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PUNCH: Population Characterization of Heterogeneity
2014
NeuroImage
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This study addresses this challenge by proposing a general method of identifying and quantifying the heterogeneity of any clinical population using a severity measure called the PUNCH (Population Characterization ...
population heterogeneity. ...
Acknowledgments This research was supported by grants from National Institutes of Health (NIMH 1RC1MH088791 to Robert T. ...
doi:10.1016/j.neuroimage.2014.04.068
pmid:24799135
pmcid:PMC4099279
fatcat:kymgh2qo5zd3phklggx65auage
Double-punching PMBL
2014
OncoTarget
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Knock-down of BCL6 / STAT6 sensitizes primary B cell lymphoma cells for treatment with current therapeutic agents. Oncoscience. 2014; 1:283-6 ...
This demonstration of an apparent intricate interplay between cells in a clonal population falls at first glance in line with several studies on intratumoral heterogeneity. ...
Notably, the distribution of these factors in clonal cell lines was heterogenous with a distribution of BCL6 and STAT6 to mutually exclusive subsets of cells [4] . ...
doi:10.18632/oncotarget.2827
pmid:25473898
pmcid:PMC4294352
fatcat:afh6qouwkbgsbdfihxscsvit7y
Identification of material parameters from punch stretch test
2013
Transactions of Nonferrous Metals Society of China
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To accurately describe the mechanical properties of aluminium alloy sheet during deformation, an inverse identification was presented to deal with material parameters from the popular punch stretch test ...
It provides a way to obtain the material parameters for FE simulations of sheet metal forming. ...
One main feature of the method, different from traditional GA, is that the population in one generation is divided into several sub-populations called 'islands', and all traditional genetic operations ...
doi:10.1016/s1003-6326(13)62614-x
fatcat:zvkvhgw7mfayxhdbmgtawaztem
Circular DNA: How Circular DNA Assists Cancer Roll with Therapeutic Punches
[chapter]
2022
Gene Expression [Working Title]
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This chapter will discuss the biogenesis and function of eccDNA and how it promotes tumor adaption under changing microtumour environmental conditions, as in the case of drugs. ...
The eccDNA has been found to promote tumor proliferation, survival, and aggressiveness in almost half of all cancers by increasing oncogene copy numbers. ...
This was done using a paired-end high sequencing technology that allowed the characterization of this form of DNA [46] . ...
doi:10.5772/intechopen.102687
fatcat:ewdhh7ouxnbjlbujow7ne6yqxu
Aircraft-Induced Hole Punch and Canal Clouds
2010
Bulletin of The American Meteorological Society - (BAMS)
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We wish to thank Jafvis for his original photographs of hole punch clouds, Jeff Schmaltz for preparing MODIS images, and the NASA Earth Observatory (http://earthobservatory.nasa.gov) for the use the original ...
The support of the NCAR Research Aviation Facility, especially Jorgen Jensen, Jeff Stith, Dave Rogers, Henry Boynton, Ed Ringleman, and Stuart Beaton, was indispensable. ...
More studies of specific aircraft are clearly warranted to characterize these conditions. ...
doi:10.1175/2009bams2905.1
fatcat:rjssp34hc5ftbltbfxvfm6o6ni
One-two punch injury to tolerance mechanisms in graft-versus-host disease
2020
Journal of Clinical Investigation
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Notably, GVHD caused irreversible damage to a population of tolerogenic stromal cells that display peripheral tissue-restricted antigens in lymph nodes, which impaired their capacity to purge and suppress ...
In this issue of the JCI, Dertschnig et al. used mouse models to investigate the basis of T cell autoreactivity following GVHD. ...
Address correspondence to: Ivan Maillard, 421 Curie Boulevard, BRB-2/3 Room 451, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ...
doi:10.1172/jci136139
pmid:32149731
fatcat:i2skntfmhfd2dkmuj5ykkignie
Acute Inflammation Loci Are Involved in Wound Healing in the Mouse Ear Punch Model
2014
Advances in Wound Care
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as these strains have heterogeneous backgrounds representing extreme phenotypes similar to those found in natural populations. ...
Convergent phenotypes in AIRmax mice were observed that were characterized by high neutrophil production in bone marrow, a high number of neutrophils in the blood, high concentrations of chemotactic agents ...
doi:10.1089/wound.2013.0494
pmid:25207201
pmcid:PMC4152789
fatcat:hli2eon7cbdepke3u6fruwhobu
HemITAM: A single tyrosine motif that packs a punch
2017
Science Signaling
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Innate lymphocytes are subdivided into natural killer (NK) cell and tissue-resident innate lymphoid cell (ILC) populations. ...
such as monocytes, DCs, and granulocytes, and a few NK cell clones, indicating a heterogeneous expression pattern. ...
doi:10.1126/scisignal.aan3676
pmid:29208681
fatcat:wx4arevnkbbnlmmiivmrc44tza
Characterizing brain metabolic function ex vivo with acute mouse slice punches
2021
STAR Protocols
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the dynamic role of energy metabolism in brain physiological function and diseases. ...
Mitochondrial dysfunction and metabolic reprogramming are implicated in a variety of neurological disorders. ...
ACKNOWLEDGMENTS This work was supported by the University of Arizona Center for Innovation in Brain Science startup fund to F.Y., NIH/NIA P01AG026572 to Roberta Diaz Brinton (Analytic Core to F.Y.), and ...
doi:10.1016/j.xpro.2021.100559
pmid:34095867
pmcid:PMC8144746
fatcat:rcpgiowajncihktwobakapmpyy
MR AND MRS PUNCH IN NINETEENTH-CENTURY ENGLAND
2006
The Historical Journal
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of changing definitions of femininity. 9 The characterization of Mr and Mrs Punch, however, presents an important contrast. ...
Urbanization and population growth challenged the utility of London's streets as entertainment venues. ...
an important contrast to Mr Punch. ...
doi:10.1017/s0018246x06005735
fatcat:d6fdolbvcvg6nh634dyqi2xoqe
Simultaneous DNA and RNA isolation from brain punches for epigenetics
2011
BMC Research Notes
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This raises a severe challenge when studying discrete, small regions of the brain where cellular heterogeneity is high and tissue quantity limited. ...
Findings: We present a refined method for the simultaneous extraction of DNA for bisulfite sequencing and RNA for expression analysis from small mouse brain tissue punches. ...
In addition, we characterized tissue specimens and cell quantities needed for this method. ...
doi:10.1186/1756-0500-4-314
pmid:21878091
pmcid:PMC3224583
fatcat:u3hsr6vemfbbna2tivtajnvieq
Comparative Accuracy of Anal and Cervical Cytology in Screening for Moderate to Severe Dysplasia by Magnification Guided Punch Biopsy: A Meta-Analysis
2011
PLoS ONE
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Heterogeneity of estimates within each screening setting suggests that other factors influence estimates of screening accuracy. ...
Random effects meta-analysis of eligible studies was performed with examination of sources of heterogeneity that included QUADAS criteria and selected covariates, in meta-regression models. ...
unavailability of comparable study populations for anal cytology studies). ...
doi:10.1371/journal.pone.0024946
pmid:21949801
pmcid:PMC3176293
fatcat:kqtfslahivdlxipn6kisza7oky
Intraepidermal Nerve Fiber Density as Measured by Skin Punch Biopsy as a Marker for Small Fiber Neuropathy: Application in Patients with Fibromyalgia
2021
Diagnostics
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A growing body of research has shown approximately 40–60% of patients carrying a diagnosis of FM have evidence of SFN on skin punch biopsy. ...
Skin punch biopsy may also be repeated for surveillance of the disease as well as measuring response to treatments. ...
Clinical procedure for skin punch biopsy for use in evaluation of IENFD. ...
doi:10.3390/diagnostics11030536
pmid:33802768
fatcat:56uhxq2fevh3bo43oyhnetok5m
Safety and Durability of RBX2660 (Microbiota Suspension) for RecurrentClostridium difficileInfection: Results of the PUNCH CD Study
2015
Clinical Infectious Diseases
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Of 188 reported AEs, diarrhea, flatulence, abdominal pain/cramping, and constipation were most common. The frequency and severity of AEs decreased over time. ...
Of the 40 patients enrolled at 11 centers in the United States between 15 August 2013 and 16 December 2013, 34 received at least 1 dose of RBX2660 and 31 completed 6-month follow-up. ...
All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. ...
doi:10.1093/cid/civ938
pmid:26565008
fatcat:duycgoi2enhovm52jccbgf64eq
A novel methodology for estimating tensile properties in a small punch test employing in-situ DIC based deflection mapping
2020
Journal of Nuclear Materials
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However, the deflection and strain accumulation in a small punch specimen is highly heterogeneous and data from a single point does not represent the gross deformation evolving in the specimen. ...
One of the crucial challenges in harnessing the full potential of this technique is formulating methodologies which correlate the small punch specimen's deflection to equivalent uniaxial tensile properties ...
Adel El-Turke, School of Physics, University of Bristol in carrying out the EBSD analysis is acknowledged. The first author is grateful for the comments and suggestions provided by Dr. ...
doi:10.1016/j.jnucmat.2020.152260
fatcat:ankzcrtsxfgqnbwyoduvhyqwn4
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