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PET imaging predicts future body weight and cocaine preference

Michael Michaelides, Panayotis K. Thanos, Ronald Kim, Jacob Cho, Mala Ananth, Gene-Jack Wang, Nora D. Volkow
2012 NeuroImage  
weight gain and cocaine preference.  ...  Measuring D2R/D3R binding availability provides a way for assessing susceptibility to weight gain and cocaine abuse in rodents and given the translational nature of PET imaging, potentially primates and  ...  Jayne and Colleen Shea for PET tracer synthesis and scheduling as well as Brenda Anderson and John Robinson for helpful comments on the manuscript as part of the dissertation of MM.  ... 
doi:10.1016/j.neuroimage.2011.08.028 pmid:21889993 pmcid:PMC3230743 fatcat:jd3o6uc3njgttfuelzkulxrmou

Environmental modulation of drug taking: Nonhuman primate models of cocaine abuse and PET neuroimaging

Michael A. Nader, Matthew L. Banks
2014 Neuropharmacology  
(PET).  ...  In this review, the role of three environmental variables - both positive and negative - are described: alternative non-drug reinforcers; social rank (as an independent variable) and punishment of cocaine  ...  Acknowledgments Preparation of this manuscript was supported in part by grants from the National Institute on Drug Abuse (DA 10584, DA017763, DA025120, DA06634, DA26946, DA012790 and DA031718).  ... 
doi:10.1016/j.neuropharm.2013.05.044 pmid:23748095 pmcid:PMC3812308 fatcat:oztsl6musjgvtoaz7qclvp3jqm

Dopamine signaling in food addiction: role of dopamine D2 receptors

Ja-Hyun Baik
2013 BMB Reports  
Increasing amounts of data from human imaging studies, together with genetic analysis, have demonstrated that obese people and drug addicts tend to show altered expression of DA D2 receptors in specific  ...  brain areas, and that similar brain areas are activated by food-related and drug-related cues.  ...  Acknowledgements This work was supported by the grant of the Korean Health Technology R&D Project (A111776) from the Ministry of Health & Welfare, and partly by the Brain Research Program  ... 
doi:10.5483/bmbrep.2013.46.11.207 pmid:24238362 pmcid:PMC4133846 fatcat:77au25vsm5bhpclcqck6l4kbae

Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction [chapter]

N. D. Volkow, G. J. Wang, J. S. Fowler, D. Tomasi, R. Baler
2011 Current topics in behavioral neurosciences  
Now, brain imaging discoveries have started to uncover common features between these two conditions and to delineate some of the overlapping brain circuits whose dysfunctions may explain stereotypic and  ...  Both drug addiction and obesity can be defined as disorders in which the saliency value of one type of reward (drugs and food, respectively) becomes abnormally enhanced relative to, and at the expense  ...  enabling energy to be stored in the body (as fat) for future use.  ... 
doi:10.1007/7854_2011_169 pmid:22016109 fatcat:kyucho3kmngtbpfbrv3opk6iwe

Neuroimaging of prenatal drug exposure

Diana L. Dow-Edwards, Helene Benveniste, Marylou Behnke, Emmalee S. Bandstra, Lynn T. Singer, Yasmin L. Hurd, L.R. Stanford
2006 Neurotoxicology and Teratology  
maternal and fetal brain as well as other body organs using a whole body PET scanning approach [7] .  ...  The figure shows the T2-weighted MRI acquired at a spatial resolution of 0.78 × 0.625 × 2 mm 3 (left), the volume rendered fused MRI and corresponding FDG PET image (middle) and a 2D fused MRI and PET  ... 
doi:10.1016/j.ntt.2006.03.003 pmid:16832875 pmcid:PMC7770627 fatcat:kj7bnuvmyvcrvflrwpjo4jryvy

Targeting the treatment of drug abuse with molecular imaging

Wynne K. Schiffer, Courtney N.B. Liebling, Vinal Patel, Stephen L. Dewey
2007 Nuclear Medicine and Biology  
Although imaging studies in and of themselves have significant contributions to the study of human behavior, imaging in drug abuse has a much broader agenda.  ...  The specific examples discussed here were chosen to illustrate how PET can be used to map the regional distribution and kinetics of compounds that may or may not have abuse liability.  ...  Acknowledgments The authors are supported by National Institutes of Health grants DA15082, DA16025, and DA15041 and performed under Brookhaven Science Associates contract DEAC0298CH10886 with the U.S.  ... 
doi:10.1016/j.nucmedbio.2007.05.004 pmid:17921034 fatcat:wpq4l5d2qje5blinkkv7rcinte

Relation of obesity to consummatory and anticipatory food reward

Eric Stice, Sonja Spoor, Janet Ng, David H. Zald
2009 Physiology and Behavior  
Emerging prospective data also suggest that abnormal activation in these brain regions increases risk for future weight gain and that genotypes associated with lowered dopamine signaling amplify these  ...  predictive effects.  ...  Preferences for high-fat and high-sugar foods predict elevated weight gain and increased risk for obesity [16, 17] .  ... 
doi:10.1016/j.physbeh.2009.03.020 pmid:19328819 pmcid:PMC2734415 fatcat:crrsquf2rndslgswiko37ommu4

Limbic activation to novel versus familiar food cues predicts food preference and alcohol intake

Michael Michaelides, Michael L. Miller, Mike Subrize, Ronald Kim, Lisa Robison, Yasmin L. Hurd, Gene-Jack Wang, Nora D. Volkow, Panayotis K. Thanos
2013 Brain Research  
In the same animals, after training, cue-induced brain activity was measured, and the relationships between activity and preference for three rewards, the conditioned foods and ethanol (EtOH), were separately  ...  Overall, these results suggest that natural variation in mesocorticolimbic sensitivity to reward-paired cues underlies behavioral preferences for and vulnerability to alcohol abuse, and support the notion  ...  FDG uptake values were reported in kBq/cc and normalized for injected dose, body weight and blood glucose levels as previously described (Thanos et al., 2008a) .  ... 
doi:10.1016/j.brainres.2013.03.006 pmid:23506787 pmcid:PMC3654647 fatcat:c5ome3t63vgnlg5efgoxskpmzi

Biomarkers for the Development of New Medications for Cocaine Dependence

Kristopher J Bough, Shashi Amur, Guifang Lao, Scott E Hemby, Nilesh S Tannu, Kyle M Kampman, Joy M Schmitz, Diana Martinez, Kalpana M Merchant, Charles Green, Jyoti Sharma, Anne H Dougherty (+1 others)
2013 Neuropsychopharmacology  
Putative diagnostic, pharmacodynamic (PD), and predictive biomarkers for cocaine dependence are discussed across a range of methodological approaches.  ...  In this review, we highlight current opportunities and difficulties pertaining to the identification and development of biomarkers for SUDs. We focus on cocaine dependence as an example.  ...  DISCLAIMER The views expressed in this presentation are those of the authors and may not necessarily reflect the position of the US FDA (SA) or NIH (KJB).  ... 
doi:10.1038/npp.2013.210 pmid:23979119 pmcid:PMC3857653 fatcat:5i5xj3bkwzfw7mkse7gafhw4iy

Ventral Striatum Binding of a Dopamine D2/3 Receptor Agonist But Not Antagonist Predicts Normal Body Mass Index

Fernando Caravaggio, Sofia Raitsin, Philip Gerretsen, Shinichiro Nakajima, Alan Wilson, Ariel Graff-Guerrero
2015 Biological Psychiatry  
Normal-weight rats given free access to high-fat diets demonstrate behavioral sensitization to D2/3R agonists but not to antagonists.  ...  Positron emission tomography research has shown that dopamine D2/3 receptor (D2/3R) availability is negatively correlated with body mass index (BMI) in obese but not in healthy subjects.  ...  Acknowledgments The authors thank the PET Centre staff at the Centre for Addiction and Mental Health, including Alvina Ng and Laura Nguyen, for technical assistance in data collection.  ... 
doi:10.1016/j.biopsych.2013.02.017 pmid:23540907 pmcid:PMC3783412 fatcat:vlx3b7o2zba5bgvmujbnhni5am

Variability in Reward Responsivity and Obesity: Evidence from Brain Imaging Studies

Kyle S. Burger, Eric Stice
2011 Current Drug Abuse Reviews  
Elevated sucrose preference in animals is associated with greater self-administration of cocaine [8] and sucrose intake reduces cocaine's reinforcing value [9] .  ...  Brain imaging techniques, including functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), are increasingly being employed to investigate the neural basis of eating behavior  ...  Research also indicates that preferences for high-fat foods predict elevated future weight gain [61, [63] [64] [65] .  ... 
doi:10.2174/1874473711104030182 pmid:21999692 pmcid:PMC3462740 fatcat:q6t3baeo2bbjxnsntlmgikw4v4

Testing The Role Of Δ9-Tetrahydrocannabinol During Adolescence As A Gateway Drug: Behavioural, Brain Imaging And Transcriptomic Studies [article]

Javier Orihuel, Roberto Capellan, David Roura-Martinez, Marcos Ucha, Laura Gomez-Rubio, Claudia Valverde, Marta Casquero-Veiga, Maria Luisa Soto-Montenegro, Manuel Desco, Marta Oteo-Vives, Marta Ibanez Moragues, Natalia Magro-Calvo (+3 others)
2020 bioRxiv   pre-print
Lastly, we studied cocaine-induced cellular activation (c-Fos) and cocaine addiction-like behaviours.  ...  We exposed rats of both sexes to THC and studied its effects on reward-related processes, brain morphology (MRI), metabolism (1H-MRS), function (PET) and the transcriptomic profiles of the nucleus accumbens  ...  This manuscript was prepared during the COVID-19 pandemic and is dedicated to those who helped our society. We honour them all.  ... 
doi:10.1101/2020.10.19.345322 fatcat:dxqucbkevjacnmib3zzw5atuca

Dopaminergic function and intertemporal choice

J Joutsa, V Voon, J Johansson, S Niemelä, J Bergman, V Kaasinen
2015 Translational Psychiatry  
Preclinical and human studies suggest a role for dopaminergic function in temporal discounting but this relationship has not yet been verified using molecular imaging of the living human brain.  ...  These findings provide insights into the relationship between striatal dopamine function and temporal discounting, and its potential role in pathological disorders and mechanisms underlying treatment interventions  ...  ACKNOWLEDGMENTS We are grateful to the staff of Turku PET Centre for their skilled assistance in the study.  ... 
doi:10.1038/tp.2014.133 pmid:25562841 pmcid:PMC4312827 fatcat:wsmtoat245crbaqgp6jwjghb2y

Obesity and addiction: neurobiological overlaps

N. D. Volkow, G.-J. Wang, D. Tomasi, R. D. Baler
2012 Obesity Reviews  
These parallels have generated interest in understanding the shared vulnerabilities between addiction and obesity. Predictably, they also engendered a heated debate.  ...  Specifically, brain imaging studies are beginning to uncover common features between these two conditions and delineate some of the overlapping brain circuits whose dysfunctions may underlie the observed  ...  were predictive of future weight gain (102) .  ... 
doi:10.1111/j.1467-789x.2012.01031.x pmid:23016694 pmcid:PMC4827343 fatcat:ipuddkqi6nfmxnaj5zbts5tq3m

Beer Flavor Provokes Striatal Dopamine Release in Male Drinkers: Mediation by Family History of Alcoholism

Brandon G Oberlin, Mario Dzemidzic, Stella M Tran, Christina M Soeurt, Daniel S Albrecht, Karmen K Yoder, David A Kareken
2013 Neuropsychopharmacology  
Forty-nine men, ranging from social to heavy drinking, mean age 25, with a varied family history of alcoholism underwent two [ 11 C]RAC PET scans: one while tasting beer, and one while tasting Gatorade  ...  Employing positron emission tomography (PET), we hypothesized that beer's flavor alone can reduce the binding potential (BP) of [ 11 C]raclopride (RAC; a reflection of striatal DA release) in the ventral  ...  ACKNOWLEDGEMENTS We gratefully acknowledge Kevin Perry, Wendy Territo, Michele Beal, Courtney Robbins (Dept. of Radiology and Imaging Sciences), Dr William Eiler, Traci Mitchell, Cari Lehigh (Dept. of  ... 
doi:10.1038/npp.2013.91 pmid:23588036 pmcid:PMC3717546 fatcat:hq4mdzlqxvgwhg7glnh44rzw6u
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