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Optical Microspherical Resonators for Biomedical Sensing

Silvia Soria, Simone Berneschi, Massimo Brenci, Franco Cosi, Gualtiero Nunzi Conti, Stefano Pelli, Giancarlo C. Righini
2011 Sensors  
Optical resonators play an ubiquitous role in modern optics.  ...  Then, we attempt to overview some of the recent advances in the development of microspherical biosensors, underlining a number of important applications in the biomedical field.  ...  This review is focused on biomedical sensing at the microscopic scale using spherical WGM resonators.  ... 
doi:10.3390/s110100785 pmid:22346603 pmcid:PMC3274111 fatcat:xcmarxzuljginc4mccqq5ure4y

Microsphere and Fiber Optics based Optical Sensors [chapter]

A. Rostami, H. Ahmadi, H. Heidarzadeh, A. Taghipour
2014 Optical Sensors - New Developments and Practical Applications  
Because of these advantages, microsphere resonators are prone structures for being competent optical biosensors.  ...  Solution of Helmholtz equation for microsphere optical resonator In order to theoretically investigate the performance of microsphere, the Maxwell wave equation in microsphere should be solved.  ... 
doi:10.5772/57465 fatcat:3l5jrvyhubfirezaw6rqrs2gwm

Combining whispering gallery mode lasers and microstructured optical fibers: limitations, applications and perspectives for in-vivo biosensing

Alexandre François, Tess Reynolds, Nicolas Riesen, Jonathan M. M. Hall, Matthew R. Henderson, Enming Zhao, Shahraam Afshar V., Tanya M. Monro
2016 MRS Advances  
The fiber also permits easy manipulation of the microresonator for dip sensing applications, and hence alleviates the need for a complex microfluidic interface.  ...  ABSTRACTWhispering gallery modes (WGMs) have been widely studied over the past 20 years for various applications, including biological sensing.  ...  [22] have for instance produced passive spheroidal resonators into which light can be coupled using free space optics for refractive index sensing in aqueous solution, alleviating the need for a coupler  ... 
doi:10.1557/adv.2016.342 fatcat:tz7qbhq4sbaavlhe4pz5m66gb4

Photonic detection and characterization of DNA using sapphire microspheres

Mohammed Sharif Murib, Weng-Siang Yeap, Daan Martens, Peter Bienstman, Ward De Ceuninck, Bart van Grinsven, Michael J. Schöning, Luc Michiels, Ken Haenen, Marcel Ameloot, Ali Serpengüzel, Patrick Wagner
2014 Journal of Biomedical Optics  
A microcavity-based deoxyribonucleic acid (DNA) optical biosensor is demonstrated for the first time using synthetic sapphire for the optical cavity.  ...  The 0.43 nm angular mode spacing of the resonances correlates well with the optical size of the sapphire sphere.  ...  He has been awarded an ERC starting grant for the Naresco-project: Novel Paradigms for Massively Parallel Nanophotonic Information Processing.  ... 
doi:10.1117/1.jbo.19.9.097006 pmid:25260868 fatcat:i4p4nxs465dxtkmqfvygzehrwi

Integrated microsphere whispering gallery mode probe for highly sensitive refractive index measurement

Hanzheng Wang, Lei Yuan, Cheol-Woon Kim, Jie Huang, Xinwei Lan, Hai Xiao
2016 Optical Engineering: The Journal of SPIE  
The probe was made by sealing a borosilicate glass microsphere into a thin-wall glass capillary pigtailed with a multimode optical fiber.  ...  We report an integrated whispering gallery mode microresonator-based sensor probe for refractive index sensing.  ...  Fig. 1 1 Schematic of thin wall capillary coupled borosilicate glass microsphere resonator for RIU sensing.  ... 
doi:10.1117/1.oe.55.6.067105 fatcat:l245pkwfvnhufovskq6v2l3rdu

Editorial for the Special Issue on Glassy Materials Based Microdevices

Giancarlo C. Righini, Nicoletta Righini
2019 Micromachines  
Microfluidics is fundamental for the development of biomedical sensing and analysis microsystems.  ...  The paper by Amiri et al. provides a basic introduction to optical waveguides and to their applications, with special attention to fiber Bragg gratings for sensing applications [15] .  ... 
doi:10.3390/mi10010039 pmid:30626152 pmcid:PMC6357125 fatcat:wkdwauklsrebxkndjvhnja7fly

Multiphysical sensing of light, sound and microwave in a microcavity Brillouin laser

Jianfan Yang, Tian Qin, Fangxing Zhang, Xianfeng Chen, Xiaoshun Jiang, Wenjie Wan
2020 Nanophotonics  
Here we experimentally demonstrate an optomechanical microdevice based on Brillouin lasing operation in an optical microcavity as a sensitive unit to sense external light, sound, and microwave signals  ...  These results pave the way towards on-chip integrable optomechanical solutions for sensing, free-space secure communication, and microwave imaging.  ...  For example, only two resonances with much higher Q factors exhibit for the optical sensing as compared to eight lower Q resonant modes in the acoustic case.  ... 
doi:10.1515/nanoph-2020-0176 fatcat:nma2fbglwrb4pevgk64qxlqjyy

Front Matter: Volume 10077

2017 Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV  
The publisher is not responsible for the validity of the information or for any outcomes resulting from reliance thereon.  ...  Please use the following format to cite material from these proceedings: Publication of record for individual papers is online in the SPIE Digital Library.  ...  nanoscopy: from fundamentals to biomedical applications (Invited Paper) [10077-28] SESSION 5 NANOSCALE IMAGING AND SPECTROSCOPY II 10077 0W Off resonance long period fiber gratings for optical  ... 
doi:10.1117/12.2276762 fatcat:dwedyet6yvdz7gvxms3ersxoky

On-chip supercontinuum optical trapping and resonance excitation of microspheres

Arthur Nitkowski, Alexander Gondarenko, Michal Lipson
2010 Optics Letters  
A supercontinuum source is used to both trap the microspheres to the surface of the waveguide and excite their resonant modes.  ...  We demonstrate the simultaneous optical manipulation and analysis of microscale particles in a microfluidic channel.  ...  Changes in the resonance wavelength and linewidth can be used to sense changes in the local fluidic environment such as adsorption of biomolecules to the microsphere's surface.  ... 
doi:10.1364/ol.35.001626 pmid:20479830 fatcat:euvkc76m3bcnrfvnpj5pnzopea

Biosensing by WGM Microspherical Resonators

Giancarlo Righini, Silvia Soria
2016 Sensors  
make these structures of great interest for lasers, optical and RF communications, quantum optics and electrodynamics and sensing [7] [8] [9] .  ...  Among the various geometries, microspheres are the simplest 3D WGM resonators; the total optical loss in such resonators can be extremely low, and the resulting extraordinarily high Q values of 10 8 -10  ...  Thermo-optic and reactive mechanisms for label-free sensing of bio-particles have been compared theoretically for WGM resonators (sphere, toroid) formed from silica and stimulated into a first order equatorial  ... 
doi:10.3390/s16060905 pmid:27322282 pmcid:PMC4934331 fatcat:pf2dxni7ezaxfpunjro5xrtb7a

Mode-Splitting for Refractive Index Sensing in Fluorescent Whispering Gallery Mode Microspheres with Broken Symmetry

Yvonne Kang, Alexandre François, Nicolas Riesen, Tanya Monro
2018 Sensors  
This novel approach takes advantage of the difference of optical pathway experienced by WGMs circulating in different equatorial planes of a single microsphere resonator, which induces mode-splitting.  ...  Investigating the refractive index sensitivity of the individual sub modes resulting from the mode-splitting unveils a new methodology for RI sensing, and enables discrimination between surrounding refractive  ...  biomedical sensing applications, where the RI of the probing liquid is very close to that of water.  ... 
doi:10.3390/s18092987 pmid:30205443 pmcid:PMC6164521 fatcat:wzvny4x46fcdhl2czdpofjl6gu

Integration of microsphere resonators with bioassay fluidics for whispering gallery mode imaging

Daniel C. Kim, Kevin P. Armendariz, Robert C. Dunn
2013 The Analyst  
One resonator design uses inexpensive high index glass microspheres that offer intrinsically superior optical characteristics, but have proven difficult to multiplex and integrate with the fluidics for  ...  Recently, we introduced a fluorescence imaging approach that enables large scale multiplexing with microsphere resonators, thus removing one obstacle for assay development.  ...  For sensing, therefore, it is highly desirable to combine the multiplexing and fluidics capabilities of microring resonators with the optical properties of microsphere resonators.  ... 
doi:10.1039/c3an00328k pmid:23615457 pmcid:PMC3734961 fatcat:i4ukon3jlfa7hd4ykzwq2gysnm

Quantum dot-embedded microspheres for remote refractive index sensing

Shuo Pang, Richard E. Beckham, Kenith E. Meissner
2008 Applied Physics Letters  
Optical resonances within a microsphere, known as whispering-gallery modes ͑WGMs͒, produce narrow spectral peaks.  ...  For sensing applications, spectral shifts of these peaks are sensitive to changes in the local refractive index.  ...  Optical microspherical cavity resonators have recently been applied in biosensing. 1, 2 The resonance modes, known as whispering-gallery modes ͑WGMs͒, arise from confinement of light within a resonant  ... 
doi:10.1063/1.2937209 pmid:19488403 pmcid:PMC2682744 fatcat:zdo7sezckfg2llsrbdauck7luu

Whispering-gallery-mode biosensing: label-free detection down to single molecules

Frank Vollmer, Stephen Arnold
2008 Nature Methods  
Optical label-free detectors, such as the venerable surface plasmon resonance (SPR) sensor, are generally favored for their ability to obtain quantitative data on intermolecular binding.  ...  However, before the recent introduction of resonant microcavities that use whispering gallery mode (WGM) recirculation, sensitivity to single binding events had not materialized.  ...  With prospects of such a bright future, we are confident that optical resonators will make grand contributions for improved health care, novel biomedical applications and for development of state-of-the-art  ... 
doi:10.1038/nmeth.1221 pmid:18587317 fatcat:cklpigslbfgcrmwnqsbfgu26bi

Whispering-Gallery Mode Resonators for Detecting Cancer

2017 Sensors  
Optical resonators are sensors well known for their high sensitivity and fast response time.  ...  We also add to the knowledge of cancer biomarker diagnosis, where we discuss the application of optical resonators for specific biomarkers.  ...  Optical resonators are used not only for biomedical detection [21, 96, 97] but also for gas detection [98] , environmental control [87] , toxin detection [99] , temperature detection [70, 100] ,  ... 
doi:10.3390/s17092095 pmid:28902169 pmcid:PMC5621035 fatcat:hzpmowrs45dtnjdcjjj22gu5s4
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