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A Hippocampal Cognitive Prosthesis: Multi-Input, Multi-Output Nonlinear Modeling and VLSI Implementation

Theodore W. Berger, Dong Song, Rosa H. M. Chan, Vasilis Z. Marmarelis, Jeff LaCoss, Jack Wills, Robert E. Hampson, Sam A. Deadwyler, John J. Granacki
2012 IEEE transactions on neural systems and rehabilitation engineering  
The animal model used is delayed nonmatch-to-sample (DNMS) behavior in the rat, and the "core" of the prosthesis is a biomimetic multi-input/multi-output (MIMO) nonlinear model that provides the capability  ...  We also outline the design in very-large-scale integration for a hardware implementation of a 16-input, 16-output MIMO model, along with spike sorting, amplification, and other functions necessary for  ...  Outputs (responses to the spike events) are computed by a single MIMO model processor, which delivers up to 32 channels of output to a charge-metering stimulus amplifier (CM).  ... 
doi:10.1109/tnsre.2012.2189133 pmid:22438335 pmcid:PMC3395724 fatcat:4v7euidbtbenffuuquw4w6gc2u

Roadmap on semiconductor–cell biointerfaces

Bozhi Tian, Shuai Xu, John A Rogers, Stefano Cestellos-Blanco, Peidong Yang, João L Carvalho-de-Souza, Francisco Bezanilla, Jia Liu, Zhenan Bao, Martin Hjort, Yuhong Cao, Nicholas Melosh (+13 others)
2018 Physical Biology  
materials play in understanding the complex biophysical dynamics at multiple length scales, as well as the design and implementation of nextgeneration electronic, optoelectronic, and mechanical devices for  ...  Acknowledgments The authors acknowledge NSF STTR 1549696, and the Joint Institute for Metrology in Biology (JIMB).  ...  Acknowledgments The authors acknowledge support from the Center for Bio-Integrated Electronics, Simpson/Querrey Institute, Northwestern University.  ... 
doi:10.1088/1478-3975/aa9f34 pmid:29205173 fatcat:oxuwox6bnfe7xnxj47o4zfhe6i

Repairing Peripheral Nerves: Is there a Role for Carbon Nanotubes?

Karen M. Oprych, Raymond L. D. Whitby, Sergey V. Mikhalovsky, Paul Tomlins, Jimi Adu
2016 Advanced Healthcare Materials  
Engineering and Physical Sciences Research Council (GR/T18387/01) and University College London/University College London Hospitals Biomedical Research Center which receives funding from the National Institute for  ...  [ 39 ] Since then, interest in CNT substrates to support and control neuronal growth, to study neuronal network formation and for coating electrodes for interfacing neurological prosthesis has increased  ...  Electrode arrays of pure CNTs can be generated on fl exible fi lms for compliant implantable neuro-prosthetics.  ... 
doi:10.1002/adhm.201500864 pmid:27027923 fatcat:xndxir7fwregbmanp7vdyxomt4

Methods and microelectronics for proprioceptive neural feedback

Ian Williams, Timothy Constandinou, Engineering And Physical Sciences Research Council
A novel charge balancing method is implemented which has a low level of accuracy on a single pulse and a much higher accuracy over a series of pulses.  ...  generating charge-balanced asymmetric pulses.  ...  "A novel charge-metering method for voltage mode neural stimulation". IEEE, 2012, pp. 2239-2242. [79] R. K. Shepherd, J. Matsushima, R. E. Millard, and G. M. Clark.  ... 
doi:10.25560/24566 fatcat:tgfm5tuydrehrpoqbvwngaciby

Bioimpedance measurement based evaluation of wound healing

Atte Kekonen, Mikael Bergelin, Jan-Erik Eriksson, Annikki Vaalasti, Heimo Ylänen, Jari Viik
2017 Physiological Measurement  
There is a need for an objective and quantitative method for determining the status of a wound without removing the wound dressings.  ...  There are various measurement setups for studying these properties.  ...  We conclude that the incorporation of existing biological knowledge is essential for the progress in using big data for cancer research.  ... 
doi:10.1088/1361-6579/aa63d6 pmid:28248191 fatcat:sjqhpdu7ubb2fgbgbyyu6hawxm

Neural control of artificial limbs

Gurpreet Singh Dhillon
Initial studies conducted for two days following electrode implantation showed that it is possible to provide discrete, unitary, painless, graded sensations of touch, joint movement and position referred  ...  Rabbit , Chair 11/28/2010 ABSTRACT Upper limb amputees desire an artificial arm that allows for multiple degrees of freedom of control over the movements of the prosthesis, coupled with direct sensory  ...  Meek for technical assistance, and G. S. Ghuman , C. Singh, and J. S. Sandhu for clinical assistance.  ... 
doi:10.26053/0h-47km-kd00 fatcat:sgbmpk7rf5fytgggxrvkkkemwy

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

Sangeeth Pillai, Akshaya Upadhyay, Darren Sayson, Bich Hong Nguyen, Simon D. Tran
2021 Molecules  
This review focuses on the recent advances made in wearable technology for remote healthcare monitoring.  ...  A brief note on the most widely used materials and their improvements in wearable sensor development is outlined along with instructions for the future of medical wearables.  ...  Nguyen for providing valuable insights on the writing and proofreading of this manuscript.  ... 
doi:10.3390/molecules27010165 pmid:35011400 pmcid:PMC8746599 fatcat:464o6oyzhbhdtiu7zyxpk3yw3y

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 1

Sue Denham, Panayiota Poirazi, Erik De Schutter, Karl Friston, Ho Ka Chan, Thomas Nowotny, Dongqi Han, Sungho Hong, Sophie Rosay, Tanja Wernle, Alessandro Treves, Sarah Goethals (+90 others)
2017 BMC Neuroscience  
This suggests a novel direction for compressive sensing theory and sampling methodology in engineered devices.  ...  This formalism underlines a potential mechanism for efficiently transmitting sparse stimulus information, and further suggests sensory pathways may have evolved to take advantage of the sparsity of visual  ...  The Okayama University-type Retinal Prosthesis (OUReP) is a new approach to retinal implant design which does not involve stimulation via micro-electrode arrays [1] .  ... 
doi:10.1186/s12868-017-0370-3 fatcat:qq2cmqlotbg7vpqlqmmcql4u5i

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3

Adam J. H. Newton, Alexandra H. Seidenstein, Robert A. McDougal, Alberto Pérez-Cervera, Gemma Huguet, Tere M-Seara, Caroline Haimerl, David Angulo-Garcia, Alessandro Torcini, Rosa Cossart, Arnaud Malvache, Kaoutar Skiker (+526 others)
2017 BMC Neuroscience  
This suggests a novel direction for compressive sensing theory and sampling methodology in engineered devices.  ...  This formalism underlines a potential mechanism for efficiently transmitting sparse stimulus information, and further suggests sensory pathways may have evolved to take advantage of the sparsity of visual  ...  The Okayama University-type Retinal Prosthesis (OUReP) is a new approach to retinal implant design which does not involve stimulation via micro-electrode arrays [1] .  ... 
doi:10.1186/s12868-017-0372-1 fatcat:q5x3vgivujgshmtthc6ki4fcfu


This is particularly important for implanted neural prosthetic systems. Safe charge density limits for commonly used electrode materials are listed in Table 4 .1.  ...  For these reasons current-controlled pulses are more commonly used for neural prosthesis applications.  ... 
doi:10.13130/frigerio-alice_phd2013-01-21 fatcat:57fe7rtemzb4legssw3auoctla

Neuro-Electronic Interface: Interrogating Neuronal Function and Circuitry with Innovative Approaches [article]

Pierre Wijdenes, University Of Calgary, University Of Calgary, Naweed Syed
Thus, the main objective of my thesis was to develop a set of novel micro-electrode arrays (MEAs) that could fill this technological gap, allowing for the detection, characterization, and modulation of  ...  Because natural replacement of injured or diseased nervous system tissue seldom, if ever, occurs, this loss of function is often irreversible and leaves patients incapacitated for life.  ...  , created by either the activation of membrane receptor proteins (chemical stimulus) or a charged electrode (electrical stimulus), initiates a depolarization (loss of charge difference) across the cell  ... 
doi:10.11575/prism/5407 fatcat:4b2iywaagvff5istdqs6ordy2i

Proceedings of the 13th Russian German Conference on Biomedical Engineering

Steffen Leonhardt, Steffen Leonhardt
The authors would like to give special thanks to Suratthani Hospital for providing some blood for doing this study.  ...  Acknowledgements J.Ch.S. is grateful for a stipend and financial support for this project from Prince of Songkla University, Thailand.  ...  stimulus modalities.  ... 
doi:10.18154/rwth-2018-224393 fatcat:vu735cealrczzc7aiwmzojoczm

Feasibility of Submaximal Force Control Training for Robot–Mediated Therapy After Stroke [chapter]

Guillermo Asín-Prieto, Aitor Martínez-Expósito, Fady Alnajjar, Shingo Shimoda, José L. Pons, Juan C. Moreno
2018 Biosystems and Biorobotics  
of hip prosthesis.  ...  In a previous study for the development of the forearm prosthesis [Iwatsuki et al., 2014] , for instance, shoulder and elbow joint angles were measured to know how much the user wanted to rotate the wrist  ... 
doi:10.1007/978-3-030-01845-0_51 fatcat:bqk7nuccgbhqnflye5jhqqlxiy

To evaluate the synergistic effect of different crosslinking strategies on collagen derivatives to develop functional biomimetic scaffolds Presentata da: Gopal Shankar Krishnakumar

Coordinatore Dottorato, Relatore Prof, Lucio Cocco, Cocco, Marcacci Maurilio, Natalia Gostynska, Gloria Belen, Ramirez Rodriguez, Tatiana Patricio, Dott Dapporto, Dott Ballardini, Elisabetta Campodoni (+1 others)
Simone Sprio and Dott.ssa Monica Sandri for their constant encouragement, kind support, suggestions and advice.  ...  Berardo Di Matteo at Rizzoli Orthopaedic Institute for their support and invaluable suggestions. It is my pleasure to thank my dear friends Dott.ssa  ...  For example, DHT was used to crosslink, (i) collagen-glycosaminoglycan scaffolds for soft tissue application [3] , (ii) collagen and gelatin based films for vascular prosthesis [6] and (iii) silk-fibroin  ... 

Mms6 expression in adipose-derived mesenchymal stem cells: development of biogenic magnetic nanoparticles and Its therapeutic potential [article]

Fransiscus Fiano Anthony Kerans, University Of Edinburgh, University Of Edinburgh, Donald Salter, Chris Boyd
MNHT for cancer treatment.  ...  Magnetic nanoparticles (MNP) are attracting interest for a range of biomedical applications being used either alone or as part of cell-based therapies.  ...  Seven lesions were fixed with intramedullary nailing after scraping out, one lesion was conducted with the prosthesis implantation after an excision and the remaining eight lesions were fixed by intramedullary  ... 
doi:10.7488/era/303 fatcat:c3dekg62yrduvo6ihmnsxapeza
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