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Oxytocin reduces neural activity in the pain circuitry when seeing pain in others

Peter A. Bos, Estrella R. Montoya, Erno J. Hermans, Christian Keysers, Jack van Honk
2015 NeuroImage  
Here, using functional neuroimaging we show robust activation in the neural circuitry of pain (insula and sensorimotor regions) when subjects observe pain in others.  ...  Our empathetic abilities allow us to feel the pain of others. This phenomenon of vicarious feeling arises because the neural circuitry of feeling pain and seeing pain in others is shared.  ...  We thank Fang Cui, Valeria Gazzola and Abdelrahman Abdelgabar for collecting and analyzing the pain localizer data together with CK.  ... 
doi:10.1016/j.neuroimage.2015.03.049 pmid:25818690 pmcid:PMC4562366 fatcat:vp5y4tjz4rdwjffwwwi5xs4xvm

Neural responses in the pain matrix when observing pain of others are unaffected by testosterone administration [article]

Sarah Heany, David Terburg, Dan Stein, Jack van Honk, Peter A Bos
2018 bioRxiv   pre-print
Using functional magnetic resonance imaging we provide affirming evidence that the empathy inducing paradigm causes changes in the activity throughout the pain circuitry, including the bilateral insula  ...  Therefore, we tested neural responses to witnessing others in pain in a within-subject placebo-controlled testosterone administration study.  ...  Hormonal factors can also affect empathy for pain, as the neuropeptide oxytocin has shown to decrease neural activation of the pain circuitry upon seeing pain in others, an effect that was independent  ... 
doi:10.1101/245001 fatcat:sp4y5becffelrgybxt4tgytrdm

Neural responses in the pain matrix when observing pain of others are unaffected by testosterone administration in women

Sarah J. Heany, David Terburg, Dan J. Stein, Jack van Honk, Peter A. Bos
2020 Experimental Brain Research  
Using functional magnetic resonance imaging, we provide affirming evidence that an empathy-inducing paradigm causes changes in the activity throughout the pain circuitry, including the bilateral insula  ...  Therefore, we tested neural responses to witnessing others in pain in a within-subject placebo-controlled testosterone administration study in healthy young women.  ...  pain circuitry when seeing pain in others .  ... 
doi:10.1007/s00221-020-05749-3 pmid:32086551 fatcat:aaimld5frfhbxlo2puri4x4mf4

The neuroevolution of empathy

Jean Decety
2011 Annals of the New York Academy of Sciences  
Activation of this circuit reflects an aversive response in the observer, and this information may act as a trigger to inhibit aggression or prompt motivation to help.  ...  Social neuroscience has begun to examine the neurobiological mechanisms that instantiate empathy, especially in response to signals of distress and pain, and how certain dispositional and contextual moderators  ...  Acknowledgements The writing of this paper was supported by a Grant (BCS-0718480) from the National Science Foundation.  ... 
doi:10.1111/j.1749-6632.2011.06027.x pmid:21651564 fatcat:we7whyl6rnfsbcvdjlfgwz4lna

The Neurobiology Shaping Affective Touch: Expectation, Motivation, and Meaning in the Multisensory Context

Dan-Mikael Ellingsen, Siri Leknes, Guro Løseth, Johan Wessberg, Håkan Olausson
2016 Frontiers in Psychology  
Finally, we discuss the central neurochemistry, specifically the µ-opioids and oxytocin systems, involved in affective touch processing, and how the functions of these neurotransmitters largely depend  ...  While a broad literature has addressed, on one hand the neurophysiological basis of ascending touch pathways, and on the other hand the central neurochemistry involved in touch behaviors, investigations  ...  On the other hand, pain and negative affect can reduce the capacity for pleasure, as demonstrated by the strong comorbidity between chronic pain, depression, and anhedonia (i.e., a lack of capacity for  ... 
doi:10.3389/fpsyg.2015.01986 pmid:26779092 pmcid:PMC4701942 fatcat:q7gdjniix5elfmxqrsvsmujhhe

Psychopathy to Altruism: Neurobiology of the Selfish–Selfless Spectrum

James W. H. Sonne, Don M. Gash
2018 Frontiers in Psychology  
and reward-activating compassion are entering the mainstream of clinical care for managing pain, depression, and stress.  ...  systems in forming and reforming neural circuitry in response to personal experience and cultural influences in determining behavior in the selfish-selfless spectrum.  ...  Wayne Bell for the encouragement in the study of critical issues in neurotheology.  ... 
doi:10.3389/fpsyg.2018.00575 pmid:29725317 pmcid:PMC5917043 fatcat:bulispzinver7hjz2hfgdtnzay

C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?

Susannah C. Walker, Paula D. Trotter, William T. Swaney, Andrew Marshall, Francis P. Mcglone
2017 Neuropeptides  
In support of this hypothesis, in this paper we review the evidence that cutaneous stimulation directly targeted to optimally activate c-tactile afferents reduces physiological arousal, carries a positive  ...  The social touch hypothesis posits that this system of nerves has evolved in mammals to signal the rewarding value of physical contact in nurturing and social interactions.  ...  While oxytocin has been reported to reduce pain and unpleasantness in the cold pressor test and acute laser evoked thermal pain (Paloyelis et al., 2016b) other experimental pain models have not shown  ... 
doi:10.1016/j.npep.2017.01.001 pmid:28162847 fatcat:x76gynxikrdlpmogxa53imrl7a

Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1

Yelena Nersesyan, Lusine Demirkhanyan, Deny Cabezas-Bratesco, Victoria Oakes, Ricardo Kusuda, Tyler Dawson, Xiaohui Sun, Chike Cao, Alejandro Martin Cohen, Bharath Chelluboina, Krishna Kumar Veeravalli, Katharina Zimmermann (+3 others)
2017 Cell Reports  
Article Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1 Graphical Abstract Highlights d TRPV1 acts as an ionotropic oxytocin receptor in cells d Oxytocin potentiates TRPV1 in cells and  ...  lipid bilayers d Oxytocin interacts with TRPV1 at the extracellular pore loop region d Oxytocin attenuates capsaicin-induced nociception via TRPV1 desensitization  ...  ACKNOWLEDGMENTS We deeply appreciate the commitment of Dr. Liskin Swint-Kruse and her immense help in critical reading of the manuscript and fruitful suggestions.  ... 
doi:10.1016/j.celrep.2017.10.063 pmid:29117570 pmcid:PMC5701661 fatcat:3rioczsbgjg5bhnyfevsgzthma

Human neuroimaging of oxytocin and vasopressin in social cognition

Caroline F. Zink, Andreas Meyer-Lindenberg
2012 Hormones and Behavior  
Here we review the findings to-date from investigations of the acute and chronic effects of oxytocin and vasopressin on neural activity underlying social cognitive processes using "pharmacological fMRI  ...  Identifying the human brain regions that are impacted by oxytocin and vasopressin in a social context is essential to fully characterize the role of oxytocin and vasopressin in complex human social cognition  ...  gyrus and right insula activity when identifying emotional states of others.  ... 
doi:10.1016/j.yhbeh.2012.01.016 pmid:22326707 pmcid:PMC3312952 fatcat:53kot3i6vfekflzahoq4xemdze

Toward a cross-species understanding of empathy

Jaak Panksepp, Jules B. Panksepp
2013 Trends in Neurosciences  
Cross-species evolutionary approaches to understanding the neural circuitry of emotional 'contagion' or 'resonance' between nearby animals, together with the underlying neurochemistries, may help to clarify  ...  Thus, the study of empathy in animals has started in earnest.  ...  Acknowledgments J.B.P. was supported by a National Institutes of Health (NIH) training grant (F32 MH096475) during the writing of this paper.  ... 
doi:10.1016/j.tins.2013.04.009 pmid:23746460 pmcid:PMC3839944 fatcat:fozuk2m7irf4bkbcldph5km3ry

Putting together phylogenetic and ontogenetic perspectives on empathy

Jean Decety, Margarita Svetlova
2012 Developmental Cognitive Neuroscience  
Moreover, empathy in humans is assisted by other abstract and domain-general high-level cognitive abilities such as executive functions, mentalizing and language, as well as the ability to differentiate  ...  We bring together neuroevolutionary and developmental perspectives on the information processing and neural mechanisms underlying empathy and caring, and show that they are grounded in multiple interacting  ...  Acknowledgement The writing of this paper was supported by a grant (BCS-0718480) from the National Science Foundation to Jean Decety.  ... 
doi:10.1016/j.dcn.2011.05.003 pmid:22682726 pmcid:PMC6987713 fatcat:2e3wqhcr7vgivog26zza5gjhaa

A New Perspective on the Pathophysiology of Borderline Personality Disorder: A Model of the Role of Oxytocin

Sabine C. Herpertz, Katja Bertsch
2015 American Journal of Psychiatry  
In addition, preliminary data point to interactions between the oxytocin and cannabinoid system, with implications for pain processing.  ...  These mechanisms, which the authors believe to be modulated by oxytocin, may not be specific for borderline personality disorder but rather may be common to a host of psychiatric disorders in which disturbed  ...  The authors report no financial relationships with commercial interests.  ... 
doi:10.1176/appi.ajp.2015.15020216 pmid:26324303 fatcat:7jd6lft4pjcytblqceppa52hgq

Keep Calm and Cuddle on: Social Touch as a Stress Buffer

India Morrison
2016 Adaptive Human Behavior and Physiology  
Social touch may play a functional role in the physiological regulation of the body's responses to acute stressors and other short-term challenges.  ...  Finally, prosocial touch, such as allogrooming and consolation, may utilize some of the same neural pathways as other, non-social means of stress regulation.  ...  , and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.  ... 
doi:10.1007/s40750-016-0052-x fatcat:rudjiw6i4vbyhjcsczi53fprly

Ageing and Oxytocin: A Call for Extending Human Oxytocin Research to Ageing Populations – A Mini-Review

Renske Huffmeijer, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg
2013 Gerontology  
This is particularly striking in two areas of study: the role of oxytocin in grandparents' behavior toward and bonding with their grandchildren and the effects of oxytocin on the neurocognitive processing  ...  Interest in oxytocin has increased rapidly, both inside the scientific community and among the general public.  ...  The neural circuitry underlying the cognitive-behavioral effects has been the topic of a number of investigations using fMRI to image brain activity.  ... 
doi:10.1159/000341333 pmid:22922544 fatcat:slh3rzshlzcibfvjf46g3xd2fq

Social neuroeconomics: the neural circuitry of social preferences

Ernst Fehr, Colin F. Camerer
2007 Trends in Cognitive Sciences  
These behaviours are consistently associated with activation in reward-related brain areas such as the striatum and with prefrontal activity implicated in cognitive control, the processing of emotions,  ...  These behaviours are consistently associated with activation in reward-related brain areas such as the striatum and with prefrontal activity implicated in cognitive control, the processing of emotions,  ...  ., et al. (2005) Oxytocin modulates neural circuitry for social cognition and fear in humans. J Neurosci 25, 11489-11493 49.  ... 
doi:10.1016/j.tics.2007.09.002 pmid:17913566 fatcat:wvm2qmscirgxzb73d6xqkmsubi
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