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Virtual Clinical Trials for the Assessment of Novel Breast Screening Modalities [chapter]

Andrew D. A. Maidment
2014 Lecture Notes in Computer Science  
We are strong proponents of a preclinical alternative, in the form of Virtual Clinical Trials (VCT), which model human anatomy, image acquisition, display and processing, and image analysis and interpretation  ...  A complete VCT pipeline was envisioned by combining the breast anatomy and image acquisition simulation pipeline developed at the University of Pennsylvania, with the MeVIC image display and observation  ...  Fig. 1 . 1 Flow chart of the VCTmanager pipeline for simulation of breast anatomy, image acquisition, display and observation Virtual Clinical Trials fo Fig. 2 . 2 Example of a breast m resulting mammogram  ... 
doi:10.1007/978-3-319-07887-8_1 fatcat:qebocd4libgk5nfdmjiyuiedfq

Virtual clinical trials in medical imaging: a review

Ehsan Abadi, William P. Segars, Benjamin M. W. Tsui, Paul E. Kinahan, Nick Bottenus, Alejandro F. Frangi, Andrew Maidment, Joseph Lo, Ehsan Samei
2020 Journal of Medical Imaging  
Virtual clinical trials (VCTs) (also known as in silico imaging trials or virtual imaging trials) offer an alternative means to efficiently evaluate medical imaging technologies virtually.  ...  This is a significant and increasing challenge for both scientific investigations and clinical applications. Evaluations would ideally be done using clinical imaging trials.  ...  Acknowledgments This work was partly supported by the National Institute of Health (Nos. R01EB001838 and R01HL131753).  ... 
doi:10.1117/1.jmi.7.4.042805 pmid:32313817 pmcid:PMC7148435 fatcat:rr3lazcfprh7bkqahixe47tl5i

Realistic Simulation of Breast Tissue Microstructure in Software Anthropomorphic Phantoms [chapter]

Predrag R. Bakic, David D. Pokrajac, Raffaele De Caro, Andrew D. A. Maidment
2014 Lecture Notes in Computer Science  
Virtual trial quality depends largely on the realism of the simulated breast anatomy.  ...  Software anthropomorphic breast phantoms have been used in virtual clinical trials for preclinical validation of breast imaging systems.  ...  Introduction Virtual clinical trials (VCTs) have received considerable attention recently; a VCT is an efficient way to perform optimization and preclinical validation of novel breast imaging systems  ... 
doi:10.1007/978-3-319-07887-8_49 fatcat:4sjgiirnavdf5dmgnpjweyrq7u

Development of realistic physical breast phantoms matched to virtual breast phantoms based on human subject data

Nooshin Kiarashi, Adam C. Nolte, Gregory M. Sturgeon, William P. Segars, Sujata V. Ghate, Loren W. Nolte, Ehsan Samei, Joseph Y. Lo
2015 Medical Physics (Lancaster)  
performing both system quality control testing and virtual clinical trials.  ...  Purpose: Physical phantoms are essential for the development, optimization, and evaluation of x-ray breast imaging systems.  ...  Boone for providing the initial dedicated breast computed tomography data of human subjects, Hilde Bosmans and Lesley Cockmartin for comparative data analysis and helpful discussions, and Lynda C.  ... 
doi:10.1118/1.4919771 pmid:26133612 fatcat:zxxl3ujm75hbbozwneryj62ygi

Development and Application of a Suite of 4-D Virtual Breast Phantoms for Optimization and Evaluation of Breast Imaging Systems

Nooshin Kiarashi, Joseph Y. Lo, Yuan Lin, Lynda C. Ikejimba, Sujata V. Ghate, Loren W. Nolte, James T. Dobbins, William P. Segars, Ehsan Samei
2014 IEEE Transactions on Medical Imaging  
Index Terms Breast phantom; contrast-enhanced breast imaging; four-dimensional (4-D) breast phantom; system evaluation; system optimization; virtual breast phantom  ...  Mammography is currently the most widely utilized tool for detection and diagnosis of breast cancer. However, in women with dense breast tissue, tissue overlap may obscure lesions.  ...  realize virtual clinical trials relevant to dynamic imaging.  ... 
doi:10.1109/tmi.2014.2312733 pmid:24691118 pmcid:PMC4226410 fatcat:apraneqgv5b23ggqirbxnh36ya

FDA Perspectives on Computer Simulations in the Evaluation of Medical Devices

Tina Morrison
2018 Figshare  
FDA routinely advises industry on the use of modeling and simulation to predict clinical outcomes, inform clinical trial designs, support evidence of effectiveness, optimize dosing, identify the most relevant  ...  FDA acknowledges the benefits to public health provided by modeling and simulation, such as those in the developing area of in silico clinical trials; in other words, the use of individualized computer  ...  17 www.fda.gov Bench Animal Clinical Trial Bench Animal Clinical Trial Virtual Patient Computer Computer TODAY FUTURE 18 www.fda.gov Physics of Device Anatomy & Physiology  ... 
doi:10.6084/m9.figshare.6030737.v1 fatcat:435tjydc4reepirvvejy7jvhom

Mixed modality treatment planning of accelerated partial breast irradiation: to improve complex dosimetry cases

Mohamed El Nemr, Steve Heymann, Rodolfe Verstraet, Bruno Biron, Fares Azoury, Hugo Marsiglia, Céline Bourgier
2011 Radiation Oncology  
of any clinical trial [1, 2] .  ...  Then, CT data were transmitted on-line to the virtual simulation system.  ...  Conflict of interest statement The authors declare that they have no competing interests.  ... 
doi:10.1186/1748-717x-6-154 pmid:22074547 pmcid:PMC3262019 fatcat:xh7lur467vdpbdthhiwhxpr5hu

Front Matter: Volume 10718

Elizabeth A. Krupinski
2018 14th International Workshop on Breast Imaging (IWBI 2018)  
Publication of record for individual papers is online in the SPIE Digital Library. SPIEDigitalLibrary.org Paper Numbering: Proceedings of SPIE follow an e-First publication model.  ...  Utilization of CIDs allows articles to be fully citable as soon as they are published online, and connects the same identifier to all online and print versions of the publication.  ...  in dense breasts 10718 1W Ultrasound transducer tracking system for correlation of masses in combined x-ray and manual breast ultrasound imaging 10718 1X Optimized simulation of breast anatomy for virtual  ... 
doi:10.1117/12.2502754 dblp:conf/iwbi/X18 fatcat:pwftmdgjcza3lnhzk4yua6npiy

Modeling "Textured" Bones in Virtual Human Phantoms

Ehsan Abadi, William P. Segars, Gregory M. Sturgeon, Brian Harrawood, Anuj Kapadia, Ehsan Samei
2018 IEEE Transactions on Radiation and Plasma Medical Sciences  
Incorporating intra-organ structures, the "textured" phantoms are envisioned to be used to conduct virtual clinical trials in the context of medical imaging in cases where the actual trials are infeasible  ...  The purpose of this study was to develop detailed and realistic models of the cortical and trabecular bones in the spine, ribs, and sternum and incorporate them into the library of virtual human phantoms  ...  Acknowledgments This study was supported by a research grant from the National Institutes of Health (2R01EB001838).  ... 
doi:10.1109/trpms.2018.2828083 pmid:31559375 pmcid:PMC6762028 fatcat:shs4pupyojc5jgv7zpoaqpxgha

Design and validation of realistic breast models for use in multiple alternative forced choice virtual clinical trials

Premkumar Elangovan, Alistair Mackenzie, David R Dance, Kenneth C Young, Victoria Cooke, Louise Wilkinson, Rosalind M Given-Wilson, Matthew G Wallis, Kevin Wells
2017 Physics in Medicine and Biology  
The models are suitable for use in virtual clinical trials requiring realistic anatomy which use the multiple alternative forced choice (AFC) paradigm and patches from the complete breast image.  ...  Keywords Virtual clinical trials, breast model, breast phantom, synthetic breast, image simulation, 2Dmammography, digital breast tomosynthesis.  ...  We are grateful to Hologic for the provision of the image processing and reconstruction software.  ... 
doi:10.1088/1361-6560/aa622c pmid:28291738 fatcat:5jxenvcgqjfbvnmj6nrlyurqoe

Three-dimensional stochastic numerical breast phantoms for enabling virtual imaging trials of ultrasound computed tomography

Fu Li, Umberto Villa, Seonyeong Park, Mark A. Anastasio
2021 IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control  
In this work, a methodology for producing realistic three-dimensional (3D) numerical breast phantoms for enabling clinically-relevant computer-simulation studies of USCT breast imaging is presented.  ...  Computer-simulation studies, also known as virtual imaging trials, provide researchers with an economical and convenient route to systematically explore imaging system designs and image reconstruction  ...  Blue Waters is a joint effort of the University of Illinois at Urbana-Champaign and its National Center for Supercomputing Applications.  ... 
doi:10.1109/tuffc.2021.3112544 pmid:34520354 pmcid:PMC8790767 fatcat:4nrwfmubdvcahkmhrwfl463eaq

Optimized generation of high resolution breast anthropomorphic software phantoms

David D. Pokrajac, Andrew D. A. Maidment, Predrag R. Bakic
2012 Medical Physics (Lancaster)  
of the large number of phantoms required in virtual clinical trials of breast imaging.  ...  Employing the same region growing principles as in their previous algorithm for breast anatomy simulation, the present method has been optimized for computational complexity to allow for fast generation  ...  This design feature is of particular importance in virtual clinical trials requiring large number of phantoms.  ... 
doi:10.1118/1.3697523 pmid:22482649 pmcid:PMC3337667 fatcat:i3jqb3guwzd4biczento7ctfz4

Front Matter: Volume 10132

2017 Medical Imaging 2017: Physics of Medical Imaging  
5B Validation of Cooper's ligament thickness in software breast phantoms 10132 5C Computer simulation of the breast subcutaneous and retromammary tissue for use in virtual clinical trials 10132 5D Improved  ...  of human lungs for virtual clinical trials [10132-61] 10132 1R A virtual clinical trial using projection-based nodule insertion to determine radiologist reader performance in lung cancer screening  ...  (Japan) Honorable Mention: Paper 10132-191, "Validation study of the thorax phantom Lungman for optimization purposes," Sunay Rodríguez Pérez, SCK CEN (Belgium) and KU Luven (Belgium) xxviii Proc. of SPIE  ... 
doi:10.1117/12.2276763 fatcat:5vgmgqm4izfdrl6p4itkq6fsjm

Virtual Clinical Trials in 2D and 3D X-ray Breast Imaging and Dosimetry: Comparison of CPU-Based and GPU-Based Monte Carlo Codes

Giovanni Mettivier, Antonio Sarno, Youfang Lai, Bruno Golosio, Viviana Fanti, Maria Elena Italiano, Xun Jia, Paolo Russo
2022 Cancers  
Computational reproductions of medical imaging tests, a form of virtual clinical trials (VCTs), are increasingly being used, particularly in breast imaging research.  ...  Moreover, for practical usage, the imaging simulation computation time should be compatible with the clinical workflow.  ...  Introduction In X-ray breast imaging, virtual clinical trials (VCTs)-i.e., computational reproductions of clinical exams-may provide a substantial reduction of the costs, investigation times, and exposure  ... 
doi:10.3390/cancers14041027 pmid:35205775 pmcid:PMC8870739 fatcat:pg3uyrwmgvde7k6yryuqb2i7he

Population of 224 realistic human subject-based computational breast phantoms

David W. Erickson, Jered R. Wells, Gregory M. Sturgeon, Ehsan Samei, James T. Dobbins, W. Paul Segars, Joseph Y. Lo
2015 Medical Physics (Lancaster)  
Purpose: To create a database of highly realistic and anatomically variable 3D virtual breast phantoms based on dedicated breast computed tomography (bCT) data.  ...  Three breast phantoms were selected for imaging with digital compression (using finite element modeling) and simple ray-tracing, and the results show promise in their potential to produce realistic simulated  ...  of such an approach for virtual clinical trials. 58 There is however a caveat to performing virtual clinical trials with a limited (finite) number of available data sets.  ... 
doi:10.1118/1.4937597 pmid:26745896 pmcid:PMC4684566 fatcat:uy3raoeexvb63ir6gruzsepqgm
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