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Experimental Genetics of Plasmodium berghei NFU in the Apicoplast Iron-Sulfur Cluster Biogenesis Pathway

Joana M. Haussig, Kai Matuschewski, Taco W. A. Kooij, Ross Frederick Waller
2013 PLoS ONE  
We show that the branched apicoplast signal is entirely abolished by azithromycin treatment, while fosmidomycin had no effect on apicoplast morphology.  ...  Two of these were predicted to target to the mitochondrion, one ISU/ IscU ortholog (PBANKA_131820) and one NFU1/NfuA ortholog (PBANKA_083170).  ...  First, the [Fe-S] cluster is assembled de novo on a scaffold protein.  ... 
doi:10.1371/journal.pone.0067269 pmid:23805304 pmcid:PMC3689711 fatcat:6glly5luczez3fmrsp2b4p5jnm

What can we do on gravity with antihydrogens? [article]

Yasunori Fujii
1998 arXiv   pre-print
We discuss the implications of the proposed gravitational redshift experiment on antihydrogens.  ...  We show that the result should be the same as on hydrogens in spite of different free-fall accelerations (WEP violation) which may occur if there is a vector fifth-force field.  ...  The text-book derivation of the gravitational redshift is a combination of the two steps: (A) Based on the static nature of the setting, one derives ∆t em = ∆t rec , (1) on the intervals of the coordinate  ... 
arXiv:gr-qc/9806092v1 fatcat:dtqhlj4nrjci5mgygeckziff5m

Iron–sulfur cluster exchange reactions mediated by the human Nfu protein

Christine Wachnowsky, Insiya Fidai, J. A. Cowan
2016 Journal of Biological Inorganic Chemistry  
Human holo Nfu shows a dimer-tetramer equilibrium with a protein to cluster ratio of 2:1, reflecting the Nfu-bridging [2Fe-2S] cluster.  ...  Nfu and the [2Fe-2S](GS) 4 cluster were mixed in a 1:1 ratio at 50 μM each and Wachnowsky et al.  ...  Human Nfu exists in two isoforms, one of which is mitochondrial and the other is cytosolic [17] .  ... 
doi:10.1007/s00775-016-1381-8 pmid:27538573 pmcid:PMC5167677 fatcat:e5bt2k3qh5fvxmpud2gocrb2mi

Thermodynamic and Structural Analysis of Human NFU Conformational Chemistry

Jingwei Li, Shu Ding, J. A. Cowan
2013 Biochemistry  
Human NFU has been implicated in the formation of inorganic sulfide required for cellular ironsulfur cluster biosyntheses.  ...  Herein we quantitatively characterize the structural stability of the two domains of human NFU, and in particular the functional C-terminal domain.  ...  The influence of N-NFU on C-NFU underlines the importance of the structural role of the N-terminal domain on the native structure of NFU.  ... 
doi:10.1021/bi400320s pmid:23796308 pmcid:PMC3855582 fatcat:uexkbjayezegrehl3ml2pmujay

Increasing Need for Uniqueness in Contemporary China: Empirical Evidence

Huajian Cai, Xi Zou, Yi Feng, Yunzhi Liu, Yiming Jing
2018 Frontiers in Psychology  
In two studies, we examine how Chinese people's need for uniqueness (NFU) also has changed. In Study 1, we found a significant crossgenerational increase in Chinese participants' self-reported NFU.  ...  These findings suggest that the NFU has been rising in China, a historically collectivistic-oriented society. Theoretical and practical implications of our findings were discussed.  ...  If younger generations report higher NFU, one possibility is that the NFU has been rising in China. In Study 2, we investigated the change of the Chinese NFU by examining Chinese baby names.  ... 
doi:10.3389/fpsyg.2018.00554 pmid:29867619 pmcid:PMC5952033 fatcat:vu6ofs2oobe2hnwity6if5li2m

Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster

W.-H. Tong, G. N. L. Jameson, B. H. Huynh, T. A. Rouault
2003 Proceedings of the National Academy of Sciences of the United States of America  
The results suggest that Nfu can assemble approximately one labile [4Fe-4S] cluster per two Nfu monomers, and support the proposal that Nfu is an alternative scaffold protein for assembly of clusters that  ...  Here we report the characterization of human Nfu.  ...  Mössbauer spectroscopy was used to characterize the Fe-S cluster assembled on Nfu.  ... 
doi:10.1073/pnas.1732541100 pmid:12886008 pmcid:PMC187839 fatcat:hlzx2alwabbixavmwadkzzfwa4

Aging Triggers H3K27 Trimethylation Hoarding in the Chromatin of Nothobranchius furzeri Skeletal Muscle

Chiara Cencioni, Johanna Heid, Anna Krepelova, Seyed Mohammad Mahdi Rasa, Carsten Kuenne, Stefan Guenther, Mario Baumgart, Alessandro Cellerino, Francesco Neri, Francesco Spallotta, Carlo Gaetano
2019 Cells  
and reduced mobility typical of old Nfu.  ...  The epigenetic analysis suggested a less accessible and more condensed chromatin in old Nfu skeletal muscle.  ...  These evidences support the bioinformatics analyses of sequencing data set performed on aging Nfu.  ... 
doi:10.3390/cells8101169 pmid:31569376 pmcid:PMC6829443 fatcat:hvvc57kk7faknbjacx7aamc7bq

Nfu facilitates the maturation of iron-sulfur proteins and participates in virulence inStaphylococcus aureus

Ameya A. Mashruwala, Yun Y. Pang, Zuelay Rosario-Cruz, Harsimranjit K. Chahal, Meredith A. Benson, Laura A. Mike, Eric P. Skaar, Victor J. Torres, William M. Nauseef, Jeffrey M. Boyd
2014 Molecular Microbiology  
Based on our bioinformatic analyses and studies conducted by alternate groups (reviewed in (Py & Barras, 2010)) we generated a working model for Fe-S cluster biogenesis and trafficking in S. aureus ( Figure  ...  An additional gene was identified (nfu; SAUSA300_0839) that displayed homology to the nfuA and nifU genes from A. vinelandii, but the shared homology is confined to the C-terminal "Nfu" domains of these  ...  We examined the effect of intracellular H 2 O 2 accumulation on a strain lacking Nfu.  ... 
doi:10.1111/mmi.12860 pmid:25388433 pmcid:PMC4428306 fatcat:naa7n2padzeevgfwuarrz7kbiu

Page 61 of The Canadian Review of Sociology Vol. 17, Issue 1 [page]

1980 The Canadian Review of Sociology  
At the provincial level, however, there is some indication that the NFU acted more immediately than Unifarm on the issue of compensation for snowed-under crops in 1973 as well as on the crisis in the livestock  ...  Canadian Agriculture in the Seventies, p. 312. 20 NFU Conventions have unanimously endorsed the principle of restrictions on who is eligible and not eligible to farm.  ... 

Iron−Sulfur Cluster Biosynthesis: Characterization of a Molten Globule Domain in Human NFU

Yushi Liu, J. A. Cowan
2009 Biochemistry  
pair of redox active cysteines and demonstrates thioredoxin-like activity by both binding to and mediating persulfide bond cleavage of sulfur-loaded IscS; the sulfide donor for [2Fe-2S] cluster assembly on  ...  Human NFU (also known as HIRIP5) has been implicated in cellular iron-sulfur cluster biosynthesis.  ...  The residue numbering shown in Table 1 is based on this sequence. CD spectra of human NFU and its domains.  ... 
doi:10.1021/bi9002524 pmid:19722697 pmcid:PMC2766508 fatcat:gcanxm7dp5eplcp2atnzuuauzy

Allele-specific mitochondrial stress induced by Multiple Mitochondrial Dysfunctions Syndrome 1 pathogenic mutations modeled in Caenorhabditis elegans

Peter A. Kropp, Jing Wu, Michael Reidy, Sanjay Shrestha, Kyle Rhodehouse, Philippa Rogers, Michael N. Sack, Andy Golden, Scott M. Williams
2021 PLoS Genetics  
Five mutant C. elegans alleles focused on the presumptive iron-sulfur cluster interaction domain were generated and analyzed for mitochondrial phenotypes including respiratory dysfunction and oxidative  ...  Phenotypes were variable between the mutant nfu-1 alleles and generally presented as an allelic series indicating that not all variants have lost complete function.  ...  We thank Iqbal Hamza and Sohini Dutt for insightful discussions and recommendations as well as all members of the NIH C. elegans community for feedback on scientific approaches.  ... 
doi:10.1371/journal.pgen.1009771 pmid:34449775 pmcid:PMC8428684 fatcat:wfrg4wwd5va4tiffmb667l2c3y

The national farmers union and the British negotiations for membership in the european economic community

Richard A. Holmes
1970 Res publica. Politiek-wetenschappelijk tijdschrift van de Lage Landen  
NFU on the negotiations.  ...  This meant that the NFU was placing a lot of trust in its , !eadership. lt also meant that the direct influence of the NFU on the talks depended on the abilities and personalities of these two men.  ... 
doi:10.21825/rp.v5i3.20063 fatcat:6mzi6sb4xjb23pkcgrq5v3m6tq

On the strength of a weak variant of the Axiom of Counting [article]

Zachiri McKenzie
2016 arXiv   pre-print
This result implies that NF+AxCount_≥ proves that consistency of TSTI, and that NFU^-AC+AxCount_≥ proves the consistency of NFU^-AC.  ...  This paper shows that NFU^-AC+AxCount_≥ proves the consistency of the Simple Theory of Types with Infinity (TSTI).  ...  And [FH] shows that if NFU −AC + AxCount ≤ is consistent then so is NFU −AC + (the function on N defined by n → V n exists).  ... 
arXiv:1601.04168v2 fatcat:36pyljzobrdmloh7h5zdbdp7fu

Determination of the 5-fluorouracil and N1(2′-furanidyl)uracil in the presence of tegafur by zero-crossing first derivative spectrometry

Irinel Badea, Dana Moja, Aurel Tudose, Dan Stoicescu
2002 Journal of Pharmaceutical and Biomedical Analysis  
Ruggedness The ruggedness was established through the spectrometric studies by different analysts on the same apparatus. A study was also performed on a different spectrometer on a different day.  ...  Spectrometric measurements The method elaborated is based on the zerocrossing first derivative spectrometry. The absorption spectra of tegafur, 5FU and NFU are shown in Fig. 1 .  ... 
doi:10.1016/s0731-7085(02)00436-3 pmid:12408928 fatcat:22e4gk7dfnfwnjw26yuzrqzthm

Iron-sulphur cluster assembly in plants: distinct NFU proteins in mitochondria and plastids from Arabidopsis thaliana

Sébastien LÉON, Brigitte TOURAINE, Cécile RIBOT, Jean-François BRIAT, Stéphane LOBÉRAUX
2003 Biochemical Journal  
Recent results are in favour of a role for NFU-like proteins in Fe-S cluster biogenesis. These polypeptides share a conserved CXXC motif in their NFU domain.  ...  AtNFU1-3 represent a new class of NFU proteins, unique to plants. These polypeptides are made of two NFU domains, the second having lost its CXXC motif.  ...  Transformed strains were grown overnight in YNB medium and 5-fold serial dilutions were spotted on YNB-agar mediums (shown from left to right on the Figure).  ... 
doi:10.1042/bj20021946 pmid:12553879 pmcid:PMC1223333 fatcat:dx5ns2d5rbevdouptkcnwx2x24
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