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., 1988; Zanetti et al., 1998 Zanetti et al., , 2001 Zanetti et al., , 2002 Clare et al., 2001; De Vreese et al., 2001; Olazaran et al., 2004 Olazaran et al., , 2010 Onder et al., 2005; Souchay et al., ... Following this evidence, a study conducted by Zanetti et al. (2001) confirmed the effectiveness of procedural memory training consisting of three consecutive weeks in 13 basic and instrumental activities ...doi:10.1016/j.neurobiolaging.2014.01.130 fatcat:snplwtur3vb65d6xdjtqv73y3e
Zanetti, A. Tommasoni, G. Lussignoli Criteri per la diagnosi clinica di malattia di alzheimer probabile 1. 2. 3. 4. 5. 6. ...doi:10.7175/cmi.v1i3.604 fatcat:2doqyorbu5e4zo6qokfbn557qq
., 1988; Zanetti et al., 1998 Zanetti et al., , 2001 Zanetti et al., , 2002 Clare et al., 2001; De Vreese et al., 2001; Olazaran et al., 2004 Olazaran et al., , 2010 Onder et al., 2005; Souchay et al., ... Following this evidence, a study conducted by Zanetti et al. (2001) confirmed the effectiveness of procedural memory training consisting of three consecutive weeks in 13 basic and instrumental activities ...doi:10.3389/fnhum.2012.00046 pmid:22408614 pmcid:PMC3297818 fatcat:rou46h2aufezvgebfdr6zfbwty
Over the last two decades, age-related anatomical and functional brain changes have been characterized by evidence acquired primarily by means of non-invasive functional neuroimaging. These functional changes are believed to favor positive reorganization driven by adaptations to system changes as compensation for cognitive decline. These functional modifications have been linked to residual brain plasticity mechanisms, suggesting that all areas of the brain remain plastic during physiologicaldoi:10.3389/fnins.2012.00120 pmid:22933989 pmcid:PMC3422757 fatcat:fbf3opjzh5avfekh7amxbw2n34
more »... d pathological aging. A technique that can be used to investigate changes in physiological and pathological aging is non-invasive brain stimulation (NIBS). The present paper reviews studies that have applied NIBS in younger and older adults and in patients with dementia to track changes in the cerebral areas involved in a language task (naming). The results of this research suggest that the left frontal and temporal areas are crucial during naming. Moreover, it is suggested that in older adults and patients with dementia, the right prefrontal cortex is also engaged during naming tasks, and naming performance correlates with age and/or the degree of the pathological process. Potential theories underlying the bilateral involvement of the prefrontal cortex are discussed, and the relationship between the bilateral engagement of the prefrontal cortex and the age or degree of pathology is explored.
Effective therapies for the so-called atypical parkinsonian syndrome (APS) such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), or corticobasal syndrome (CBS) are not available. Dopamine agonists (DA) are not often used in APS because of inefficacy and in a minority of case, their side effects, like dyskinesias, impairment of extrapyramidal symptoms or the appearance of psychosis, and REM sleep behavioral disorders (RBD). Transdermal rotigotine (RTG) is a non-ergotdoi:10.3389/fneur.2014.00085 pmid:24926284 pmcid:PMC4046164 fatcat:j4ywnmlcw5c2zdldlxn5pamfu4
more »... ne agonist indicated for use in early and advanced Parkinson's disease with a good tolerability and safety. Moreover, its action on a wide range of dopamine receptors, D1, D2, D3, unlike other DA, could make it a good option in APS, where a massive dopamine cell loss is documented. In this pilot, observational open-label study we evaluate the efficacy and tolerability of RTG in patients affected by APS. Thirty-two subjects with diagnosis of APS were treated with transdermal RTG. APS diagnosis was: MSA parkinsonian type (MSA-P), MSA cerebellar type (MSA-C), PSP, and CBS. Patients were evaluated by UPDRS-III, neuropsychiatric inventory, mini mental state examination at baseline, and after 6, 12, and 18 months. The titration schedule was maintained very flexible, searching the major clinical effect and the minor possible adverse events (AEs) at each visit. AEs were recorded. APS patients treated with RTG show an overall decrease of UPDRS-III scores without increasing behavioral disturbances. Only three patients were dropped out of the study. Main AEs were hypotension, nausea, vomiting, drowsiness, and tachycardia. The electroencephalographic recording power spectra analysis shows a decrease of theta and an increase of low alpha power. In conclusion, transdermal RTG seems to be effective and well tolerated in APS patients.
Author Affiliations: Laboratory of Epidemiology and Neuroimaging (Drs Geroldi and Frisoni) and Alzheimer's Unit (Drs Geroldi and Zanetti), Istituto di Ricovero e Cura a Carattere Scientifico San Giovanni ...doi:10.1001/archneur.62.7.1067 pmid:16009759 fatcat:nam7oz7aizaofmul4wcx6htfce
Brain and Cognition
Recent studies have demonstrated that patients suffering from frontotemporal lobar degeneration (FTLD) show impairments in empathy and emotional processing. In this study, we examined two different aspects of these abilities in a patient with semantic dementia (SD), a variant of FTLD. The first aspect was the assessment of the cognitive and emotional components of empathy through the Interpersonal Reactivity Index. The second was the naming and comprehension of emotions using the Ekman 60 Facesdoi:10.1016/j.bandc.2009.02.009 pmid:19339096 fatcat:wzsasmdwwrh6hncdrf7ktdatuy
more »... Test. The patient's emotion word knowledge was spared and the emotional aspects of empathy preserved. Conversely, the patient performed below average for all of the basic emotions when an emotion word had to be matched with a picture. When picture-to-picture matching was tested, however, the patient was able to recognize happiness. This case is a good example of a dissociation of covert and overt emotional functioning in SD. Results are discussed in terms of the impaired empathic behavior and emotional functioning in FTLD.
RENZO ROZZINI, MD ORAZIO ZANETTI, MD ANGELO BIANCHETTI, MD MARCO TRABUCCHI, MD University Centre for the Study of the Elderly Condition, Brescia, Italy REFERENCE Hale W, Perkins LL, May FE et al: Symptoms ...doi:10.1111/j.1532-5415.1987.tb02332.x pmid:3819274 fatcat:3do5heewd5germ6fka4v6yqow4
Brain and Cognition
Repetition priming (RP) has been employed as a measure of implicit processing in patients suffering from a breakdown of semantic memory, as in the case of semantic dementia (SD), a subtype of frontotemporal lobar degeneration (FTLD). Here, we investigated face-name representation in a case of SD using a paradigm of within-and cross-domain repetition priming. Compared to ten healthy participants, SD patient did not show any facilitation when a famous name was primed by its own facedoi:10.1016/j.bandc.2009.02.005 pmid:19285772 fatcat:tsheyiuhl5ftvoantnsdurb36a
more »... or when the prime was the same proper name (within-domain). Results are discussed within the hypothesis of a degradation of face and name representation, one of the most consistent accounts explaining semantic deficits in SD.
We described a 56-years-old man with a diagnosis of "non-fluent primary progressive aphasia" (NfPPA). An accurate neuropsychological, neurological and neuroimaging evaluation was performed in order to assess clinical and behavioural features of the patient.From a neuropsychological point of view, the patient showed a typical cognitive profile of subjects affected by NfPPA: a prominent language deficit, associated with impairments in several cognitive domains after three years from the onset ofdoi:10.1155/2007/423631 pmid:18430983 pmcid:PMC5469964 fatcat:iszooxygcvewzp3n5szcv2r6ue
more »... he symptomatology.The most intriguing feature is that SPECT revealed hypoperfusion in the right frontal cortex, albeit the patient is right-handed.This unexpected finding shows that NfPPA may arise not only from cortical abnormalities in the language-dominant left hemisphere, but also from right hemisphere involvement in a right hander (crossed aphasia).
Consistent evidence indicates the involvement of the brain-derived neurotrophic factor (BDNF) in neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). In the present study, we compared serum BDNF in 624 subjects: 266 patients affected by AD, 28 by frontotemporal dementia (FTD), 40 by Lewy body dementia (LBD), 91 by vascular dementia (VAD), 30 by PD, and 169 controls. Our results evidenced lower BDNF serum levels in AD, FTD, LBD, and VAD patients (P<0.001)doi:10.1155/2013/901082 pmid:24024214 pmcid:PMC3760208 fatcat:odvh442u4zgdhm2odki3dm4wka
more »... a higher BDNF concentration in patients affected by PD (P=0.045). Analyses of effects of pharmacological treatments suggested significantly higher BDNF serum levels in patients taking mood stabilizers/antiepileptics (P=0.009) and L-DOPA (P<0.001) and significant reductions in patients taking benzodiazepines (P=0.020). In conclusion, our results support the role of BDNF alterations in neurodegenerative mechanisms common to different forms of neurological disorders and underline the importance of including drug treatment in the analyses to avoid confounding effects.
2011): Brain stimulation improves associative memory in an individual with amnestic mild cognitive impairment, Neurocase,doi:10.1080/13554794.2011.588176 pmid:21879993 fatcat:5ah5topwjzerzctusr3l2vowsm
Word-retrieval difficulties commonly occur in healthy aging. Recent studies report an improved ability to name pictures after the administration of high-frequency repetitive transcranial magnetic stimulation (rTMS) in healthy younger adults and in patients with neurological disease. The aim of this study was to assess the effect of high-frequency rTMS applied to the dorsolateral prefrontal cortex (DLPFC) on picture naming in healthy older adults. High-frequency rTMS was applied to the left anddoi:10.3389/fnagi.2010.00151 pmid:21151376 pmcid:PMC2996246 fatcat:debkhvueundatpspsoeyh3ilue
more »... ight DLPFC during object and action naming in 13 healthy older adults. The naming latency for actions was shortened after stimulation of the left and right DLPFC compared to application of the sham stimulation. Stimulation was not observed to have any effect on correctness of naming. Our data demonstrate the involvement of the left and right DLPFC in a sample of healthy aging subjects during an action-naming task. The bilateral involvement of the DLPFC in these participants is discussed together with data on younger adults and on Alzheimer's patients.
Objective: Given the limited effectiveness of pharmacological treatments, non-pharmacological interventions to treat Alzheimer's disease (AD) have gained attention in recent years. The aim of the present study is to investigate the effects of anodal tDCS (AtDCS) combined with memory training on face-name associations in an AD patient sample. Methods: Thirty six AD patients were randomly assigned to one of three study groups: Group 1, AtDCS plus individualized computerized memory training; Groupdoi:10.3389/fnagi.2014.00038 pmid:24678298 pmcid:PMC3958642 fatcat:cp45twu2njgkpgjgikf4s3lg5i
more »... 2, placebo tDCS plus individualized computerized memory training; Group 3, AtDCS plus motor training. Results: A general improvement in performance was observed after 2 weeks of memory training. Both the anodal tDCS plus individualized computerized memory training and the placebo tDCS plus individualized computerized memory training groups had significantly improved performances at 2 weeks compared with the AtDCS plus motor training group. Conclusion: Our findings suggest a beneficial effect of individualized memory rehabilitation in AD patients.
0.75) Anxiety 12.383.7 11.582.4 0.54 (0.36-0.72) 0.74 (0.59-0.90) Apathy 13.684.5 13.684.2 0.53 (0.35-0.71) Irritability/lability 12.583.4 10.681.7 0.66 (0.49-0.82) Galluzzi /Sheu /Zanetti ...doi:10.1159/000083499 pmid:15677867 fatcat:hxe3elvgbfhhxhma63baugfnjy
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