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Morphometry can be a useful method for distinguishing activated macrophages from tumoral Langerhans cells. ... Furthermore, these activated macrophages showed greater anisocytosis and anisokaryosis and a lower nuclear: cytoplasmic ratio than tumoral Langerhans cells in the first stages of tumor regression. ... Nuclear morphometry has been shown to be an effective auxiliary tool for differential diagnosis of histiocytoma, mastocytoma and transmissible venereal tumor in dogs (De Andrade Waldemarin et al. 2004 ...doi:10.2478/pjvs-2014-0059 fatcat:w6dpgkij3rc3hdlj4prggk4sna