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Oxytocin reduces neural activity in the pain circuitry when seeing pain in others
2015
NeuroImage
Here, using functional neuroimaging we show robust activation in the neural circuitry of pain (insula and sensorimotor regions) when subjects observe pain in others. ...
Our empathetic abilities allow us to feel the pain of others. This phenomenon of vicarious feeling arises because the neural circuitry of feeling pain and seeing pain in others is shared. ...
We thank Fang Cui, Valeria Gazzola and Abdelrahman Abdelgabar for collecting and analyzing the pain localizer data together with CK. ...
doi:10.1016/j.neuroimage.2015.03.049
pmid:25818690
pmcid:PMC4562366
fatcat:vp5y4tjz4rdwjffwwwi5xs4xvm
Neural responses in the pain matrix when observing pain of others are unaffected by testosterone administration
[article]
2018
bioRxiv
pre-print
Using functional magnetic resonance imaging we provide affirming evidence that the empathy inducing paradigm causes changes in the activity throughout the pain circuitry, including the bilateral insula ...
Therefore, we tested neural responses to witnessing others in pain in a within-subject placebo-controlled testosterone administration study. ...
Hormonal factors can also affect empathy for pain, as the neuropeptide oxytocin has shown to decrease neural activation of the pain circuitry upon seeing pain in others, an effect that was independent ...
doi:10.1101/245001
fatcat:sp4y5becffelrgybxt4tgytrdm
Neural responses in the pain matrix when observing pain of others are unaffected by testosterone administration in women
2020
Experimental Brain Research
Using functional magnetic resonance imaging, we provide affirming evidence that an empathy-inducing paradigm causes changes in the activity throughout the pain circuitry, including the bilateral insula ...
Therefore, we tested neural responses to witnessing others in pain in a within-subject placebo-controlled testosterone administration study in healthy young women. ...
pain circuitry when seeing pain in others . ...
doi:10.1007/s00221-020-05749-3
pmid:32086551
fatcat:aaimld5frfhbxlo2puri4x4mf4
The neuroevolution of empathy
2011
Annals of the New York Academy of Sciences
Activation of this circuit reflects an aversive response in the observer, and this information may act as a trigger to inhibit aggression or prompt motivation to help. ...
Social neuroscience has begun to examine the neurobiological mechanisms that instantiate empathy, especially in response to signals of distress and pain, and how certain dispositional and contextual moderators ...
Acknowledgements The writing of this paper was supported by a Grant (BCS-0718480) from the National Science Foundation. ...
doi:10.1111/j.1749-6632.2011.06027.x
pmid:21651564
fatcat:we7whyl6rnfsbcvdjlfgwz4lna
The Neurobiology Shaping Affective Touch: Expectation, Motivation, and Meaning in the Multisensory Context
2016
Frontiers in Psychology
Finally, we discuss the central neurochemistry, specifically the µ-opioids and oxytocin systems, involved in affective touch processing, and how the functions of these neurotransmitters largely depend ...
While a broad literature has addressed, on one hand the neurophysiological basis of ascending touch pathways, and on the other hand the central neurochemistry involved in touch behaviors, investigations ...
On the other hand, pain and negative affect can reduce the capacity for pleasure, as demonstrated by the strong comorbidity between chronic pain, depression, and anhedonia (i.e., a lack of capacity for ...
doi:10.3389/fpsyg.2015.01986
pmid:26779092
pmcid:PMC4701942
fatcat:q7gdjniix5elfmxqrsvsmujhhe
Psychopathy to Altruism: Neurobiology of the Selfish–Selfless Spectrum
2018
Frontiers in Psychology
and reward-activating compassion are entering the mainstream of clinical care for managing pain, depression, and stress. ...
systems in forming and reforming neural circuitry in response to personal experience and cultural influences in determining behavior in the selfish-selfless spectrum. ...
Wayne Bell for the encouragement in the study of critical issues in neurotheology. ...
doi:10.3389/fpsyg.2018.00575
pmid:29725317
pmcid:PMC5917043
fatcat:bulispzinver7hjz2hfgdtnzay
C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?
2017
Neuropeptides
In support of this hypothesis, in this paper we review the evidence that cutaneous stimulation directly targeted to optimally activate c-tactile afferents reduces physiological arousal, carries a positive ...
The social touch hypothesis posits that this system of nerves has evolved in mammals to signal the rewarding value of physical contact in nurturing and social interactions. ...
While oxytocin has been reported to reduce pain and unpleasantness in the cold pressor test and acute laser evoked thermal pain (Paloyelis et al., 2016b) other experimental pain models have not shown ...
doi:10.1016/j.npep.2017.01.001
pmid:28162847
fatcat:x76gynxikrdlpmogxa53imrl7a
Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1
2017
Cell Reports
Article Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1 Graphical Abstract Highlights d TRPV1 acts as an ionotropic oxytocin receptor in cells d Oxytocin potentiates TRPV1 in cells and ...
lipid bilayers d Oxytocin interacts with TRPV1 at the extracellular pore loop region d Oxytocin attenuates capsaicin-induced nociception via TRPV1 desensitization ...
ACKNOWLEDGMENTS We deeply appreciate the commitment of Dr. Liskin Swint-Kruse and her immense help in critical reading of the manuscript and fruitful suggestions. ...
doi:10.1016/j.celrep.2017.10.063
pmid:29117570
pmcid:PMC5701661
fatcat:3rioczsbgjg5bhnyfevsgzthma
Human neuroimaging of oxytocin and vasopressin in social cognition
2012
Hormones and Behavior
Here we review the findings to-date from investigations of the acute and chronic effects of oxytocin and vasopressin on neural activity underlying social cognitive processes using "pharmacological fMRI ...
Identifying the human brain regions that are impacted by oxytocin and vasopressin in a social context is essential to fully characterize the role of oxytocin and vasopressin in complex human social cognition ...
gyrus and right insula activity when identifying emotional states of others. ...
doi:10.1016/j.yhbeh.2012.01.016
pmid:22326707
pmcid:PMC3312952
fatcat:53kot3i6vfekflzahoq4xemdze
Toward a cross-species understanding of empathy
2013
Trends in Neurosciences
Cross-species evolutionary approaches to understanding the neural circuitry of emotional 'contagion' or 'resonance' between nearby animals, together with the underlying neurochemistries, may help to clarify ...
Thus, the study of empathy in animals has started in earnest. ...
Acknowledgments J.B.P. was supported by a National Institutes of Health (NIH) training grant (F32 MH096475) during the writing of this paper. ...
doi:10.1016/j.tins.2013.04.009
pmid:23746460
pmcid:PMC3839944
fatcat:fozuk2m7irf4bkbcldph5km3ry
Putting together phylogenetic and ontogenetic perspectives on empathy
2012
Developmental Cognitive Neuroscience
Moreover, empathy in humans is assisted by other abstract and domain-general high-level cognitive abilities such as executive functions, mentalizing and language, as well as the ability to differentiate ...
We bring together neuroevolutionary and developmental perspectives on the information processing and neural mechanisms underlying empathy and caring, and show that they are grounded in multiple interacting ...
Acknowledgement The writing of this paper was supported by a grant (BCS-0718480) from the National Science Foundation to Jean Decety. ...
doi:10.1016/j.dcn.2011.05.003
pmid:22682726
pmcid:PMC6987713
fatcat:2e3wqhcr7vgivog26zza5gjhaa
A New Perspective on the Pathophysiology of Borderline Personality Disorder: A Model of the Role of Oxytocin
2015
American Journal of Psychiatry
In addition, preliminary data point to interactions between the oxytocin and cannabinoid system, with implications for pain processing. ...
These mechanisms, which the authors believe to be modulated by oxytocin, may not be specific for borderline personality disorder but rather may be common to a host of psychiatric disorders in which disturbed ...
The authors report no financial relationships with commercial interests. ...
doi:10.1176/appi.ajp.2015.15020216
pmid:26324303
fatcat:7jd6lft4pjcytblqceppa52hgq
Keep Calm and Cuddle on: Social Touch as a Stress Buffer
2016
Adaptive Human Behavior and Physiology
Social touch may play a functional role in the physiological regulation of the body's responses to acute stressors and other short-term challenges. ...
Finally, prosocial touch, such as allogrooming and consolation, may utilize some of the same neural pathways as other, non-social means of stress regulation. ...
, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. ...
doi:10.1007/s40750-016-0052-x
fatcat:rudjiw6i4vbyhjcsczi53fprly
Ageing and Oxytocin: A Call for Extending Human Oxytocin Research to Ageing Populations – A Mini-Review
2013
Gerontology
This is particularly striking in two areas of study: the role of oxytocin in grandparents' behavior toward and bonding with their grandchildren and the effects of oxytocin on the neurocognitive processing ...
Interest in oxytocin has increased rapidly, both inside the scientific community and among the general public. ...
The neural circuitry underlying the cognitive-behavioral effects has been the topic of a number of investigations using fMRI to image brain activity. ...
doi:10.1159/000341333
pmid:22922544
fatcat:slh3rzshlzcibfvjf46g3xd2fq
Social neuroeconomics: the neural circuitry of social preferences
2007
Trends in Cognitive Sciences
These behaviours are consistently associated with activation in reward-related brain areas such as the striatum and with prefrontal activity implicated in cognitive control, the processing of emotions, ...
These behaviours are consistently associated with activation in reward-related brain areas such as the striatum and with prefrontal activity implicated in cognitive control, the processing of emotions, ...
., et al. (2005) Oxytocin modulates neural circuitry for social cognition and fear in humans. J Neurosci 25, 11489-11493 49. ...
doi:10.1016/j.tics.2007.09.002
pmid:17913566
fatcat:wvm2qmscirgxzb73d6xqkmsubi
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