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Structural Basis for Allosteric Control of the SERCA-Phospholamban Membrane Complex by Ca2+ and Phosphorylation

Gianluigi Veglia, Daniel K Weber, Venkateswara U Reddy, Songlin Wang, Erik K Larsen, Tata Gopinath, Martin B Gustavsson, Razvan Cornea, David D T. Thomas, Alfonso De Simone
2021 eLife  
Using oriented-sample solid-state NMR spectroscopy and replica-averaged NMR-restrained structural refinement, we reveal that phosphorylation of PLN's cytoplasmic regulatory domain signals the disruption  ...  Phospholamban (PLN) is a mini-membrane protein that directly controls the cardiac Ca2+-transport response to β-adrenergic stimulation, thus modulating cardiac output during the fight-or-flight response  ...  into 2 mL of dimethylformamide and stirred under nitrogen for 16 h at 40C. 569 584 Oriented solid-state NMR spectroscopy 585All 15 N spectra were acquired on a Varian VNMRS spectrometer equipped with  ... 
doi:10.7554/elife.66226 pmid:33978571 pmcid:PMC8184213 fatcat:jnixzldlijcb3hrgbzr73irnju