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Remote-Controlled Fully Implantable Neural Stimulator for Freely Moving Small Animal

Seunghyeon Yun, Chin Su Koh, Joonsoo Jeong, Jungmin Seo, Seung-Hee Ahn, Gwang Jin Choi, Shinyong Shim, Jaewoo Shin, Hyun Ho Jung, Jin Woo Chang, Sung June Kim
2019 Electronics  
The application of a neural stimulator to small animals is highly desired for the investigation of electrophysiological studies and development of neuroprosthetic devices.  ...  Here, we present a fully implantable stimulator with remote controllability, compact size, and minimal power consumption.  ...  With such ultimate goals in mind, the aim of this study is to demonstrate a novel wireless, fully implantable, and miniaturized neural stimulator system for remote control of animal locomotion ( Figure  ... 
doi:10.3390/electronics8060706 fatcat:3ukwy4zynfd27drfoa6hdnpaie

Distributed sensor and actuator networks for closed-loop bioelectronic medicine

Gauri Bhave, Joshua C. Chen, Amanda Singer, Aditi Sharma, Jacob T. Robinson
2021 Materials Today  
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper  ...  This strategy has been investigated and FIGURE 4 Developments in miniaturization of implantable neural stimulation systems using various wireless power transfer modalities.  ...  Maximized efficiency of distant miniature implants is achieved by combining near field inductive and far field radiative modes of transmitter at low GHz mid-field frequency range.  ... 
doi:10.1016/j.mattod.2020.12.020 fatcat:m6v2fdkykbhcnjtdtp2ctlwtwm

Heterogeneous Integration

2020 Advancing Microelectronics Magazine  
Such tiny power modules can now power miniaturized biophotonic systems along with neural stimulation or recording systems.  ...  Here, we demonstrate this concept through a novel ultra-compact X-band front-end design where the electronics and the antenna are co-located.  ...  Thermal Conductivity & Electrical Insulation UNDERFILL EPOXY o ers When it comes to today's military, aerospace, and medical applications, the reliability and performance requirements of electronic components  ... 
doi:10.4071/2380-7016-47.6.1 fatcat:dc7midce2jf3zihnzjkdys77su

Silicon-Integrated High-Density Electrocortical Interfaces

Sohmyung Ha, Abraham Akinin, Jiwoong Park, Chul Kim, Hui Wang, Christoph Maier, Patrick P. Mercier, Gert Cauwenberghs
2017 Proceedings of the IEEE  
Along with state-of-the-art implantable ECoG interface systems, we introduce a modular ECoG system concept based on a fully encapsulated neural interfacing acquisition chip (ENIAC).  ...  frontends, stimulation drivers, and circuits and antennas for wireless communications and power delivery.  ...  McNaughton, and J. Viventi for critical input and stimulating discussions on clinical and fundamental neuroscience applications of high-density ECoG neural interfaces.  ... 
doi:10.1109/jproc.2016.2587690 fatcat:j5kbvqfkv5aidf3fijx7mux2la

A mm-sized implantable device with ultrasonic energy transfer and RF data uplink for high-power applications

Jayant Charthad, Marcus J. Weber, Ting Chia Chang, Mahmoud Saadat, Amin Arbabian
2014 Proceedings of the IEEE 2014 Custom Integrated Circuits Conference  
A first proof-of-concept mm-sized implant based on ultrasonic power transfer and RF uplink data transmission is presented.  ...  The implant supports a DC load power of 100 µW allowing for high-power applications.  ...  ACKNOWLEDGEMENT The authors thank Professor Khuri-Yakub and Dr. Nikoozadeh for useful discussions and Rohde & Schwarz for assisting with test equipment.  ... 
doi:10.1109/cicc.2014.6946071 dblp:conf/cicc/CharthadWCSA14 fatcat:aoqh5tw33ne6teipd2ifwgspiy

Challenges in Scaling Down of Free-Floating Implantable Neural Interfaces to Millimeter Scale

Kai-Wen Yang, Keonghwan Oh, Sohmyung Ha
2020 IEEE Access  
To exempt the need of connecting wires or waveguides, a light source that can be integrated to the neural implant is desirable, which translates to the need of its miniaturization.  ...  In this paper, we highlighted the significance and promising applications of miniaturized neural implants.  ... 
doi:10.1109/access.2020.3007517 fatcat:s2od2xcnnfe65ct5urcdgpt7yi

A mm-Sized Implantable Medical Device (IMD) With Ultrasonic Power Transfer and a Hybrid Bi-Directional Data Link

Jayant Charthad, Marcus J. Weber, Ting Chia Chang, Amin Arbabian
2015 IEEE Journal of Solid-State Circuits  
Ultrasonic power transfer enables miniaturization of the implant and operation deep inside the body, while still achieving safe and high power levels (100 W to a few mWs) required for most implant applications  ...  A first proof-of-concept mm-sized implantable device using ultrasonic power transfer and a hybrid bi-directional data communication link is presented.  ...  ACKNOWLEDGMENT The authors acknowledge the help of Mahmoud Saadat and discussions with Prof. Khuri-Yakub and Dr. Nikoozadeh.  ... 
doi:10.1109/jssc.2015.2427336 fatcat:ykayspdpnjbethjczhk7ett3za

Next-Generation Healthcare: Enabling Technologies for Emerging Bioelectromagnetics Applications

Asimina Kiourti, Amin M. Abbosh, Maria Athanasiou, Toni Bjorninen, Aline Eid, Cynthia Furse, Koichi Ito, Gianluca Lazzi, Mohamed Manoufali, Matteo Pastorino, Manos M. Tentzeris, Katrina Tisdale (+5 others)
2022 IEEE Open Journal of Antennas and Propagation  
Next-generation wearables and implants are seamlessly providing round-the-clock monitoring.  ...  Rapid advances in antennas, propagation, electromagnetics, and materials are opening new and unexplored opportunities in body area sensing and stimulation.  ...  For inductive power transfer, the wireless link in combination with an integrated circuit (IC) on the implant serves to rectify and regulate the power provided for amplification.  ... 
doi:10.1109/ojap.2022.3162110 fatcat:q6qzm5qg5bb2hcb4ig6arbvsea

Skin-Integrated Wearable Systems and Implantable Biosensors: A Comprehensive Review

Daniela Rodrigues, Ana I. Barbosa, Rita Rebelo, Il Keun Kwon, Rui L. Reis, Vitor M. Correlo
2020 Biosensors  
This review presents an overview of the biosensors field, highlighting the current research and development of bio-integrated and implanted biosensors.  ...  For this, most of the skin-integrated and implanted biosensors use a polymer layer as a versatile and flexible structural support, combined with a functional/active material, to generate, transmit and  ...  Miniaturization is achieved through size reduction of sensing electrodes, driving electronics for power generation, data communication and their subsequent integration/packaging.  ... 
doi:10.3390/bios10070079 pmid:32708103 fatcat:qorje4o56nghjcwv3v5cxergdq

Technology and Signal Processing for Brain-Machine Interfaces

Justin Sanchez, Jose Principe, Toshikazu Nishida, Rizwan Bashirullah, John Harris, Jose Fortes
2008 IEEE Signal Processing Magazine  
ACKNOWLEDGMENTS This work is supported in part by the National Science Foundation (CNS-0540304) and National Institutes of Health (NS053561).  ...  This fully integrated implantable device has a flexible substrate electrode interface, 40-dB amplification per channel, and a wireless output with a capacity equivalent to 500 kb/s using a novel low-power  ...  A 16-channel system sampling 8 bits at a 25-kHz rate requires a transmission bandwidth of 3.2 Mb/s, which is difficult to achieve for power and size limitations of miniature implants.  ... 
doi:10.1109/msp.2008.4408440 fatcat:fgfvygtcq5agfibxaapl4jeixu

Novel front-end circuit architectures for integrated bio-electronic interfaces

Carlotta Guiducci, Alexandre Schmid, Frank K. Gürkaynak, Yusuf Leblebici
2008 Proceedings of the conference on Design, automation and test in Europe - DATE '08  
In particular, the advantages of scaling and higher density integration must be balanced against the requirements of low noise design, uniform power density and surface temperature distribution, better  ...  The prospective use of upcoming nanometer CMOS technology nodes (65nm, 45nm, and beyond) in bioelectronic interfaces is raising a number of important issues concerning circuit architectures and design.  ...  integration and miniaturization limits of the transducer technology.  ... 
doi:10.1145/1403375.1403695 fatcat:7dcb2vpe3bgtrl4nob3g7b6rsq

A Review on Miniaturized Ultrasonic Wireless Power Transfer to Implantable Medical Devices

Rajesh V. Taalla, Md. Shamsul Arefin, Akif Kaynak, Abbas Z. Kouzani
2019 IEEE Access  
To power implantable devices such as neural, cochlear, and artificial heart devices, the inductive coupling approach is being used.  ...  Inductive coupling is a conventional approach for the transmission of power to implantable devices.  ...  ACKNOWLEDGMENT The authors would like to thank Swarna Kumary Srungarakavi Venkata, School of Engineering, Deakin University, for her assistance with developing this paper.  ... 
doi:10.1109/access.2018.2886780 fatcat:6p6oovulzzarfdxwylwiv323gm

Implantable Neural Probes for Brain-Machine Interfaces – Current Developments and Future Prospects

Jong-ryul Choi, Seong-Min Kim, Rae-Hyung Ryu, Sung-Phil Kim, Jeong-woo Sohn
2018 Experimental Neurobiology  
Specifically, we focus on three key topics: (1) novel implantable neural probes that decrease the level of invasiveness without sacrificing performance, (2) multi-modal neural probes that measure both  ...  In this report, we review research regarding implantable neural probes and their applications to BMIs.  ...  For these reasons, it is also necessary to choose appropriate packaging techniques to enhance the biocompatibility of implantable neural probes.  ... 
doi:10.5607/en.2018.27.6.453 pmid:30636899 pmcid:PMC6318554 fatcat:ivtfqlso7rc33axqao2kqiphde

Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics

Choong Yeon Kim, Min Jeong Ku, Raza Qazi, Hong Jae Nam, Jong Woo Park, Kum Seok Nam, Shane Oh, Inho Kang, Jae-Hyung Jang, Wha Young Kim, Jeong-Hoon Kim, Jae-Woong Jeong
2021 Nature Communications  
AbstractOptogenetics is a powerful technique that allows target-specific spatiotemporal manipulation of neuronal activity for dissection of neural circuits and therapeutic interventions.  ...  Combining advantageous features of both battery-powered and battery-free designs, this device system enables seamless full implantation into animals, reliable ubiquitous operation, and intervention-free  ...  With integration of these miniaturized state-of-the-art electronic components, future devices will be able to both facilitate its seamless surgical implantation into animals as small as mice and reduce  ... 
doi:10.1038/s41467-020-20803-y pmid:33483493 fatcat:x7vzzq6j5ffttpe46nhnjw4rj4

A 100-Channel Hermetically Sealed Implantable Device for Chronic Wireless Neurosensing Applications

Ming Yin, D. A. Borton, J. Aceros, W. R. Patterson, A. V. Nurmikko
2013 IEEE Transactions on Biomedical Circuits and Systems  
A 100-channel fully implantable wireless broadband neural recording system was developed.  ...  It features 100 parallel broadband (0.1 Hz-7.8 kHz) neural recording channels, a medical grade 200 mAh Li-ion battery recharged inductively at 150 kHz, and data telemetry using 3.2 GHz to 3.8 GHz FSK modulated  ...  Acknowledgments The authors acknowledge the roles of Cirtec Medical Inc., Microconnex Inc., CVInc., and Blackrock Microsystems Inc., in their important role for fabricating specific components of the implantable  ... 
doi:10.1109/tbcas.2013.2255874 pmid:23853294 pmcid:PMC3904295 fatcat:eojzydjqdfc3xhtwqfw54rctaa
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