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Optimal adaptation for early stopping in statistical inverse problems [article]

Gilles Blanchard, Marc Hoffmann, Markus Reiß
<span title="2017-10-26">2017</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Adaptive early stopping for the Landweber method is studied in further detail and illustrated numerically.  ...  In the context of statistical estimation with stochastic noise ξ, we study oracle adaptation (that is, compared to the best possible stopping iteration) in strong squared-error E[μ̂^(τ)-μ^2].  ...  This state of the art for statistical inverse problems stands in contrast with the deterministic inverse problem setting, in which the noise ξ in the model (1.5) is assumed fixed and of norm bounded by  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1606.07702v2">arXiv:1606.07702v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/l6ilzclj4jcztdwzzil7jypugu">fatcat:l6ilzclj4jcztdwzzil7jypugu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200907114525/https://arxiv.org/pdf/1606.07702v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f1/fe/f1fe416ae952b3573ea6db379dd1e9a2f8d428af.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1606.07702v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Optimal Adaptation for Early Stopping in Statistical Inverse Problems

Gilles Blanchard, Marc Hoffmann, Markus Reiß
<span title="">2018</span> <i title="Society for Industrial &amp; Applied Mathematics (SIAM)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/urysiflaw5ezrk6feu5kukoqhq" style="color: black;">SIAM/ASA Journal on Uncertainty Quantification</a> </i> &nbsp;
In the context of statistical estimation with stochastic noise ξ, we study oracle adaptation in strong squared-error E µ (τ ) − µ 2 . We give precise lower bounds for estimation by early stopping.  ...  For Sobolev balls the adaptation bounds are shown to match the lower bounds. Adaptive early stopping for the Landweber and spectral cutoff methods are studied in further detail.  ...  Finally, let us point out that regularisation by early stopping is frequently used, e.g. in L 2 -boosting, see Bissantz et al. [6] for its connection to inverse problems.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1137/17m1154096">doi:10.1137/17m1154096</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kxxmj5t6vvhxzky6slcrult4zu">fatcat:kxxmj5t6vvhxzky6slcrult4zu</a> </span>
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Optimality criteria for futility stopping boundaries for group sequential designs with a continuous endpoint

Xieran Li, Carolin Herrmann, Geraldine Rauch
<span title="2020-11-05">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/llc2bilew5glxlrb6bkj3lko2a" style="color: black;">BMC Medical Research Methodology</a> </i> &nbsp;
In contrast, group sequential designs allow an early stopping of the trial at interim, either for efficacy when the treatment effect is significant or for futility when the treatment effect seems too small  ...  Efficacy stopping boundaries based on alpha spending functions have been widely discussed in the statistical literature, and there is also solid work on the choice of adequate futility stopping boundaries  ...  Stopping a trial early for efficacy implies a successful trial with reduced costs.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12874-020-01141-5">doi:10.1186/s12874-020-01141-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33153438">pmid:33153438</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ffli2u3gfbhyjd7yvsis35s56m">fatcat:ffli2u3gfbhyjd7yvsis35s56m</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201107202002/https://bmcmedresmethodol.biomedcentral.com/track/pdf/10.1186/s12874-020-01141-5" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/34/65/346524217b77063f3e4c616157d0e85c1f2d164e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12874-020-01141-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>

Early stopping for statistical inverse problems via truncated SVD estimation [article]

Gilles Blanchard, Marc Hoffmann, Markus Reiß
<span title="2018-09-07">2018</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
We analyse in detail whether sequential early stopping rules of this type can preserve statistical optimality.  ...  We consider truncated SVD (or spectral cut-off, projection) estimators for a prototypical statistical inverse problem in dimension D.  ...  This research was supported by the DFG via SFB 1294 Data Assimilation and via Research Unit 1735 Structural Inference in Statistics, which has made possible a six months visit by MH to Humboldt-Universität  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1710.07278v3">arXiv:1710.07278v3</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/t6cwhiwl5jbvppeojtkcdbxy5i">fatcat:t6cwhiwl5jbvppeojtkcdbxy5i</a> </span>
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The adoptr Package: Adaptive Optimal Designs for Clinical Trials in R

Kevin Kunzmann, Maximilian Pilz, Carolin Herrmann, Geraldine Rauch, Meinhard Kieser
<span title="">2021</span> <i title="Foundation for Open Access Statistic"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yr3cv2yayvhvdcoj6lb4qw36kq" style="color: black;">Journal of Statistical Software</a> </i> &nbsp;
Even though adaptive two-stage designs with unblinded interim analyses are becoming increasingly popular in clinical trial designs, there is a lack of statistical software to make their application more  ...  In contrast to previous approaches, adoptr optimizes the entire design upfront which allows maximal efficiency.  ...  For the Gaussian quadrature used during optimization, one also has to specify the order of the integration rule, i.e., the number of pivot points between early stopping for futility and early stopping  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18637/jss.v098.i09">doi:10.18637/jss.v098.i09</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jrp4rl2v6zgsfniqumsoscdeva">fatcat:jrp4rl2v6zgsfniqumsoscdeva</a> </span>
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Mesh Optimization for Monte Carlo-Based Optical Tomography

Andrew Edmans, Xavier Intes
<span title="2015-04-09">2015</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/cnxq6dmp2ng33eo7iwn2sru7ea" style="color: black;">Photonics</a> </i> &nbsp;
Mesh-based Monte Carlo techniques for optical imaging allow for accurate modeling of light propagation in complex biological tissues.  ...  However, commonly employed adaptive mesh discretization techniques have not yet been implemented for Monte Carlo based tomography.  ...  Acknowledgments The authors thank Cameron Smith (Scientific Computation Research Center, Rensselaer Polytechnic Institute, Troy, NY 12180) for help with the mesh optimization tool.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/photonics2020375">doi:10.3390/photonics2020375</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26566523">pmid:26566523</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4640680/">pmcid:PMC4640680</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vcohfn4bqbe7vnvjhq3rj4trni">fatcat:vcohfn4bqbe7vnvjhq3rj4trni</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20151010082201/http://www.mdpi.com:80/2304-6732/2/2/375/pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/06/c6/06c625f122a703a7404c5e8a4c22a829b0bf1807.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/photonics2020375"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640680" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Mesh optimization for Monte Carlo based optical tomography

Andrew Edmans, Xavier Intes, Cameron Smith
<span title="">2014</span> <i title="IEEE"> 2014 40th Annual Northeast Bioengineering Conference (NEBEC) </i> &nbsp;
Mesh-based Monte Carlo techniques for optical imaging allow for accurate modeling of light propagation in complex biological tissues.  ...  However, commonly employed adaptive mesh discretization techniques have not yet been implemented for Monte Carlo based tomography.  ...  Acknowledgments The authors thank Cameron Smith (Scientific Computation Research Center, Rensselaer Polytechnic Institute, Troy, NY 12180) for help with the mesh optimization tool.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/nebec.2014.6972782">doi:10.1109/nebec.2014.6972782</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6ldzaj5uljaezep6qewt3hby7u">fatcat:6ldzaj5uljaezep6qewt3hby7u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20151010082201/http://www.mdpi.com:80/2304-6732/2/2/375/pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/06/c6/06c625f122a703a7404c5e8a4c22a829b0bf1807.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/nebec.2014.6972782"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Optimal planning of adaptive two‐stage designs

Maximilian Pilz, Kevin Kunzmann, Carolin Herrmann, Geraldine Rauch, Meinhard Kieser
<span title="2021-03-18">2021</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6c6ulvjkkvgbhburvxae2cigoy" style="color: black;">Statistics in Medicine</a> </i> &nbsp;
In this article, we strive to motivate the application of optimal adaptive designs and give guidance on how to determine them.  ...  Furthermore, we show that in many practical situations, optimal group-sequential designs show an almost negligible performance loss compared to optimal adaptive designs.  ...  All R code that was used to compute the examples on optimal designs is available as supplementary material. R E F E R E N C E S  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/sim.8953">doi:10.1002/sim.8953</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33738842">pmid:33738842</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wfnoobc2xnhnvd4uh4qum4oggm">fatcat:wfnoobc2xnhnvd4uh4qum4oggm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210718032344/https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sim.8953" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ac/cb/accb09b4295b26ad61fe2749e9138883af890ff3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/sim.8953"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> wiley.com </button> </a>

Efficient Gaussian Sampling for Solving Large-Scale Inverse Problems Using MCMC

Clement Gilavert, Said Moussaoui, Jerome Idier
<span title="">2015</span> <i title="Institute of Electrical and Electronics Engineers (IEEE)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/gkn2pu46ozb4tmkxczacnmtvkq" style="color: black;">IEEE Transactions on Signal Processing</a> </i> &nbsp;
The resolution of many large-scale inverse problems using MCMC methods requires a step of drawing samples from a high dimensional Gaussian distribution.  ...  The connection between this algorithm and some existing strategies is discussed and its efficiency is illustrated on a linear inverse problem of image resolution enhancement.  ...  In practice, early stopping of an iterative solver such as the linear conjugate gradient algorithm is used, yielding the Truncated Perturbation Optimization (T-PO) version.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/tsp.2014.2367457">doi:10.1109/tsp.2014.2367457</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5jfle26wjzdxtigssf4ou6y6bi">fatcat:5jfle26wjzdxtigssf4ou6y6bi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170928031254/https://hal.archives-ouvertes.fr/hal-01059414/document" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/62/da/62dab5f62ab2113398dc97042f75dfd56f010883.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/tsp.2014.2367457"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

From Group Sequential to Adaptive Designs [chapter]

Christopher Jennison, Bruce Turnbull
<span title="2010-10-25">2010</span> <i title="CRC Press"> Handbook of Adaptive Designs in Pharmaceutical and Clinical Development </i> &nbsp;
Savings in time and money can result if the answers to the research questions become evident early -before the planned conclusion of the trial. Ethical.  ...  It is now standard practice for larger Phase III clinical trials to have a Data Monitoring Committee (DMC) to oversee the study and consider the option of early termination.  ...  For example, in a one-sided or two-sided test it may only be desirable to stop early only for futility and not for efficacy.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1201/b10279-6">doi:10.1201/b10279-6</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/d2j64sk6rje4nfj2uml7n25am4">fatcat:d2j64sk6rje4nfj2uml7n25am4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20150528215928/http://people.bath.ac.uk:80/mascj/papers/crc_book_chapter.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/02/87/02875958e89a1c2137ee1a81fe9b0f31ed50aafa.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1201/b10279-6"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Necessary and Sufficient Conditions for Inverse Reinforcement Learning of Bayesian Stopping Time Problems [article]

Kunal Pattanayak, Vikram Krishnamurthy
<span title="2022-02-20">2022</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
This paper presents an inverse reinforcement learning~(IRL) framework for Bayesian stopping time problems.  ...  In a Bayesian (partially observed) setting, the inverse learner can at best identify optimality wrt the observed actions.  ...  Acknowledgments This research was funded in part the U. S.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2007.03481v4">arXiv:2007.03481v4</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/yr6wldlmofdwbhuhffkdfg2vji">fatcat:yr6wldlmofdwbhuhffkdfg2vji</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210726163815/https://arxiv.org/pdf/2007.03481v3.pdf" title="fulltext PDF download [not primary version]" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <span style="color: #f43e3e;">&#10033;</span> <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e2/1d/e21d1f577c008aae2f57ee1f26a6f78052f5a66b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2007.03481v4" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Statistical analysis of learning dynamics

Noboru Murata, Shun-ichi Amari
<span title="">1999</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/63drx5tykbartetpkracmzzfwu" style="color: black;">Signal Processing</a> </i> &nbsp;
On-line learning is slow in general but works well in the changing environment. The present paper gives a unified framework of statistical analysis for batch and on-line learning.  ...  It provides an effective method for blind separation and deconvolution in signal processing. Two different types of learning are used, namely batch learning and on-line learning.  ...  Figure 3 : 3 Optimal stopping pointθ * by validation examples. Figure 4 : 4 Geometrical picture of the early stopping effect for pre-asymptotic range.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0165-1684(98)00206-0">doi:10.1016/s0165-1684(98)00206-0</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zkcn5zq2ibef5ljrsen65526ta">fatcat:zkcn5zq2ibef5ljrsen65526ta</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20040513215451/http://www.murata.elec.waseda.ac.jp:80/~mura/paper/mura99_sigproc.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/33/80/3380f30e85577f67f7e178b70bf9f120ec16a3bc.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/s0165-1684(98)00206-0"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Inverse Kinematics Using Particle Swarm Optimization, A Statistical Analysis

Nizar Rokbani, Adel.M. Alimi
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5i4djr4tgnbobnjegejzpw7nny" style="color: black;">Procedia Engineering</a> </i> &nbsp;
Inverse kinematics is a key issue in robotics; for problems such as path planning, motion generation or trajectories optimization, they are classically involved.  ...  In this paper the IK-PSO, Inverse Kinematics PSO, is applied to a double link articulated system.  ...  To use techniques such as PSO, ANT or Bee colony optimization algorithms, the inverse kinematics problem is transformed into and optimization problem using a forward kinematics and a fitness function,  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.proeng.2013.09.242">doi:10.1016/j.proeng.2013.09.242</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4gz3ldrihvezlitkghfn2vxfz4">fatcat:4gz3ldrihvezlitkghfn2vxfz4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171001110617/http://publisher-connector.core.ac.uk/resourcesync/data/elsevier/pdf/a20/aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS9zMTg3NzcwNTgxMzAxNzU2Ng%3D%3D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/88/41/8841566a6dae71cc5ea990fbed78a7b72de6d446.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.proeng.2013.09.242"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a>

Adaptive Optimal Designs for Dose-Finding Studies with Time-to-Event Outcomes

Yevgen Ryeznik, Oleksandr Sverdlov, Andrew C. Hooker
<span title="2017-12-28">2017</span> <i title="American Association of Pharmaceutical Scientists (AAPS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/pgenyoiihzh5jejyszancarsyu" style="color: black;">AAPS Journal</a> </i> &nbsp;
The issues of sample size planning/early stopping for an adaptive trial are investigated as well.  ...  The adaptive D-optimal design with early stopping can potentially reduce study size while achieving similar estimation precision as the fixed allocation design.  ...  Here, we propose an adaptive design with early stopping based on the accuracy of estimation precision.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1208/s12248-017-0166-5">doi:10.1208/s12248-017-0166-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29285730">pmid:29285730</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/as4felkndrf67abx2o4h2neuza">fatcat:as4felkndrf67abx2o4h2neuza</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719215246/http://uu.diva-portal.org/smash/get/diva2:1195643/FULLTEXT01" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7e/4e/7e4e744e040ce4149c36de93f8c8f70f71b8f07c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1208/s12248-017-0166-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Randomization procedures that depend on the covariates [chapter]

<span title="2015-04-06">2015</span> <i title="Chapman and Hall/CRC"> Adaptive Designs for Sequential Treatment Allocation </i> &nbsp;
Acknowledgments We are grateful to all our colleagues who showed their encouragement and gave us useful advice, in particular Anthony C.  ...  We are also deeply indebted to the referees who read early versions of the manuscript and helped us with their constructive remarks.  ...  So far, however, this research area is still in its early days, and statisticians do not seem to have capitalized on statistical design ideas for making their simulations as effective and informative as  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1201/b18306-12">doi:10.1201/b18306-12</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/delkt6rb3fdbjphw6ioqjbc4li">fatcat:delkt6rb3fdbjphw6ioqjbc4li</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201231195103/https://s3-euw1-ap-pe-ws4-capi2-distribution-p.s3-eu-west-1.amazonaws.com/books/9780429088780/HUBPMP/9780429088780_googleScholarPDF.pdf?response-content-disposition=attachment%3B%20filename%3D%229780429088780_googlepreview.pdf%22&amp;response-content-type=application%2Fpdf&amp;x-amz-security-token=IQoJb3JpZ2luX2VjENv%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCWV1LXdlc3QtMSJGMEQCIBjLgtIReI%2BXZnaorqkILKIaVbtiCfA12LHzD1Mode0xAiBZx%2FjDBBd82L%2BKpxU2LfMX%2FqIpPHyk96zYzLrXlJKXTyq9AwiU%2F%2F%2F%2F%2F%2F%2F%2F%2F%2F8BEAIaDDAxMjE3NzI2NDUxMSIMMt3f4Be%2BgJAavA4xKpEDcXAE0cWPZoKwnLgIP7s1KnnCHiJaa92zS7XE670vWexmy4jbEUgHccOh5PqBU2qX9P6b2LOJtd9vgybmMD7ifQeRzVXM2tB9MmJ5803sfKwqJc6OwGwUAcYDiIEXFiI0vEF%2BDydN0qx52ZckFVsQ4bNFZ7wC11usN%2BetevvA3jbpItlmYRuEsOtzKFf%2BIMTjk7ueFdluhK0qcFBHzU9GJVfgyzn%2BOD%2Fe9qwcfRGTfETwYKt19ZUlw6%2FrqMjgGFepynzbmntQNfVeRwOsV%2BgFNnAn3CXeiy8MY2IAiYAvWHbyVnUkKZPV5bJ6mzLH8cfnNH%2FMlOmLgHPui1t2feRBGeuZhM68HOK0itrQYSzRKatSp1baCXzW588%2FbDy2%2FKLUQBNKOWecNfIX0QQYs4hRI4rcXuJt%2B2lKVUOxGDyR6TubR83VX8CgWzmsw6wXwua8UElvMGp1H6IcNrrSr6lDbS5H5SG0OrpC6IZ3BYwtJTeBnaDF58pdgff5RjuLqRGsDuTQhZC8c4ImJqxcTt9elXYw2ry4%2FwU67AFv4g2%2FtEb6UXkBnySUuK0wFMR6BWJ%2FcpaH4VbXpE8UlOMAQDnNmrui72qkRpbXjdcC3a5Mlpwn%2B9%2FmJPEZetDXfoedOIxHKdx9P%2BBqUxXOR2CWuqBG401F9zqkH4DscOon%2Bhg9j7n1%2FR6SC5Bxt%2BNd4h3e7OWqKU2CLzDChh1v8wSaMzq48CvBoyMG25dQ7647LKuSq8fhvgpfyvoeYlEkjWO1e%2FYKP7bSHXGOXFX9e4BAQbRy6ar0y9FBt5xbxsTbUGLhoeml9en8PGD0lhYp8fqB0TVkNL9vccYu5vkaPQQjlbofeCfQ798sSA%3D%3D&amp;AWSAccessKeyId=ASIAQFVOSJ57UFBPOAB3&amp;Expires=1610049062&amp;Signature=z%2FmjshrUE1ERLaueRyvvqF819qI%3D" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/43/83/4383ecc75adc6efc6c6a2f26d9ba50251698c431.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1201/b18306-12"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>
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