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NutriChem: a systems chemical biology resource to explore the medicinal value of plant-based foods

Kasper Jensen, Gianni Panagiotou, Irene Kouskoumvekaki
2014 Nucleic Acids Research  
To the best of our knowledge this database is the only resource linking the chemical space of plant-based foods with human disease phenotypes and provides a foundation for understanding mechanistically  ...  However, there is currently no exhaustive resource on the health benefits associated to specific dietary interventions, or a resource covering the broad molecular content of food.  ...  PhD student Bernard Yueqiong Ni is also acknowledged for his feedback as user of the NutriChem server. Conflict of interest statement. None declared.  ... 
doi:10.1093/nar/gku724 pmid:25106869 pmcid:PMC4383999 fatcat:5gralzkrv5hcva7fdyrxnnq6ye

Developing a Molecular Roadmap of Drug-Food Interactions

Kasper Jensen, Yueqiong Ni, Gianni Panagiotou, Irene Kouskoumvekaki, Kai Tan
2015 PLoS Computational Biology  
This systems chemical biology approach provides the basis for the identification and study of the substances in plant-based foods that affect the human proteins that are relevant for the pharmacokinetics  ...  The overall objective of this work was to sketch a comprehensive picture of the interference of * 4,000 dietary components present in *1800 plant-based foods with the pharmacokinetics and pharmacodynamics  ...  Acknowledgments GP would like to thank the University of Hong Kong (e-SRT on Integrative Biology) for support.  ... 
doi:10.1371/journal.pcbi.1004048 pmid:25668218 pmcid:PMC4323218 fatcat:b4dndvaasjc4dcaayylw3xxava

IMPPAT: A curated database of Indian Medicinal Plants, Phytochemistry And Therapeutics

Karthikeyan Mohanraj, Bagavathy Shanmugam Karthikeyan, R. P. Vivek-Ananth, R. P. Bharath Chand, S. R. Aparna, Pattulingam Mangalapandi, Areejit Samal
2018 Scientific Reports  
A comprehensive online database on the phytochemistry of Indian medicinal plants will enable the application of systems biology and cheminformatic approaches towards natural product based drug discovery  ...  Phytochemical constituents of medicinal plants encompass a diverse space of chemical scaffolds which can be used for rational design of novel drugs.  ...  , pharmacophore-based virtual screening 9,10 , systems biology 11, 12 , systems pharmacology 13 , network pharmacology 14 to expand the novel chemical scaffold libraries for drug discovery.  ... 
doi:10.1038/s41598-018-22631-z pmid:29531263 pmcid:PMC5847565 fatcat:fh5zi7k2mjc4lcubq35sjwgjsu

IMPPAT: A curated database of Indian Medicinal Plants, Phytochemistry And Therapeutics [article]

Karthikeyan Mohanraj, Bagavathy Shanmugam Karthikeyan, R. P. Vivek-Ananth, R. P. Bharath Chand, S. R. Aparna, P. Mangalapandi, Areejit Samal
2017 bioRxiv   pre-print
A comprehensive online database on the phytochemistry of Indian medicinal plants will enable the application of systems biology and cheminformatic approaches towards natural product based drug discovery  ...  Phytochemical constituents of medicinal plants encompass a diverse space of chemical scaffolds which can be used for rational design of novel drugs.  ...  , pharmacophore-based virtual screening 9,10 , systems biology 11, 12 , systems pharmacology 13 , network pharmacology 14 to expand the novel chemical scaffold libraries for drug discovery.  ... 
doi:10.1101/206995 fatcat:xfw4lwspavdizaxohwkdyycije

Generating the Blood Exposome Database Using a Comprehensive Text Mining and Database Fusion Approach

Dinesh Kumar Barupal, Oliver Fiehn
2019 Environmental Health Perspectives  
A vast volume of blood-related literature is available via the PubMed database for data mining.  ...  Blood chemicals are routinely measured in clinical or preclinical research studies to diagnose diseases, assess risks in epidemiological research, or use metabolomic phenotyping in response to treatments  ...  D.K.B. and O.F. conceptualized the study, performed the analysis, and wrote the manuscripts.  ... 
doi:10.1289/ehp4713 pmid:31557052 pmcid:PMC6794490 fatcat:52bbvoxl7vgudj4aqgfqbgdyvq

Internet Databases of the Properties, Enzymatic Reactions, and Metabolism of Small Molecules—Search Options and Applications in Food Science

Piotr Minkiewicz, Małgorzata Darewicz, Anna Iwaniak, Justyna Bucholska, Piotr Starowicz, Emilia Czyrko
2016 International Journal of Molecular Sciences  
A dataset of DNA inhibitors of methyltransferases applied by is an example of this approach to data mining. The advantages mentioned above make computer databases useful tools in education.  ...  Application of databases follows recent worldwide trends in the use of information resources.  ...  ) [44] and the TCM database (Laboratory of Computational and Systems Biology, China Medical University, Taichung, Taiwan) of natural products used in traditional Chinese medicine [47] .  ... 
doi:10.3390/ijms17122039 pmid:27929431 pmcid:PMC5187839 fatcat:rbggkt4xcbbu3pnkh33zpovxju

Definition of data models and APIs

Karl Presser, Mark Roe, Agnieszka Matuszczak, Paul Finglas
2021 Zenodo  
This deliverable reviews andprovides a map of food data areas relevant to FNS-Cloud and, for each data area, recommends a data exchange model, thesauri, and APIs.  ...  Existing data standards, thesauri and APIs that can form the basis of data exchange in FNS-Cloud are evaluated.  ...  For example, the two principal resources for data on polyphenols in foods, EuroFIR's eBASIS database and Phenol-Explorer (coordinated by a team at INRA), both use the LanguaL system for classification  ... 
doi:10.5281/zenodo.6965954 fatcat:texctyfywzbhhc7thk4zfwshg4

Artificial Intelligence in Functional Food Ingredient Discovery and Characterisation: A Focus on Bioactive Plant and Food Peptides

Aoife Doherty, Audrey Wall, Nora Khaldi, Martin Kussmann
2021 Frontiers in Genetics  
Consequently, a nutrition industry is being formed around natural foods and FFIs, the economic growth of which is increasingly driven by consumer decisions.  ...  The arrival of the AI-led technological revolution allows for the comprehensive characterisation and understanding of the universe of FFI molecules, enabling the mining of the food and natural product  ...  NutriChem: A Systems Chemical Biology Resource to Explore the Medicinal Value of Plant-Based Foods.  ... 
doi:10.3389/fgene.2021.768979 pmid:34868255 pmcid:PMC8640466 fatcat:2cqfslvdqna6hklztl3lqscmh4