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Online prediction of ovarian cancer [article]

Fedor Zhdanov, Vladimir Vovk, Brian Burford, Dmitry Devetyarov, Ilia Nouretdinov, Alex Gammerman
2009 arXiv   pre-print
In this paper we apply computer learning methods to diagnosing ovarian cancer using the level of the standard biomarker CA125 in conjunction with information provided by mass-spectrometry.  ...  We are working with a new data set collected over a period of 7 years. Using the level of CA125 and mass-spectrometry peaks, our algorithm gives probability predictions for the disease.  ...  grant "Development of new methods of conformal prediction with application to medical diagnosis" from the Cyprus Research Promotion Foundation, Veterinary Laboratories Agency of DEFRA grant "Development  ... 
arXiv:0904.1579v1 fatcat:ebbf7cmidjagnoa4j7hfyau3cy

Downregulation of NEK11 is associated with drug resistance in ovarian cancer

2014 International Journal of Oncology  
In addition, among the eight microRNAs predicted to be most strongly targeting NEK11, the majority were involved in drug resistance in ovarian and other cancers.  ...  ovarian cancer cells, and interacted with 22 proteins and 4 small molecules which all were contributed to drug resistance in ovarian cancer.  ...  Likewise, ovarian cancer is one of the five leading types of cancer death in women (1, 2) .  ... 
doi:10.3892/ijo.2014.2503 pmid:24969318 fatcat:3pbultjysvg35b2mwl5sk6rokq

Downregulation of HNF1 homeobox B is associated with drug resistance in ovarian cancer

2014 Oncology Reports  
On the basis of array data retrieved from Oncomine and Gene Expression Omnibus (GEO) online database, we found that the mRNA expression of HNF1B in 586 ovarian serous cystadenocarcinomas and in platinum-resistant  ...  A2780 epithelial ovarian cancer cells was significantly decreased, indicating a potential role of HNF1B in drug resistance in ovarian cancer.  ...  The mRNA expression data of HNF1B in ovarian cancers and in platinumresistant A2780 ovarian cancer cells was retrieved from the Oncomine and GEO profile online database, respectively.  ... 
doi:10.3892/or.2014.3297 pmid:24968817 fatcat:blx5fzcxgndcdkzw3tgwemaedm

Increased expression of TET3 predicts unfavorable prognosis in patients with ovarian cancer-a bioinformatics integrative analysis

Tiefeng Cao, Wenwei Pan, Xiaoli Sun, Huimin Shen
2019 Journal of Ovarian Research  
Previous studies indicated that TET3 is overexpressed in ovarian cancer tissues. However, the clinic-pathological functions and prognostic values of TET3 remain unclear.  ...  Ovarian carcinoma is a lethal gynecological malignancy. Women with ovarian cancer (OC) are highly recurrent and typically diagnosed at late stage.  ...  online tools and resources.  ... 
doi:10.1186/s13048-019-0575-4 pmid:31656201 pmcid:PMC6816171 fatcat:j4jgymxc25emnle6u2gwnsnjqa

Upregulation of NEK2 is associated with drug resistance in ovarian cancer

2013 Oncology Reports  
In the present study, on the basis of microarray results from Oncomine and the GEO Profiles online database, we revealed that NEK2 mRNA expression in ovarian cancer tissues is upregulated.  ...  The association of NEK2 with drug resistance in ovarian cancer has not yet been reported.  ...  Acknowledgements The present study was supported by the National Natural Science Foundation of China (grant no. 81302283) and the Youth Science Foundation of Guangxi Medical University (no.  ... 
doi:10.3892/or.2013.2910 pmid:24337664 fatcat:fn4hhkbuungt7igyuaw5nf2i5y

Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer

2014 Oncology Reports  
Accordingly, we hypothesized that the downregulation of RNASET2 and GGNBP2 is involved in the development of drug resistance in ovarian cancer.  ...  Ribonuclease T2 (RNASET2) and gametogenetin binding protein 2 (GGNBP2) are tumor suppressor genes whose expression is downregulated in ovarian and other types of cancer.  ...  Acknowledgements This study was supported by the National Natural Science Foundation of China (grant no. 81302283), and the Youth Science Foundation of Guangxi Medical University (no. GXMUYSF201205).  ... 
doi:10.3892/or.2014.3175 pmid:24842157 fatcat:e5cqcilcdvga7hwkc3x4dr5goe

Penetrance of Breast and Ovarian Cancer in Women Who Carry a BRCA1/2 Mutation and Do Not Use Risk-Reducing Salpingo-Oophorectomy: An Updated Meta-Analysis

Jinbo Chen, Eunchan Bae, Lingjiao Zhang, Kevin Hughes, Giovanni Parmigiani, Danielle Braun, Timothy R Rebbeck
2020 JNCI Cancer Spectrum  
It is important to adjust for RRSO use in the estimation of BRCA1/2 penetrance of breast and ovarian cancer.  ...  Background Use of risk-reducing Salpingo-oophorectomy (RRSO) substantially reduces the risk of ovarian and breast cancer for women who carry a BRCA1/2 mutation.  ...  Acknowledgments: JC and TRR are independent of any commercial funder, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis  ... 
doi:10.1093/jncics/pkaa029 pmid:32676552 pmcid:PMC7353955 fatcat:ilxvsz2ihrg47mqzy2ywt3lzp4

Determination of Potential Therapeutic Targets and Prognostic Markers of Ovarian Cancer by Bioinformatics Analysis

Jing Zhang, Shouguo Huang, Lini Quan, Qiu Meng, Haiyan Wang, Jie Wang, Jin Chen, A.Seval Ozgu-Erdinc
2021 BioMed Research International  
This study is to study the expression of CXCRs in ovarian cancer tissues and their value in prognosis.  ...  The expressions of CXCR1-CXCR7 mRNA between ovarian tumor tissues and normal tissues and in different pathological types of ovarian tumor tissues were compared by ONCOMINE online tool.  ...  It may be an important indicator for predicting metastasis, recurrence, and drug resistance of ovarian cancer and may be used for diagnosis, therapy, and prognostic of ovarian cancer.  ... 
doi:10.1155/2021/8883800 pmid:33829065 pmcid:PMC8004373 fatcat:nnadvv633fcalphd2pgmbdtuym

Bioinformatic analysis of chemokine (C-C motif) ligand 21 and SPARC-like protein 1 revealing their associations with drug resistance in ovarian cancer

2013 International Journal of Oncology  
This study provided important information for further investigation of drug resistance-related functions of CCL21 and SPARCL1 in ovarian cancer.  ...  Although the expression of CCL21 and SPARCL1 is downregulated in many solid tumors, their roles in ovarian cancer and their associations with drug resistance have rarely been studied.  ...  Figure 1 . 1 The co-occurrence analysis of CCL21 and SPARCL1 to the exact keyword expression 'ovarian cancer' by Pubgene online database and tool.  ... 
doi:10.3892/ijo.2013.1819 pmid:23404140 fatcat:oqtll7pjdvffjl5alisu4rtvoq

Risk Prediction for Late-Stage Ovarian Cancer by Meta-analysis of 1525 Patient Samples

Markus Riester, Wei Wei, Levi Waldron, Aedin C. Culhane, Lorenzo Trippa, Esther Oliva, Sung-hoon Kim, Franziska Michor, Curtis Huttenhower, Giovanni Parmigiani, Michael J. Birrer
2014 Journal of the National Cancer Institute  
Figure 2 . 2 Leave-one-dataset-out validation of performance of the new gene signature in predicting overall survival in late-stage ovarian cancer.  ...  Advanced ovarian cancer (stages III and IV) accounted for the majority of the estimated 22 000 new cases of epithelial ovarian cancer in 2012 in the United States (1) .  ... 
doi:10.1093/jnci/dju048 pmid:24700803 pmcid:PMC4580556 fatcat:tdpfp7uia5bulki6ijueh3k64a

Exploration of ovarian cancer micro array data focus on gene expression patterns relevant to survival using artificial neural networks

Clare Coveney, Dong-Ling Tong, David J. Boocock, Robert C. Rees, Graham R. Ball
2014 International Work-Conference on Bioinformatics and Biomedical Engineering  
Hundreds of genes have been significantly associated with ovarian cancer, few have yet been verified.  ...  of 44 genes that significantly predicted survival length of a blind validation set (p=0.00073).  ...  STRING [8] is an online, comprehensive, biological database of known and predicted protein-protein interactions.  ... 
dblp:conf/iwbbio/CoveneyTBRB14 fatcat:6jfag6n34zfrbijls2s4ogx2h4

Predictors of recovery of ovarian function during aromatase inhibitor therapy

N. L. Henry, R. Xia, M. Banerjee, C. Gersch, D. McConnell, D. Giacherio, A. F. Schott, M. Pearlman, V. Stearns, A. H. Partridge, D. F. Hayes
2013 Annals of Oncology  
J Natl Cancer Inst 2000; 92: 205-216. 16. LoRusso PM, Jones SF, Koch KM et al. Phase I and pharmacokinetic study of lapatinib and docetaxel in patients with advanced cancer.  ...  Complete remission of recurrent breast cancer with multiple liver metastases after oral capecitabine and injected trastuzumab. Breast Cancer 2007; 14: 297-301. 19.  ...  Our results suggest that FSH is not predictive of ovarian function recovery.  ... 
doi:10.1093/annonc/mdt149 pmid:23613476 pmcid:PMC3718506 fatcat:uj2wekczrzedlhkr4qu44qad6a

Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers

Karoline B Kuchenbaecker, Lesley McGuffog, Daniel Barrowdale, Andrew Lee, Penny Soucy, Joe Dennis, Susan M Domchek, Mark Robson, Amanda B Spurdle, Susan J Ramus, Nasim Mavaddat, Mary Beth Terry (+9 others)
2017 Journal of the National Cancer Institute  
†P value for a one-sided test using a weighted cohort Cox regression with time to breast or ovarian cancer diagnosis, respectively, as the outcome. ARTICLE K. B. Kuchenbaecker et al. | 3 of 15  ...  Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk.  ...  We would like to thank Geoffrey Lindeman, Marion Harris, Martin Delatycki of the Victorian Familial Cancer Trials Group.  ... 
doi:10.1093/jnci/djw302 pmid:28376175 pmcid:PMC5408990 fatcat:xd4jxs24dzejxggdgebuwkssme

Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients

Balázs Győrffy, András Lánczky, Zoltán Szállási
2012 Endocrine-Related Cancer  
We implemented an online tool to assess the prognostic value of the expression levels of all microarray-quantified genes in ovarian cancer patients.  ...  In summary, we developed a global online biomarker validation platform that mines all available microarray data to assess the prognostic power of 22 277 genes in 1287 ovarian cancer patients.  ...  The capability of these genes to predict survival was measured by using the probe set IDs in the online analysis tool.  ... 
doi:10.1530/erc-11-0329 pmid:22277193 fatcat:jb5v6jsyxfhw7ofimwjomsmioy

OSov: An Interactive Web Server to Evaluate Prognostic Biomarkers for Ovarian Cancer

Zhongyi Yan, Qiang Wang, Susu Zhao, Longxiang Xie, Lu Zhang, Yali Han, Baokun Zhang, Huimin Li, Xiangqian Guo
2021 Biology  
of ovarian cancer.  ...  Ovarian cancer is one of the most aggressive and highly lethal gynecological cancers.  ...  In addition, the CRYAB gene is less risk than that of stage or histology to predict ovarian cancer survival.  ... 
doi:10.3390/biology11010023 pmid:35053021 pmcid:PMC8773055 fatcat:w72ozy2lhzfqrimdutyi5ta4zq
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