters. Not all data, however, are composed of globular clusters.  ...  in a cluster in a way that closer objects have a greater contribution to the density than farther objects.  ... 
doi:10.1137/1.9781611973440.96 dblp:conf/sdm/MoulaviJCZS14 fatcat:5aqklhk7endhngetidubg6vh3q

Impact of missing data imputation methods on gene expression clustering and classification

Marcilio CP de Souto, Pablo A Jaskowiak, Ivan G Costa
2015 BMC Bioinformatics  
Our results suggest that the imputation methods evaluated have a minor impact on the classification and downstream clustering analyses.  ...  In the past few years, researchers have been putting a great deal of effort into presenting systematic evaluations of the different imputation algorithms.  ...  Such a method has a computational complexity of O(npk). • BPCA combines a principal component regression with a Bayesian expectation maximization method to estimate the missing values [12] .  ... 
doi:10.1186/s12859-015-0494-3 pmid:25888091 pmcid:PMC4350881 fatcat:kkuokzdsc5antoof67qpzbbzyq

The Area Under the ROC Curve as a Measure of Clustering Quality [article]

Pablo Andretta Jaskowiak, Ivan Gesteira Costa, Ricardo José Gabrielli Barreto Campello
2021 arXiv   pre-print
solution from a broader, qualitative perspective as well.  ...  We show that the AUCC of a given candidate clustering solution has an expected value under a null model of random clustering solutions, regardless of the size of the dataset and, more importantly, regardless  ...  The Area Under the ROC Curve as a Measure of Clustering Quality Pablo A. Jaskowiak1,∗, Ivan G.  ... 
arXiv:2009.02400v2 fatcat:mzcqldfyunahfh6jcm45fcctca

Playing NES Tetris with No Piece Rotations

Adler A. L. Soster, Michael Birken, Pablo A. Jaskowiak
2021 Anais Estendidos do XX Simpósio Brasileiro de Games e Entretenimento Digital (SBGames Estendido 2021)   unpublished
In a recent work, M.  ...  A. Metrics We considered a total of 19 metrics in our investigation. Below we provide a brief description of each one.  ... 
doi:10.5753/sbgames_estendido.2021.19664 fatcat:p6hlmk5q5jbv7espdv35aunr3i

Comparação de Métodos de Deep Learning Pré-Treinados da Biblioteca OpenCV para Detecção de Pessoas em Ambientes Internos

Pablo Andretta Jaskowiak, Jesuino Vieira Filho
2020 Revista de Iniciação Científica  
A detecção precisa e rápida de pessoas pode vir a auxiliar futuramente, por exemplo, na estimação da carga térmica observada e consequente ajuste de sistemas de condicionamento de ar.  ...  Os métodos foram comparados quanto à sua precisão, revocação e tempo de detecção.  ...  Materiais e Métodos A seguir são discutidos os modelos comparados, a base de dados e critérios de avaliação.  ... 
doi:10.5753/reic.2020.1766 fatcat:rmzwy5paxzfkdleutaxgxes4w4

The Role of Structural Maintenance of Chromosomes Complexes in Meiosis and Genome Maintenance: Translating Biomedical and Model Plant Research Into Crop Breeding Opportunities

Pablo Bolaños-Villegas
2021 Frontiers in Plant Science  
In Arabidopsis and maize, the SMC1/SMC3 heterodimer is a key determinant of meiosis.  ...  Cohesin is a multi-unit protein complex from the structural maintenance of chromosomes (SMC) family, required for holding sister chromatids together during mitosis and meiosis.  ...  ACKNOWLEDGMENTS I would like to thank Vicerrectoría de Investigación at the University of Costa Rica for kind financial support and payment of publishing fees, Christopher A.  ... 
doi:10.3389/fpls.2021.659558 pmid:33868354 pmcid:PMC8044525 fatcat:tpq5osoglbbedlxldlifzmnb7a

ESICM LIVES 2016: part two

S. Sivakumar, F. S. Taccone, K. A. Desai, C. Lazaridis, M. Skarzynski, M. Sekhon, W. Henderson, D. Griesdale, L. Chapple, A. Deane, L. Williams, R. Strickland (+2488 others)
2016 Intensive Care Medicine Experimental  
A sample size of 370 was calculated based on a population of 10,000 physician members, a 5 % margin error, and 95 % confidence interval.  ...  A chi-square test was used to compare proportions of responses between NIs and OIs with a significance p < 0.05.  ...  Moral distress is the inability of a moral agent to act according to his or her core values and perceived obligations due to internal and external constraints.  ... 
doi:10.1186/s40635-016-0099-9 fatcat:rry7hn5zvrgp3o4ukdsslsmd3q

ESICM LIVES 2016: part one

L. Bos, L. Schouten, L. van Vught, M. Wiewel, D. Ong, O. Cremer, A. Artigas, I. Martin-Loeches, A. Hoogendijk, T. van der Poll, J. Horn, N. Juffermans (+2434 others)
2016 Intensive Care Medicine Experimental  
Mean time in the ED was 8.4 hours (±5.7), with a skewed distribution to the left.  ...  Methods We conducted a retrospective study of patients admitted from 2011 to 2015.  ...  a sensitivity of 74 % and a specificity of 90 %.  ... 
doi:10.1186/s40635-016-0098-x fatcat:5257rny3rfc7hpwmqijwjtsabu

Detection of active transcription factor binding sites with the combination of DNase hypersensitivity and histone modifications

Eduardo G. Gusmao, Christoph Dieterich, Martin Zenke, Ivan G. Costa
2014 Computer applications in the biosciences : CABIOS  
In a comparative analysis, our method obtained a good trade-off between sensitivity versus specificity and superior area under the curve statistics than competing methods.  ...  We have created a framework that includes treatment of genomic signals, model training and genome-wide application.  ...  ACKNOWLEDGEMENTS The authors would like to thank Pablo A.  ... 
doi:10.1093/bioinformatics/btu519 pmid:25086003 fatcat:4sz73jxnqvbovct22kg2laz4dm

Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice

Kerstin Abshagen, Matthias König, Andreas Hoppe, Isabell Müller, Matthias Ebert, Honglei Weng, Herrmann-Georg Holzhütter, Ulrich M. Zanger, Johannes Bode, Brigitte Vollmar, Maria Thomas, Steven Dooley
2015 BMC Systems Biology  
at identifying a set of parameters that could be used as robust biomarkers for transition of different disease progression phases.  ...  Interestingly, a small set of selected parameters can be used as diagnostic markers to predict disease stages in mice with cholestatic liver disease.  ...  The authors thank Pablo Jaskowiak for helpful discussions.  ... 
doi:10.1186/s12918-015-0229-0 pmid:26589287 pmcid:PMC4654904 fatcat:wm2lmbqpbbdvfidaa2b754rb4i

Comparative Study of Photovoltaic Power Forecasting Methods

Angelo Pelisson, Thiago Covoes, Anderson Spengler, Pablo Jaskowiak
2020 Anais do Encontro Nacional de Inteligência Artificial e Computacional (ENIAC 2020)   unpublished
Renewable energy resources, such as solar energy, play a crucial role in this scenario, contributing to satisfy demand sustainability.  ...  In this work we evaluate the performance of regression methods applied to forecast short term (next day) energy production of a PV Plant.  ...  Short term models aim to predict power output for a few hours ahead, up to seven days. Medium term models consider a broader horizon, ranging from a week to a month.  ... 
doi:10.5753/eniac.2020.12159 fatcat:rg4ttgzc3fbc3kn6ecokzmx7xm

Thursday posters

2005 Journal of the American Society for Mass Spectrometry  
Haddow; Darryl Hardie; Robert, W Olafson; UVic-Genome BC Proteomics Centre,, Victoria, BC, Canada ThP 400 111S ThP 445 Cornelia Koy 1 ; Juliane Heitner 2 ; Martin Resch 3 ; Michael Kreutzer 1 ; Pablo  ...  Services, Ringoes, NJ ThP 132 Simultaneous Determination of CKD-602 Lactone and Carboxylate Forms in Human Plasma using LC/MS/MS Technique; Yaodong Xu; Yongjin Yao; Ran Hu; Rebecca Davis; Jennifer Jaskowiak  ... 
doi:10.1016/j.jasms.2005.03.047 fatcat:nb63s2aa2rclrln5a3ej4we4my

Zoon Politikon Warszawa 2016 rocznik naukowy Zespół Redakcyjny Stanisław Mocek (redaktor naczelny) Barbara Markowska (zastępca redaktora naczelnego) Xymena Bukowska (sekretarz redakcji) Monika Nowicka (sekretariat redakcji) Redaktorzy tematyczni Redaktorzy prowadzący numeru Rada Naukowa

Katarzyna Iwińska, Rafał Krenz, Bohdan Skrzypczak, Jacek Bieliński, Marek Gawron, Łukasz Jurczyszyn, Paweł Kuczyński, Marek Rymsza, Kaja Gadowska, Ursula Van Beek, Hana Cervinkova, Szkoła Dolnośląska (+16 others)
unpublished
Jacek Jaśkowiak wygrał z Ryszardem Grobelnym. W Warszawie Miasto Jest Nasze zdobyło siedem miejsc w radach dzielnic i prawie 30 tysięcy głosów.  ...  populistów zagrożeniem są zarówno muzułmańscy uchodźcy "zapraszani przez liberalne elity", eurokraci wymuszający szkodliwe dla narodu "zaciskanie pasa", jak i wszędobylska "międzynarodowa finansjera" (Pablo  ...  Interesujące z punktu widzenia oceny jakości programowania było ustalenie zakresu spójności między rozpoznaniem istniejącego stanu a planowanymi działaniami.  ... 
fatcat:iv4twlatenav7l6sw5v33dnyge