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Diabetic Retinopathy and Laser Therapy in Rats: A Protein-Protein Interaction Network Analysis

Akram Safaei, Mostafa Rezaei Tavirani, Mona Zamanian Azodi, Alireza Lashay, Seyed Farzad Mohammadi, Mohamad Ghasemi Broumand, Ali Asghar Peyvandi, Farshad Okhovatian, Hassan Peyvandi, Mohammad Rostami Nejad
<span title="2017-08-29">2017</span> <i title="International Society for Phytocosmetic Sciences"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/337b3b43vveefl3swfgyedivxi" style="color: black;">Journal of lasers in medical sciences</a> </i> &nbsp;
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes which can cause vision loss or blindness ultimately.  ...  The networks of related differentially expressed proteins were explored using Cytoscape version 3.3.0, the PPI analysis methods and ClueGO.  ...  Acknowledgments This research was supported by Shahid Beheshti University of Medical Sciences.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.15171/jlms.2017.s4">doi:10.15171/jlms.2017.s4</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29071030">pmid:29071030</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5642173/">pmcid:PMC5642173</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jnb22iio3bfv5aqrgnjwz5mgs4">fatcat:jnb22iio3bfv5aqrgnjwz5mgs4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180721144646/http://journals.sbmu.ac.ir/jlms/article/download/14386/4" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/06/8e/068e48991fa01561cb8e476739679b59e30adfbc.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.15171/jlms.2017.s4"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642173" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Hub Genes Associated with the Diagnosis of Diabetic Retinopathy

Yanhui Tang, Qi Tang, Haicheng Wei, Pinzhang Hu, Donghua Zou, Rixiong Liang, Yu Ling
<span title="2021-05-06">2021</span> <i title="Dove Medical Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/g3ntizzdb5gjhbnnl6xwvw5rwq" style="color: black;">International Journal of General Medicine</a> </i> &nbsp;
This study aimed to identify genes that may be effective in diagnosing or treating diabetic retinopathy (DR), the most common complication of diabetes mellitus (DM).  ...  Enrichment analysis was used to explore the biological characteristics.  ...  Disclosure The authors report no conflicts of interest related to this work.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2147/ijgm.s311683">doi:10.2147/ijgm.s311683</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33986612">pmid:33986612</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8110263/">pmcid:PMC8110263</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cvnka5devbdmdjlm4l3yg3kbli">fatcat:cvnka5devbdmdjlm4l3yg3kbli</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210515030038/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8110263&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/89/d7/89d788ab9027373843d96c0b7cd644aeba9f6be4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2147/ijgm.s311683"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110263" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Exploring the Mechanism of Action Compound-Xueshuantong Capsule in Diabetic Retinopathy Treatment Based on Network Pharmacology

Haoran Li, Biao Li, Yanlin Zheng
<span title="2020-09-09">2020</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zncaxvmd7zbqjjpq55yaq6a3ay" style="color: black;">Evidence-Based Complementary and Alternative Medicine</a> </i> &nbsp;
Aim of the Study. To study the mechanism of Compound-Xueshuantong Capsule in diabetic retinopathy treatment based on network pharmacology. Materials and Methods.  ...  Compound-Xueshuantong Capsule can treat diabetic retinopathy through multitarget, multipathway, and multipathway regulation of the biomolecular network.  ...  Figure 2 : 2 Protein-protein interaction (PPI) network of Compound-Xueshuantong Capsule in diabetic retinopathy treatment.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2020/8467046">doi:10.1155/2020/8467046</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32963574">pmid:32963574</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7499338/">pmcid:PMC7499338</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mkyfpzjtvzb3bp5eazbwlvj3fq">fatcat:mkyfpzjtvzb3bp5eazbwlvj3fq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200926234238/http://downloads.hindawi.com/journals/ecam/2020/8467046.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/07/58/075839e3f0853e7a3ae16eca736e4ddc030915c0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2020/8467046"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499338" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Bioinformatic analysis of retinal gene function and expression in diabetic rats

Wenjuan Zhao, Dong Wang, Jun Zhao, Wenqing Zhao
<span title="2017-07-19">2017</span> <i title="Spandidos Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zpl7c47akvfnhjqqqfeeqzmgnu" style="color: black;">Experimental and Therapeutic Medicine</a> </i> &nbsp;
Gene ontology (GO) enrichment analysis of DEGs was performed followed by a principal component and pathway enrichment analysis of the selected DEGs along with protein-protein interaction network construction  ...  The aim of the present study was to investigate the changes in retinal gene expression at three time points and assess the underlying molecular mechanisms of diabetic retinopathy (DR) in a streptozotocin  ...  GO enrichment analysis of DEGs involved in PPI network. As presented in Table II , the DEGs in the PPI network at 1, 4 and 12 weeks were enriched in 12, 7 and 10 GO categories, respectively.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3892/etm.2017.4805">doi:10.3892/etm.2017.4805</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28962184">pmid:28962184</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5609221/">pmcid:PMC5609221</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/subiarlbrvcbhfaizo55uxonei">fatcat:subiarlbrvcbhfaizo55uxonei</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180722101158/https://www.spandidos-publications.com/etm/14/3/2485/download" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/82/17/821780adf7356732561bbf40b591cb4225566ce9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3892/etm.2017.4805"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609221" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Identification and Validation of Autophagy-Related Genes in Diabetic Retinopathy

Nan Wang, Linfeng Wei, Die Liu, Quyan Zhang, Xiaobo Xia, Lexi Ding, Siqi Xiong
<span title="2022-04-29">2022</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lrxowc5ubndyzpoqeyubgpzigm" style="color: black;">Frontiers in Endocrinology</a> </i> &nbsp;
Then 10 hub genes were identified by PPI network analysis and construction of key modules.  ...  Genomes (KEGG) pathway enrichment analysis and protein-protein interaction (PPI) network analysis.  ...  Then, functional enrichment and protein-protein interaction (PPI) network analysis were used to clarify the interaction and biological function of these genes. 10 hub genes were identified by PPI network  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fendo.2022.867600">doi:10.3389/fendo.2022.867600</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35574010">pmid:35574010</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC9098829/">pmcid:PMC9098829</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7z3kjhfm7zfevhcxm7f5vz6koi">fatcat:7z3kjhfm7zfevhcxm7f5vz6koi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220505121810/https://fjfsdata01prod.blob.core.windows.net/articles/files/867600/pubmed-zip/.versions/1/.package-entries/fendo-13-867600.pdf?sv=2018-03-28&amp;sr=b&amp;sig=9shxvrdXfoVnoRalYMUUUNe8vymEqmCc5hBap6RXaek%3D&amp;se=2022-05-05T12%3A18%3A39Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fendo-13-867600.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2c/20/2c2092245aa023cf9ba6f6fbbff6f275b31b3f12.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fendo.2022.867600"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098829" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Investigating the Mechanisms of Pollen Typhae in the Treatment of Diabetic Retinopathy Based on Network Pharmacology and Molecular Docking

Rongrong Zhou, De Jin, Yuqing Zhang, Liyun Duan, Yuehong Zhang, Yingying Duan, Xiaomin Kang, Fengmei Lian, Samuel Martins Silvestre
<span title="2022-01-03">2022</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zncaxvmd7zbqjjpq55yaq6a3ay" style="color: black;">Evidence-Based Complementary and Alternative Medicine</a> </i> &nbsp;
To explore the main bioactive compounds and investigate the underlying mechanism of Pollen Typhae (PT) against diabetic retinopathy (DR) by network pharmacology and molecular docking analysis.  ...  Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were visualized through DAVID database and Bioinformatics.  ...  Based on the PPI analysis and ingredient-gene-pathway network, core target proteins (PTGS2, AKT1, VEGFA, MAPK3, TNF, and EGFR) were obtained.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2022/5728408">doi:10.1155/2022/5728408</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35024051">pmid:35024051</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8747905/">pmcid:PMC8747905</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qzjanrjs6vhv3g7iinb6htfzea">fatcat:qzjanrjs6vhv3g7iinb6htfzea</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220201082611/https://downloads.hindawi.com/journals/ecam/2022/5728408.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a7/b2/a7b280d2c4580a023f50b6b04d36bbee5de720e1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2022/5728408"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747905" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Comprehensive analysis of angiogenesis-related genes and pathways in early diabetic retinopathy

Chufeng Gu, Thashi Lhamo, Chen Zou, Chuandi Zhou, Tong Su, Deji Draga, Dawei Luo, Zhi Zheng, Lili Yin, Qinghua Qiu
<span title="2020-09-29">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/rbtzjpig4jcsfbjr5yo23sjnj4" style="color: black;">BMC Medical Genomics</a> </i> &nbsp;
Background Angiogenesis is an important parameter in the development of diabetic retinopathy (DR), and it is indicative of an early stage evolving into a late phase.  ...  We identified 10 hub genes associated with neovascularization by constructing a protein-protein interaction (PPI) network: TNF, VEGFA, PIK3CB, TGFB1, EDN1, MMP9, TLR4, PDGFB, MMP2, and THBS1.  ...  The collection, analysis, and interpretation of data were supported by the National Science and Technology Major Project of China (2017ZX09304010) and the National Key R&D Program of China (2016YFC0904800  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12920-020-00799-6">doi:10.1186/s12920-020-00799-6</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32993645">pmid:32993645</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7526206/">pmcid:PMC7526206</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/a2qqsbdbnraznfk4x2b5ukidsu">fatcat:a2qqsbdbnraznfk4x2b5ukidsu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200930054757/https://bmcmedgenomics.biomedcentral.com/track/pdf/10.1186/s12920-020-00799-6" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5a/d0/5ad03b0fae06db51c41b7b91def0011d3ff8818e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12920-020-00799-6"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526206" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Identification of potential molecular targets associated with proliferative diabetic retinopathy

Dewang Shao, Shouzhi He, Zi Ye, Xiaoquan Zhu, Wei Sun, Wei Fu, Tianju Ma, Zhaohui Li
<span title="2020-04-14">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fk7hkiq7wzhunbmhiofsqfcny4" style="color: black;">BMC Ophthalmology</a> </i> &nbsp;
This study aimed to identify and evaluate potential molecular targets associated with the development of proliferative diabetic retinopathy (DR).  ...  Functional enrichment analysis, and protein-protein interactions (PPI) network and module analyses were performed on the upregulated and downregulated coDEGs.  ...  Background Diabetic retinopathy (DR) is one of the most common microvascular complications in diabetes mellitus, and a primary cause of blindness and visual disturbance globally [1] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12886-020-01381-5">doi:10.1186/s12886-020-01381-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32290826">pmid:32290826</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/btzz2aw3qzacbebxk4c5vhanzm">fatcat:btzz2aw3qzacbebxk4c5vhanzm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200507083344/https://bmcophthalmol.biomedcentral.com/track/pdf/10.1186/s12886-020-01381-5" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9b/1b/9b1b2cf85e8cec628dfa1180c5332b6cf93bbe9d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12886-020-01381-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>

Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research

Mengxia Yuan, Qi He, Zhiyong Long, Xiaofei Zhu, Wang Xiang, Yonghe Wu, Shibin Lin, Yu Hsiang Kuan
<span title="2021-08-02">2021</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zncaxvmd7zbqjjpq55yaq6a3ay" style="color: black;">Evidence-Based Complementary and Alternative Medicine</a> </i> &nbsp;
Five networks were constructed and analyzed: (1) diabetic retinopathy genes' PPI network; (2) compound-compound target network of LDD; (3) LDD-DR PPI network; (4) compound-known target network of LDD;  ...  Cytoscape was used to construct and analyze network DR and LDD's network, and DAVID was used for Gene Ontology (GO) and pathway enrichment analysis.  ...  Table S3 : DR genes. Table S4 : enrichment analysis of clusters based on Gene Ontology (GO) annotation of DR PPI network. Table S5 : pathway enrichment analysis of DR PPI network.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2021/5544518">doi:10.1155/2021/5544518</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34394383">pmid:34394383</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8356007/">pmcid:PMC8356007</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kaqf6lggkngqxceaew2pvdm7yi">fatcat:kaqf6lggkngqxceaew2pvdm7yi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210804215256/https://downloads.hindawi.com/journals/ecam/2021/5544518.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7a/63/7a638266905ba731a092533ac2fe0ff24261248f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2021/5544518"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356007" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A Network Pharmacology to Explore the Mechanism of Astragalus Membranaceus in the Treatment of Diabetic Retinopathy

Qi Jin, Xiao-Feng Hao, Li-Ke Xie, Jing Xu, Mei Sun, Hang Yuan, Shi-Hui Wang, Gai-Ping Wu, Meng-Lu Miao, Subashani Maniam
<span title="2020-11-02">2020</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zncaxvmd7zbqjjpq55yaq6a3ay" style="color: black;">Evidence-Based Complementary and Alternative Medicine</a> </i> &nbsp;
The Metascape data platform was used to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on the core targets.  ...  Diabetic retinopathy (DR) includes a series of typical lesions affected by retinal microvascular damage caused by diabetes mellitus (DM), which not only seriously damages the vision, affecting the life's  ...  Pathway-target network Step 3 Network construction GO and KEGG analysis Step 2 Target analysis Known potential targets of DR Genecards and OMIM Step 1: Target prediction Diabetic retinopathy (DR) Results  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2020/8878569">doi:10.1155/2020/8878569</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33204295">pmid:33204295</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7652614/">pmcid:PMC7652614</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/pezz5yreibdt7ep547mozrxscq">fatcat:pezz5yreibdt7ep547mozrxscq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201104004929/http://downloads.hindawi.com/journals/ecam/2020/8878569.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/59/01/5901eac51cbf8e80d25e0d51c79ae237f8170431.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2020/8878569"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652614" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Network Pharmacology-Based Approach to Comparatively Predict the Active Ingredients and Molecular Targets of Compound Xueshuantong Capsule and Hexuemingmu Tablet in the Treatment of Proliferative Diabetic Retinopathy

Hongyan Yao, Danli Xin, Zongyi Zhan, Zijing Li
<span title="2021-03-05">2021</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zncaxvmd7zbqjjpq55yaq6a3ay" style="color: black;">Evidence-Based Complementary and Alternative Medicine</a> </i> &nbsp;
Then, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed, and the ingredient-target networks, protein-protein interaction networks, and KEGG-target (KEGG-T) networks  ...  The top 5 pathways with the highest gene ratio in both networks were the AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, relaxin signaling pathway, IL-17 signaling pathway,  ...  encyclopedia of genes and genomes DR: Diabetic retinopathy DM: Diabetes mellitus mRNA: Messenger RNA DEmRNA: Differentially expressed messenger RNA I-T: Ingredient-target PPI: Protein-protein interaction  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2021/6642600">doi:10.1155/2021/6642600</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33747106">pmid:33747106</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7954618/">pmcid:PMC7954618</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wpnzykr7wzhgjoylqmv2ijszye">fatcat:wpnzykr7wzhgjoylqmv2ijszye</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210323224638/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7954618&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c0/17/c0177cef2de04d133005d4b0cb6212b411b37758.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2021/6642600"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954618" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Uncovering the protective mechanism of Taohong Siwu decoction against diabetic retinopathy via HIF-1 signaling pathway based on network analysis and experimental validation

Lei Wang, Shuyan Li, Leilei Wang, Kai Lin, Jialun Du, Wanhong Miao, Lei Zhang
<span title="2020-10-06">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/7ggsqn5oarf27f2ndlqmi66apy" style="color: black;">BMC Complementary Medicine and Therapies</a> </i> &nbsp;
Background Diabetic retinopathy (DR) is a common and serious microvascular complication of diabetes.  ...  DAVID database and ClueGo plug-in software were used to carry out the gene ontology (GO) and KEGG enrichment analysis.  ...  Two hundred sixty three diabetic retinopathy (DR)-associated genes.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12906-020-03086-0">doi:10.1186/s12906-020-03086-0</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33023593">pmid:33023593</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/njtncz62crgrvmu33ujj25tsoa">fatcat:njtncz62crgrvmu33ujj25tsoa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201007101444/https://bmccomplementmedtherapies.biomedcentral.com/track/pdf/10.1186/s12906-020-03086-0" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/be/62/be62abf28cbd61e2c9a6796a38844a7a70dd3ceb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12906-020-03086-0"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>

Network pharmacology and molecular docking study on the active ingredients of qidengmingmu capsule for the treatment of diabetic retinopathy

Mingxu Zhang, Jiawei Yang, Xiulan Zhao, Ying Zhao, Siquan Zhu
<span title="2021-04-01">2021</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tnqhc2x2aneavcd3gx5h7mswhm" style="color: black;">Scientific Reports</a> </i> &nbsp;
AbstractDiabetic retinopathy (DR) is a leading cause of irreversible blindness globally.  ...  Based on the results of the PPI network and KEGG enrichment analyses, we selected AKT1, HIF-1α, VEGFA, TNFα and their corresponding active ingredients for molecular docking.  ...  Acknowledgements All drawings in Fig. 6 of the article were drawn by author Mingxu Zhang, and there is no copyright conflict with existing compositions.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41598-021-86914-8">doi:10.1038/s41598-021-86914-8</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33795817">pmid:33795817</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8016862/">pmcid:PMC8016862</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ey2rcrcy7bhlniewg4o2ftswq4">fatcat:ey2rcrcy7bhlniewg4o2ftswq4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210718120332/https://www.nature.com/articles/s41598-021-86914-8.pdf?error=cookies_not_supported&amp;code=22151d55-1395-47a4-843c-f0fe634d4d26" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2b/54/2b54c1a1dbe5fa9446b45ae8dc4aa0e4934f2166.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41598-021-86914-8"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016862" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Identification and validation of hub genes for diabetic retinopathy

Li Peng, Wei Ma, Qing Xie, Baihua Chen
<span title="2021-09-13">2021</span> <i title="PeerJ"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/eyfkjqp7sva5bbnwatk5zazi7q" style="color: black;">PeerJ</a> </i> &nbsp;
Conclusion Gene co-expression network analysis highlights the importance of mitochondria and oxidative stress in the pathophysiology of DR.  ...  We identified significant gene modules via the Weighted Gene Co-expression Network Analysis, which was conducted by the Protein-Protein Interaction (PPI) Network via Cytoscape and from this we screened  ...  The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ADDITIONAL INFORMATION AND DECLARATIONS  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.7717/peerj.12126">doi:10.7717/peerj.12126</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34603851">pmid:34603851</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8445088/">pmcid:PMC8445088</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ds65mmpzp5g7lhzxubtrozmdmu">fatcat:ds65mmpzp5g7lhzxubtrozmdmu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210913173512/https://peerj.com/articles/12126.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/39/56/3956c63ddf0727f72dd49a2bcc080cd89de6018b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.7717/peerj.12126"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445088" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Identification of key genes and pathways in syphilis combined with diabetes: a bioinformatics study

Wei Li, Chunyi Luo, Xiaoping Xie, Yongjian Xiao, Feijun Zhao, Jialun Cai, Xiangping Zhou, Tiebing Zeng, Bo Fu, Yimou Wu, Xinhua Xiao, Shuangquan Liu
<span title="2020-04-27">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ogooi6sdujfo7cev4jenwqqaay" style="color: black;">AMB Express</a> </i> &nbsp;
Molecular Complex Detection (MCODE) plugins were used to visualize protein-protein interaction (PPI) network of DEGs and Screening for hub genes and gene modules.  ...  ALB, FN1, CASP3, MMP9, IL8, CTGF, STAT3, IGF1, VCAM-1 and HGF were filtrated as the hub genes according to the degree of connectivity from the PPI network.  ...  We also constructed the PPI network with the DEGs to identify interactions, according the degree of importance, we chose 3 significant modules from the PPI network complex for further analysis using MCODE  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13568-020-01009-3">doi:10.1186/s13568-020-01009-3</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32342229">pmid:32342229</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zuzkbo45crhjhdho57ycwv7wbu">fatcat:zuzkbo45crhjhdho57ycwv7wbu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200505164301/https://amb-express.springeropen.com/track/pdf/10.1186/s13568-020-01009-3" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fd/92/fd92588c9303d434abec24db21761346f9b2c7f6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13568-020-01009-3"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>
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