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Metallofluorescent Nanoparticles for Multimodal Applications

Antonio Delgado-Gonzalez, Emilio Garcia-Fernandez, Teresa Valero, M. Victoria Cano-Cortes, Maria J. Ruedas-Rama, Asier Unciti-Broceta, Rosario M. Sanchez-Martin, Juan J. Diaz-Mochon, Angel Orte
2018 ACS Omega  
We demonstrate that these particles are easily nanofected into living cells, allowing them to be used for effective fingerprinting in multimodal fluorescence-based and mass spectrometry-based flow cytometry  ...  These particles were treated with Pd(OAc) 2 , following the same protocol as that described for fabricating Pd(II)-Cy5-PEG-NP 500 and Pd(0)-Cy5-PEG-NP 500 .  ...  These novel NPs can be used simultaneously in FACS and CyToF as a new and versatile method for cell barcoding. ■ RESULTS AND DISCUSSION Fluorescent, Dual-Band-Emitting Particles.  ... 
doi:10.1021/acsomega.7b01984 pmid:30023770 pmcid:PMC6044963 fatcat:zqf6slaw6fdwpofsiiwdscwovq

Synthesis of 1-Substituted 1H-1,2,3,4-Tetrazoles Using Biosynthesized Ag/Sodium Borosilicate Nanocomposite

Mahmoud Nasrollahzadeh, Mohaddeseh Sajjadi, Mohammad Reza Tahsili, Mohammadreza Shokouhimehr, Rajender S. Varma
2019 ACS Omega  
An expedient solvent-free methodology has been developed to produce 1-substituted 1H-1,2,3,4-tetrazoles using sodium borosilicate glass-supported silver nanoparticles (Ag NPs) as a novel heterogeneous  ...  To extend the application of the ASBN, the performance of the quantitative structure-activity relationships model was investigated for protein binding and toxicity hazard considerations.  ...  54 nanocomposite (ASBN) as a novel and efficient heterogeneous catalyst.  ... 
doi:10.1021/acsomega.9b00800 pmid:31459987 pmcid:PMC6648263 fatcat:vaxvki4s7ra4nc5fdtu2qckkfy

Heterogeneously Catalyzed Pechmann Condensation Employing the Tailored Zn0.925Ti0.075O NPs: Synthesis of Coumarin

Nirajkumar H. Jadhav, Sachin S. Sakate, Nishant K. Rasal, Dnyaneshwar R. Shinde, Ramdas A. Pawar
2019 ACS Omega  
A novel heterogeneous catalytic method was developed for the synthesis of coumarin and its derivatives using the Ti(IV)-doped ZnO matrix forming catalyst Zn0.925Ti0.075O having a high surface area and  ...  The methodology was further extended for the synthesis of ayapin molecules. The catalyst also shows recycle activity up to seven cycles with very good stability.  ...  Goswami 39 had developed the catalytic protocol for Pechmann condensation using ZnO and pyridine dicarboxylic acid together as a dually activated organo-and nanocatalyst of various phenols and β-ketoesters  ... 
doi:10.1021/acsomega.9b00257 pmid:31459942 pmcid:PMC6648791 fatcat:tlb3a4cr6jfc3hi5mdakszmtia

Immunonucleochemistry: a new method for in situ detection of antigens in the nucleus of cells in culture

Il Soo Moon, HyunSook Lee, Sung Dong Park, Dae-Hyun Seog
2010 Cytotechnology (Dordrecht)  
Since the present protocol has been designed for immunostaining of 'naked' nuclei from cultured or isolated cells, we have coined a new term to refer to this procedure as 'immunonucleochemistry' ('INC'  ...  for abbreviation).  ...  Scale bar, 20 lm Put coverslips on a glass slide (cell-side up) Flow chart of the present protocol for 'immunonucleochemistry' ConclusionWe have presented a novel method for immunostaining 'naked' nuclei  ... 
doi:10.1007/s10616-010-9266-0 pmid:20383580 pmcid:PMC2873989 fatcat:krg3mvs32jeerk2vzhgylbtjvi

Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice

Kento Sawane, Takahiro Nagatake, Koji Hosomi, So-ichiro Hirata, Jun Adachi, Yuichi Abe, Junko Isoyama, Hidehiko Suzuki, Ayu Matsunaga, Satoshi Fukumitsu, Kazuhiko Aida, Takeshi Tomonaga (+2 others)
2019 Nutrients  
The metabolism and generation of bioactive lipid mediators are key events in the exertion of the beneficial effects of dietary omega-3 fatty acids in the regulation of allergic inflammation.  ...  These findings identify 15-HEPE as a novel EPA-derived, and eosinophil-dependent anti-allergic metabolite, and provide a preventive and therapeutic strategy against allergic rhinitis.  ...  Acknowledgments: We thank our laboratory members for helpful discussions. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/nu11122868 pmid:31766714 pmcid:PMC6950470 fatcat:px2jm2zbh5dohjhgiccugak3cq

Efficient Optical and UV–Vis Chemosensor Based on Chromo Probes–Polymeric Nanocomposite Hybrid for Selective Recognition of Fluoride Ions

Roya Sedghi, Hamed Javadi, Bahareh Heidari, Ali Rostami, Rajender S. Varma
2019 ACS Omega  
A novel colorimetric sensor based on the TiO2/poly(acrylamide-co-methylene bis acrylamide-co-2-(3-(4-nitro-phenyl)thioureido)ethyl methacrylate) nanocomposite was synthesized via a surface modification  ...  strategy; methacryloxypropyltrimethoxysilane was used to provide reactive vinyl groups on the surface of TiO2 nanoparticles for the successful surface polymerization of Am (acrylamide), MBA (methylenbisacrylamide  ...  Finally, it was dried at 50°C for 24 h (Scheme 2). ACS Omega Article Absorption Measurement and Colorimetric Detection of Fluoride Anions by a Chemosensor.  ... 
doi:10.1021/acsomega.9b02098 pmid:31592470 pmcid:PMC6777305 fatcat:2tdmqlb2gbhslfely7cbgnb2vy

Polymer Nanoparticle Engineering for Podocyte Repair: From in Vitro Models to New Nanotherapeutics in Kidney Diseases

Claudio Colombo, Min Li, Shojiro Watanabe, Piergiorgio Messa, Alberto Edefonti, Giovanni Montini, Davide Moscatelli, Maria Pia Rastaldi, Francesco Cellesi
2017 ACS Omega  
Finally, a three-dimensional in vitro system of co-culture of endothelial cells and podocytes was exploited as a new tool for mimicking the mechanisms of NP interaction with glomerular cells and the repair  ...  NP cytotoxicity, uptake, and cytoskeletal effects on podocytes were first assessed.  ...  NPs on podocyte repair, aiming at designing novel polymeric nanocarriers, which may potentially target podocytes in proteinuric diseases.  ... 
doi:10.1021/acsomega.6b00423 pmid:30023613 pmcid:PMC6044764 fatcat:ojkiygz2ejeunadvzinernirke

Micropatterning of Au NPs on PEG Hydrogels Using Different Silanes To Control Cell Adhesion on the Nanocomposites

Cigdem Yesildag, Christoph Bartsch, Marga C. Lensen
2018 ACS Omega  
Furthermore, these materials are great candidates for plasmon-based biosensor applications and also for various medical applications, such as for drug delivery systems or photothermal therapies.  ...  This micropattern of amino-silane is used to specifically adsorb Au NPs.  ...  ■ CONCLUSIONS In this work a novel, cheap, and fast surface micropatterning procedure based on soft lithography for micropatterning of Au NPs first on silicon wafers were proposed, which were then transferred  ... 
doi:10.1021/acsomega.8b00863 pmid:30087909 pmcid:PMC6068692 fatcat:pyloaccx3zcnjhrnobyzrafijm

Exchange-driven Collective Behavior in a 3D Array of Nanoparticles [article]

Ha M. Nguyen, Pai-Yi Hsiao
2009 arXiv   pre-print
However, no universal collapse is seen for the fully-scaled data of chi " (T, omega).  ...  at T-g/J approximate to 1.20 in the in-phase part, chi'(T, omega), of chi (T, omega) while the out-of-phase part, chi " (T, omega), shows only one peak.  ...  FIG. 1 : 1 DC magnetic measurements for both the ZFC and the FC protocols with various applied fields for the D/J = 3.5 case.  ... 
arXiv:0903.1571v1 fatcat:esxoc5dbmnbr3pd3baqsz34l3q

Nanoprobes for Multimodal Visualization of Bone Mineral Phase in Magnetic Resonance and Near-Infrared Optical Imaging

Pradeep P. Wyss, Laura C. Herrera, Nel S. Bouteghmes, Melika Sarem, Wilfried Reichardt, Jochen Leupold, Jürgen Hennig, V. Prasad Shastri
2016 ACS Omega  
These post-Aln-modified NPs exhibit 8- to 10-fold higher affinity for synthetic and biogenic hydroxyapatite in comparison to NPs where Aln was introduced before NP formation and shorten the T2 relaxation  ...  The system presented herein meets many of the criteria for clinical translation and therefore opens new opportunities for bone imaging and targeted therapeutics.  ...  After 24 h of incubation, cell viability was investigated with the protocol provided by the supplier (Invitrogen). Untreated cells served as controls for the experiment.  ... 
doi:10.1021/acsomega.6b00088 pmid:30023476 pmcid:PMC6044643 fatcat:5ee5a62bjbelzo2vcugxl6by2y

Copper Nanocluster-Doped Luminescent Hydroxyapatite Nanoparticles for Antibacterial and Antibiofilm Applications

Anitha T. Simon, Deepanjalee Dutta, Arun Chattopadhyay, Siddhartha Sankar Ghosh
2019 ACS Omega  
Novel strategies in the field of nanotechnology for the development of suitable multifunctional drug delivery vehicles have been pursued with promising upshots.  ...  After being incorporated with copper nanoclusters (Cu NCs), the doped HAP NPs were applied for the bioimaging of bacterial cells. The biocompatibility of doped HAP NPs was also studied in HeLa cells.  ...  The quantum yield measurements of doped HAP NPs were carried out using a standard protocol. Quinine sulfate in 0.1 M H 2 SO 4 was used as a reference for the study.  ... 
doi:10.1021/acsomega.8b03076 pmid:31459656 pmcid:PMC6648608 fatcat:747sjzgqc5fkpj2zx6vn57an54

Aneurysmal Subarachnoid Hemorrhage and Resolution of Inflammation [chapter]

Geisi Saito, Rodrigo Zapata
2019 Intracranial Aneurysms [Working Title]  
Here, we review the rationale for future clinical trials of omega-3 FAs in SAH.  ...  Current Western diets provide insufficient amounts of omega-3 FAs to compensate for the loss of brain DHA following SAH.  ...  Indeed, some research centers in Europe do not include TCD ultrasound or endovascular rescue therapy in their treatment protocols for SAH patients [92] .  ... 
doi:10.5772/intechopen.88297 fatcat:pny2pxjmljfipel4ay2lsr3mwy

Green Nanotechnology-Driven Drug Delivery Assemblies

Rohini Kanwar, Jyoti Rathee, Deepak B. Salunke, Surinder K. Mehta
2019 ACS Omega  
The burgeoning demand for green nanotechnology-driven drug delivery systems has led to the development of different types of delivery devices, like inorganic (metallic) nanoparticles, quantum dots, organic  ...  In today's scenario, plant-mediated eco-friendly protocols and surfactants provide a green tool for the synthesis of nanomaterials.  ...  In addition, novel MSNs having the hierarchical sievelike structure of NPs were synthesized by Gao and co-workers 73 using the centrifugal method at room temperature.  ... 
doi:10.1021/acsomega.9b00304 pmid:31459969 pmcid:PMC6648705 fatcat:5fpmxndh3bhalmhmyichanxpci

Boosting Aerobic Oxidation of Alcohols via Synergistic Effect between TEMPO and a Composite Fe3O4/Cu-BDC/GO Nanocatalyst

Hassan Alamgholiloo, Sadegh Rostamnia, Kaiqiang Zhang, Tae Hyung Lee, Yoon-Sik Lee, Rajender S. Varma, Ho Won Jang, Mohammadreza Shokouhimehr
2020 ACS Omega  
Fabrication of a nanocomposite catalyst via a novel and efficient strategy remains a challenge; Fe3O4 nanoparticles anchored on graphene oxide (GO) sheet-supported metal-organic frameworks (MOFs).  ...  The salient features of the nanocomposite such as Cu-MOF, synergistic effect with GO sheets, and magnetic separation characteristics make it an excellent ternary heterostructure for aerobic oxidation of  ...  increasing demand for clean synthesis has stimulated the development of efficient metal-free oxidation protocols.  ... 
doi:10.1021/acsomega.9b04209 pmid:32201806 pmcid:PMC7081426 fatcat:y5rsqnux5fd7xnk4rfwn57mgva

Preparation of Gold Nanocomposites with Tunable Charge and Hydrophobicity via the Application of Polymer/Surfactant Complexation

Krisztina Bali, György Sáfrán, Béla Pécz, Róbert Mészáros
2017 ACS Omega  
In the present article, we demonstrate that the association of poly(ethyleneimine) (PEI) capped gold NPs with sodium alkyl sulfates provide a powerful route for the manipulation of these interfacial properties  ...  During the synthesis of gold nanoparticle (NP) assemblies, the interfacial charge and hydrophobicity of the primary particles play a distinguished role.  ...  Finally, the synthesis of biosurfactant/polymer-coated NPs in the future may lead to novel nanocomposites with potential biomedical applications. ■ METHODS Materials.  ... 
doi:10.1021/acsomega.7b01623 pmid:31457402 pmcid:PMC6645515 fatcat:ugjgezcyyjezrolqhyjkorvpfi
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