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2A2-A07 Robot-on-a-chip : Part1: On-chip Generation of Droplets and Size Control

Lin FENG, Yoko YAMANISHI, Tomohiro KAWAHARA, Masaya HAGIWARA, Kazuhiro KOSUGE, Fumihito ARAI
2010 The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec)  
We have successfully produeed emulsion droplets on a chip both achieved size-centrol and on-demand droplet generation by using magnetically driven microtool (MMT) which has a parallel plate structure to  ...  This system eontributes to emulsification process for biotechnology and nano-medieine applications, Kay Plords: Droplet dispensing, Magnetically driven microtoel, Robot'on'a-chip, Mlcrosensor  ...  ACKNOWLEDGEMENT This werk is financially supported by JST-SENTAN.  ... 
doi:10.1299/jsmermd.2010._2a2-a07_1 fatcat:yn54crfgrrepxnycjl3ctijsqe

Accurate dispensing system for single oocytes using air ejection

Lin Feng, Yiling Sun, Chisato Ohsumi, Fumihito Arai
2013 Biomicrofluidics  
By using this device, we achieved a highly accurate single-oocyte dispensing process with a success rate of 100%.  ...  pressure acting on the oocyte.  ...  ACKNOWLEDGMENTS This work was partially supported by SENTAN, JST, the Nagoya University Global COE program for Education and Research of Micro-Nano Mechatronics, and the Japan Society for the Promotion  ... 
doi:10.1063/1.4824394 pmid:24404076 pmcid:PMC3799720 fatcat:3z36jay3qrbq7lu5sy7rci2huq

Fabrication of Nanopillar Micropatterns by Hybrid Mask Lithography for Surface-Directed Liquid Flow

Shinya Sakuma, Masakuni Sugita, Fumihito Arai
2013 Micromachines  
when the micro-tool was actuated, was dramatically reduced by using a surface-directed liquid flow.  ...  The nanopillar density is controlled by varying the weight ratio of nanoparticles in the composite mask. Hybrid mask lithography was used to fabricate a surface-directed liquid flow.  ...  Acknowledgments This work is supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (23106002) and also the Japan Society for the Promotion  ... 
doi:10.3390/mi4020232 fatcat:6fqhxggmlzfjjgia66gklvufge

Approaches to automated protein crystal harvesting

Marc C. Deller, Bernhard Rupp
2014 Acta Crystallographica Section F Structural Biology Communications  
Several automated protein crystal harvesting systems have been developed, including systems utilizing microcapillaries, microtools, microgrippers, acoustic droplet ejection and optical traps.  ...  For this reason, protein crystal harvesting is the single step that remains entirely dependent on skilled human intervention.  ...  The UMR robotics system was supported by the NIH and NIGMS under STTR Phase II Grant No. R42 GM073278-02A1 and supplement.  ... 
doi:10.1107/s2053230x14000387 pmid:24637746 pmcid:PMC3936438 fatcat:d3zsjragezgthcgm4sadqm4ahm

Cell Injection Millirobot Development and Evaluation in Microfluidic Chip

Lin Feng, Qiang Zhou, Bin Song, Yanmin Feng, Jun Cai, Yonggang Jiang, Deyuan Zhang
2018 Micromachines  
We propose an innovative design of millirobot, which can achieve donor cell suction, delivery, and injection in a mammalian oocyte on a microfluidic chip.  ...  Specifically, a controller changes the hollow volume by balancing the magnetic and elastic forces of a membrane along with the motion of stages in the XY plane.  ...  A piezoelectric ceramic was applied to induce ultrasonic vibration in the microfluidic chip, and high-frequency vibration significantly reduced the effective friction on a magnetically driven microtool  ... 
doi:10.3390/mi9110590 pmid:30428554 pmcid:PMC6266326 fatcat:56tsba7qq5evnpguple3wqiv7q

Latest Updates on the Advancement of Polymer-Based Biomicroelectromechanical Systems for Animal Cell Studies

Ricardo Garcia-Ramirez, Ana S. Cerda-Kipper, Damaris Alvarez, Sofia Reveles-Huizar, Jorge A. Garza-Abdala, Samira Hosseini, Kinga Pielichowska
2021 Advances in Polymer Technology  
hydrodynamic focusing, and flows were driven by gravity.  ...  The device is capable to induce cell sorting based on DEP by encapsulating particles in droplets and applying a voltage potential in a single step.  ... 
doi:10.1155/2021/8816564 fatcat:tcxmupgkoffzfnsedxemkeonga

1A2-B08 High-Speed Single Cell Dispenser : Air-Flow based Single Cell Dispenser with Dual-Capacitance Sensors(Nano/Micro Fluid System)
1A2-B08 高速単一細胞ディスペンサ : 分注率向上を目指した空気圧式単一細胞分注(ナノ・マイクロ流体システム)

Tomohiro KAWAHARA, Shigeo OHASHI, Yoko YAMANISHI, Fumihito ARAI
2011 The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec)  
Ara, ' LOn − demand delivery of oocyte in microchannei using magnetically driven microtools , TRANSDUCERS , 2011 ( accep 【ed ) .  ...  To improve success rate of single ce1 且dispensing , the developed system is composed of a cell loader , an inkjet mechanism and two pair ofcapacitanee sensors to dispense a droplet with a single eell .  ... 
doi:10.1299/jsmermd.2011._1a2-b08_1 fatcat:w473lbnonzbk7e3lql3xe3llcy

A review on 3D micro-additive manufacturing technologies

Mohammad Vaezi, Hermann Seitz, Shoufeng Yang
2012 The International Journal of Advanced Manufacturing Technology  
New microproducts need the utilization of a diversity of materials and have complicated three-dimensional (3D) microstructures with high aspect ratios.  ...  The aptitude to process a broad range of materials and the ability to fabricate functional and geometrically complicated 3D microstructures provides the additive manufacturing (AM) processes some profits  ...  Furthermore, the RPBOD system was improved to include a new manufacture method, called dual dispensing system as besides the pneumatic dispenser, a mechanical dispenser which was driven by a stepper motor  ... 
doi:10.1007/s00170-012-4605-2 fatcat:xnfnsfrgg5fnnbc2v4bjxdsogy

Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices

G. T. Vladisavljević, Isao Kobayashi, Mitsutoshi Nakajima
2012 Microfluidics and Nanofluidics  
Microchannel emulsification is a 2 very promising technique for production of monodispersed droplets with droplet throughputs of up to 100 litres per hour. . (2007b) 'Fabrication of monodisperse gel shells  ...  Glass capillary microfluidic devices are very suitable for production of core/shell drops of controllable shell thickness and multiple emulsions containing a controlled number of inner droplets and/or  ...  (e) injection of two distinct inner phases of double emulsions using a two-bore injection tube (Sun et al., 2010) . or magnetically driven microtools (Yamanichi et al., 2009).  ... 
doi:10.1007/s10404-012-0948-0 fatcat:omnsa2yu5zc33b47m4pruni774

How to Build a Biological Machine Using Engineering Materials and Methods

Alex Ellery
2020 Biomimetics  
Life must have emerged from the available raw material on Earth and, similarly, a self-replicating machine must exploit and leverage the available resources on the Moon.  ...  We then examine these lessons to explore the construction of a self-replicating machine using a universal constructor. It is through the universal constructor that the actuator emerges as critical.  ...  Acknowledgments: I would like to thank Oak Ridge National Laboratory for their 3D printed rare earth magnets. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/biomimetics5030035 pmid:32722540 pmcid:PMC7558640 fatcat:dti5lsql7faptgrruyxetbn3qy

Nonlinear waves in metamaterials: state of the art

A. D. Boardman, P. Egan, R. C. Mitchell-Thomas, M. McCall, Y. G. Rapoport, Allan D. Boardman, Nader Engheta, Mikhail A. Noginov, Nikolay I. Zheludev
2011 Metamaterials: Fundamentals and Applications IV  
Consequently Marangoni flows are generated and exert a force upon the droplet. It is this optically driven force that can be used to move the drop in a controlled manner.  ...  Specifically, we demonstrate nanoscale confinement of light by the use of silicon plasmonic nanotapers on a chip.  ...  We observe Poole-Frenkel transport that crosses over to phonon-assisted tunneling at higher fields, with a tunneling time found to depend predominantly on fundamental physical constants as predicted by  ... 
doi:10.1117/12.892463 fatcat:fv5gdkxgn5cztc5w65zzgkbt3e

Microfluidic Bioreactors for Cell Culturing: A Review

Godfrey Pasirayi, Vincent Auger, Simon M. Scott, Pattanathu K.S.M. Rahman, Meez Islam, Liam O'Hare, Zulfiqur Ali
2011 Micro and Nanosystems  
The use of microfluidic bioreactor platforms for cell culturing holds considerable promise for a range of fields which include drug discovery, tissue engineering, bioprocessing optimisation and cell based  ...  Due to their small footprint microbioreactor platforms offer a number of advantages over conventional macroscale systems including improved biological function, higher quality cell-based data, reduced  ...  [287 demonstrated the removal of the zona pellucid of a swine oocyte using magnetically driven microtool in a microfluidic bioreactor chip.  ... 
doi:10.2174/1876402911103020137 fatcat:y3viivrc4bbfdmxm33b7cxcusm

Micro-scale Instruments Applied to a Bovine Nuclear Transfer System [article]

Andrew Leif Clow, University Of Canterbury
2010
Many miniaturised lab-on-chip systems rely on cell transportation. One illustration in the baseline procedure is the on-chip transport of cells to the cell fusion device.  ...  Designs suitable for implementation in microscale lab-on-chip systems were evaluated. Tool development was predominantly experimental, assisted by numerical modelling.  ...  Dispensing the exact quantity to fill the reservoir and obtaining a droplet pinned exactly to the outline of the reservoir was not achieved by manual pipetting.  ... 
doi:10.26021/2780 fatcat:dda3sr73orgkbjthmcqfadvhje

2 Spark Health Design, USA, and 3 Jana Care

Holger Becker Microfluidic Chipshop, Germany, Steven Soper, Michael Breadmore, Rosanne Guijt, Nial Macdonald, Greg Nordin, Joel Voldman, Aman Russom, Werner Haselmayr, Robert Wille, Andreas Grimmer (+272 others)
unpublished
Niu University of Southampton, UK T083d MAGNETIC ''MECHANICAL HAND'': 3D MANIPULATION OF DROPLETS USING A SUPERHYDROPHOBIC ELECTROMAGNET NEEDLE C. Yang and G.  ...  Roth 1 1 Hans Knoll Institute, GERMANY and 2 Friedrich Schiller University, GERMANY M079d CONTROLLED ONE CELL-ONE BEAD ENCAPSULATION IN DROPLETS BY LIQUID-LIQUID INTERFACIAL SHEARING G.K.  ... 
fatcat:jhgumgyeyjdfja23tdqm637gou

Exploitation of Super(de)wettability via Scalable Hierarchical Surface Texturing [article]

William Sai Yau Wong, University, The Australian National, University, The Australian National
2018
Between 1804 and 1805, Thomas Young described the concept of a wetting contact angle, which controls the equilibrium shape of a fluid droplet on a surface, thus making wettability a quantified branch of  ...  In 1997, almost exactly 20 years ago, the field was rejuvenated by the corresponding discoveries of superhydrophilicity (water droplets spread into a sheet) and superhydrophobicity (water droplets ball  ...  on "sticky" chips for "drop-on drop-off" micro-reactors  ... 
doi:10.25911/5d51431f0f11d fatcat:2i2tf3yitrckbgzbgsm7ax66iy
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