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Tendon healing in a bone tunnel. Part II

Andreas Weiler, Reinhard F.G. Hoffmann, Hermann J. Bail, Oliver Rehm, Norbert P. Südkamp
2002 Arthroscopy: The Journal of Arthroscopy And Related  
Purpose: Tendon-to-bone healing of soft-tissue grafts has been described to progress by the development of a fibrous interzone that undergoes a maturation process leading to the development of an indirect type of ligament insertion. Previous studies used extra-articular models or fixation far away from the joint line; thus, no data are available investigating tendon-to-bone healing of a soft-tissue graft fixed anatomically. Therefore, we studied the tendon-to-bone healing of the anatomic
more » ... ssue graft interference fit fixation in a model of anterior cruciate ligament (ACL) reconstruction in sheep. Type of Study: Animal study. Methods: Thirty-five mature sheep underwent ACL reconstruction with an autologous Achilles tendon split graft. Grafts were directly fixed with biodegradable poly-(D,L-lactide) interference screws. Animals were euthanized after 6, 9, 12, 24, and 52 weeks and histologic evaluations were performed. Undecalcified specimens were evaluated under normal and polarized light. Additionally, animals received a polychrome sequential labeling (tetracycline, xylenol orange, and calcein green) to determine bone growth per time under fluorescent light. Results: Intratunnel histologic findings at 6 weeks showed a tendon-bone junction with only a partial fibrous interzone between the graft tissue and the surrounding bone. A mature intratunnel tendon-bone junction with a zone of fibrocartilage was found at 9 to 12 weeks. At the tunnel entrance site a wide regular ligamentous insertion site was seen in all specimens after 24 weeks. This insertion showed regular patterns such as the direct type of insertion of a normal ligament with a dense basophilic transition zone consisting of mineralized cartilage. Conclusions: A fibrous interzone between the graft tissue and the bone tunnel was only partially developed, which is in contrast to all previous studies in which nonanatomic fixation was used. Thus, it is reasonable to assume that the tendon-to-bone healing in the present study may progress partially by direct-contact healing without the development of a fibrous interzone. To our knowledge, this is the first report describing the development of a direct type of ligament insertion after ACL replacement with a soft-tissue graft. This is in contrast to previous studies reporting the development of an indirect type of insertion when using nonanatomic fixation far away from the joint line. Thus, histologic data strongly indicate that anatomic interference fit fixation is beneficial for tendon-to-bone incorporation by leading to the development of a direct type of ligament insertion.
doi:10.1053/jars.2002.30657 pmid:11830805 fatcat:uipykc5h65fvror7u5igcmx2pa

Feasibility and outcome of substitution treatment of heroin-dependent patients in specialized substitution centers and primary care facilities in Germany: A naturalistic study in 2694 patients

Hans-Ulrich Wittchen, Sabine M. Apelt, Michael Soyka, Markus Gastpar, Markus Backmund, Jörg Gölz, Michael R. Kraus, Felix Tretter, Martin Schäfer, Jens Siegert, Norbert Scherbaum, Jürgen Rehm (+1 others)
2008 Drug and Alcohol Dependence  
Jürgen Rehm has provided substantial comments on the writing of the manuscript as well as consulting for the statistical analysis and its presentation.  ...  Rehm and Jens Siegert declare they have no conflicts of interest. Dr.  ... 
doi:10.1016/j.drugalcdep.2008.01.015 pmid:18337025 fatcat:f6g5kj6ajjhjhihlquwoo72hei

Clinical and patient reported outcomes of direct-acting antivirals for the treatment of chronic hepatitis C among patients in opioid agonist treatment: A real-world prospective cohort study

Bernd Schulte, Christiane S Schmidt, Jakob Manthey, Lisa Strada, Stefan Christensen, Konrad Cimander, Herbert Görne, Pavel Khaykin, Norbert Scherbaum, Stefan Walcher, Stefan Mauss, Ingo Schäfer (+3 others)
2020 Open Forum Infectious Diseases  
Background Patient reported outcomes (PRO) can help to reduce uncertainties about hepatitis C (HCV) treatment with direct-acting antivirals (DAA) among people who inject drugs and increase the treatment uptake in this high-risk group. Besides clinical data, this study analysed for the first time PRO in a real-world sample of patients in opioid agonist treatment (OAT) and HCV treatment with DAAs. Methods HCV treatment data including virological response, adherence, safety and PRO of 328 German
more » ... tients in OAT were analysed in a pragmatic prospective cohort study during 2016-2018. Clinical effectiveness was defined as sustained virological response (SVR) at week 12 after end of treatment and calculated in per protocol (PP) and intention-to-treat (ITT) analyses. Changes over time in PRO on health-related quality of life, physical and mental health, functioning and medication tolerability, fatigue, concentration and memory were analysed by repeated-measure analyses of variances (ANOVA). Results We found high adherence as well as treatment completion rates, a low number of mainly mild adverse events and high SVR rates (PP: 97.5% (n = 285); ITT: 84.5% (N = 328)). Missing SVR data in the ITT sample were mainly caused by patients lost to follow-up after treatment completion. Most PRO showed statistically significant but modest improvements over time, with more pronounced improvements in highly impaired patients. Conclusions This real-world study confirms that DAA treatment among OAT patients is feasible, safe and effective. PRO show that all patients, but particularly those with higher somatic, mental and social burden, benefit from DAA treatment.
doi:10.1093/ofid/ofaa317 pmid:32875003 pmcid:PMC7452367 fatcat:wuuq26rw6rbkjczaevt7hy6ae4


1992 BIBLIOTHEK Forschung und Praxis  
Norbert Kamp: Die Entstehung der Städtischen Bücherhalle Essen ren 260 Bibliographische Übersichten Wilbert Ubbens u.  ...  (Rez.: Hans Joachim Kuhlmann) 15,266-267 Bibliotheksgeschichte / Öffentliche Bibliothek / Essen / Städtische Bücherhalle Kamp, Norbert: Die Entstehung der Städtischen Bü- cherhalle Essen 15,364-389  ... 
doi:10.1515/bfup.1992.16.1.u fatcat:jypgjja7jffgjlbynpx4db7lii

Page 212 of Journal of European Studies Vol. 17, Issue 67 [page]

1987 Journal of European Studies  
Philippe Ariés, L’ Homme devant la mort, 2nd edn (2 vols, Paris, 1977), ii, 295-8; Norbert Elias, Uber die Einsamkeit der Sterbenden (Frankfurt-am-Main, 1984), 47ff. .  ...  Walther Rehm, Orpheus. Der Dichter und die Toten: Selbstdeutung und Totenkult bei Novalis - Holderlin - Rilke, first published 1950, 2nd revised edn (Darmstadt, 1972), 516-17. .  ... 

Page 322 of National Union Catalog Vol. 7, Issue [page]

1948 National Union Catalog  
BY Bans Norbert, Joint author. HG3821.F77 1939 332.45 44-23054 rev® Louis, accountant.  ...  , Library TX719.S35 48-39844° Jean L’affaire Réhm- Hitler. Paris, Gallimard ,1939, 244 p. ” cm. ConTEents.—Les person Les complots?  ... 

Page 367 of Guernsey Breeders' Journal Vol. 136, Issue 4 [page]

1975 Guernsey Breeders' Journal  
.; Norbert Pritzl, Cato, Wis.; Chance & Roger Gustafson, Bamum, Minn.; Harold Olson, Bamum, Minn.; Ivan & Robert Woodman, Janesvflle, Wis.; Wayne Boese, Morristown, Miim.; Os(^ Weaver, Go^n, Ind.; Sid  ...  & Ralph Jones, Bangor, Wis.; Leon Zweegman, Lynden, Wash.; Fred Rehm, Lynden, Wash.; James Drake, Coopersville, Mich.; James Heizer, Greenville, Va.; Harry Monniger, Noblesville, Ind.; Stuart Jaffe, Monroe  ... 

Inhalt [chapter]

1987 MP Jahrgang 1, Heft 7  
Programmieren mit MACRO-SM (Teil I) 207 MP-Börse 211 Eckhardt Fehse: Integrierter Systemtakt- generator DL 8127 D 213 Wolfgang Rehm: Echtzeit-Debugger DRTC8000 215 Achim Hennecke, Franz Janitzek, Norbert  ... 
doi:10.1515/9783112610626-toc fatcat:quyt2kay7baehkorvlwtoa2lou

Page 782 of The American Journal of International Law Vol. 55, Issue 3 [page]

1961 The American Journal of International Law  
Rehm. ——, March 10, 1961 (Vol. 16, No. 5). Das Algerien-Problem vor der Lésung!  ...  Die Konsolidierung der Européischen Wirtschaftsgemeinschaft (pp. 63-72), Norbert Welter; Die Britische Arbeiterbewegung und die Atomare Bewaffnung (pp. 73-84), W.  ... 

Page 498 of MLN Vol. 42, Issue 7 [page]

1927 MLN  
Schwade, Norbert.—Die Urfassung von Gottfried Kellers sieben Legenden. Diss. Jena: 1927. 55 pp. Seilliére, Ernest—Morales et religions nouvelles en Allemagne. Le Néoromantis- me au dela du Rhin.  ...  Rehm, Walther.—Geschichte des deut- schen Romans. 2 Bde. [Sammlung Géschen. Nr. 229, 956]. Berlin: de Gruyter, 1927, 175, 104 pp. Cloth, M. 1.50 each. Rheinisches Wéorterbuch.—Hrsg. v. Josef Miiller.  ... 

Page 315 of The Journal of Modern History Vol. 25, Issue 3 [page]

1953 The Journal of Modern History  
By NORBERT MUHLEN. Chicago: Regnery, 1953. Pp. 302. $4.50. Zwischen Petersburg und Washington: ein Diploma- ; tenleben. By FRIEDRICH VON PRITTWITZ UND | GaFrron. Munich: Isar Verlag, 1952.  ...  the latter are relationship of wehrmacht and Nazi party until 1923, a sociological examination of the composition of Nazi party voters until 1933, elimination of trade-unions in the Third Reich, the Réhm  ... 

Page 1165 of Guernsey Breeders' Journal Vol. 110, Issue 11 [page]

1962 Guernsey Breeders' Journal  
Survivors are her husband, a daughter, 1 lelene, and two sons, Milton and Norbert. VVe extend sin¬ cere sympathy to the Borcherding family.  ...  Sandell, Bellingham; Fred Rehm and Son, Lyn- den; Marius R. V^ander Griend, Lynden; Joan Raymond, Bellingham; J. D. and F. Squires, Sr. and Jr., Bow; C. A. Robinson and Son, 5^uim; Herbert V.  ... 

Page 430 of Psychological Abstracts Vol. 63, Issue 2 [page]

1980 Psychological Abstracts  
Sorgatz, Hardo & Priimm, Norbert. (Ruhr-U Bochum, Psychologische Inst, West Germany) Feeling of improvement in flooding: Some analogue data.  ...  Rehm (see PA, Vol 59:1431) reported on a group- administered, behavioral, self-control therapy program that was Clinically effective in modifying depression.  ... 

Page 607 of National Union Catalog Vol. 49, Issue [page]

1958 National Union Catalog  
Schwabe ,c1958; Wélfflin, Heinrich, 1864-1945 see Rehm, Walther, 1901- Heinrich WOlfflin als Literarhistoriker...  ...  The —— of programs of vocational agriculture and industrial educa- 1, Nelson, Norbert James, 1916- 61-62844 rev * eee ional education. es) LBs.  ... 

Page 454 of Mathematical Reviews Vol. , Issue 86a [page]

1986 Mathematical Reviews  
See Sauer, Norbert Sauer, Norbert Saunders, D. J. ....... Savage, M. Savageau, Michael A. Savenko, S. M. Savenkov, A. I. Savits, Thomas H. Schaefer, H. H. Schaeffer, D. ..........  ...  Redheffer, Ray Redlinger, Reinhard 35080,35139 Reed, M*- aael Rege, M. ....... aa *65015 Rehm, Ronald G. ..... 65088 ee res See Reich, Simeon Reich, Simeon Reid, Constance Reid, Miles Reilly, I.  ... 
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