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High precision magnetically driven microtools with ultrasonic vibration for enucleation of oocytes

Masaya Hagiwara, Tomohiro Kawahara, Lin Feng, Yoko Yamanishi, Fumihito Arai
2010 2010 International Symposium on Micro-NanoMechatronics and Human Science  
A piezoelectric ceramic is used to induce nanoscale vibration to the microfluidic chip to reduce the friction on the MMT. The enucleation process has been conducted by the dual arm MMTs.  ...  This paper presents innovative driving method for the magnetically driven microtools (MMT) which is micrometer positioning accuracy by horizontally arranged permanent magnets.  ...  ACKNOWLEDGEMENT This work is partially supported by JST-SENTAN and the Nagoya University Global COE program for Education and Research of Micro-Nano Mechatronics.  ... 
doi:10.1109/mhs.2010.5669580 fatcat:nqwmrgu2bbcmzehlzwxpfvipq4

On-Chip Enucleation of Bovine Oocytes using Microrobot-Assisted Flow-Speed Control

Lin Feng, Masaya Hagiwara, Akihiko Ichikawa, Fumihito Arai
2013 Micromachines  
In this study, we developed a microfluidic chip with a magnetically driven microrobot for oocyte enucleation.  ...  The novelties of the developed microfluidic system are as follows: (1) the cutting speed improved significantly owing to the local fluid flow control; (2) the cutting volume of the oocyte can be adjusted  ...  Acknowledgements This work is partially supported by SENTAN, JST; the Nagoya University Global COE program for Education and Research of Micro-Nano Mechatronics; and Scientific Research from the Ministry  ... 
doi:10.3390/mi4020272 fatcat:nyvx5qqjcrbsxh6rnyndvuztii

High-Speed Magnetic Microrobot Actuation in a Microfluidic Chip by a Fine V-Groove Surface

Masaya Hagiwara, Tomohiro Kawahara, Toru Iijima, Fumihito Arai
2013 IEEE Transactions on robotics  
Index Terms-Friction reduction, high speed, lab on a chip, magnetically driven microtool (MMT), microfluidics, microrobot.  ...  In addition to the advantage of environmental control by a microfluidic chip, robots enable physical operations on the cell with high throughput.  ...  A magnetically driven microtool (MMT) actuated by a permanent magnet can output a force on the order of milli-Newtons with keeping the small size of the drive unit.  ... 
doi:10.1109/tro.2012.2228310 fatcat:wzrg4qvienapxaezbxahdulqnm

Magnetically Driven Bionic Millirobots with a Low-Delay Automated Actuation System for Bioparticles Manipulation

Xue Bai, Dixiao Chen, Wei Zhang, Heulin Ossian, Yuanyuan Chen, Yanmin Feng, Lin Feng, Fumihito Arai
2020 Micromachines  
This system is mainly applied in magnetically driven robots. An innovative manta ray-like robot was designed to increase stability of robots in a non-contaminated manipulation environment.  ...  In biotechnology, precise transportation of cells is used for the enucleation, microinjection, and investigation of the characteristics of a single cell.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/mi11020231 pmid:32102365 pmcid:PMC7074837 fatcat:bj3qmd5twvd25javylsowjwthq

Cell Injection Millirobot Development and Evaluation in Microfluidic Chip

Lin Feng, Qiang Zhou, Bin Song, Yanmin Feng, Jun Cai, Yonggang Jiang, Deyuan Zhang
2018 Micromachines  
We propose an innovative design of millirobot, which can achieve donor cell suction, delivery, and injection in a mammalian oocyte on a microfluidic chip.  ...  Specifically, a controller changes the hollow volume by balancing the magnetic and elastic forces of a membrane along with the motion of stages in the XY plane.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/mi9110590 pmid:30428554 pmcid:PMC6266326 fatcat:56tsba7qq5evnpguple3wqiv7q

Micro-scale Instruments Applied to a Bovine Nuclear Transfer System [article]

Andrew Leif Clow, University Of Canterbury
2010
Manual handling of biological cells is routine in most laboratories. This is gradually changing with the development of robotic cell handling systems, and micro-scale lab-on-chip devices.  ...  Many miniaturised lab-on-chip systems rely on cell transportation. One illustration in the baseline procedure is the on-chip transport of cells to the cell fusion device.  ...  Microtool design differed from many lab-on-chip devices because the operation of these other devices concern fluids rather than particulates or cells.  ... 
doi:10.26021/2780 fatcat:dda3sr73orgkbjthmcqfadvhje