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Picoliter Drop-On-Demand Dispensing for Multiplex Liquid Cell Transmission Electron Microscopy

Joseph P. Patterson, Lucas R. Parent, Joshua Cantlon, Holger Eickhoff, Guido Bared, James E. Evans, Nathan C. Gianneschi
2016 Microscopy and Microanalysis  
Controlling the addition of multiple solutions to the liquid cell remains a key hurdle in our ability to increase throughput and to study processes dependent on solution mixing including chemical reactions  ...  This proof-of-concept study highlights the great potential of picoliter dispensing in combination with LCTEM for observing nanoparticle mixing in the solution phase and the creation of chemical gradients  ...  ACKNOWLEDGMENTS The authors acknowledge support for this work from the AFOSR via a PECASE (FA9550-11-1-0105), ARO STIR W911NF-15-1-0080, and ARO W911NF-15-1-0189 to N.C.G. and via a AFOSR Basic Research  ... 
doi:10.1017/s1431927616000659 pmid:27135268 pmcid:PMC5235328 fatcat:rc575jqrubfkhjvyvososdl4fe

Inkjet-like printing of single-cells

Azmi Yusof, Helen Keegan, Cathy D. Spillane, Orla M. Sheils, Cara M. Martin, John J. O'Leary, Roland Zengerle, Peter Koltay
2011 Lab on a Chip  
chip prior to printing, and appropriate automation equipment to print single-cells onto defined locations on a substrate.  ...  The single-cell-manipulator (SCM) developed for this purpose consists of a dispenser chip to print cells contained in a free flying droplet, a computer vision system to detect single-cells inside the dispenser  ...  Coombe Women and Infants University Hospital, Dublin, Ireland for providing HeLa cell samples.  ... 
doi:10.1039/c1lc20176j pmid:21655638 fatcat:wbg7tsfr2vhcjaauvi3pum6aui

One-step pipetting and assembly of encoded chemical-laden microparticles for high-throughput multiplexed bioassays

Su Eun Chung, Jiyun Kim, Dong Yoon Oh, Younghoon Song, Sung Hoon Lee, Seungki Min, Sunghoon Kwon
2014 Nature Communications  
The combination of this heterogeneous particle chip and a cell chip induces the release of the chemicals from the hydrogels and, eventually, the chemicals treat the targets.  ...  One quantitative liquid handling method in conventional assay processes is pipetting, which delivers a precise volume of one sample at a time.  ...  Three particle wells compose a single combination set in the particle chip, and this set is aligned and combined face-to-face with a single cell well of the cell chip, enabling various combinations of  ... 
doi:10.1038/ncomms4468 pmid:24632848 fatcat:4hbqmckdsvhopiyq4vanczkhr4

On-chip fluorescence-activated particle counting and sorting system

Yuejun Kang, Xudong Wu, Yao-Nan Wang, Dongqing Li
2008 Analytica Chimica Acta  
Microfluidics Lab-on-a-chip Electrokinetic flow switching Particle dispensing a b s t r a c t A fluorescence-activated particle counting and sorting system is developed for lab-on-achip applications.  ...  A direct current electric pulse is generated to dispense the fluorescent particles to the collection reservoir.  ...  Acknowledgements The authors appreciate the funding support from the School of Engineering, Vanderbilt University and the H. Fort Flowers Foundation.  ... 
doi:10.1016/j.aca.2008.07.043 pmid:18761126 fatcat:scqeuyvnlfhw7nldoskfuu7lyy

Flow rate-controlled pipetting for microfluidics: second-generation flexible hydraulic reservoir (FHRv2)

Atakan Atay, Alper Topuz, Büşra Sarıarslan, Ender Yıldırım, Jérôme Charmet, Kevin Couling, Barbaros Çetin
2021 Microfluidics and Nanofluidics  
Importantly, we also demonstrate that the FHRv2 prevents sedimentation-induced artifacts typically encountered in typical syringe pumps when dispensing particles.  ...  Syringe and pressure pumps are typically used in the lab environment; however, their operations generate considerable dead volume that is often larger than the volume of the chip itself, leading to considerable  ...  JC and KC would like to acknowledge funding from the Newton Fund-Institutional Links grant (ID 352360246) for the experimental work on the fabrication of the FHRv2 with rapid prototyping injection moulding  ... 
doi:10.1007/s10404-020-02402-x fatcat:y3uyh5lagvacbb65xewophqh6u

"Droplet-Interfaced Separations as an Emerging Tool for High-Throughput Microchip Electrophoresis"

Sammerul Hassan
2019 Research in Medical & Engineering Sciences  
The MCE cross-chip consists of two channels, i.e. the sample loading channel and the separation channel.  ...  The type of charge on the particles and electric field strength determines the electrophoretic movement of charged particles.  ...  Acknowledgment We thank the funding from the Economic and Social Research Council UK (ES/S000208/1).  ... 
doi:10.31031/rmes.2019.08.000679 fatcat:ffozl5uyxfaotoygl7ezcmv36y

High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress

Jia Wang, R Michael van Dam
2020 Molecular Imaging  
activity levels, and discuss advantages and limitations and the future outlook of these innovative devices.  ...  New platforms are enabling radiochemistry to be carried out in tiny, microliter-scale volumes, and this capability has enormous benefits for the production of radiopharmaceuticals.  ...  Overall, the yield of tracers synthesized on the F]fluoride mixture dispenser and 10 droplets (1 mL each; dyed yellow) were loaded at the reaction site.  ... 
doi:10.1177/1536012120973099 pmid:33296272 pmcid:PMC7731702 fatcat:ib646zzowbcajcec4uj2447ra4

Single-beam Zeeman slower and magneto-optical trap using a nanofabricated grating [article]

D. S. Barker, E. B. Norrgard, N. N. Klimov, J. A. Fedchak, J. Scherschligt, S. Eckel
2019 arXiv   pre-print
An aperture in the grating allows atoms from the dispenser to be loaded from behind the chip, increasing the interaction distance of atoms with the cooling light.  ...  We demonstrate a compact (0.25 L) system for laser cooling and trapping atoms from a heated dispenser source.  ...  McGehee and S. Maxwell, for their careful reading of the manuscript. The authors also thank the CNST NanoFab staff for allowing them to use the facility to fabricate grating chips. D. S. B. and E. B.  ... 
arXiv:1811.09180v2 fatcat:obq5ha5efver5eqecggrcoocpq

Visualization and numerical modelling of microfluidic on-chip injection processes

David Sinton, Liqing Ren, Dongqing Li
2003 Journal of Colloid and Interface Science  
The ability to load and subsequently dispense these large axial extent samples is predicted numerically and verified experimentally by direct visualization.  ...  Sample injection processes accomplished using a microfluidic-cross chip are investigated experimentally and numerically.  ...  Sinton, and an Ontario Graduate Scholarship to L. Ren.  ... 
doi:10.1016/s0021-9797(02)00181-9 pmid:12686196 fatcat:kfdvrhe76rawjcrsqshqjwdsmq

Digital Microfluidics for the Detection of Selected Inorganic Ions in Aerosols

Shuquan Huang, Jessica Connolly, Andrei Khlystov, Richard B. Fair
2020 Sensors  
To create a standard curve for each analyte, six different concentrations of liquid standards were chosen for each assay and dispensed from on-chip reservoirs.  ...  The deposited air particles are densely concentrated in well-defined deposits on the bottom plate containing droplet actuation electrodes of the chip in fixed areas.  ...  The key feature of this technology is that it allows a seamless integration of aerosol collection and analysis on a single chip-after a brief collection phase, particles collected on the surface of the  ... 
doi:10.3390/s20051281 pmid:32120873 fatcat:ezedykwdonabxn3h3tdmw3jq7m

Digital microfluidics: is a true lab-on-a-chip possible?

R. B. Fair
2007 Microfluidics and Nanofluidics  
And, it provides a path toward realizing the true lab-on-a-chip.  ...  To understand the opportunities and limitations of EWD microfluidics, this paper looks at the development of lab-on-chip applications in a hierarchical approach.  ...  Smith Kline, and the Duke University Medical Center.  ... 
doi:10.1007/s10404-007-0161-8 fatcat:a2x5dw2aqzdadp4o2s3rvpvp5i

Microfluidic for Lab-on-a-Chip [chapter]

Stefan Haeberle, Roland Zengerle
2008 Comprehensive Microsystems  
The chip is operated in two different modes, loading and processing.  ...  (Source: Yamada M, Seki M 2005 Hydrodynamic filtration for on-chip particle concentration and classification utilizing microfluidics.  ...  , lab-on-a-chip systems, thermal sensors, miniaturized fuel cells as well as micro-and nanofluidics simulation.  ... 
doi:10.1016/b978-044452190-3.00038-0 fatcat:wzffrolbuzal5j7qudkpxeb2iu

Flip chip microassembly of a silicon triaxial force sensor on flexible substrates

Arne Sieber, Pietro Valdastri, Keith Houston, Arianna Menciassi, Paolo Dario
2008 Sensors and Actuators A-Physical  
Miniaturization of microelectromechanical systems (MEMS) based devices can be achieved by flip chip assembly directly onto a flexible circuit substrate.  ...  The main goal of this work was the selection of a suitable bonding material and process to enable scaling down of MEMS sensorized devices for biomedical applications.  ...  Filippeschi for his continuous and invaluable help.  ... 
doi:10.1016/j.sna.2007.02.042 fatcat:ownrjcmtqrap7fo2htfsixcm5q

Single-Cell Printer

Andre Gross, Jonas Schöndube, Sonja Niekrawitz, Wolfgang Streule, Lutz Riegger, Roland Zengerle, Peter Koltay
2013 Journal of Laboratory Automation  
The presented technology is based on a transparent microfluidic drop-on-demand dispenser chip coupled with a camera-assisted automatic detection system.  ...  Cells inside the chip are detected and classified with this detection system before they are expelled from the nozzle confined in microdroplets, thus enabling a "one cell per droplet" printing mode.  ...  Acknowledgments We appreciate the contribution and valuable suggestions of all PASCA consortium members regarding specification, development, intense testing, and evaluation of the prototype system.  ... 
doi:10.1177/2211068213497204 pmid:24222537 fatcat:jqakss66ebcz5iiyizkhml4qke

Effects of Silica Filler and Diluent on Material Properties and Reliability of Nonconductive Pastes (NCPs) for Flip-Chip Applications

K.-W. Jang, W.-S. Kwon, M.-J. Yim, K.-W. Paik
2004 IEEE transactions on components and packaging technologies  
Based on these results, three candidates of NCPs with various silica filler and diluent contents were selected and used as adhesives for reliability test of flip chip assemblies.  ...  In this paper, thermomechanical and rheological properties of nonconductive pastes (NCPs) depending on silica filler contents and diluent contents were investigated.  ...  First, gold stud bumps on chips and I/O pads on test substrates were aligned. And then NCPs were dispensed on a substrate to interconnect chips.  ... 
doi:10.1109/tcapt.2004.832054 fatcat:qjpbetzbuvghvd7lvacma6dp4a
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