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Sex Differences in Midbrain Dopamine D2-Type Receptor Availability and Association with Nicotine Dependence

Kyoji Okita, Nicole Petersen, Chelsea L Robertson, Andy C Dean, Mark A Mandelkern, Edythe D London
<span title="2016-06-22">2016</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zscwnf3bera7vcvkm7bgnh2sbu" style="color: black;">Neuropsychopharmacology</a> </i> &nbsp;
Because dopamine D2-type autoreceptors in the midbrain influence striatal dopamine release, a function that has been linked to addiction, we tested for sex differences in midbrain dopamine D2-type receptor  ...  Unlike female smokers, male smokers have lower striatal dopamine D2-type receptor availability (binding potential, BPND) than nonsmokers and exhibit greater smoking-induced striatal dopamine release.  ...  Yet another study suggested that at least five administrations of nicotine are required to evoke dopamine release in naive rats (Cadoni and Di Chiara, 2000) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/npp.2016.105">doi:10.1038/npp.2016.105</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27329684">pmid:27329684</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5061883/">pmcid:PMC5061883</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mynjakdntves5i62z7hjxyq64e">fatcat:mynjakdntves5i62z7hjxyq64e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200511052435/https://www.nature.com/articles/npp2016105.pdf?error=cookies_not_supported&amp;code=20bd7051-5fab-48b4-b81b-d19d5b8ce4ad" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a7/90/a7907842c063380d67aa68491e1fa3dbd05378b3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/npp.2016.105"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061883" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction?

Paul Cumming, Daniele Caprioli, Jeffrey W Dalley
<span title="2011-07-25">2011</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/wsc2264oo5gpvk5scotezp75pu" style="color: black;">British Journal of Pharmacology</a> </i> &nbsp;
This article is part of a themed section on Imaging.  ...  of nicotine, which releases dopamine by an entirely different mechanism (Kim and Han, 2009) .  ...  of dopamine D2/3 receptors measured with [ 18 F]DMFP-PET in the ventral striatum of detoxified alcoholics (Heinz et al., 2004) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1476-5381.2010.01036.x">doi:10.1111/j.1476-5381.2010.01036.x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20846139">pmid:20846139</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3166689/">pmcid:PMC3166689</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/n4dlfxivwnc2zkcf5k7nwdrkly">fatcat:n4dlfxivwnc2zkcf5k7nwdrkly</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200206040848/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3166689&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0a/93/0a9349cfcc430e8fcd66e3e54a7c401fffe7166d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1476-5381.2010.01036.x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166689" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

In vivo Effects of the Anatoxin-a on Striatal Dopamine Release

F. Campos, R. Durán, L. Vidal, L. R. F. Faro, M. Alfonso
<span title="">2006</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/pncjnihh6rempdfj744jw3pm7q" style="color: black;">Neurochemical Research</a> </i> &nbsp;
This study test the effect of anatoxin-a on striatal in vivo dopamine release by microdialysis.The results of this work show that anatoxin-a evoked dopamine release in a concentration-dependent way.  ...  *nicotinic AChRs are implicated in the regulation of striatal dopamine release.  ...  These results show that anatoxin-a acts through nicotinic receptors evoking dopamine release.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11064-006-9042-x">doi:10.1007/s11064-006-9042-x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/16758357">pmid:16758357</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/obxlqp3mkbcjxfxghkgagc25ky">fatcat:obxlqp3mkbcjxfxghkgagc25ky</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170812102833/http://pallares.webs.uvigo.es/articulos/Articulos%202006/2006_Neurochem%20Res31_Anatoxin.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ed/4d/ed4d0c784b93d39c6432303fdafd9a56abe3a867.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11064-006-9042-x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Molecular imaging of schizophrenia: neurochemical findings in a heterogeneous and evolving disorder

Paul Cumming, Anissa Abi-Dargham, Gerhard Gründer
<span title="2020-11-13">2020</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ewewbkkyvfat3ngsktdrzbzog4" style="color: black;">Behavioural Brain Research</a> </i> &nbsp;
Similarly, competition SPECT studies show greater basal and amphetamine-evoked dopamine occupancy at post-synaptic dopamine D2/3 receptors in patients with schizophrenia, but the difference is likewise  ...  There is a general lack of consistent findings of abnormality in serotonin markers, but some evidence for decreased levels of nicotinic receptors in patients.  ...  Psychosocial stress evoked an elevated striatal dopamine release as measured by PET examination with the D 3 -prefering agonist [ 11 C]PHNO in a group of (n = 25) immigrants with high risk for schizophrenia  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bbr.2020.113004">doi:10.1016/j.bbr.2020.113004</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33197459">pmid:33197459</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jqyyyyat7zhwrldtt5xwndupcu">fatcat:jqyyyyat7zhwrldtt5xwndupcu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210427185912/https://boris.unibe.ch/148569/1/Cumming_Molecular%20imaging%20of%20schizophrenia%20Neurochemical%20findings%20in%20a%20heterogeneous%20and%20evolving%20disorder.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4f/ca/4fca0d666dc0fa3fd66c744963f4e879f1326727.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bbr.2020.113004"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

The interactive effects of ketamine and nicotine on human cerebral blood flow

Laura M. Rowland, Lori Beason-Held, Carol A. Tamminga, Henry H. Holcomb
<span title="2010-01-13">2010</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/476xkwimnredro3yrtvqfs2ujq" style="color: black;">Psychopharmacology</a> </i> &nbsp;
Method-Following 2-4 h of nicotine abstinence, healthy chronic smokers participated in four sets of rCBF studies, H 2 15 O positron emission tomography, during a simple sensory motor control task.  ...  Aim-The purpose of this study was to determine if acute nicotine attenuated ketamine-induced regional cerebral blood flow (rCBF).  ...  Dannals, David Clough, Hayden Ravert, Robert Smoot, and Karen Edmonds of the Johns Hopkins Cyclotron Facility, and Nancy Kakoyannis, Ning Ma, and Adrienne Lahti of the University of Maryland School of  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00213-009-1758-2">doi:10.1007/s00213-009-1758-2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20066400">pmid:20066400</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2891406/">pmcid:PMC2891406</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/z5tto6t76fabfpurgjzzp42nxm">fatcat:z5tto6t76fabfpurgjzzp42nxm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200210183711/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2891406&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/50/da/50da7ea2c3daf7a6bc2c53fdac2338ba4589396c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00213-009-1758-2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891406" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Monoamine Oxidase Inhibition by Plant-Derived β-Carbolines; Implications for the Psychopharmacology of Tobacco and Ayahuasca

Ilana Berlowitz, Klemens Egger, Paul Cumming
<span title="2022-05-02">2022</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/qigargnicncadmdn56ei23yjnu" style="color: black;">Frontiers in Pharmacology</a> </i> &nbsp;
Whereas serotonin is the preferred substrate of MAO-A, phenylethylamine is metabolized by MAO-B, and dopamine and tyramine are nearly ambivalent with respect to the two isozymes. β-Carboline alkaloids  ...  Furthermore, MAO inhibitors of diverse structures are present in a wide variety of medicinal plants, but their pharmacological relevance in many instances remains to be established.  ...  the amphetamine-evoked dopamine release (Busto, 2009) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fphar.2022.886408">doi:10.3389/fphar.2022.886408</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35600851">pmid:35600851</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC9121195/">pmcid:PMC9121195</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hbr62f57jbccjcrdjrgmeoyazi">fatcat:hbr62f57jbccjcrdjrgmeoyazi</a> </span>
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In vivo modulation of α7 nicotinic receptors on striatal glutamate release induced by anatoxin-A

F. Campos, M. Alfonso, R. Durán
<span title="">2010</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/w7ey64vjgva4tbfeqvc3tlcnkm" style="color: black;">Neurochemistry International</a> </i> &nbsp;
Using in vivo microdialysis technique, our results have shown that anatoxin-a evokes glutamate release in a dependent way of activation a7 nicotinic receptors.  ...  These results represent a clear in vivo evidence of the striatal modulation of dopamine by means of glutamate release through a7 nicotinic receptors. ß  ...  The involvement of the b2 nicotinic receptors on dopamine release evoked by anatoxin-a had never been checked in vivo, for this reason, the effects of the antagonist DHbE have been studied in the present  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuint.2010.03.010">doi:10.1016/j.neuint.2010.03.010</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20347906">pmid:20347906</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2pvlsanr6jdzziae2osweiazyu">fatcat:2pvlsanr6jdzziae2osweiazyu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170812102816/http://pallares.webs.uvigo.es/articulos/2010%20Neurochem%20Int%20In%20vivo%20modualtion.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c5/7d/c57df0ccad997d40849e7cb8826fab8a1a6c4ede.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuint.2010.03.010"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

PET Molecular Imaging Research of Levodopa-Induced Dyskinesias in Parkinson's Disease

Gennaro Pagano, Tayyabah Yousaf, Marios Politis
<span title="2017-10-03">2017</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vfuopykppzgstehggsohanpwq4" style="color: black;">Current Neurology and Neuroscience Reports</a> </i> &nbsp;
between dopaminergic and serotonergic terminals, with the latter playing a key role in mishandling presynaptic dopamine release.  ...  Recent Findings Recent PET studies have provided robust evidence that LIDs in PD are associated with elevated and fluctuating striatal dopamine synaptic levels, which is a consequence of the imbalance  ...  Molecular Imaging of the Dopaminergic System Dopamine release can be measured by PET with [ 11 C]raclopride, a D 2 receptor antagonist radioligand which competes with endogenous dopamine for D 2 receptor  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11910-017-0794-2">doi:10.1007/s11910-017-0794-2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28975571">pmid:28975571</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5626800/">pmcid:PMC5626800</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vogy2ji6u5eg7fb3mldso57zme">fatcat:vogy2ji6u5eg7fb3mldso57zme</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180730160857/https://link.springer.com/content/pdf/10.1007%2Fs11910-017-0794-2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/09/fe/09fef80143a43b5f2e23842e9ab7d257d5bba6d9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11910-017-0794-2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626800" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Neuroimaging in Psychiatric Pharmacogenetics Research: The Promise and Pitfalls

Mary Falcone, Ryan M Smith, Meghan J Chenoweth, Abesh Kumar Bhattacharjee, John R Kelsoe, Rachel F Tyndale, Caryn Lerman
<span title="2013-06-24">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zscwnf3bera7vcvkm7bgnh2sbu" style="color: black;">Neuropsychopharmacology</a> </i> &nbsp;
Neuroimaging may provide a more sensitive early measure of treatment response in genetically defined patient groups, and could facilitate development of novel therapies based on an improved understanding  ...  of pathogenic mechanisms underlying pharmacogenetic associations.  ...  Genetic variation in the mu-opioid receptor, which has downstream effects on dopamine release, is also related to dopamine release following an alcohol challenge (Ramchandani et al, 2011) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/npp.2013.152">doi:10.1038/npp.2013.152</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23793356">pmid:23793356</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3799069/">pmcid:PMC3799069</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qhapaiqufzerfortgxxujxyjme">fatcat:qhapaiqufzerfortgxxujxyjme</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200313031322/https://www.nature.com/articles/npp2013152.pdf?error=cookies_not_supported&amp;code=bfbaa92c-8b1d-43c7-8362-a9163148da4d" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/83/98/8398f415ad747ad1cca19ab9c2b5f7431fe2f722.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/npp.2013.152"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799069" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Neuroimaging, genetics and the treatment of nicotine addiction

Riju Ray, James Loughead, Ze Wang, John Detre, Edward Yang, Ruben Gur, Caryn Lerman
<span title="">2008</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ewewbkkyvfat3ngsktdrzbzog4" style="color: black;">Behavioural Brain Research</a> </i> &nbsp;
To date, only a few neuroimaging studies have explored effects of nicotine or abstinence on brain activity as a function of genotype.  ...  Neuroimaging studies have begun to elucidate the functional neuroanatomy and neurochemistry underlying effects of nicotine and nicotine abstinence.  ...  PET studies with the specific radio-labeled ligand for the dopamine D2 receptor ( 11 C) raclopride have documented nicotine effects on dopamine release.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bbr.2008.05.021">doi:10.1016/j.bbr.2008.05.021</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18599130">pmid:18599130</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2600518/">pmcid:PMC2600518</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fgkl36pnfvcopjkfqre524hmci">fatcat:fgkl36pnfvcopjkfqre524hmci</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200428050858/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2600518&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1d/a2/1da266a6dfe83d1120801281f65b197f6cf29b77.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bbr.2008.05.021"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600518" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET study

Andrew J. Montgomery, Anne R. Lingford-Hughes, Alice Egerton, David J. Nutt, Paul M. Grasby
<span title="">2007</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/kzrl2qswhrg3ja62lnhxhu7pvq" style="color: black;">Synapse</a> </i> &nbsp;
In this experiment we measured the effect of nicotine, administered via a nasal spray, on DA release using [ 11 C]raclopride PET, in 10 regular smokers.  ...  Brain microdialysis studies in rodents have consistently shown increases in extrasynaptic DA levels in the striatum after administration of nicotine but PET experiments in primates have given contradicting  ...  In this study we measured the response of the DA system to nicotine in a group of smokers using bolusinfusion [ 11 C]raclopride PET.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/syn.20419">doi:10.1002/syn.20419</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17492764">pmid:17492764</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7ekzlelsubhalfvbfi2hshj7ni">fatcat:7ekzlelsubhalfvbfi2hshj7ni</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20151017092151/http://tauruspet.med.yale.edu/staff/edm42/papers/raclo-smoking-effects/Montgomery-Synapse-2007.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/41/96/4196e2f62cf29db6fb3099ebddf67e6202347a07.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/syn.20419"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> wiley.com </button> </a>

Two Players in the Field: Hierarchical Model of Interaction between the Dopamine and Acetylcholine Signaling Systems in the Striatum

Jaromir Myslivecek
<span title="2021-01-01">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jgmgd4z6dzhzziggcczoforhve" style="color: black;">Biomedicines</a> </i> &nbsp;
An increase in dopamine release is activated by stopping acetylcholine release. The coordinated timing or synchrony of the direct and indirect pathways is critical for refined movements.  ...  In general, drugs increase striatal dopamine release, and others can potentiate both dopamine and acetylcholine release. Both neurotransmitters and their receptors show diurnal variations.  ...  As the dopamine level in humans cannot be measured directly, there are only indirect data on dopamine synthesis capacity [54] , or indirect measurement based on the competition of PET ligands with dopamine  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/biomedicines9010025">doi:10.3390/biomedicines9010025</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33401461">pmid:33401461</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fenyv2yhhjcrbkriitryceylcq">fatcat:fenyv2yhhjcrbkriitryceylcq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210106102616/https://res.mdpi.com/d_attachment/biomedicines/biomedicines-09-00025/article_deploy/biomedicines-09-00025.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5c/84/5c84b5953e0f92d8b5f2c9605c117391b54ab553.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/biomedicines9010025"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>

Application of cross-species PET imaging to assess neurotransmitter release in brain

Sjoerd J. Finnema, Mika Scheinin, Mohammed Shahid, Jussi Lehto, Edilio Borroni, Benny Bang-Andersen, Jukka Sallinen, Erik Wong, Lars Farde, Christer Halldin, Sarah Grimwood
<span title="2015-04-30">2015</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/476xkwimnredro3yrtvqfs2ujq" style="color: black;">Psychopharmacology</a> </i> &nbsp;
and Schizophrenia( NEWMEDS) in 2009, PET radioligands sensitive to an endogenous neurotransmitter were only validated for dopamine.  ...  Here, we discuss these efforts and review other recently published reports on the use of radioligands to assess changes in endogenous levels of dopamine, serotonin, noradrenaline, γ-aminobutyric acid,  ...  Sjoerd Finnema has received compensation as a member of a scientific advisory board of F. Hoffmann-La Roche.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00213-015-3938-6">doi:10.1007/s00213-015-3938-6</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25921033">pmid:25921033</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4600473/">pmcid:PMC4600473</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6lufnlpz7jfvdmnfnxb7qm5agm">fatcat:6lufnlpz7jfvdmnfnxb7qm5agm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170915172212/https://link.springer.com/content/pdf/10.1007%2Fs00213-015-3938-6.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f5/f8/f5f8b39b3f37d3a3ee3927860dc9b48499d20204.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00213-015-3938-6"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600473" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Page 4231 of Psychological Abstracts Vol. 88, Issue 11 [page]

<span title="">2001</span> <i title="American Psychological Association"> <a target="_blank" rel="noopener" href="https://archive.org/details/pub_psychological-abstracts" style="color: black;">Psychological Abstracts </a> </i> &nbsp;
(Aichi Medical Coll, Dept of Neuropsychiatry, Aichi- gun, Japan) Inhibition of K+-evoked release of rat striatal 5-hydrox- ytryptamine by an atypical antidepressant: Trazodone.  ...  In rats treated with trazodone, K+-evoked elevations of 5-HT were less than five times the bas- al level. Multiple trazodone administrations prolonged the duration of inhi- bition of 5-HT release.  ... 
<span class="external-identifiers"> </span>
<a target="_blank" rel="noopener" href="https://archive.org/details/sim_psychological-abstracts_2001-11_88_11/page/4231" title="read fulltext microfilm" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Archive [Microfilm] <div class="menu fulltext-thumbnail"> <img src="https://archive.org/serve/sim_psychological-abstracts_2001-11_88_11/__ia_thumb.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a>

Do Preclinical Findings of Methamphetamine-Induced Motor Abnormalities Translate to an Observable Clinical Phenotype?

Michael P Caligiuri, Casey Buitenhuys
<span title="2005-08-10">2005</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zscwnf3bera7vcvkm7bgnh2sbu" style="color: black;">Neuropsychopharmacology</a> </i> &nbsp;
of altered dopamine function.  ...  This review summarizes the preclinical literature of the effects of methamphetamine (MA) on subcortical dopaminergic and GABAergic mechanisms underlying motor behavior with the goal of elucidating the  ...  Two studies reported direct effects of kappa receptor agonists on MA-induced dopamine release.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.npp.1300859">doi:10.1038/sj.npp.1300859</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/16123755">pmid:16123755</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wlacikg7bva6zo6szidsov7u3e">fatcat:wlacikg7bva6zo6szidsov7u3e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200313095640/https://www.nature.com/articles/1300859.pdf?error=cookies_not_supported&amp;code=379fe947-ecee-4e24-8c91-3c858b95b8c4" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ff/4c/ff4c956e6b72b930c40c7bffd37804ea4d60be16.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.npp.1300859"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>
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