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Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study

Yolanda Ohene, Ian F. Harrison, Payam Nahavandi, Ozama Ismail, Eleanor V. Bird, Ole P. Ottersen, Erlend A. Nagelhus, David L. Thomas, Mark F. Lythgoe, Jack A. Wells
<span title="2018-12-15">2019</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
We apply a multiple echo time (multi-TE) arterial spin labelling (ASL) MRI technique to the mouse brain to assess BBI water permeability via calculation of the exchange time (Texw), the time for magnetically  ...  There is currently a lack of non-invasive tools to assess water transport in healthy and pathological brain tissue.  ...  Acknowledgements We would like to thank Tom Roberts for his assistance with the Matlab scripts for the data analysis of this study, Phoebe Evans for her design skills for the technique schematic and George  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2018.12.026">doi:10.1016/j.neuroimage.2018.12.026</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30557661">pmid:30557661</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6414399/">pmcid:PMC6414399</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7bzxtqyntjgehmtjhyxdkrw3z4">fatcat:7bzxtqyntjgehmtjhyxdkrw3z4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190430160253/http://discovery.ucl.ac.uk/10065171/1/1-s2.0-S1053811918321700-main.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9d/18/9d18a331aa8480b579360fa4b1fbb4871e43b6cd.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2018.12.026"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414399" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Neurofluid Dynamics and the Glymphatic System: A Neuroimaging Perspective

Toshiaki Taoka, Shinji Naganawa
<span title="2020-08-11">2020</span> <i title="The Korean Society of Radiology"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/c6pm5ttsdzfx3eaeb2ndqzlyje" style="color: black;">Korean Journal of Radiology</a> </i> &nbsp;
CSF guided to the perivascular space around the arteries enters the interstitium of brain tissue via aquaporin-4 water channels to clear waste proteins into the perivascular space around the veins before  ...  The glymphatic system hypothesis is a concept describing the clearance of waste products from the brain.  ...  An animal study applied multiple echo time arterial spin labeling to the mouse brain to assess blood-brain interface water permeability by calculating the exchange time of magnetically labeled intravascular  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3348/kjr.2020.0042">doi:10.3348/kjr.2020.0042</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32783417">pmid:32783417</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7462760/">pmcid:PMC7462760</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hdn42apkurdnlb7rjvzni3isby">fatcat:hdn42apkurdnlb7rjvzni3isby</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200814005326/https://kjronline.org/Synapse/Data/PDFData/0068KJR/kjr-21-e139.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/63/66/636609edd6b7c7cbb43ab4cc460d6b4b85b54a6f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3348/kjr.2020.0042"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462760" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging

Shinji Naganawa, Toshiaki Taoka
<span title="2020-11-27">2020</span> <i title="Japanese Society for Magnetic Resonance in Medicine"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bp7c2gl4e5a7vbyzuvm6llfbsi" style="color: black;">Magnetic Resonance in Medical Sciences</a> </i> &nbsp;
In this hypothesis, cerebrospinal fluid (CSF) enters the periarterial spaces, enters the interstitial space of the brain parenchyma via aquaporin-4 (AQP4) channels in the astrocyte end feet, and then exits  ...  Many researchers have attempted to visualize the function and structure of the glymphatic system and meningeal lymphatics in vivo using MR imaging.  ...  Flows as slow as 1 μm/s were measured and validated using controlled water flow through a pipe at 4.7T. 55 Method using ultra-long echo time arterial spin labelling (ASL) A method for non-invasive measurement  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2463/mrms.rev.2020-0122">doi:10.2463/mrms.rev.2020-0122</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33250472">pmid:33250472</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ifxywms4v5e3ho7mmor46eukme">fatcat:ifxywms4v5e3ho7mmor46eukme</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201129201253/https://www.jstage.jst.go.jp/article/mrms/advpub/0/advpub_rev.2020-0122/_pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5e/f4/5ef403ac414fe38a9dd79d8a542ae67c7dd641e7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2463/mrms.rev.2020-0122"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Loss or Mislocalization of Aquaporin-4 Affects Diffusion Properties and Intermediary Metabolism in Gray Matter of Mice

T. Pavlin, E. A. Nagelhus, C. Brekken, E. M. Eyjolfsson, A. Thoren, O. Haraldseth, U. Sonnewald, O. P. Ottersen, A. K. Håberg
<span title="2016-12-30">2016</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/pncjnihh6rempdfj744jw3pm7q" style="color: black;">Neurochemical Research</a> </i> &nbsp;
1 The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 2 (AQP4) water channels affects membrane permeability for water in the mouse brain grey 3 matter in the steady  ...  In 14 the metabolic analyses, significantly lower amounts of [4-13 C]glutamate and [4-15 13 C]glutamine, and percent enrichment in [4-13 C]glutamate were detected in the α-syn KO 16 mice. [1,2-13 C]acetate  ...  Another option would be to obtain reliable short-1 time diffusion data using an oscillating-gradient spin echo diffusion sequence [61] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11064-016-2139-y">doi:10.1007/s11064-016-2139-y</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28039592">pmid:28039592</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/idzxsc4ujfbkjgn67mkj6f4a3u">fatcat:idzxsc4ujfbkjgn67mkj6f4a3u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200311050627/http://bora.uib.no/bitstream/handle/1956/17021/AQP_Paper_Postprint.pdf;jsessionid=FD36707B285C9E711EC06DBE0F257798.bora-uib_worker?sequence=4" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/25/d1/25d14fed8dc981562df81610508ef281530db8d0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11064-016-2139-y"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

All Central Nervous System Neuro- and Vascular-Communication Channels Are Surrounded With Cerebrospinal Fluid

Lara M. Fahmy, Yongsheng Chen, Stephanie Xuan, E. Mark Haacke, Jiani Hu, Quan Jiang
<span title="2021-06-17">2021</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4kchoxo3jrfubkck3y7nfncina" style="color: black;">Frontiers in Neurology</a> </i> &nbsp;
Therefore, the objective of this study was to use magnetic resonance imaging (MRI) to simultaneously map the presence of CSF within all peri-neural (cranial and spinal nerves) and peri-vascular spaces  ...  Four MRI protocols each with five participants were used to image the CSF in the brain and spinal cord.  ...  A significant portion of the subarachnoid CSF penetrates the brain parenchyma through para-arterial routes, facilitated by aquaporin-4 protein water channels (AQP4) on astrocytic end-feet (7) (8) (9)  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2021.614636">doi:10.3389/fneur.2021.614636</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34220663">pmid:34220663</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8247447/">pmcid:PMC8247447</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xa74fwlrpbcb3gd5cmhyuofpem">fatcat:xa74fwlrpbcb3gd5cmhyuofpem</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210618054659/https://fjfsdata01prod.blob.core.windows.net/articles/files/614636/pubmed-zip/.versions/1/.package-entries/fneur-12-614636/fneur-12-614636.pdf?sv=2018-03-28&amp;sr=b&amp;sig=iby0WjyExuDiiAg%2BoCieyRKqqsh%2FniYLnnUnEu7WFAQ%3D&amp;se=2021-06-18T05%3A47%3A28Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fneur-12-614636.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5a/1c/5a1c4b43f38dd6b701a9e36a86446aa86534ce43.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2021.614636"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247447" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Aberrant Neurogliovascular Unit Dynamics in Cerebral Small Vessel Disease: A Rheological Clue to Vascular Parkinsonism

Che Mohd Nasril Che Mohd Nassir, Thenmoly Damodaran, Siti R. Yusof, Anwar Norazit, Geetha Chilla, Isaac Huen, Bhanu Prakash K. N., Norlinah Mohamed Ibrahim, Muzaimi Mustapha
<span title="2021-08-05">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/eyicatbz75hkld675oqybzylzu" style="color: black;">Pharmaceutics</a> </i> &nbsp;
This homeostasis intricately involves the glymphatic system that manages the flow of interstitial solutes, metabolic waste, and clearance through the venous circulation.  ...  VaP is widely regarded as an atypical parkinsonism, described by cardinal motor manifestations and the presence of cerebrovascular disease, particularly white matter hyperintensities (WMHs) in the basal  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/pharmaceutics13081207">doi:10.3390/pharmaceutics13081207</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34452169">pmid:34452169</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8398765/">pmcid:PMC8398765</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ztexjcfrwjbdtjhlhtpb3v62ki">fatcat:ztexjcfrwjbdtjhlhtpb3v62ki</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210810043334/https://res.mdpi.com/d_attachment/pharmaceutics/pharmaceutics-13-01207/article_deploy/pharmaceutics-13-01207.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c3/b7/c3b78d29fd4b41cd34303c381b401c0c37d7fabc.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/pharmaceutics13081207"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398765" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Liver Fibrosis Conventional and Molecular Imaging Diagnosis Update

Shujing Li, Xicui Sun, Minjie Chen, Zhekang Ying, Yamin Wan, Liya Pi, Bin Ren, Qi Cao
<span title="2019-01-22">2019</span> <i title="OMICS Publishing Group"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/7dfdqgnl25f4ralonsa5veyzjy" style="color: black;">Journal of Liver</a> </i> &nbsp;
There is a clear need for safe, effective, and reliable non-invasive assessment modalities to determine liver fibrosis in order to manage it precisely in personalized medicine.  ...  We provide an overview of recent advances in molecular imaging for the diagnosis and staging of liver fibrosis which will enable clinicians to monitor the progression of disease and potentially reverse  ...  This work was supported by research Grants from the National Institute On Alcohol Abuse And Alcoholism of the National Institutes of Health (Award Number K08AA024895  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31341723">pmid:31341723</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6653681/">pmcid:PMC6653681</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ms566766vzfb7hm333awsmqblu">fatcat:ms566766vzfb7hm333awsmqblu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200322103453/https://www.longdom.org/open-access/liver-fibrosis-conventional-and-molecular-imaging-diagnosis-update.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a6/de/a6de4ab2d981152a613495fbbe756701a8f98440.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653681" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology

Kaylene Gouveia-Freitas, António J. Bastos-Leite
<span title="2021-05-21">2021</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/na5fvete3zgchm7q2aibnq2yhm" style="color: black;">Neuroradiology</a> </i> &nbsp;
PVS are involved in clearing brain waste and belong to the "glymphatic" system and/or the "intramural periarterial drainage" pathway through the basement membranes of the arteries.  ...  Related brain waste clearance systems include the blood–brain barrier, scavenger cells, cerebrospinal fluid, perineural lymphatic drainage pathways and the newly characterised meningeal lymphatic vessels  ...  In addition, non-invasive MRI tracer studies using inversion pulses (i.e. spatial modulation of magnetisation and arterial spin labelling) and phase-contrast methods were investigated, but it is currently  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00234-021-02718-7">doi:10.1007/s00234-021-02718-7</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34019111">pmid:34019111</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8460534/">pmcid:PMC8460534</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7xixcvjytvf4zkicfancas4uke">fatcat:7xixcvjytvf4zkicfancas4uke</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210718111749/https://link.springer.com/content/pdf/10.1007/s00234-021-02718-7.pdf?error=cookies_not_supported&amp;code=83e27245-ace7-4fa3-a205-f738f0cc3b88" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7c/ad/7cad83d86b7beecdd05cde60040a9fecf83781f1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00234-021-02718-7"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460534" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

Conrad E Johanson, John A Duncan, Petra M Klinge, Thomas Brinker, Edward G Stopa, Gerald D Silverberg
<span title="">2008</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2i7jmvye7jcc3ayiih6q4bjhim" style="color: black;">Cerebrospinal Fluid Research</a> </i> &nbsp;
Finally, CSF reabsorption via multiple pathways (olfactory and spinal arachnoidal bulk flow) is likely complemented by fluid clearance across capillary walls (aquaporin 4) and arachnoid villi when CSFP  ...  ), aquaporin 1 regulation, and plasticity of receptors for fluid-regulating neuropeptides.  ...  Similarly, dynamic MRI of CSF flow, using a multi-slice spin echo approach, was used to compare aqueductal CSF flow rates before and after ventriculostomy to repair non-communicating hydrocephalus [182  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1743-8454-5-10">doi:10.1186/1743-8454-5-10</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18479516">pmid:18479516</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2412840/">pmcid:PMC2412840</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4vi4tle72vbjxplkq7ncn4iyoy">fatcat:4vi4tle72vbjxplkq7ncn4iyoy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20130717221444/http://www.biomedcentral.com:80/content/pdf/1743-8454-5-10.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/79/a5/79a5577338ae65ebd61bbbdb32d7c8f102e7b400.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1743-8454-5-10"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2412840" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Water Diffusivity Changes Along the Perivascular Space After Lumboperitoneal Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus

Junko Kikuta, Koji Kamagata, Toshiaki Taoka, Kaito Takabayashi, Wataru Uchida, Yuya Saito, Christina Andica, Akihiko Wada, Kaito Kawamura, Chihiro Akiba, Madoka Nakajima, Masakazu Miyajima (+2 others)
<span title="2022-02-28">2022</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4kchoxo3jrfubkck3y7nfncina" style="color: black;">Frontiers in Neurology</a> </i> &nbsp;
In the responder or non-responder subjects, the mean ALPS indices in the pre- and post-operative iNPH groups were compared using Wilcoxon signed-rank tests.  ...  BackgroundThe aim of this study was to evaluate the water diffusivity changes along the perivascular space after lumboperitoneal shunt (LPS) surgery in idiopathic normal pressure hydrocephalus.MethodsNine  ...  Diffusion-weighted imaging (DWI) with 32 non-collinear directions was acquired using a single-shot spin-echo echo-planar imaging sequence.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2022.843883">doi:10.3389/fneur.2022.843883</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35295837">pmid:35295837</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8918529/">pmcid:PMC8918529</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gn4qu45s7nhnpgytf3aa6jdlta">fatcat:gn4qu45s7nhnpgytf3aa6jdlta</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220507163249/https://fjfsdata01prod.blob.core.windows.net/articles/files/843883/pubmed-zip/.versions/1/.package-entries/fneur-13-843883/fneur-13-843883.pdf?sv=2018-03-28&amp;sr=b&amp;sig=XrkxLze0F4A6dFr%2BNZGAkxGu%2Bsm5fzbi8X%2B9eANxca0%3D&amp;se=2022-05-07T16%3A33%3A18Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fneur-13-843883.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/27/a0/27a02ef63eeaba2531b041eb05acd599e7ddf550.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2022.843883"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918529" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Decoupling of global brain activity and cerebrospinal fluid flow in Parkinson's cognitive decline [article]

Feng Han, Gregory L. Brown, Yalin Zhu, Aaron E. Belkin-Rosen, Mechelle M. Lewis, Guangwei Du, Yameng Gu, Paul J. Eslinger, Richard B. Mailman, Xuemei Huang, Xiao Liu
<span title="2021-01-09">2021</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
The glymphatic system may play an important role in the clearance of these toxic proteins via cerebrospinal fluid (CSF) flow through perivascular and interstitial spaces.  ...  Recent studies discovered that sleep-dependent global brain activity is coupled to CSF flow that may reflect glymphatic function.  ...  Non-1 invasive imaging of CSF-mediated brain clearance 424 pathways via assessment of perivascular fluid movement with diffusion tensor MRI. Elife. 2018; 7: 425 e34028. 426 25.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.01.08.425953">doi:10.1101/2021.01.08.425953</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ky4feik34vhf3d5gpdtvysjdz4">fatcat:ky4feik34vhf3d5gpdtvysjdz4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210429041803/https://www.biorxiv.org/content/biorxiv/early/2021/01/09/2021.01.08.425953.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/89/f8/89f8cf5ea11d35a7a907e975ce4e6349b43e3c5b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.01.08.425953"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury

Alison Cash, Michelle H. Theus
<span title="2020-05-08">2020</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3loumxx7kzamnlu4h6x3xoz6ay" style="color: black;">International Journal of Molecular Sciences</a> </i> &nbsp;
A mechanical consequence of trauma involves dysregulation of the blood–brain barrier (BBB) which contributes to secondary injury and exposure of peripheral components to the brain parenchyma.  ...  Recent studies have shed light on the mechanisms of BBB breakdown in TBI including novel intracellular signaling and cell–cell interactions within the BBB niche.  ...  Importantly, mapping water exchange across the BBB can be achieved using 3D diffusion-prepared or multiple echo time arterial-spin-labeled (ASL) perfusion MRI.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/ijms21093344">doi:10.3390/ijms21093344</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32397302">pmid:32397302</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7246537/">pmcid:PMC7246537</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gvknuu7x3nh3pfaafitj5odjli">fatcat:gvknuu7x3nh3pfaafitj5odjli</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200509055400/https://res.mdpi.com/d_attachment/ijms/ijms-21-03344/article_deploy/ijms-21-03344.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/48/a4/48a4810301d4976c04f23d5f6e8aec8630a8b1c3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/ijms21093344"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246537" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations

Michael J. Thrippleton, Walter H. Backes, Steven Sourbron, Michael Ingrisch, Matthias J.P. van Osch, Martin Dichgans, Franz Fazekas, Stefan Ropele, Richard Frayne, Robert J. van Oostenbrugge, Eric E. Smith, Joanna M. Wardlaw
<span title="2019-04-25">2019</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/skzqffpatvawfgf7uspguqs4yu" style="color: black;">Alzheimer&#39;s &amp; Dementia</a> </i> &nbsp;
The purpose of this work, authored by members of the HARNESS Initiative, is to provide an in-depth review and position statement on magnetic resonance imaging measurement of subtle BBB leakage in clinical  ...  Recent years have seen increasing use of imaging, primarily dynamic contrast-enhanced magnetic resonance imaging, to assess BBB leakage, but there is considerable variability in the approaches and findings  ...  A method for estimating global water BBB permeability has also been recently proposed, derived from the arterial spin labeling signal measured in veins [49] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.jalz.2019.01.013">doi:10.1016/j.jalz.2019.01.013</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31031101">pmid:31031101</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6565805/">pmcid:PMC6565805</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uatiq43tara73iihjmctfi3j5q">fatcat:uatiq43tara73iihjmctfi3j5q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200505163603/https://www.pure.ed.ac.uk/ws/files/87393441/PIIS1552526019300457.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/50/41/504194d473d54a7499c7bf237878fe0f6947a456.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.jalz.2019.01.013"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565805" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Vascular density and distribution in neocortex

Franca Schmid, Matthew J.P. Barrett, Patrick Jenny, Bruno Weber
<span title="">2017</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
An amazingly wide range of complex behavior emerges from the cerebral cortex.  ...  Abstract An amazingly wide range of complex behavior emerges from the cerebral cortex.  ...  BW is a member of the Clinical Research Priority Program of the University of Zurich on Molecular Imaging. MB is supported by the Forschungskredit of the University of Zurich.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2017.06.046">doi:10.1016/j.neuroimage.2017.06.046</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28669910">pmid:28669910</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ipntassnpjflbgqsdrt7ssvoh4">fatcat:ipntassnpjflbgqsdrt7ssvoh4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200221195320/https://www.zora.uzh.ch/id/eprint/146003/7/CorticalVascularSystemNIMG_Final.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/16/f6/16f650c2e4ccfdaf856b1e1d3838a7a2f10c1669.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2017.06.046"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a>

In contrast to BOLD: signal enhancement by extravascular water protons as an alternative mechanism of endogenous fMRI signal change

Chase R. Figley, Jordan K. Leitch, Patrick W. Stroman
<span title="">2010</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dyab7yakdjgl3idr6oqhmg6ukq" style="color: black;">Magnetic Resonance Imaging</a> </i> &nbsp;
General Abstract Functional magnetic resonance imaging (fMRI) has become a widely used technique for non-invasive brain mapping, and methods have now evolved to allow fMRI of the spinal cord (spinal fMRI  ...  For example, multiple studies had previously suggested that the majority of structured physiological noise, such as spinal cord motion and cerebrospinal fluid (CSF) flow, appeared to be synchronous with  ...  However, at short echo times, spin-echo sequences show considerable deviations from the BOLD model, implying a second, non-BOLD component of signal change.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.mri.2010.01.005">doi:10.1016/j.mri.2010.01.005</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20299173">pmid:20299173</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tnwldgkgc5dfxdadzmhsmjuqgu">fatcat:tnwldgkgc5dfxdadzmhsmjuqgu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170829192702/http://qspace.library.queensu.ca/bitstream/handle/1974/5984/Figley_Chase_R_201008_PhD.pdf?sequence=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/30/84/3084c2c188b6cb7eb383bc391cb23af93f2813f2.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.mri.2010.01.005"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>
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