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Online feedback control of functional electrical stimulation using dorsal root ganglia recordings

M. J. Bauman, T. M. Bruns, J. B. Wagenaar, R. A. Gaunt, D. J. Weber
2011 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society  
In neuroprostheses that use functional electrical stimulation (FES) to restore motor function, closed-loop feedback control may compensate for muscle fatigue, perturbations and nonlinearities in the behavior  ...  Kinematic state information is naturally represented in the firing rates of primary afferent neurons, which may be recorded with multi-electrode arrays at the level of the dorsal root ganglia (DRG).  ...  Acknowledgments The authors thank members of the Rehabilitation Neural Engineering Lab for their assistance during the animal experiments and with data analysis: Ingrid Albrecht, Chris Ayers, Dennis Bourbeau  ... 
doi:10.1109/iembs.2011.6091831 pmid:22256011 pmcid:PMC3464480 dblp:conf/embc/BaumanBWGW11 fatcat:7tcxldkqu5bphcudvbbk22oyui

Dimethylarginine dimethylaminohydrolase 1 is involved in spinal nociceptive plasticity

Richard D'Mello, Claire A. Sand, Sophie Pezet, James M. Leiper, Egle Gaurilcikaite, Stephen B. McMahon, Anthony H. Dickenson, Manasi Nandi
2015 Pain  
in cultured dorsal root ganglia neurons.  ...  DDAH-1 was found to be expressed in sensory neurons within both the dorsal root ganglia and spinal dorsal horn; L-291 (N G -[2-Methoxyethyl]-L-arginine methyl ester), a DDAH-1 inhibitor, reduced NO synthesis  ...  Conflict of interest statement The authors have no conflicts of interest to declare.  ... 
doi:10.1097/j.pain.0000000000000269 pmid:26098438 pmcid:PMC4770343 fatcat:zlqzwsjqgbdu7awfvzj4yd7bqy

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Nikolaus Wenger, Eduardo Martin Moraud, Jerome Gandar, Pavel Musienko, Marco Capogrosso, Laetitia Baud, Camille G Le Goff, Quentin Barraud, Natalia Pavlova, Nadia Dominici, Ivan R Minev, Leonie Asboth (+15 others)
2016 Nature Medicine  
Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans.  ...  Computer simulations identified optimal electrode locations to target each synergy through the recruitment of proprioceptive feedback circuits.  ...  For each spinal segment, the dorsal root ganglia were identified. The corresponding root was retracted cranially and laterally.  ... 
doi:10.1038/nm.4025 pmid:26779815 pmcid:PMC5061079 fatcat:tjxhcjtqvbckrmrnfmqelzvdh4

Decoding hind limb kinematics from neuronal activity of the dorsal horn neurons using multiple level learning algorithm

Hamed Yeganegi, Yaser Fathi, Abbas Erfanian
2018 Scientific Reports  
Decoding continuous hind limb joint angles from sensory recordings of neural system provides a feedback for closed-loop control of hind limb movement using functional electrical stimulation.  ...  ., ankle, knee, and hip joint angles) from the neural activity of a few neurons in the L7 dorsal root ganglia of three cats has been investigated during walking using a linear filter 2,6 .  ...  electrical stimulations 8, 9 .  ... 
doi:10.1038/s41598-017-18971-x pmid:29330489 pmcid:PMC5766487 fatcat:jzvkxjb4xje7baxp7fjceabpze

Impact of Bioelectronic Medicine on the Neural Regulation of Pelvic Visceral Function

William C. de Groat, Changfeng Tai
2015 Bioelectronic Medicine  
Modulation of lower urinary tract function has also been induced by stimulation and block of pudendal nerve axons by using a wireless-controlled implantable stimulator in cats (79) .  ...  MECHANISMS OF NEUROMODULATION Neuromodulation of pelvic organ functions induced by electrical stimulation of sacral spinal nerve roots or peripheral nerves originating in the lumbosacral segments of the  ... 
doi:10.15424/bioelectronmed.2015.00003 fatcat:qohu5bcypbfypb3eylol4bj4fm

Neurophysiology and neural engineering: a review

Arthur Prochazka
2017 Journal of Neurophysiology  
stimulators, neuroprostheses, cochlear implants, brain-24 computer interface, functional electrical stimulation 25 26 27 nerve.  ...  Bladder voiding by combined high frequency electrical pudendal 743 nerve block and sacral root stimulation. Neurourol Urodyn 2007. 744 Boggs JW, Wenzel BJ, Gustafson KJ, and Grill WM.  ...  The latest recordings from sensory afferents in freely moving animals were obtained in the context of 508 using dorsal root recordings as feedback signals to control motor NSs.  ... 
doi:10.1152/jn.00149.2017 pmid:28566462 pmcid:PMC5558026 fatcat:ehccmmdaebdmzdzwigjuyt3p4u

Electrical Activity Suppresses Axon Growth through Cav1.2 Channels in Adult Primary Sensory Neurons

Joana Enes, Nicole Langwieser, Jörg Ruschel, Melissa M. Carballosa-Gonzalez, Achim Klug, Matthias H. Traut, Bhavna Ylera, Sabina Tahirovic, Franz Hofmann, Valentin Stein, Sven Moosmang, Ian D. Hentall (+1 others)
2010 Current Biology  
Primary sensory neurons of the dorsal root ganglia (DRG) regenerate their spinal cord axon if the peripheral nerve axon has previously been cut.  ...  We first verified that firing in sensory fibers, as recorded from dorsal roots in vivo, declined after peripheral lesioning but was not altered after central lesioning.  ...  F.B. is a recipient of a Career Development Award from the Human Frontier Science Program.  ... 
doi:10.1016/j.cub.2010.05.055 pmid:20579880 fatcat:gqv72sgxtnfvrpbisiru4kzeb4

The Modulation of Pain by Circadian and Sleep-Dependent Processes: A Review of the Experimental Evidence [article]

Megan Hastings Hagenauer, Jennifer A. Crodelle, Sofia H. Piltz, Natalia Toporikova, Paige Ferguson, Victoria Booth
2017 bioRxiv   pre-print
To do this comparison, we normalize the results from experimental pain studies relative to the range of physiologically-meaningful stimulation levels.  ...  To explore the interaction between these two biological processes using modeling, we first compare the magnitude of their effects across a variety of experimental pain studies in humans.  ...  Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.  ... 
doi:10.1101/098269 fatcat:n6rjdqcnvrdmnkhm2smcgv2jku

Microstimulation of the lumbar DRG recruits primary afferent neurons in localized regions of lower limb

Christopher A. Ayers, Lee E. Fisher, Robert A. Gaunt, Douglas J. Weber
2016 Journal of Neurophysiology  
This sensory input might be useful for restoring tactile and proprioceptive feedback to a lowerlimb amputee. dorsal root ganglia; sensory feedback; neuroprostheses; selective stimulation NEW & NOTEWORTHY  ...  This study demonstrates the patterns of primary afferent activity that can be evoked by microstimulation of the lumbar dorsal root ganglia.  ...  DISCLOSURES No conflicts of interest, financial or otherwise, are declared by the authors.  ... 
doi:10.1152/jn.00961.2015 pmid:27052583 pmcid:PMC4961745 fatcat:bzcef7zdkvejtjel3d5h35xnme

Flexible microelectrode array for interfacing with the surface of neural ganglia

Zachariah J Sperry, Kyounghwan Na, Saman S Parizi, Hillel J Chiel, John Seymour, Euisik Yoon, Tim M Bruns
2018 Journal of Neural Engineering  
The buccal ganglia of invertebrate sea slug Aplysia californica were used to develop handling and recording techniques with ganglionic surface electrode arrays (GSEAs).  ...  Objective-The dorsal root ganglia (DRG) are promising nerve structures for sensory neural interfaces because they provide centralized access to primary afferent cell bodies and spinal reflex circuitry.  ...  The authors would therefore like to thank the members of those laboratories for support and advice in designing, fabricating, and testing the surface array. In particular, we acknowledge Aileen  ... 
doi:10.1088/1741-2552/aab55f pmid:29521279 pmcid:PMC5938739 fatcat:nz25o2mvn5d6lbow3zo5oyqkta

Characterization of mechanosensitive splanchnic nerve afferent fibers innervating the rat stomach

Noriyuki Ozaki, G. F. Gebhart
2001 American Journal of Physiology - Gastrointestinal and Liver Physiology  
-Splanchnic nerve fibers innervating the stomach were studied in anesthetized rats; 997 fibers in the T 9 or T10 dorsal roots were identified by electrical stimulation of the splanchnic nerve.  ...  Intragastric instillation of 12% glycerol or an inflammatory soup (bradykinin 10 Ϫ5 M, PGE2 10 Ϫ5 M, serotonin 10 Ϫ5 M, histamine 10 Ϫ5 M, and KCl 10 Ϫ3 M) and prior heat stimulation sensitized responses  ...  Ozaki is an exchange scientist from the Department of Anatomy, Fukushima Medical University, Fukushima, Japan.  ... 
doi:10.1152/ajpgi.2001.281.6.g1449 pmid:11705750 fatcat:uspyvo2lbrbkldl3hgihrfshau

A subcortical circuit linking the cerebellum to the basal ganglia engaged in vocal learning [article]

Ludivine Pidoux, Pascale Leblanc, Arthur Leblois
2017 bioRxiv   pre-print
Cerebellar signals are transmitted to the basal ganglia via a disynaptic connection through the thalamus and then conveyed to their cortical target and to the premotor nucleus controlling song production  ...  These subcortical structures interact indirectly through their respective loops with thalamo-cortical and brainstem networks, and directly via subcortical pathways, but the role of their interaction during  ...  by the square root of the product of 675 their auto-correlation function.  ... 
doi:10.1101/198317 fatcat:fau7xvjvrnhkvgbqvkcbiqw4pi

The Modulation of Pain by Circadian and Sleep-Dependent Processes: A Review of the Experimental Evidence [chapter]

Megan Hastings Hagenauer, Jennifer A. Crodelle, Sofia H. Piltz, Natalia Toporikova, Paige Ferguson, Victoria Booth
2017 Association for Women in Mathematics Series  
This proceedings paper is the first in a series of three papers developing mathematical models for the complex relationship between pain and the sleep-wake cycle.  ...  Pain sensitivity is also modulated by sleep behavior, with pain sensitivity increasing in response to the build up of homeostatic sleep pressure following sleep deprivation or sleep disruption.  ...  Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.  ... 
doi:10.1007/978-3-319-60304-9_1 fatcat:2yf73euwe5b7hbx74ik6jnpvui

Chill coma in the locust, Locusta migratoria, is initiated by spreading depolarization in the central nervous system

R. Meldrum Robertson, Kristin E. Spong, Phinyaphat Srithiphaphirom
2017 Scientific Reports  
We used thermolimit respirometry and electromyography in whole animals and extracellular and intracellular recording techniques in semi-intact preparations to characterize neural events during chilling  ...  The ability of chill-sensitive insects to function at low temperatures limits their geographic ranges.  ...  Acknowledgements We thank JD Gantz for help collecting some of the data and for comments on a previous version of the manuscript.  ... 
doi:10.1038/s41598-017-10586-6 pmid:28860653 pmcid:PMC5579280 fatcat:t6zwijdm7fekjo4p3qxt3zpfy4

Metathoracic neurons integrating intersegmental sensory information in the locust

Tom Matheson
2002 Journal of Comparative Neurology  
The responses of the interneurons described here shed new light on both local and intersegmental network function in this model system.  ...  Neurons of each population have a characteristic pattern of responses to stimulation of the mesothoracic or metathoracic wing nerves, and some respond to tactile stimulation or movements of a hind leg.  ...  Neuroanatomy and abbreviations Morphological descriptions are derived from dorsal views of whole ganglia mounted in Canada balsam and from 9 m sections of ganglia embedded in paraffin wax, drawn using  ... 
doi:10.1002/cne.10140 pmid:11835184 fatcat:qawzxdvihzcoxhjlmpyghtkgpe
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