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Genetics and functional genomics of type 2 diabetes mellitus
2003
Genome Biology
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These findings help unravel the complex pathogenesis and inheritance of polygenic type 2 diabetes mellitus. ...
Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined ...
Genetic markers and dense genetic maps allow extensive searches for gene variants that co-segregate with the disease. ...
doi:10.1186/gb-2003-4-12-241
pmid:14659011
pmcid:PMC329413
fatcat:csqdaa4bjvbalakjyjm2d6bo54
Extensive metabolic remodeling after limiting mitochondrial lipid burden is consistent with an improved metabolic health profile
2019
Journal of Biological Chemistry
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, shifts in nucleotide metabolites, and biogenesis of mitochondria and peroxisomes. ...
Limiting mitochondrial fat entry predictably improves glucose homeostasis; however, remodeling of glucose metabolism pathways pales compared with adaptations in amino acid and lipid metabolism pathways ...
This coincides well with the KEGG map for the pyruvate handling pathway (Fig. ...
doi:10.1074/jbc.ra118.006074
pmid:31097541
pmcid:PMC6699851
fatcat:br4dgtpwsrexlhy7q4zb2hta3e
Literature-aided interpretation of gene expression data with the weighted global test
2010
Briefings in Bioinformatics
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, tissues and other types of concepts. ...
The weights are the literature association scores and reflect the importance of a gene for the concept of interest. ...
Christoffels and G. Hooiveld for useful discussions and critical reading of the article. ...
doi:10.1093/bib/bbq082
pmid:21183478
fatcat:4q7lybxnojh3jlemfin4fjtpmy
The challenges for molecular nutrition research 4: the "nutritional systems biology level"
2008
Genes & Nutrition
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Although the achievement of this proposition may currently sound unrealistic, many initiatives in theoretical biology and biomedical sciences work on parts of the solution. ...
This review provides examples and some recommendations for the molecular nutrition research arena to move onto the systems level. ...
Finally, a data warehouse with knowledge system allowing the query of these studies (results coupled to their study description) will be useful, as this will allow optimal comparison and integration of ...
doi:10.1007/s12263-008-0090-5
pmid:18825427
pmcid:PMC2593015
fatcat:pnneycfvunhg3ifswecxkkea64
Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension
2010
BMC Medical Genomics
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Conclusion: The findings provide a novel comprehensive approach for understanding the pathogenesis of various co-associated chronic inflammatory diseases by combining the power of pathway analysis with ...
Results: By analyzing the genes related to T2D, HT and OBS, a highly regulated gene-disease integrated network model has been developed that provides useful functional linkages among groups of genes and ...
Acknowledgements We thank Dr Zaheed Husain (Division of Interdisciplinary Medicine & Biotechnology, BIDMC, Department of Medicine, Harvard Medical School, Boston) for valuable comments and suggestions ...
doi:10.1186/1755-8794-3-45
pmid:20942928
pmcid:PMC2965702
fatcat:mcunumuqjvca7mn43jo2kikuoy
Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases
2022
Frontiers in Cardiovascular Medicine
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Like other fields, CVD research has benefitted from the deluge of multiomics biomedical data. ...
Systems biology offers an alternative to traditional reductionist approaches and provides impetus for a comprehensive outlook toward diseases. ...
For example, extracting a cardiovascular-specific subnetwork along with mass spectrometry data enabled "knowledge-integrated biomarker discovery" in CVD (46) . ...
doi:10.3389/fcvm.2022.873582
fatcat:tii5uxtjl5c3poqbeso3om2znm
T2D-Db: An integrated platform to study the molecular basis of Type 2 diabetes
2008
BMC Genomics
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with type 2 diabetes and appears to contribute to the evidence for linkage in an ...
Conclusion: Information available in T2D-Db provides an integrated platform for the better molecular level understanding of type 2 diabetes mellitus and its pathogenesis. ...
Acknowledgements The authors gratefully acknowledge Philips Research Asia, Bangalore, India and Institute of Bioinformatics and Applied Biotechnology, Bangalore, India for funding this project. ...
doi:10.1186/1471-2164-9-320
pmid:18605991
pmcid:PMC2491641
fatcat:nwn7yrtbrrccrjmochw26zovku
Creating a Structured Adverse Outcome Pathway Knowledgebase via Ontology-Based Annotations
2017
Applied In Vitro Toxicology
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Results-AOP Key Events (KEs) were assigned ontology terms using a concept called the Event Component, which consists of a Process, an Object, and an Action term, with each term originating from ontologies ...
Introduction-The Adverse Outcome Pathway framework is increasingly used to integrate data generated based on traditional and emerging toxicity testing paradigms. ...
We also thank the members of the OECD EAGMST Ontology Working Group for guidance with ontology selection and feedback on the extensions made to the AOP ontology. ...
doi:10.1089/aivt.2017.0017
pmid:30057931
pmcid:PMC6060416
fatcat:qvd4vsl6wfbolnqj7s2plhlnqa
The Emerging Paradigm of Network Medicine in the Study of Human Disease
2012
Circulation Research
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This review introduces the fundamental concepts of network medicine and explores the feasibility and potential impact of network-based methods for predicting individual manifestations of human disease ...
The molecular pathways that govern human disease consist of molecular circuits that coalesce into complex, overlapping networks. ...
Acknowledgments We thank Stephanie Tribuna for expert administrative assistance and Sol Chan for assistance with figures. ...
doi:10.1161/circresaha.111.258541
pmid:22821909
pmcid:PMC3425394
fatcat:m4zwmfv42vejrpd3kkbpx2k4h4
Nutrigenomics: The Impact of Biomics Technology on Nutrition Research
2005
Annals of Nutrition and Metabolism
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The interaction between the human body and nutrition is an extremely complex process involving multi-organ physiology with molecular mechanisms on all levels of regulation (genes, gene expression, proteins ...
Both the challenges and promises that are offered by the merge of 'biomics' technologies and mechanistic nutrition research are huge, but will eventually evolve in a new nutrition research concept: nutritional ...
The opinions expressed herein are those of the authors and do not necessarily represent the views of ILSI and ILSI Europe. ...
doi:10.1159/000088315
pmid:16179781
fatcat:rzrz6tgvabce7ebywkn3qvplgy
DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes
2015
Database: The Journal of Biological Databases and Curation
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DisGeNET integrates expert-curated databases with text-mined data, covers information on Mendelian and complex diseases, and includes data from animal disease models. ...
DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes. ...
Funding for open access charge: Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional (PI13/00082). ...
doi:10.1093/database/bav028
pmid:25877637
pmcid:PMC4397996
fatcat:rf3dotjr2bbz3odfwvsuefnlli
A sample copy of the textbook Principles of Cell and Tissue Biology
2020
Biomedical Reviews
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proteases) by mitochondrial cytochrome c is a key step in the apoptosis pathway, MOMP being the key trigger of that pathway. ...
Of course, we should know the scientific facts, but I believe that they are required primarily to incorporate them into knowledge, hypotheses, and concepts. ...
And in the heart, heart, heart, heart. It is the same for love-of-knowledge. Educating the mind without educating the heart is no education at all. ...
doi:10.14748/bmr.v31.7716
fatcat:7tgzg72st5gl5kpmk3qhzimfha
Harnessing Systems Biology Approaches to Engineer Functional Microvascular Networks
2010
Tissue engineering. Part B, Reviews
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Systems biology integrates complex biological data from a variety of experimental sources (-omics) and analyzes how the interactions of the system components can give rise to the function and behavior ...
Despite a continued growth in the understanding of signaling pathways involved in the formation and maturation of new blood vessels, approximately half of all compounds entering clinical trials will fail ...
Botchwey and NSF CAREER award #0643548 to Dr. J.A. Papin.
Disclosure Statement No competing financial interests exist. ...
doi:10.1089/ten.teb.2009.0611
pmid:20121415
pmcid:PMC2946904
fatcat:64beiuj6qvhqvkrlw2dttqnc7i
Systems Biology Elucidates Common Pathogenic Mechanisms between Nonalcoholic and Alcoholic-Fatty Liver Disease
2013
PLoS ONE
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We observed that the leading disease pathways associated with NAFLD did not significantly differ from those of AFLD. ...
Our primary aim was to integrate omics and physiological data to answer the question of whether NAFLD and AFLD share molecular processes that lead to disease development. ...
Hence, the results of this study only integrate the published knowledge about both the diseases. ...
doi:10.1371/journal.pone.0058895
pmid:23516571
pmcid:PMC3596348
fatcat:ccotipqsdzh7zfuhtlqa42hozm
Exploring the human diseasome: the human disease network
2012
Briefings in Functional Genomics
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Advances in genome-scale molecular biology and molecular genetics have greatly elevated our knowledge on the basic components of human biology and diseases. ...
The use of the diseasome in combination with various interactome networks and other disease-related factors is also reviewed. ...
Acknowledgement We thank Joseph Song for a careful proofreading of this article. ...
doi:10.1093/bfgp/els032
pmid:23063808
fatcat:s5k7rc7brzf4tda6ngym4cq4ba
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