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Hemodynamic and Metabolic Assessment of Neonates With Punctate White Matter Lesions Using Phase-Contrast MRI and T2-Relaxation-Under-Spin-Tagging (TRUST) MRI

Ying Qi, Peiying Liu, Zixuan Lin, Hanzhang Lu, Xiaoming Wang
2018 Frontiers in Physiology  
It is feasible to use non-invasive MRI methods to measure cerebral oxygen supply and consumption in neonates with PWML. Newborns with PWML have lower oxygen consumption.  ...  extraction fraction (OEF) in neonates with PWML, for better understanding of the pathophysiology of PWML.  ...  T2-Relaxation-Under-Spin-Tagging (TRUST) MRI is one of the MRI techniques that measures venous oxygenation non-invasively (Lu and Ge, 2008; Xu et al., 2012) and has been validated in adults .  ... 
doi:10.3389/fphys.2018.00233 pmid:29615927 pmcid:PMC5868490 fatcat:33p2loyjv5aabpu5jhos6yatse

Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications

Silvina L. Ferradal, Koichi Yuki, Rutvi Vyas, Christopher G. Ha, Francesca Yi, Christian Stopp, David Wypij, Henry H. Cheng, Jane W. Newburger, Aditya K. Kaza, Maria A. Franceschini, Barry D. Kussman (+1 others)
2017 Scientific Reports  
non-invasively and in real-time.  ...  This pilot study aims to evaluate cerebral blood flow (CBF) and oxygen metabolism (CMRO 2 ) intraoperatively in neonates by combining two novel non-invasive optical techniques: frequency-domain near-infrared  ...  Acknowledgements We are grateful to the patients and families for their participation. We thank Daniel Wigmore and Erica McDavitt for assisting with recruitment. We would also like to thank Dr.  ... 
doi:10.1038/srep44117 pmid:28276534 pmcid:PMC5343476 fatcat:qgr4ykqn5ffzdapge5jwirum5e

Use of near-infrared spectroscopy (NIRS) in cerebral tissue oxygenation monitoring in neonates

Rene Gumulak, Lucia Casnocha Lucanova, Mirko Zibolen
2017 Biomedical Papers of the Faculty of Medicine of Palacky University  
Near-infrared spectroscopy (NIRS) is a technology capable of non-invasive, continuous measuring of regional tissue oxygen saturation (StO 2 ).  ...  Cerebral tissue oxygenation (cStO 2 ) and cerebral fractional tissue extraction (cFTOE) are reported in a large number of clinical studies.  ...  INTRODUCTION Non-invasive measurement of cerebral tissue oxygenation using near-infrared spectroscopy (NIRS) is attracting increasing attention in neonatology 1 .  ... 
doi:10.5507/bp.2017.012 pmid:28360433 fatcat:vytom5mtw5gpxn3gow2kls6x24

Cerebral oxygen extraction fraction MRI: techniques and applications [article]

Dengrong Jiang, Hanzhang Lu
2022 arXiv   pre-print
The rate of the brain's oxygen utilization can be determined from the knowledge of cerebral blood flow and oxygen extraction fraction (OEF).  ...  Compared to 15O positron emission tomography, which is considered the "gold standard" for OEF measurement, MRI-based techniques are non-invasive, radiation-free, and have broader availabilities.  ...  The fraction of oxygen extracted by the tissue is OEF.  ... 
arXiv:2202.01350v1 fatcat:hefhe7f5hbabzjtm4pmudscdpy

Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates

Nadege Roche-Labarbe, Angela Fenoglio, Harsha Radhakrishnan, Marcia Kocienski-Filip, Stefan A. Carp, Jay Dubb, David A. Boas, P. Ellen Grant, Maria Angela Franceschini
2014 NeuroImage  
By combining these measures we estimated relative changes in the cerebral metabolic rate of oxygen consumption (rCMRO 2 ).  ...  Measurement of all hemodynamic components and oxygen metabolism is critical for understanding neurovascular coupling in the developing brain.  ...  Acknowledgments The authors thank all the families for their participation in this study and the nurses, physicians, and staff in the Neonatal ICU at Brigham and Women's Hospital for their help and support  ... 
doi:10.1016/j.neuroimage.2013.01.035 pmid:23370052 pmcid:PMC3686986 fatcat:2xrgdufppnbmresbky5vwzroja

Preoperative cerebral hemodynamics from birth to surgery in neonates with critical congenital heart disease

Jennifer M. Lynch, Tiffany Ko, David R. Busch, John J. Newland, Madeline E. Winters, Kobina Mensah-Brown, Timothy W. Boorady, Rui Xiao, Susan C. Nicolson, Lisa M. Montenegro, J. William Gaynor, Thomas L. Spray (+3 others)
2018 Journal of Thoracic and Cardiovascular Surgery  
(ScO 2 ), cerebral oxygen extraction fraction (OEF), and cerebral blood flow (CBF) using diffuse optical spectroscopy and diffuse correlation spectroscopy, two non-invasive optical techniques.  ...  Methods-Neonates with either transposition of the great arteries (TGA) or hypoplastic left heart syndrome (HLHS) were recruited for pre-operative non-invasive optical monitoring of cerebral oxygen saturation  ...  Daily DOS/DCS measurements of cerebral tissue oxygen saturation (ScO 2 ), oxygen extraction fraction (OEF), and cerebral blood flow (CBF) were made as soon as consent was obtained, with the last measurement  ... 
doi:10.1016/j.jtcvs.2018.04.098 pmid:29859676 pmcid:PMC6166233 fatcat:gonigdstzfaavbej24m52zl4oi

Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia

Lori C. Jordan, Melissa C. Gindville, Allison O. Scott, Meher R. Juttukonda, Megan K. Strother, Adetola A. Kassim, Sheau-Chiann Chen, Hanzhang Lu, Sumit Pruthi, Yu Shyr, Manus J. Donahue
2016 Brain  
These data provide support for T 2 -relaxation-under-spin-tagging being able to quickly and non-invasively detect elevated oxygen extraction fraction in individuals with sickle cell anaemia with higher  ...  The specific goal is to determine to what extent elevated oxygen extraction fraction may be uniquely present in patients with higher levels of clinical impairment and therefore may represent a candidate  ...  Acknowledgements We are grateful to Carlos Faraco, Christopher Thompson, Claire Kurtenbach, Chaohui Tang, Kristen George-Durrett, and Leslie McIntosh for experimental support.  ... 
doi:10.1093/brain/awv397 pmid:26823369 pmcid:PMC5014126 fatcat:se4ig5vqn5gdfb55ifjdymqg2y

Detailing renal hemodynamics and oxygenation in rats by a combined near-infrared spectroscopy and invasive probe approach

Dirk Grosenick, Kathleen Cantow, Karen Arakelyan, Heidrun Wabnitz, Bert Flemming, Angela Skalweit, Mechthild Ladwig, Rainer Macdonald, Thoralf Niendorf, Erdmann Seeliger
2015 Biomedical Optics Express  
We hypothesize that combining quantitative near-infrared spectroscopy (NIRS) with established invasive techniques will enable advanced insights into renal hemodynamics and oxygenation in small animal models  ...  We developed a NIRS technique to monitor absolute values of oxygenated and deoxygenated hemoglobin and of oxygen saturation of hemoglobin within the renal cortex of rats.  ...  Acknowledgement We would like to acknowledge Richard Schäfer, Ariane Anger and Andrea Gerhardt for expert technical assistance during measurements and data analysis.  ... 
doi:10.1364/boe.6.000309 pmid:25780726 pmcid:PMC4354597 fatcat:jaamhzyygvflhmqniiwp3z4kxa

Anaemia in the Premature Infant and Red Blood Cell Transfusion: New Approaches to an Age-Old Problem

Chad C. Andersen, Amy K. Keir, Haresh M. Kirpalani, Michael J. Stark
2015 Current Treatment Options in Pediatrics  
This effectively reframes the potential role of RBC transfusion in the very preterm infant and demands a new generation of clinical trials.  ...  Little attention has been given to the potentially favourable effect of RBC transfusion on oxygen kinetics, particularly in the interval after birth when the risk of hypoxic ischaemia is high.  ...  The use of arterial oxygen content requires both invasive arterial access and consideration of oxygen saturation stability at the time of measurement.  ... 
doi:10.1007/s40746-015-0021-9 fatcat:3ce45k6xg5hhbab5olkiilifdy

Quantitative assessment of cerebral metabolism and hemodynamics in small-for-gestational-age (SGA) newborns

Ying Qi, Xiaoming Wang, Jian Mao
2021 Quantitative Imaging in Medicine and Surgery  
fraction (OEF), global cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO2) to elucidate pathophysiological vulnerabilities of SGA neonates.  ...  In this study, we employed several advanced imaging techniques-including T2-relaxation-under-spin-tagging (TRUST) magnetic resonance imaging (MRI), and phase-contrast (PC) MRI-to quantify oxygen extraction  ...  Acknowledgments Funding: This study was supported by the Science and Technology Planning Project of Shenyang (No.  ... 
doi:10.21037/qims-20-1040 pmid:34079704 pmcid:PMC8107312 fatcat:qopjvh2lsvef7nf5yllopcvxu4

Perioperative cerebral hemodynamics and oxygen metabolism in neonates with single-ventricle physiology

Mathieu Dehaes, Henry H. Cheng, Erin M. Buckley, Pei-Yi Lin, Silvina Ferradal, Kathryn Williams, Rutvi Vyas, Katherine Hagan, Daniel Wigmore, Erica McDavitt, Janet S. Soul, Maria Angela Franceschini (+2 others)
2015 Biomedical Optics Express  
Preoperatively, SV patients showed decreased cerebral blood flow (CBFi ), cerebral oxygen metabolism (CMRO 2i ) and SO 2; and increased oxygen extraction fraction (OEF) compared to controls.  ...  In this study, we used bedside frequency-domain near infrared spectroscopy (FDNIRS) and diffuse correlation spectroscopy (DCS) to assess cerebral hemodynamics and oxygen metabolism in neonates with single-ventricle  ...  Disclosure/Conflict of interest Maria Angela Franceschini holds patents on the technology employed in this article. The other authors declare no conflict of interest.  ... 
doi:10.1364/boe.6.004749 pmid:26713191 pmcid:PMC4679251 fatcat:pjmepiajtndvxkrpqmtgpbteky

Hemodynamic Monitoring in Neonates [chapter]

Petja Fister, Štefan Grosek
2018 Selected Topics in Neonatal Care  
In the treatment of hemodynamically unstable neonate venous filling, contractility of the heart muscle, blood pressure in the aorta, systemic blood flow, and regional distribution of blood flow should  ...  Using new techniques will clarify the pathophysiology of cardiovascular failure in sick neonates, assess the effects of drugs on blood pressure and perfusion of the heart and other organs.  ...  It measures the index of tissue oxygenation and enables the calculation of the extraction of oxygen of the tissues in the target organ.  ... 
doi:10.5772/intechopen.69215 fatcat:ho3qrrm7ija5hb7bdbtjmrqe5m

Cerebral Oxygen Metabolism in Neonatal Hypoxic Ischemic Encephalopathy during and after Therapeutic Hypothermia

Mathieu Dehaes, Alpna Aggarwal, Pei-Yi Lin, C Rosa Fortuno, Angela Fenoglio, Nadège Roche-Labarbe, Janet S Soul, Maria Angela Franceschini, P Ellen Grant
2013 Journal of Cerebral Blood Flow and Metabolism  
A combination of frequency domain near infrared spectroscopy (FDNIRS) and diffuse correlation spectroscopy (DCS) systems was used to non-invasively measure cerebral hemodynamic and metabolic variables  ...  Also, cerebral blood volume (CBV) and hemoglobin oxygen saturation (SO 2 ) were significantly higher in neonates with HIE during TH compared with age-matched control neonates.  ...  ACKNOWLEDGMENTS The authors thank all the families and the nurses, physicians, and staff in the NICU, the Special Care Nursery, Pediatric Neurology, and the maternity units at Brigham and Women's Hospital  ... 
doi:10.1038/jcbfm.2013.165 pmid:24064492 pmcid:PMC3887346 fatcat:olxlsaqjd5ay5c4xyhzbbwa35a

Quantification of normal cerebral oxygen extraction and oxygen metabolism by phase-based MRI susceptometry: evaluation of repeatability using two different imaging protocols

Robin Kämpe, Emelie Lind, Freddy Ståhlberg, Danielle van Westen, Linda Knutsson, Ronnie Wirestam
2015 Clinical Physiology and Functional Imaging  
Abstract Introduction: Global oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO 2 ) were quantified in a test-retest study.  ...  Quantification of normal cerebral oxygen extraction and oxygen metabolism by phase-based MRI susceptometry: evaluation of repeatability using two different imaging protocols.  ...  Conflict of Interest The authors have no conflicts of interest.  ... 
doi:10.1111/cpf.12288 pmid:26490359 fatcat:5sjepmk4tbbqjognvwofgz3wdq

The "neurovascular unit approach" to evaluate mechanisms of dysfunctional autoregulation in asphyxiated newborns in the era of hypothermia therapy

Lina F. Chalak, Takashi Tarumi, Rong Zhang
2014 Early Human Development  
Despite improvements in obstetrical and neonatal care, and introduction of hypothermia as a neuroprotective therapy, perinatal brain injury remains a frequent cause of cerebral palsy, mental retardation  ...  monitoring methodology such as NIRS (near infrared spectroscopy), and TCD (transcutaneous Doppler), and 3) clinical implications of monitoring in the neonatal intensive care setting in asphyxiated newborns  ...  Chalak is supported by NIH Grant K23HD069521 and a Gerber Foundation grant. Abbreviations HIE Hypoxic-ischemic encephalopathy MRI magnetic resonance imaging  ... 
doi:10.1016/j.earlhumdev.2014.06.013 pmid:25062804 pmcid:PMC4170014 fatcat:zone32juzbcgbj456wpmocxdma
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