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PSSV: a novel pattern-based probabilistic approach for somatic structural variation identification

Xi Chen, Xu Shi, Leena Hilakivi-Clarke, Ayesha N. Shajahan-Haq, Robert Clarke, Jianhua Xuan
2016 Bioinformatics  
Results: We present a novel pattern-based probabilistic approach, PSSV, to identify somatic structural variations from WGS data.  ...  Large-scale identification of somatic structural variations (SVs) for a specific cancer type will deepen our understanding of driver mechanisms in cancer progression.  ...  Discussion A pattern based probabilistic model (PSSV) has been developed for somatic SV prediction using paired tumor-normal WGS data.  ... 
doi:10.1093/bioinformatics/btw605 pmid:27659451 pmcid:PMC5254081 fatcat:pqehpwzvt5bczhe5h4ftf7x5ua