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Image-Based Noninvasive Evaluation of Colorectal Mucosal Injury in Sheep After Topical Application of Microbicides

Kathleen Listiak Vincent, Gracie Vargas, Nigel Bourne, Valerie Galvan-Turner, Jamal I. Saada, Gabriel H. Lee, Elena Sbrana, Massoud Motamedi
2013 Sexually Transmitted Diseases  
In the current study, we evaluated the potential application of colonoscopy and OCT to visualize and quantify the effects of topical products on sheep colorectal tissue as assessed by advanced imaging  ...  Methods-Yearling virginal female sheep were treated rectally with a single 8mL dose of 0.2% BZK (benzalkonium chloride) solution or PBS control.  ...  Funding sources included National Institutes of Health 5R33AI07606205 and 3R33AI076062-03S1  ... 
doi:10.1097/olq.0000000000000039 pmid:24113407 pmcid:PMC3901848 fatcat:4ryq7rq5zzhj5aslvtg7ixaz6y

Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model

Elina Korpela, Darren Yohan, Lee CL Chin, Anthony Kim, Xiaoyong Huang, Shachar Sade, Paul Van Slyke, Daniel J Dumont, Stanley K Liu
2014 BMC Cancer  
Appreciable differences between treatment groups were assessed mainly using parametric and non-parametric statistical tests comparing areas under curves, followed by post-hoc comparisons.  ...  Methods: Athymic mice were treated intraperitoneally with saline or Vasculotide and their flank skin was irradiated with a single large dose of ionizing radiation.  ...  To quantitatively monitor this inflammation, we performed non-invasive DOS measurements of oxyHb signal in the mouse skin.  ... 
doi:10.1186/1471-2407-14-614 pmid:25159192 pmcid:PMC4159535 fatcat:7wtrli4hijeqjm267jeqqmriia

Preclinical Validation of the Utility of BLZ-100 in Providing Fluorescence Contrast for Imaging Spontaneous Solid Tumors

J. Fidel, K. C. Kennedy, W. S. Dernell, S. Hansen, V. Wiss, M. R. Stroud, J. I. Molho, S. E. Knoblaugh, J. Meganck, J. M. Olson, B. Rice, J. Parrish-Novak
2015 Cancer Research  
In this study, we provide a preclinical proof of concept for use of this imaging contrast agent as administered before surgery to dogs with a variety of naturally occurring spontaneous tumors.  ...  The Tumor Paint agent BLZ-100 is a peptide-fluorophore conjugate that can specifically bind solid tumors and fluoresce in the near-infrared range, minimizing light scatter and signal attenuation.  ...  Acknowledgments The authors thank Betsy Wheeler, Rebekah Lewis, Annie Chen-Allen, Krystina Flores, and Rachel Kimbrel for medical and surgical support; Dennis Miller for expert advice on clinical tolerability  ... 
doi:10.1158/0008-5472.can-15-0471 pmid:26471914 pmcid:PMC4610180 fatcat:bpuboeirhfcq3jdra5udxifhku

International Society for Biophysics and Imaging of the Skin - ISBS 2016 - Proceedings

Abdouni et all
2016 Journal Biomedical and Biopharmaceutical Research (BBR)  
Two in vivo studies on the finger of 40 subjects (20 of each gender) of four age groups of 26±3, 35+-3, 45+-2 and 58±6 have been performed.  ...  The objectives are to better understand the age and gender effects on contact and mechanical properties of the human finger with in vivo systems.  ...  Moderate monotonic relationship was observed between instrumentally derived ITA° values and clinical grading of the skin tone and clarity (Spearman ρ = 0.4 -0.5, p-value < 0.0001).  ... 
doi:10.19277/bbr.2016.5.1 fatcat:4b7pnbhipzdt3h5bltlj3r2nvy

In vitro and in vivo trypanocidal effect of lipophilic extracts of medicinal plants from Mali and Burkina Faso

Birgit Aderbauer, Peter-Henning Clausen, Olivia Kershaw, Matthias F. Melzig
2008 Journal of Ethnopharmacology  
Conclusions: The reduction of side effects, the improvement of the clinical evolution and non-compromising the parasiticide effect, show that the association of the benznidazole medication in ponderal  ...  Results: It was observed a reduction of side effects associated with clinical improvement of the animals treated with the combination of BZ in ponderal dose and highly diluted given 4 days after (BZp+hT4A  ...  Methods: Here we describe the in vitro inhibition of invasion and the in vivo antimetastatic potential after M8 treatment by inhalation in the B16F10 lung metastasis model.  ... 
doi:10.1016/j.jep.2008.06.024 pmid:18638537 fatcat:3gghxymrjrcl5faeouapxxbsae

Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models

Layla Pires, Valentin Demidov, Brian C. Wilson, Ana Gabriela Salvio, Lilian Moriyama, Vanderlei S. Bagnato, I. Alex Vitkin, Cristina Kurachi
2020 Cancers  
These studies are the first to demonstrate complete melanoma response to PDT in an immunocompromised model in vivo, with quantitative assessment of tumor volume and thickness, confirmed by (immuno) histological  ...  The optical clearing had minimal therapeutic effect on the in control, non-pigmented cutaneous melanomas but a statistically significant effect (p < 0.05) in pigmented lesions for both single- and dual-photosensitizer  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/cancers12071956 pmid:32708501 fatcat:gqskwabx2vhgtfwgprp3ebsasy

Guidelines for the welfare and use of animals in cancer research

P Workman, E O Aboagye, F Balkwill, A Balmain, G Bruder, D J Chaplin, J A Double, J Everitt, D A H Farningham, M J Glennie, L R Kelland, V Robinson (+5 others)
2010 British Journal of Cancer  
Guidelines for the welfare and use of animals in cancer research P Workman et al  ...  Enables real-time visualisation of angiogenesis Highly invasive procedure.  ...  ACKNOWLEDGEMENTS We thank authors Professor Fran Balkwill, Dr David Farningham, Professor Gill Tozer, Professor Sue Watson and Dr Steve Wedge for leading and coordinating subgroups of the committee dealing  ... 
doi:10.1038/sj.bjc.6605642 pmid:20502460 pmcid:PMC2883160 fatcat:a4vij4qd7bbcpb3f35nt5ogktm

Enhanced EPR directed and Imaging guided Photothermal Therapy using Vitamin E Modified Toco-Photoxil

Deepak S Chauhan, Amirali B Bukhari, Gayathri Ravichandran, Ramkrishn Gupta, Liya George, Radhika Poojari, Aravind Ingle, Aravind K Rengan, Asifkhan Shanavas, Rohit Srivastava, Abhijit De
2018 Scientific Reports  
may pave its way for fast track clinical trial in future.  ...  In comparison to its surface modified counterparts such as IR780-Toco-Photoxil, FA-Toco-Photoxil or FA-IR780-Toco-Photoxil accumulation are merely ~0.3% ID, ~0.025% ID and ~0.005% ID in folate receptor  ...  The authors would also like to acknowledge SAIF-IIT Bombay for extending help with particle characterization; special thanks to lab mates and facilities at IIT Bombay and ACTREC for experimental supports  ... 
doi:10.1038/s41598-018-34898-3 pmid:30420735 pmcid:PMC6232175 fatcat:glsxg32qhjeprkym6pss4yqmk4

M-protein based vaccine induces immunogenicity and protection from Streptococcus pyogenes when delivered on a high-density microarray patch (HD-MAP)

Jamie-Lee S. Mills, Cesar M. Flores Jayashi, Simone Reynolds, Christine Wun, Ainslie Calcutt, S. Ben Baker, Senthil Murugappan, Alexandra C. I. Depelsenaire, Jessica Dooley, Paul V. Fahey, Angus H. Forster, Manisha Pandey (+1 others)
2020 npj Vaccines  
Based on the results of this study, the use of J8-DT/HD-MAP should be considered in future clinical development and control programs against S. pyogenes.  ...  We evaluated the effect of dose reduction and the number of vaccinations on the antibody response profile of vaccinated mice.  ...  APP1132975, APP1037304, APP1083548 and APP1174091); National Foundation of Medical Research and Innovation (NFMRI, Australia); an Australian Tropical Medicine Commercialization grant; and Vaxxas Pty Ltd  ... 
doi:10.1038/s41541-020-00222-2 pmid:32802413 pmcid:PMC7414110 fatcat:23bvlep5bbfvjbdr3arnmty6wy

Photonanomedicine: a convergence of photodynamic therapy and nanotechnology

Girgis Obaid, Mans Broekgaarden, Anne-Laure Bulin, Huang-Chiao Huang, Jerrin Kuriakose, Joyce Liu, Tayyaba Hasan
2016 Nanoscale  
As clinical nanomedicine has emerged over the past two decades, phototherapeutic advancements using nanotechnology have also evolved and impacted disease management.  ...  In addition to their photochemical therapeutic effects, these hard nanoparticles can image disease tissues via multiple non-invasive and minimally-invasive imaging methods, such as photoacoustic imaging  ...  A more realistic method of clinically assessing the degree of 1 O2 generation, and thus treatment response, is the dynamic monitoring of PS photobleaching.  ... 
doi:10.1039/c5nr08691d pmid:27328309 pmcid:PMC4956486 fatcat:3w4odsfbt5c5zdee45a7ylp2b4

Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate

Ismaiel A. Tekko, Gaoyun Chen, Juan Domínguez-Robles, Raghu Raj Singh Thakur, Iman M.N. Hamdan, Lalitkumar Vora, Eneko Larrañeta, James C. McElnay, Helen O. McCarthy, Madeleine Rooney, Ryan F. Donnelly
2020 International Journal of Pharmaceutics  
Both the HFMN and MTX-RV were fully characterised and then combined to form an integrated patch, which was evaluated ex vivo and in preclinical studies.  ...  The MTX-RV incorporated a high dose of MTX (150.3 ± 5.3 µg/mg) without precipitation. The integrated patch delivered MTX at a steady-state flux of 506.8 ± 136.9 µg.cm2/h in an ex vivo setup.  ...  Thanks to Stephen Lloyd for his help in drug dosing to the animals in the in vivo study. Conflict of Interest The authors have no conflict of interest to declare.  ... 
doi:10.1016/j.ijpharm.2020.119580 pmid:32593650 fatcat:uhxotf6u3bgmtja2yjppq6izfu

Toward nodal staging of axillary lymph node basins through intradermal administration of fluorescent imaging agents

Funda Meric-Bernstam, John C. Rasmussen, Savitri Krishnamurthy, I-Chih Tan, Banghe Zhu, Jamie L. Wagner, Gildy V. Babiera, Elizabeth A. Mittendorf, Eva M. Sevick-Muraca
2013 Biomedical Optics Express  
Lymphatic vessels and nodes were assessed in vivo. Ex vivo images demonstrated that 87% of excised lymph nodes, including 81% of tumor-positive lymph nodes, were fluorescent.  ...  nodes following intraparenchymal breast injections and intradermal arm injections in 20 subjects with advanced breast carcinoma and undergoing complete axillary lymph node dissection.  ...  Rodriguez, Theresa Morlock, Wendy Botnick, and Sheila Taylor for providing assistance in the clinic.  ... 
doi:10.1364/boe.5.000183 pmid:24466486 pmcid:PMC3891331 fatcat:zr7alekhe5a5jp3plplc3ip4va

Radiation Therapy

A. Charkravarti, M. Wang, I. Robins, A. Guha, W. Curren, D. Brachman, C. Schultz, A. Choucair, M. Dolled-Filhart, J. Christiansen, M. Gustavson, A. Molinaro (+154 others)
2010 Neuro-Oncology  
METHODS: We used RNAi screens, mouse xenograft models, and bioinformatic analysis of clinically annotated gene expression data sets.  ...  The dose was kept to the lowest levels for the surface of brain stem (,12 Gy) and optic apparatus (,8 Gy).  ... 
doi:10.1093/neuonc/noq116.s15 fatcat:rwtntei5crafjhosb7znf3acyu

MINI ORAL SESSIONS

2015 Journal of Thoracic Oncology  
With an increase in patients presenting with multiple nodules, we sought to develop a set of criteria for c-staging on imaging and to determine the agreement between clinical and pathological staging in  ...  Methods: In 2013 and 2014, there were a total of 48 consecutive cases with available imaging resected with multiple tumours, ranging from 2 to 5 nodules.  ...  In the overall patient population, investigator-assessed disease control rate (DCR) was 77.1% and median duration of response (DOR) 9.7 months. (Figure) .  ... 
doi:10.1016/s1556-0864(16)30011-9 fatcat:nlhtgbimt5fu5dx4syerr2hjmu

Image-guided interventional therapy for cancer with radiotherapeutic nanoparticles

William T. Phillips, Ande Bao, Andrew J. Brenner, Beth A. Goins
2014 Advanced Drug Delivery Reviews  
With this approach, very high doses of radiation can be delivered to solid tumors while sparing normal organs.  ...  Examples will be shown describing how this new approach has promise for the treatment of brain, head and neck, and other types of solid tumors.  ...  Acknowledgments This research was supported in part by NIH grants 5 P30 CA054174-16 and R01 CA131039. The authors also appreciate Jonathan Sumner for his help in figure preparation.  ... 
doi:10.1016/j.addr.2014.07.001 pmid:25016083 pmcid:PMC4414016 fatcat:jt6myadewffxxfnbi6t6adeohq
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