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PUNCH: Population Characterization of Heterogeneity

Birkan Tunc, Yasser Ghanbari, Alex R. Smith, Juhi Pandey, Aaron Browne, Robert T. Schultz, Ragini Verma
2014 NeuroImage  
This study addresses this challenge by proposing a general method of identifying and quantifying the heterogeneity of any clinical population using a severity measure called the PUNCH (Population Characterization  ...  population heterogeneity.  ...  Acknowledgments This research was supported by grants from National Institutes of Health (NIMH 1RC1MH088791 to Robert T.  ... 
doi:10.1016/j.neuroimage.2014.04.068 pmid:24799135 pmcid:PMC4099279 fatcat:kymgh2qo5zd3phklggx65auage

Double-punching PMBL

Jochen K. Lennerz
2014 OncoTarget  
Knock-down of BCL6 / STAT6 sensitizes primary B cell lymphoma cells for treatment with current therapeutic agents. Oncoscience. 2014; 1:283-6  ...  This demonstration of an apparent intricate interplay between cells in a clonal population falls at first glance in line with several studies on intratumoral heterogeneity.  ...  Notably, the distribution of these factors in clonal cell lines was heterogenous with a distribution of BCL6 and STAT6 to mutually exclusive subsets of cells [4] .  ... 
doi:10.18632/oncotarget.2827 pmid:25473898 pmcid:PMC4294352 fatcat:afh6qouwkbgsbdfihxscsvit7y

Identification of material parameters from punch stretch test

Xiao-qiang LI, De-hua HE
2013 Transactions of Nonferrous Metals Society of China  
To accurately describe the mechanical properties of aluminium alloy sheet during deformation, an inverse identification was presented to deal with material parameters from the popular punch stretch test  ...  It provides a way to obtain the material parameters for FE simulations of sheet metal forming.  ...  One main feature of the method, different from traditional GA, is that the population in one generation is divided into several sub-populations called 'islands', and all traditional genetic operations  ... 
doi:10.1016/s1003-6326(13)62614-x fatcat:zvkvhgw7mfayxhdbmgtawaztem

Circular DNA: How Circular DNA Assists Cancer Roll with Therapeutic Punches [chapter]

Parvaiz Yousuf
2022 Gene Expression [Working Title]  
This chapter will discuss the biogenesis and function of eccDNA and how it promotes tumor adaption under changing microtumour environmental conditions, as in the case of drugs.  ...  The eccDNA has been found to promote tumor proliferation, survival, and aggressiveness in almost half of all cancers by increasing oncogene copy numbers.  ...  This was done using a paired-end high sequencing technology that allowed the characterization of this form of DNA [46] .  ... 
doi:10.5772/intechopen.102687 fatcat:ewdhh7ouxnbjlbujow7ne6yqxu

Aircraft-Induced Hole Punch and Canal Clouds

Andrew J. Heymsfield, Patrick C. Kennedy, Steve Massie, Carl Schmitt, Zhien Wang, Samuel Haimov, Art Rangno
2010 Bulletin of The American Meteorological Society - (BAMS)  
We wish to thank Jafvis for his original photographs of hole punch clouds, Jeff Schmaltz for preparing MODIS images, and the NASA Earth Observatory ( for the use the original  ...  The support of the NCAR Research Aviation Facility, especially Jorgen Jensen, Jeff Stith, Dave Rogers, Henry Boynton, Ed Ringleman, and Stuart Beaton, was indispensable.  ...  More studies of specific aircraft are clearly warranted to characterize these conditions.  ... 
doi:10.1175/2009bams2905.1 fatcat:rjssp34hc5ftbltbfxvfm6o6ni

One-two punch injury to tolerance mechanisms in graft-versus-host disease

Léolène J. Carrington, Ivan Maillard
2020 Journal of Clinical Investigation  
Notably, GVHD caused irreversible damage to a population of tolerogenic stromal cells that display peripheral tissue-restricted antigens in lymph nodes, which impaired their capacity to purge and suppress  ...  In this issue of the JCI, Dertschnig et al. used mouse models to investigate the basis of T cell autoreactivity following GVHD.  ...  Address correspondence to: Ivan Maillard, 421 Curie Boulevard, BRB-2/3 Room 451, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.  ... 
doi:10.1172/jci136139 pmid:32149731 fatcat:i2skntfmhfd2dkmuj5ykkignie

Acute Inflammation Loci Are Involved in Wound Healing in the Mouse Ear Punch Model

Tatiane Canhamero, Ludmila Valino Garcia, Marcelo De Franco
2014 Advances in Wound Care  
as these strains have heterogeneous backgrounds representing extreme phenotypes similar to those found in natural populations.  ...  Convergent phenotypes in AIRmax mice were observed that were characterized by high neutrophil production in bone marrow, a high number of neutrophils in the blood, high concentrations of chemotactic agents  ... 
doi:10.1089/wound.2013.0494 pmid:25207201 pmcid:PMC4152789 fatcat:hli2eon7cbdepke3u6fruwhobu

HemITAM: A single tyrosine motif that packs a punch

Björn Bauer, Alexander Steinle
2017 Science Signaling  
Innate lymphocytes are subdivided into natural killer (NK) cell and tissue-resident innate lymphoid cell (ILC) populations.  ...  such as monocytes, DCs, and granulocytes, and a few NK cell clones, indicating a heterogeneous expression pattern.  ... 
doi:10.1126/scisignal.aan3676 pmid:29208681 fatcat:wx4arevnkbbnlmmiivmrc44tza

Characterizing brain metabolic function ex vivo with acute mouse slice punches

Guoyuan Qi, Yashi Mi, Fei Yin
2021 STAR Protocols  
the dynamic role of energy metabolism in brain physiological function and diseases.  ...  Mitochondrial dysfunction and metabolic reprogramming are implicated in a variety of neurological disorders.  ...  ACKNOWLEDGMENTS This work was supported by the University of Arizona Center for Innovation in Brain Science startup fund to F.Y., NIH/NIA P01AG026572 to Roberta Diaz Brinton (Analytic Core to F.Y.), and  ... 
doi:10.1016/j.xpro.2021.100559 pmid:34095867 pmcid:PMC8144746 fatcat:rcpgiowajncihktwobakapmpyy


2006 The Historical Journal  
of changing definitions of femininity. 9 The characterization of Mr and Mrs Punch, however, presents an important contrast.  ...  Urbanization and population growth challenged the utility of London's streets as entertainment venues.  ...  an important contrast to Mr Punch.  ... 
doi:10.1017/s0018246x06005735 fatcat:d6fdolbvcvg6nh634dyqi2xoqe

Simultaneous DNA and RNA isolation from brain punches for epigenetics

Marc Bettscheider, Chris Murgatroyd, Dietmar Spengler
2011 BMC Research Notes  
This raises a severe challenge when studying discrete, small regions of the brain where cellular heterogeneity is high and tissue quantity limited.  ...  Findings: We present a refined method for the simultaneous extraction of DNA for bisulfite sequencing and RNA for expression analysis from small mouse brain tissue punches.  ...  In addition, we characterized tissue specimens and cell quantities needed for this method.  ... 
doi:10.1186/1756-0500-4-314 pmid:21878091 pmcid:PMC3224583 fatcat:u3hsr6vemfbbna2tivtajnvieq

Comparative Accuracy of Anal and Cervical Cytology in Screening for Moderate to Severe Dysplasia by Magnification Guided Punch Biopsy: A Meta-Analysis

Wm. Christopher Mathews, Wollelaw Agmas, Edward Cachay, Julian Little
2011 PLoS ONE  
Heterogeneity of estimates within each screening setting suggests that other factors influence estimates of screening accuracy.  ...  Random effects meta-analysis of eligible studies was performed with examination of sources of heterogeneity that included QUADAS criteria and selected covariates, in meta-regression models.  ...  unavailability of comparable study populations for anal cytology studies).  ... 
doi:10.1371/journal.pone.0024946 pmid:21949801 pmcid:PMC3176293 fatcat:kqtfslahivdlxipn6kisza7oky

Intraepidermal Nerve Fiber Density as Measured by Skin Punch Biopsy as a Marker for Small Fiber Neuropathy: Application in Patients with Fibromyalgia

Mary A. Kelley, Kevin V. Hackshaw
2021 Diagnostics  
A growing body of research has shown approximately 40–60% of patients carrying a diagnosis of FM have evidence of SFN on skin punch biopsy.  ...  Skin punch biopsy may also be repeated for surveillance of the disease as well as measuring response to treatments.  ...  Clinical procedure for skin punch biopsy for use in evaluation of IENFD.  ... 
doi:10.3390/diagnostics11030536 pmid:33802768 fatcat:56uhxq2fevh3bo43oyhnetok5m

Safety and Durability of RBX2660 (Microbiota Suspension) for RecurrentClostridium difficileInfection: Results of the PUNCH CD Study

Robert Orenstein, Erik Dubberke, Robert Hardi, Arnab Ray, Kathleen Mullane, Darrell S. Pardi, Mayur S. Ramesh
2015 Clinical Infectious Diseases  
Of 188 reported AEs, diarrhea, flatulence, abdominal pain/cramping, and constipation were most common. The frequency and severity of AEs decreased over time.  ...  Of the 40 patients enrolled at 11 centers in the United States between 15 August 2013 and 16 December 2013, 34 received at least 1 dose of RBX2660 and 31 completed 6-month follow-up.  ...  All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.  ... 
doi:10.1093/cid/civ938 pmid:26565008 fatcat:duycgoi2enhovm52jccbgf64eq

A novel methodology for estimating tensile properties in a small punch test employing in-situ DIC based deflection mapping

V.D. Vijayanand, M. Mokhtarishirazabad, J. Peng, Y. Wang, M. Gorley, D.M. Knowles, M. Mostafavi
2020 Journal of Nuclear Materials  
However, the deflection and strain accumulation in a small punch specimen is highly heterogeneous and data from a single point does not represent the gross deformation evolving in the specimen.  ...  One of the crucial challenges in harnessing the full potential of this technique is formulating methodologies which correlate the small punch specimen's deflection to equivalent uniaxial tensile properties  ...  Adel El-Turke, School of Physics, University of Bristol in carrying out the EBSD analysis is acknowledged. The first author is grateful for the comments and suggestions provided by Dr.  ... 
doi:10.1016/j.jnucmat.2020.152260 fatcat:ankzcrtsxfgqnbwyoduvhyqwn4
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