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A Proteomic Approach to Investigating Gene Cluster Expression and Secondary Metabolite Functionality in Aspergillus fumigatus

Rebecca A. Owens, Stephen Hammel, Kevin J. Sheridan, Gary W. Jones, Sean Doyle, Kap-Hoon Han
2014 PLoS ONE  
maps: proteins with multiple transmembrane regions, hydrophobic proteins and proteins with extremes of molecular mass and pI.  ...  Here, implementation of a shotgun proteomic strategy led to the identification of non-redundant mycelial proteins (n = 414) from A. fumigatus including proteins typically under-represented in 2-D proteome  ...  Contributed to the writing of the manuscript: RAO GWJ SD.  ... 
doi:10.1371/journal.pone.0106942 pmid:25198175 pmcid:PMC4157829 fatcat:ljc5xbgxejarvloadyimm75t3u

Identification and characterization of potential druggable targets among Essential Hypothetical Proteins of A. baumannii

Bydaa ATRON
2021 International journal of life sciences and biotechnology  
Acinetobacter baumannii is a critical pathogen responsible for a wide range of infections.  ...  A. baumannii exhibits resistance to a variety of antibiotic classes, emphasizing that new therapeutic targets are urgently needed. In A. baumannii, ATCC 179778.  ...  hydropathicity (GRAVY).  ... 
doi:10.38001/ijlsb.1009800 fatcat:u3y23cg5szerxnvxny4c4p7eda

Root Proteomics Reveals the Effects of Wood Vinegar on Wheat Growth and Subsequent Tolerance to Drought Stress

Yuying Wang, Ling Qiu, Qilu Song, Shuping Wang, Yajun Wang, Yihong Ge
2019 International Journal of Molecular Sciences  
Wood vinegar (WV) or pyroligneous acid (PA) is a reddish-brown liquid created during the dry distillation of biomass, a process called pyrolysis.  ...  However, its mechanism of action remains unknown. Our results after presoaking wheat seeds with various concentrations of WV indicate that a 1:900 WV concentration can significantly enhance growth.  ...  The grand average of hydropathicity (GRAVY) value for each DAP was calculated using the Protein GRAVY tool (http: //www.bioinformatics.org/sms2/protein_gravy.html).  ... 
doi:10.3390/ijms20040943 fatcat:6fnxdvodm5fx5iaacxapltqytu

Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V

2013 Naunyn-Schmiedeberg's Archives of Pharmacology  
, C., Jagla, W., Russ, A., Popp, A., Josephs, M., Marquardt, A., Laufs, J., Schmittwolf, C., Wagner, H., Pfeffer, K., and Mudde, G.C. (2005) Immunity 22 ...........................................  ...  Acknowledgement: This work has been financially supported by DFG and Tubitak with a travel stipend to Aylin Üstündag. [1] Yu, P., Constien, R., Dear, N., Katan, M., Hanke, P., Bunney, T.D., Kunder, S.,  ...  The oxidation of guanine to 8-oxo-2'-deoxyguanosine (8-oxo-dG) is one of the most abundant and best studied oxidative DNA lesions and is commonly used as a biomarker for oxidative stress.  ... 
doi:10.1007/s00210-013-0832-9 pmid:23334796 fatcat:vp56yyyimzfgdgrczauhpodxou

The protein interaction network of Treponema pallidum - a minimal proteome

Björn Titz
2006
In this thesis, a proteome-wide binary protein interaction map for Treponema pallidum, the Syphilis spirochete, is presented.  ...  In parallel to this study, the Y2H interaction map of Campylobacter jejuni was analyzed (Parish et al., pers. comm.).  ...  a whole plate to a new vector, and extracting the overall status for a list of genes.  ... 
doi:10.5445/ir/1000005334 fatcat:652kdgctjvcezhzog4a24qgwcy

Midwestern Regional Meeting

2018 Journal of Investigative Medicine  
Conclusions A significant reduction in sedentary time during working hours was identified with utilization of a sit-stand desk for 12 weeks.  ...  Femoral FMD improved an average of 3.6% (4.7±1.8 to 7.1±1.6, p=0.019, figure 2 ) while there was a non-significant trend toward improvement in brachial FMD (7.7±3.1 to 9.9±1.9, p=0.07).  ...  Background Myasthenia gravis (MG) is a neuromuscular disorder requiring chronic immunosuppression.  ... 
doi:10.1136/jim-2018-000745.1 fatcat:55kbmqb4m5b4bahiwtxshuaeba

Enrichment and Identification of Methylation at the Proteome Level

Alexandra Star, Université D'Ottawa / University Of Ottawa, Université D'Ottawa / University Of Ottawa
2016
This ProMENADe enrichment strategy yielded 95 novel methylation sites to the field and can be a key tool in the field of methylation allowing for the enrichment and identification of methylated proteins  ...  Methylation is a post-translational modification which occurs on lysine and arginine residues. Methylation is difficult to detect due to its low abundance and lack of charge.  ...  Gene Ontology Analysis The gene names of the identified methylated proteins were extracted and imported into the Gene Ontology (GO) tool in the Database for Annotation, Visualization and Integrated Discovery  ... 
doi:10.20381/ruor-2635 fatcat:3aooglv2frdhtbm77oyv26pxgq

ETA Abstracts [chapter]

2011 35th Annual Meeting of the European Thyroid Association  
After DNA isolation and extraction from archived FNAB smears and corresponding FFPE samples, sets of 49 / 99 FNAB and corresponding FFPE samples were screened for the BRAF V600E or NRAS mutations, respectively  ...  Conclusions: The anterior endoderm is a novel source of embryonic C-cell precursors and Foxa2, a bona fide regulator of endoderm development and differentiation, is a potential biomarker of C-cell-derived  ...  Aim of the study was to assess the frequency of thyroid dysfunction in previously healthy adult population of Krakow.  ... 
doi:10.1159/000330565 fatcat:5qvmofknovblvcpzxr7jqog2ku