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Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study

Laura M. Raffield, Amanda J. Cox, Christina E. Hugenschmidt, Barry I. Freedman, Carl D. Langefeld, Jeff D. Williamson, Fang-Chi Hsu, Joseph A. Maldjian, Donald W. Bowden
2015 Neurobiology of Aging  
All neuroimaging measures analysed were significantly heritable (ĥ 2 =0.55-0.99 in unadjusted models).  ...  This study examined multiple neuroimaging measures in 465 participants from 238 families with extensive genotype data in the type 2 diabetes enriched Diabetes Heart Study-Mind cohort.  ...  This analysis was performed in a cohort enriched for type 2 diabetes. All neuroimaging measures assessed were significantly heritable.  ... 
doi:10.1016/j.neurobiolaging.2014.11.008 pmid:25523635 pmcid:PMC4346514 fatcat:z4gmjxtzwrhmhgefpkglkkorby

Beyond heritability: improving discoverability in imaging genetics

Chun Chieh Fan, Olav B Smeland, Andrew J Schork, Chi-Hua Chen, Dominic Holland, Min-Tzu Lo, V S Sundar, Oleksandr Frei, Terry L Jernigan, Ole A Andreassen, Anders M Dale
2018 Human Molecular Genetics  
Structural neuroimaging measures based on magnetic resonance imaging have been at the forefront of imaging genetics.  ...  However, not many novel genetic variants have been identified by these GWAS, despite the high heritability of structural neuroimaging measures.  ...  Heritability Does Not Predict Discoverability From twin/family studies, the variance explained by genetic effects in structural neuroimaging measures, such as volume of hippocampus, volume of putamen,  ... 
doi:10.1093/hmg/ddy082 pmid:29522091 fatcat:hhrr6rzrabblvbcmwsezlhvlgq

Meeting the Challenges of Neuroimaging Genetics

Greig I. de Zubicaray, Ming-Chang Chiang, Katie L. McMahon, David W. Shattuck, Arthur W. Toga, Nicholas G. Martin, Margaret J. Wright, Paul M. Thompson
2008 Brain Imaging and Behavior  
As research encompassing neuroimaging and genetics gains momentum, extraordinary information will be uncovered on the genetic architecture of the human brain.  ...  , and offer some opinions about future directions in the field.  ...  From macrostructure to microstructure In addition to employing large samples, neuroimaging genetics studies will need to optimize the sensitivity of their image acquisitions and analyses to detect subtle  ... 
doi:10.1007/s11682-008-9029-0 pmid:20016769 pmcid:PMC2794202 fatcat:5qldmeczjjbpdp5anp26sjnksq

Homogenizing Estimates of Heritability Among SOLAR-Eclipse, OpenMx, APACE, and FPHI Software Packages in Neuroimaging Data

Peter Kochunov, Binish Patel, Habib Ganjgahi, Brian Donohue, Meghann Ryan, Elliot L. Hong, Xu Chen, Bhim Adhikari, Neda Jahanshad, Paul M. Thompson, Dennis Van't Ent, Anouk den Braber (+9 others)
2019 Frontiers in Neuroinformatics  
We tested the agreement between heritability estimates provided by four methods that are used for heritability estimates in neuroimaging traits.  ...  Imaging genetic analyses use heritability calculations to measure the fraction of phenotypic variance attributable to additive genetic factors.  ...  The four software packages were used to compare additive genetic contribution (heritability) in simulated and experimental data using twin family study designs.  ... 
doi:10.3389/fninf.2019.00016 pmid:30914942 pmcid:PMC6422938 fatcat:zo5ci45nwra7jcwcvthim5xury

Neuroimaging endophenotypes: Strategies for finding genes influencing brain structure and function

David C. Glahn, Paul M. Thompson, John Blangero
2007 Human Brain Mapping  
In addition, we review genetic approaches that capitalize on the use of quantitative traits, including those derived from brain images. Hum Brain Mapp 28:488-501, 2007.  ...  V V C 2007 Wiley-Liss, Inc. in Wiley InterScience (www. interscience.wiley.com).  ...  Given these concerns, the complexity of functional neuroimaging analyses and the relatively high cost of collecting these data, few studies have examined genetic influences on functional neuroimaging signals  ... 
doi:10.1002/hbm.20401 pmid:17440953 fatcat:4dvmpw7pzvetrpk25zzav5jzda

Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data

Peter Kochunov, Neda Jahanshad, Daniel Marcus, Anderson Winkler, Emma Sprooten, Thomas E. Nichols, Susan N. Wright, L. Elliot Hong, Binish Patel, Timothy Behrens, Saad Jbabdi, Jesper Andersson (+41 others)
2015 NeuroImage  
FA measurements from the HCP cohort for eleven major white matter tracts were highly heritable (h 2 = 0.53-0.90, p b 10 −5 ), and NeuroImage 111 (2015) 300-311 NeuroImage j o u r n a l h o m e p a g e  ...  Uniquely, the measurements of additive genetic contribution performed in this study can be repeated using online genetic analysis tools provided by the HCP ConnectomeDB web application.  ...  The HCP study uses a twin-sibling study design and heritability estimates obtained using this design can be higher than those calculated in extended families (Kochunov et al., 2014) .  ... 
doi:10.1016/j.neuroimage.2015.02.050 pmid:25747917 pmcid:PMC4387079 fatcat:s4lpvm3wozd27fdqjc36aewfoe

Structural brain magnetic resonance imaging of pediatric twins

Jay N. Giedd, James Eric Schmitt, Michael C. Neale
2007 Human Brain Mapping  
In this report, we discuss methodologic issues related to pediatric neuroimaging twin studies and synthesize results to date from the project.  ...  V V C 2007 Wiley-Liss, Inc. in Wiley InterScience (www. interscience.wiley.com). V V C 2007 Wiley-Liss, Inc. r Human Brain Mapping 28:474-481 (2007) r r Pediatric Neuroimaging of Twins r r 479 r  ...  Figure 2 . 2 The extended twin design. Figure 3 . 3 Examples of extensions into multivariate analyses. For simplicity, only one member of a twin pair is shown in each model.  ... 
doi:10.1002/hbm.20403 pmid:17437295 fatcat:grni7ippe5cbxoq3ciwu7ijtya

Intrinsic functional connectivity in families genetically enriched for social anxiety disorder – an endophenotype study

Janna Marie Bas-Hoogendam, Henk van Steenbergen, Kathrin Cohen Kadosh, P. Michiel Westenberg, Nic J.A. van der Wee
2021 EBioMedicine  
Using data from the Leiden Family Lab study on SAD, including two generations of families genetically enriched for SAD, we investigated whether social anxiety (SA) co-segregated with changes in intrinsic  ...  Subsequently, heritability was estimated.  ...  In a study recently published in EBioMedicine [2] , Bas-Hoogendam and colleagues analysed 109 resting-state fMRI data from the LFLSAD.  ... 
doi:10.1016/j.ebiom.2021.103445 pmid:34161885 pmcid:PMC8237289 fatcat:i4foedr72nbjfnh7lrzlbvavw4

Associations Between Physical Fitness and Brain Structure in Young Adulthood

John R. Best, Elizabeth Dao, Ryan Churchill, Theodore D. Cosco
2020 Frontiers in Psychology  
Brain structure was assessed using magnetic resonance imaging on a Siemens 3T customized 'Connectome Skyra' at Washington University in St. Louis, using a 32-channel Siemens head coil.  ...  Performance-based measures of fitness (i.e., endurance and grip strength) were not associated with any structural neuroimaging markers.  ...  Additional details on the participants and study design can be found elsewhere (Van Essen et al., 2013) .  ... 
doi:10.3389/fpsyg.2020.608049 pmid:33281692 pmcid:PMC7705380 fatcat:7n7wbv2j4bfjnpx3jybcuplmpe

Altered neurobiological processing of unintentional social norm violations: a multiplex, multigenerational fMRI study on social anxiety endophenotypes

Janna Marie Bas-Hoogendam, Henk van Steenbergen, Renaud L.M. Tissier, Nic J.A. van der Wee, P. Michiel Westenberg
2019 Biological Psychiatry: Cognitive Neuroscience and Neuroimaging  
Here, we used data from the multiplex, multigenerational LFLSAD (Leiden Family Lab study on Social Anxiety Disorder), which involved two generations of families genetically enriched for SAD, and investigated  ...  As expected, voxelwise functional magnetic resonance imaging analyses revealed positive associations between SA levels and brain activation in the medial prefrontal cortex and medial temporal gyrus, superior  ...  ACKNOWLEDGMENTS AND DISCLOSURES The Leiden Family Lab study on Social Anxiety Disorder and Janna Marie Bas-Hoogendam are funded by Leiden University Research Profile "Health, Prevention and the Human Life  ... 
doi:10.1016/j.bpsc.2019.03.003 pmid:31031203 fatcat:5yuwfqx2rzgyhj7x62unpbomle

Heritability estimates for cognitive factors and brain white matter integrity as markers of schizophrenia

Hilary Bertisch, Dawei Li, Matthew J. Hoptman, Lynn E. DeLisi
2010 American Journal of Medical Genetics Part B: Neuropsychiatric Genetics  
In an effort to explore the validity of a selection of cognitive and neuroimaging endophenotypes, the present study was designed to determine estimates of their heritability.  ...  In addition, other cognitive and neuroimaging variables that were not studied here may be candidates for schizophrenia endophenotypes.  ...  Subjects from the complete cohort were included in the final heritability analyses if they had available cognitive test scores and/or DTI indices within each designated variable.  ... 
doi:10.1002/ajmg.b.31054 pmid:20052692 pmcid:PMC3446203 fatcat:4syyr5miqncbhbn7bvsa6irdsa

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Paul M. Thompson, Jason L. Stein, Sarah E. Medland, Derrek P. Hibar, Alejandro Arias Vasquez, Miguel E. Renteria, Roberto Toro, Neda Jahanshad, Gunter Schumann, Barbara Franke, Margaret J. Wright, Nicholas G. Martin (+277 others)
2014 Brain Imaging and Behavior  
Some ENIGMA investigators contributed to the design and implementation of ENIGMA or provided data but did not participate in the analysis or writing of this report.  ...  of ADNI or provided data but did not participate in the analysis or writing of this report.  ...  By 2009, a number of GWAS studies had been performed on neuroimaging data.  ... 
doi:10.1007/s11682-013-9269-5 pmid:24399358 pmcid:PMC4008818 fatcat:ujnpcizkpfdaxg6egpb43sskai

Attention-Deficit/Hyperactivity Disorder Endophenotypes

Alysa E. Doyle, Erik G. Willcutt, Larry J. Seidman, Joseph Biederman, Virginie-Anne Chouinard, Julie Silva, Stephen V. Faraone
2005 Biological Psychiatry  
Neuropsychological impairments, as well as measures from neuroimaging and electrophysiological paradigms, show correlations with ADHD and evidence of heritability, but the familial or genetic overlap between  ...  For complex conditions such as this, biologically based phenotypes that lie in the pathway from genes to behavior may provide a more powerful target for molecular genetic studies than the disorder as a  ...  This would allow for quantitative trait analyses and could also capitalize on statistically powerful designs using discordant relative pairs in which one is high and the other low on a quantitative trait  ... 
doi:10.1016/j.biopsych.2005.03.015 pmid:15950005 fatcat:otjpkchhqzc6dcc2lsm5yhxkda

Neuroimaging endophenotypes of type 2 diabetes mellitus: a discordant sibling pair study

Dong Zhang, Lin Shi, Xiubao Song, Changzheng Shi, Pan Sun, Wutao Lou, Defeng Wang, Liangping Luo
2019 Quantitative Imaging in Medicine and Surgery  
Based on a sibling pair design, we aimed to find the neuroimaging endophenotypes of T2DM and investigate the role of inherent neurological disorders in the pathogenesis and deterioration of T2DM.  ...  Twenty-six pairs of diagnosed T2DM patients with unaffected siblings and 26 unrelated controls were included in this study.  ...  -2.67 Discussion Based on the familial aggregation in T2DM and the observed high prevalence in the siblings of affected individuals, we designed a sibling pair study, attempted to verify the neuroimaging  ... 
doi:10.21037/qims.2019.05.18 pmid:31367554 pmcid:PMC6629556 fatcat:nfmf74hidrhvnovz2qteoaptde

Enhancing the Informativeness and Replicability of Imaging Genomics Studies

Cameron S. Carter, Carrie E. Bearden, Edward T. Bullmore, Daniel H. Geschwind, David C. Glahn, Raquel E. Gur, Andreas Meyer-Lindenberg, Daniel R. Weinberger
2017 Biological Psychiatry  
these studies.  ...  Imaging genomics is a new field of investigation that seeks to gain insights into the impact of human genetic variation on the structure, chemistry and function of neural systems in health and disease.  ...  Careful implementation of best practices in the design and analysis of imaging studies, including appropriate correction for the number of comparisons and the number of analyses, will have a similar positive  ... 
doi:10.1016/j.biopsych.2016.08.019 pmid:27793332 pmcid:PMC5318285 fatcat:557jc4nqynffbdmgcq3pigvvdy
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