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Simultaneous PET and Multispectral 3-Dimensional Fluorescence Optical Tomography Imaging System

C. Li, Y. Yang, G. S. Mitchell, S. R. Cherry
2011 Journal of Nuclear Medicine  
Integrated PET and 3-dimensional (3D) fluorescence optical tomography (FOT) imaging has unique and attractive features for in vivo molecular imaging applications.  ...  Insertion of the conical mirror into the gantry of a small-animal PET scanner allowed simultaneous PET and 3D FOT imaging.  ...  This work was funded by NIH grant R01 CA121783, DOE grant DE-SC0002294, and an SNM Postdoctoral Molecular Imaging Scholarship.  ... 
doi:10.2967/jnumed.110.082859 pmid:21810591 pmcid:PMC4557773 fatcat:bjtdawvl7jgldggjz2wcs47rk4

Non-contact small animal fluorescence imaging system for simultaneous multi-directional angular-dependent data acquisition

Jong Hwan Lee, Hyun Keol Kim, Chandhanarat Chandhanayingyong, Francis Young-In Lee, Andreas H. Hielscher
2014 Biomedical Optics Express  
We present a novel non-contact small animal fluorescent molecular tomography (FMT) imaging system.  ...  Using numerical simulations, measurements on a well-defined phantom and a live animal, we evaluate the system performance and show the advantages of our approach.  ...  Luu, MD of University of Chicago Medicine without whom the animal experiment would not have been possible.  ... 
doi:10.1364/boe.5.002301 pmid:25071965 pmcid:PMC4102365 fatcat:ha4x76tfz5hw5kg77t7o6rxcs4

A three-dimensional multispectral fluorescence optical tomography imaging system for small animals based on a conical mirror design

Changqing Li, Gregory S. Mitchell, Joyita Dutta, Sangtae Ahn, Richard M. Leahy, Simon R. Cherry
2009 Optics Express  
We have developed a three dimensional (3D) multispectral fluorescence optical tomography small animal imaging system with an innovative geometry using a truncated conical mirror, allowing simultaneous  ...  The reconstruction algorithm and the system feasibility are evaluated by phantom experiments.  ...  In vivo imaging and cryosectioning was carried out with assistance from the UC Davis Center for Molecular and Genomic Imaging (subsidized by the UC Davis Cancer Center Support Grant P30 CA93373).  ... 
doi:10.1364/oe.17.007571 pmid:19399136 pmcid:PMC2852255 fatcat:664fcrsapzawtk6i6ucz2vix2i

3D mouse shape reconstruction based on phase-shifting algorithm for fluorescence molecular tomography imaging system

Yue Zhao, Dianwen Zhu, Reheman Baikejiang, Changqing Li
2015 Applied Optics  
We introduce a fast, low cost, and robust method, based on fringe pattern and phase shifting, to obtain three-dimensional (3D) mouse surface geometry for fluorescence molecular tomography (FMT) imaging  ...  An FMT experiment of a mouse shaped phantom with one embedded fluorescence capillary target is performed.  ...  This research is partially supported by Startup Fund from University of California, Merced and graduate student summer fellowship from Biological Engineering and Small-scale Technologies (BEST) program  ... 
doi:10.1364/ao.54.009573 pmid:26560789 fatcat:burau7f37rcp7gwej2jf6akvc4

Front Matter: Volume 9788

2016 Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging  
using a Base 36 numbering system employing both numerals and letters.  ...  The papers reflect the work and thoughts of the authors and are published herein as submitted.  ...  -25] 9788 0R Optimization and performance evaluation of a conical mirror based fluorescence molecular tomography imaging system [9788-26] 9788 0T A novel reconstruction algorithm for bioluminescent  ... 
doi:10.1117/12.2240426 dblp:conf/mibam/X16 fatcat:msxwbg54kbegriwgvgcw4dnzu4

JointL1and total variation regularization for fluorescence molecular tomography

Joyita Dutta, Sangtae Ahn, Changqing Li, Simon R Cherry, Richard M Leahy
2012 Physics in Medicine and Biology  
Acknowledgments We thank Dr Anand A Joshi at the University of Southern California for assistance with the DigiWarp tool for atlas warping.  ...  This work was supported by the National Cancer Institute under grants R01CA121783 and R44CA138243.  ...  The fluorescence data were then mapped to the warped atlas surface using a calibrated mapping technique developed for the conical mirror-based imaging system (Dutta 2011) .  ... 
doi:10.1088/0031-9155/57/6/1459 pmid:22390906 pmcid:PMC3380088 fatcat:es32bpx6sfg27lwbh7euflagba

Comparison of Regularization Methods in Fluorescence Molecular Tomography

Dianwen Zhu, Yue Zhao, Reheman Baikejiang, Zhen Yuan, Changqing Li
2014 Photonics  
In vivo fluorescence molecular tomography (FMT) has been a popular functional imaging modality in research labs in the past two decades.  ...  In this paper, we adopt a uniform optimization transfer framework for these regularization methods in FMT and compare their individual, as well as the combined effects on both small, localized targets,  ...  Dianwen Zhu, Yue Zhao and Reheman Baikejiang performed the analysis. Dianwen Zhu wrote the first draft of the manuscript. All authors contributed and approved the final manuscript.  ... 
doi:10.3390/photonics1020095 fatcat:x2erqpi2abhghodoezci2hkwmi

Small animal fluorescence and bioluminescence tomography: a review of approaches, algorithms and technology update

Chinmay Darne, Yujie Lu, Eva M Sevick-Muraca
2013 Physics in Medicine and Biology  
Acknowledgments This work was supported by R01 CA135673 (EMS) and a training fellowship from the Keck Center Computational Cancer Biology Training Program of the Gulf Coast Consortia (CPRIT grant no RP101489  ...  Conical mirror for viewing entire phantom.  ...  fluorescence molecular imaging studies.  ... 
doi:10.1088/0031-9155/59/1/r1 pmid:24334634 fatcat:tm7nvbyx4rdxlnhy37nojp7hwe

3D Optical Imaging of Fluorescent Agents in Biological Tissues [chapter]

Manuel Freiberger, Hermann Scharfetter
2012 Molecular Imaging  
The optical instrumentation comprised a PMT-based 124 Molecular Imaging www.intechopen.com 3D Optical Imaging of Fluorescent Agents in Biological Tissues 9 single-photon counting system.  ...  A recently developed free-space system (Li et al. (2009) ) includes a conical mirror which partially encloses the sample and thus collects significantly more light than a camera alone or systems with  ... 
doi:10.5772/32432 fatcat:unxhexs5lzhirb6dqczlviy2ee

Fluorescence Molecular Tomography: Principles and Potential for Pharmaceutical Research

Florian Stuker, Jorge Ripoll, Markus Rudin
2011 Pharmaceutics  
Fluorescence microscopic imaging is widely used in biomedical research to study molecular and cellular processes in cell culture or tissue samples.  ...  Acknowledgements We all acknowledge Swiss National Foundation under Grant SNF 3100-112835 and Grant 310030-126029 and FMT-XCT EU FP7 Grant. J.R. acknowledges the Bill and Melinda Gates Foundation.  ...  Yet another interesting setup used to image tumor bearing mice was proposed by Li et al. and is based on a conical mirror design [73] .  ... 
doi:10.3390/pharmaceutics3020229 pmid:24310495 pmcid:PMC3864234 fatcat:oyflhcyu4rbaflinrekxvddiiy

Fusion of [18F]FDG PET with Fluorescence Diffuse Optical Tomography to Improve Validation of Probes and Tumor Imaging

Anikitos Garofalakis, Albertine Dubois, Benoît Thézé, Bertrand Czarny, Bertrand Tavitian, Frédéric Ducongé
2012 Molecular Imaging and Biology  
Procedures: Sequential fDOT/PET/computed tomography (CT) imaging of mice was performed with a custom multimodal mouse support that allows the subject to be transferred between the fDOT and the PET/CT scanners  ...  of 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ 18 F]FDG) in tumors with three fluorescent probes: a glucose analog, a protease activatable optical probe, and a ligand of αvβ3 integrin.  ...  This work was supported by grants from the FMT-XCT European program (grant agreement number 201792), the European Molecular Imaging Laboratory (EMIL) network (EU contract LSH-2004-503569), the "Agence  ... 
doi:10.1007/s11307-012-0581-z pmid:22927057 pmcid:PMC3647087 fatcat:ho7pluvfirhgjil2uf7qzwvree

Imaging in Ophthalmology [chapter]

Umit Yolcu, Omer Faruk Sahin, Fatih C. Gundogan
2014 Ophthalmology - Current Clinical and Research Updates  
Computerized Tomography (CT) Computed tomography is a useful imaging tool in the evaluation of most orbital and ocular lesions.  ...  Therefore, slice thickness should be balanced based on the requirement of the case. Optimal slice thickness for eye and orbit is 2 mm [109] .  ... 
doi:10.5772/58314 fatcat:l2hnokek7zfyhg24fa7er3k2ce

A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Victor T.C. Tsang, Xiufeng Li, Terence T.W. Wong
2020 Sensors  
Photoacoustic (PA) tomography (PAT) is a rapidly growing hybrid imaging modality that is capable of acoustically detecting optical contrast.  ...  PAT's versatile design and non-invasive nature have proven its great potential as a biomedical imaging tool for a multitude of biomedical applications.  ...  Conflicts of Interest: Terence T. W. Wong is the founder and shareholder of PhoMedics Limited, and Victor T. C. Tsang is a shareholder of PhoMedics Limited, which, however, did not support this work.  ... 
doi:10.3390/s20195595 pmid:33003566 fatcat:hdrxjrxlmjawxaqdzwclke2twq

Photoacoustic Imaging in Biomedicine and Life Sciences

Alexey Neprokin, Christian Broadway, Teemu Myllylä, Alexander Bykov, Igor Meglinski
2022 Life  
The detection of acoustic waves produced by a pulsed laser source yields a high scaling range, from organ level photo-acoustic tomography to sub-cellular or even molecular imaging.  ...  Photo-acoustic imaging, also known as opto-acoustic imaging, has become a widely popular modality for biomedical applications.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/life12040588 pmid:35455079 pmcid:PMC9028050 fatcat:mrryuulk7fhsrnydmvmdwwsmjy

Multi-modal molecular diffuse optical tomography system for small animal imaging

James A Guggenheim, Hector R A Basevi, Jon Frampton, Iain B Styles, Hamid Dehghani
2013 Measurement science and technology  
A multi-modal optical imaging system for quantitative 3D bioluminescence and functional diffuse imaging is presented, which has no moving parts and uses mirrors to provide multi-view tomographic data for  ...  Additionally, the first use of a recently developed multi-view optical surface capture technique is shown and its application to model-based image reconstruction and free-space light modelling is demonstrated  ...  Acknowledgments The authors gratefully acknowledge the assistance of Mark Cobbold, Laura Morton and David Millar from the University  ... 
doi:10.1088/0957-0233/24/10/105405 pmid:24954977 pmcid:PMC4061700 fatcat:tiberx6ivjeqbfuffi6frmm4wm
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