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Existing crosstalk inference methods conduct network-structure learning based on a single phenotypic feature (e.g. abundance) of a biomarker. ... The result is a multi-feature, sparse network that parsimoniously captures direct and strong interactions across phenotypic attributes of multiple biomarkers. ... Discussion We propose PHOCOS as a framework for inferring multi-feature crosstalk networks from perturbation assays. ...doi:10.1093/bioinformatics/btw251 pmid:27307643 pmcid:PMC4908335 fatcat:2yva7voznvdtxaw2jn23z7zzym