2,141 Hits in 2.4 sec

Adelson, Leone. All ready for school. New York (55 fifth avenue): David McKay Company, Inc., 1957. 32 p. $2.75

1959 Science Education  
New York (55 Fifth Avenue): David McKay Company, Inc., 1957. 32 P. $2.50. Oliver Orange is a kitten who never seemed to do anything right.  ...  New York (55 Fifth Avenue) : David McKay Com- pany, Inc., 1957. 32 P. $2.75. This Junior Literary Guild selection is suitable for beginners in school—kindergarten or first grade.  ... 
doi:10.1002/sce.3730430121 fatcat:y2fncqyb6zf2hfrwq6pzs6c72a

Operative Techniques in Paediatric Neurosurgery. 2000. By A. Leland Albright, Ian F. Pollack, P. David Adelson. Published by Thieme. 312pages. C$263.13 approx

D. Douglas Cochrane
2001 Canadian Journal of Neurological Sciences  
Pollack, P. David Adelson. Published by Thieme. 312 pages. C$263.13 approx.  ...  Both chapters, however, provide excellent illustrations, most of which are found in P r i n c i p l e s and Practice.  ... 
doi:10.1017/s0317167100019211 fatcat:nkb6fwwxmfdufgamfvpfe25udu

Hypothermia following Pediatric Traumatic Brain Injury

P. David Adelson
2009 Journal of Neurotrauma  
( p ¼ 0.08).  ...  91% ( p < 0.01).  ... 
doi:10.1089/neu.2008.0571 pmid:19271965 pmcid:PMC2744377 fatcat:e75t3zk4abbdpctzqq75wu52z4

Upper cervical spine fusion in the pediatric population

David W. Lowry, Ian F. Pollack, Brent Clyde, A. Leland Albright, P. David Adelson
1997 Neurosurgical Focus  
The outcomes of 25 pediatric patients who underwent upper cervical or occipitocervical fusion at the authors' institution since 1983 were reviewed. At a mean age of 9 years, the patients presented with spinal instability that was associated with os odontoideum in 11 cases, rotatory subluxation in five cases, odontoid fracture in two cases, atlantooccipital dislocation in two cases, and congenital atlantoaxial instability in five patients, four of whom had Down's syndrome (trisomy 21). Ten
more » ... en had abnormal findings on neurological examination preoperatively; however, nine experienced improvement or resolution of deficits as of their latest follow-up evaluation (mean 17 months). Fusion was achieved with the first operation in 21 of 25 patients; eventually it was attained in all but one. Four patients exhibited persistent spinal instability after an initial procedure. This was caused by erosion of a multistranded cable through the intact arch of C-2 in two cases, by pin site infection necessitating early halo removal in one case, and by slippage in a halo following a Gallie procedure, which was revised with a Brooks fusion in one case. This series, the largest yet published, shows that with appropriate surgical management, posterior upper cervical fusion in the pediatric population is highly successful. Careful attention to halo pin site care and caution in using multistranded cable in young patients may improve results.
doi:10.3171/foc.1997.3.3.1 fatcat:ob7ne44urvcoxastewjwifjqcq

Editorial: Pediatric TBI - Current State of the Art and Future Perspective

Elham Rostami, Anthony Figaji, P. David Adelson
2021 Frontiers in Neurology  
Editorial on the Research Topic Pediatric TBI -Current State of the Art and Future Perspective Traumatic Brain Injury (TBI) remains a leading cause of death and disability in children worldwide and those who survive may suffer long-term cognitive and physical disabilities, The mechanism of injury often differs between high income and low-and middle-income countries, where road traffic accidents and interpersonal violence are comparatively more common. In the publication of Riemann et al. using
more » ... ata collected through CENTER-TBI which is a multicenter study conducted in Europe and Israel, they found that road-traffic incidents were the most common cause of injury overall and those admitted to ICU, while incidental falls were most common in patients admitted to the hospital wards. The overall mortality rate was 3% and the rate of unfavorable outcome 10%, where Glasgow Coma Score (GCS) and the occurrence of secondary insults were identified as independent predictors for an unfavorable outcome. Monitoring the injured brain is crucial in the management of TBI in order to prevent and detect secondary insults. Brain imaging and multimodal neuromonitoring in adults with TBI have improved diagnostics and management of these patients but there is limited experience in the pediatric population. As Appavu et al. describe in their paper methods of monitoring real-time cerebral physiology are also needed in the pediatric population to better understand when secondary brain injury develops and what treatment strategies may alleviate or prevent such injury. They discuss several different emerging technologies to better understand intracranial pressure (ICP), cerebral blood flow, metabolism, oxygenation, and electrical activity. While recent guidelines recommend ICP monitoring and a treatment threshold of 20 mmHg for 5 min, Hornshoj Pedersen et al. highlight the lack of data on normal ICP in healthy children to understand and guide treatment of TBI. Although age-differentiated ICP thresholds in pediatric TBI are needed, only one study reported this and it did not correlate with outcome. The issue with age-differentiated thresholds is also discussed by Rostami et al. regarding CBF. Monitoring of CBF and autoregulation following TBI is crucial. However, there is still lack of fundamental knowledge about normal physiology in children for both across the age spectrum and between genders. Few studies available report on differences across the age range. Following TBI, low initial CBF correlates with poor outcome, as does impaired cerebral pressure autoregulation, but the relationship between the two still needs clarification. Current studies are few and mainly based on small number of patients between the broad age span of 0-18 years. Larger studies across narrower age ranges are needed. The age range affects physiology, mechanism of injury, and outcome. For example, TBI outcome is age dependant: children under the age of 4-5 years have the worse outcome and the rates of TBI-related emergency department visits in this group have increased by more than 50% in US during recent years. Children under the age
doi:10.3389/fneur.2021.649676 pmid:33679597 pmcid:PMC7929992 fatcat:5gwzns2whzgdjfsnsgp4opvplq

Microglia: dismantling and rebuilding circuits after acute neurological injury

Jenna M. Ziebell, P. David Adelson, Jonathan Lifshitz
2014 Metabolic brain disease  
The brain is comprised of neurons and its support system including astrocytes, glial cells and microglia, thereby forming neurovascular units. Neurons require support from glial cells to establish and maintain functional circuits, but microglia are often overlooked. Microglia function as the immune cell of the central nervous system, acting to monitor the microenvironment for changes in signaling, pathogens and injury. More recently, other functional roles for microglia within the healthy brain
more » ... have been identified, including regulating synapse formation, elimination and function. This review aims to highlight and discuss these alternate microglial roles in the healthy and in contrast, diseased brain with a focus on two acute neurological diseases, traumatic brain injury and epilepsy. In these conditions, microglial roles in synaptic stripping and stabilization as part of neuronal:glial interactions may position them as mediators of the transition between injury-induced circuit dismantling and subsequent reorganization. Increased understanding of microglia roles could identify therapeutic targets to mitigate the consequences of neurological disease. Keywords Microglia . Synaptic stripping . Neurological disease . Traumatic brain injury . Epilepsy Microglia: amoeboid to ramified and back again
doi:10.1007/s11011-014-9539-y pmid:24733573 pmcid:PMC4198517 fatcat:2uy5xo4nv5ejperyumhqoqlpyi

Approaches to Multimodality Monitoring in Pediatric Traumatic Brain Injury

Brian Appavu, Brian T Burrows, Stephen Foldes, P David Adelson
2019 Frontiers in Neurology  
A prospective observational study of 52 children with severe TBI investigating the association of P bt O 2 values and outcomes and found that worsened outcomes were associated with P bt O 2 values <10  ...  The sensitivity was low (20%) and observations of elevated P bt O 2 values in some patients with ICH and compromised CPP suggested the need to better understand the relationship of P bt O 2 with outcomes  ...  Copyright © 2019 Appavu, Burrows, Foldes and Adelson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fneur.2019.01261 pmid:32038449 pmcid:PMC6988791 fatcat:scdhwdnjzjfwvpdftlm2sqmbku

Physiologic Characteristics of Hyperosmolar Therapy After Pediatric Traumatic Brain Injury

Jeffrey Wellard, Michael Kuwabara, P. David Adelson, Brian Appavu
2021 Frontiers in Neurology  
ICH reduction after HT was associated with reduced ICP (p = 0.0064), ABP (p = 0.0126), PRx (p = 0.0063), increased HRsd (p = 0.0408), and decreased pretreatment RAC (p = 0.0115) and wPRx (p = 0.0072).  ...  HT-responsive patients were older and had improved outcomes (p = 0.0394).  ...  In terms of indices of CVPR, we observed that HT is associated with increases in PRx (p < 0.0001) and decreases in PAx (p = 0.0005), wPRx (p < 0.0001), and RAC (p < 0.0001).  ... 
doi:10.3389/fneur.2021.662089 pmid:33959090 pmcid:PMC8093760 fatcat:cn2xx27zhzgxrmkjn4izc522ue

Asymmetric detrended fluctuation analysis in neonatal stress

Matej Šapina, Marcin Kośmider, Karolina Kramarić, Matthieu Garcin, P David Adelson, Marko Pirić, Krešimir Milas, Dario Brdarić
2018 Physiological Measurement  
0.006 and p=0.017).  ...  However, . ) increased significantly in the stress phases (1.34±0.19 in phase 2, and 1.31±0.2 in phase 4, p<0.001).  ... 
doi:10.1088/1361-6579/aad425 pmid:30019692 fatcat:sznhbbdx6bc65nk6yaprnfn4g4

Carbon Dioxide Reactivity of Brain Tissue Oxygenation after Pediatric Traumatic Brain Injury

Damla Hanalioglu, Ann Oh, M'Hamed Temkit, P. David Adelson, Brian Appavu
2022 Children  
Compared to patients with intact CO2 reactivity, those with impaired reactivity had increased ICP (p < 0.0000), lower PbtO2 (p < 0.0000) and higher PRx (p = 0.0134).  ...  CO 2 Reactivity to PbtO 2 Intact CO 2 Reactivity of PbtO 2 , Median [IQR] Impaired CO 2 Reactivity of PbtO 2 , Median [IQR] p-Value Children 2022, 9, 409 9 of 14 PbtO 2 36.0 [21.0, 52.0] 21.1 [14.2, 26.0  ... 
doi:10.3390/children9030409 pmid:35327781 pmcid:PMC8947728 fatcat:kwfxaa7mevdchboeoewbpi7qhu

Strengthening neurotrauma care systems in low and middle income countries

Andres M. Rubiano, Juan C. Puyana, Charles N. Mock, M. Ross Bullock, P. David Adelson
2013 Brain Injury  
Admission to a lower trauma designation level facility was an independent predictor of mortality (p < 0.001), complications (p < 0.001) and progression of neurological insult (p < 0.001).  ...  Paralysis was significantly lower at trauma centres (p < 0.001). Non-trauma centres with higher admission caseload were associated with worse outcome.  ... 
doi:10.3109/02699052.2012.750742 pmid:23438347 fatcat:fbcwg3ucuveglhkibhesea5s3y

Using anesthetics and analgesics in experimental traumatic brain injury

Rachel K. Rowe, Jordan L. Harrison, Theresa C. Thomas, James R. Pauly, P. David Adelson, Jonathan Lifshitz
2013 Lab animal  
The use of animal modeling in traumatic brain injury (TBI) research is justified by the lack of sufficiently comprehensive in vitro and computer modeling that incorporates all components of the neurovascular unit. Valid animal modeling of TBI requires accurate replication of both the mechanical forces and secondary injury conditions observed in human patients. Regulatory requirements for animal modeling emphasize the administration of appropriate anesthetics and analgesics unless withholding
more » ... se drugs is scientifically justified. The objective of this review is to present scientific justification for standardizing the use of anesthetics and analgesics, within a study, when modeling TBI in order to preserve study validity. Evidence for the interference of anesthetics and analgesics in the natural course of brain injury calls for consistent consideration of pain management regimens when conducting TBI research. Anesthetics administered at the time of or shortly after induction of brain injury can alter cognitive, motor, and histological outcomes following TBI. A consistent anesthesia protocol based on experimental objectives within each individual study is imperative when conducting TBI studies to control for the confounding effects of anesthesia on outcome parameters. Experimental studies that replicate the clinical condition are essential to gain further understanding and evaluate possible treatments for TBI. However, with animal models of TBI it is essential that investigators assure a uniform drug delivery protocol that minimizes confounding variables, while minimizing pain and suffering. Additional Considerations Differences in outcome among physically similar individuals following equivalent traumatic brain injuries can be particularly noticeable. Minimizing confounds of analgesic and anesthetic drugs are only one step toward conducting valid and reproducible animal modeling of TBI. Differences in weight, sex, age at injury, and genetic background can influence recovery by altering how individuals sustain the mechanical forces and endure the secondary injury processes of brain injury. NIH Public Access
doi:10.1038/laban.257 pmid:23877609 pmcid:PMC3876742 fatcat:ee5qgd4myra53ct5duj6pc7r5u

Traumatic Brain Injury Induces Rapid Enhancement of Cortical Excitability in Juvenile Rats

Joshua Nichols, Roxy Perez, Chen Wu, P. David Adelson, Trent Anderson
2014 CNS Neuroscience & Therapeutics  
MΩ(control); 192.3 ±12.9 MΩ (CCI), P<0.76).  ...  We found no significant change in amplitude (24.6 ± 2.4 pA (control) vs 24.9 ± 3.3 pA (CCI)( P=0.95) or interevent interval (385.1 ± 85.9 ms (control) vs 328.2 ± 50.4 ms (CCI)(P=0.55).  ... 
doi:10.1111/cns.12351 pmid:25475223 pmcid:PMC5880220 fatcat:gxp4k3vnhfcvbetijdxbboei4a

Delineation of somatosensory finger areas using vibrotactile stimulation, an ECoG study

Rémy Wahnoun, Michelle Benson, Stephen Helms-Tillery, P. David Adelson
2015 Brain and Behavior  
This method results in clusters of adjacent time-space or time-frequency-space samples with significant P-values.  ...  We used the maximum P-value of each cluster and ran 1000 Monte Carlo random partitions to calculate significance probability.  ... 
doi:10.1002/brb3.369 pmid:26516605 pmcid:PMC4614049 fatcat:c7dsdljnubaltks3uxqarmufo4

Validity of a Pediatric Version of the Glasgow Outcome Scale–Extended

Sue R. Beers, Stephen R. Wisniewski, Pamela Garcia-Filion, Ye Tian, Thomas Hahner, Rachel P. Berger, Michael J. Bell, P. David Adelson
2012 Journal of Neurotrauma  
Wisniewski, Rachel Berger, and P. David Adelson, and partial salary support for Michael Bell was provided by the National Institutes of Health. The other authors have no competing financial interests.  ...  *p < 0.001; { p < 0.01; { p < 0.05.  ...  *p £ 0.001; { p £ 0.01; { p £ 0.05.  ... 
doi:10.1089/neu.2011.2272 pmid:22220819 pmcid:PMC3325553 fatcat:ni5cy4ef7rbtbe3njbsky73nha
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