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Hippocampus-specific fMRI group activation analysis using the continuous medial representation
2007
NeuroImage
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We present a new shape-based approach for regional group activation analysis in fMRI studies. ...
We apply the technique to the hippocampus evaluate it using data from a visual scene encoding fMRI study, where activation in the hippocampus is expected. ...
Results
Hippocampus-Specific Analysis If we think of non-uniform smoothing as a way of increasing specificity, it is encouraging to find that it does not necessarily lower sensitivity. ...
doi:10.1016/j.neuroimage.2007.01.029
pmid:17383900
pmcid:PMC2262289
fatcat:xqhjj37tkzhv3imazjboo4t7lm
Aberrant Hippocampal Subregion Networks Associated with the Classifications of aMCI Subjects: A Longitudinal Resting-State Study
2011
PLoS ONE
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samples of aMCI converters from non-converters (sensitivity was 83.3%, specificity was 83.3%) and controls (sensitivity was 83.3%, specificity was 91.7%). ...
However, little is known about the disrupted functional connectivity of hippocampus subregional networks in aMCI subjects. ...
analysis using three unrelated groups (i.e. these subjects were not included in aMCI group-1 and controls group-1) who only underwent the baseline fMRI scan, such as aMCI group-2 (n = 12), control group ...
doi:10.1371/journal.pone.0029288
pmid:22216234
pmcid:PMC3246487
fatcat:sm2imgpbebekri7w26ac6ke4fm
Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding
2018
Proceedings of the National Academy of Sciences of the United States of America
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Participants Among the initial 898 participants provided in the HCP S900 release, we selected only those 816 that completed all four rs-fMRI scans and in whom structural MRI data (i.e., T2w, T1w, 1.25mm ...
We combined one group of monozygotic twins with one group of unrelated individuals as discovery dataset and used the remaining group of unrelated participants for validation. ...
Data analysis Analysis was carried out using SurfStat for MATLAB (22) , available at http://www.math.mcgill.ca/~keith/surfstat. a) Subfield-specific connectivity analysis. ...
doi:10.1073/pnas.1803667115
pmid:30249658
pmcid:PMC6176604
fatcat:s3nhca577rctnfc2jiem2txgsa
Altered regional connectivity reflecting effects of different anaesthesia protocols in the mouse brain
2017
NeuroImage
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Regional homogeneity (ReHo) was used to map local synchronization in the brain, followed by analysis of several brain areas based on ReHo maps. ...
The results revealed high local coherence in most brain areas. The primary somatosensory cortex and caudate-putamen showed agent-specific properties. ...
Under the common observation of non-uniform local connectivity across the brain, regions yielding high ReHo were not the same between groups, suggesting the possibly drug-specific responses in some areas ...
doi:10.1016/j.neuroimage.2017.01.074
pmid:28159688
fatcat:v2dc5flqe5dudho5hpz4y7ryau
Head Motion and Correction Methods in Resting-state Functional MRI
2016
Magnetic Resonance in Medical Sciences
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Following the unexpected previous result that group differences in head motion between control and patient groups caused group differences in the resting-state network with RS-fMRI, we reviewed the effects ...
Development of a more effective correction method would improve the accuracy of RS-fMRI analysis. ...
Acknowledgments This study was supported by a Grant-in-Aid for Scientific Research on Innovative Areas (Comprehensive Brain Science Network) from the Ministry of Education, Science, Sports and Culture ...
doi:10.2463/mrms.rev.2015-0060
pmid:26701695
pmcid:PMC5600054
fatcat:zw5roy3ywfestjoio2igdby52u
Altered Effective Connectivity in Schizophrenic Patients With Auditory Verbal Hallucinations: A Resting-State fMRI Study With Granger Causality Analysis
2020
Frontiers in Psychiatry
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in the AVH group compared with the non-AVH group. ...
Eighteen patients with schizophrenia with AVH and eighteen matched patients without AVH who received resting-state fMRI scans were enrolled in the study. ...
lower in the AVH group than in the non-AVH group. ...
doi:10.3389/fpsyt.2020.00575
pmid:32670108
pmcid:PMC7327618
fatcat:p34gz6vmgbfwxkq3iflrxcdvfq
Topographic profiling of memory-related pattern separation processes in humans
[article]
2020
bioRxiv
pre-print
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Administering a pattern separation fMRI paradigm to a group of healthy adults, we detected task-related activation in bilateral hippocampal and distributed neocortical areas. ...
Converging evidence suggests a pivotal role of the hippocampus, in concert with neocortical areas, in this process. ...
To account for spatial autocorrelations, we used non-parametric spin tests ( c) Single subject analysis. In addition to group-wise analysis, we verified results at the single subject level. ...
doi:10.1101/2020.06.22.165290
fatcat:x4lvlnyw6bdlvflfkmih2hhxca
Healthy versus Entorhinal Cortical Atrophy Identification in Asymptomatic APOE4 Carriers at Risk for Alzheimer's Disease
2018
Journal of Alzheimer's Disease
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APOE 4 allele carriers that predominantly use nonspatial strategies have decreased fMRI activity in the hippocampus and increased atrophy in the hippocampus, entorhinal cortex, and fimbria compared to ...
Using a virtual navigation task developed in-house, specifically designed to assess spatial versus non-spatial strategies, the current study is the first to differentiate functional and structural differences ...
Importantly, response learners in the non-4 groups showed no early fMRI activity in the hippocampus, as per our earlier findings. ...
doi:10.3233/jad-170540
pmid:29278888
pmcid:PMC5798531
fatcat:ewcgauaukrgm3f36iv2qnoisde
Heterogeneity of functional activation during memory encoding across hippocampal subfields in temporal lobe epilepsy
2011
NeuroImage
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patients and between epileptogenic and non-epeileptogenic sides in patients. • The disease effects vary in severity between subfields. ...
hippocampus region showing the greatest effects. ...
Acknowledgments This work was supported in part by the following grants: NIH R21 NS061111, NIH K25 AG02778, NIH K24 NS058386, NIH P30 NS045839, NIH T32 EB000814. ...
doi:10.1016/j.neuroimage.2011.06.085
pmid:21763431
pmcid:PMC3285462
fatcat:2uzj3no5a5c4hbseuuurprmlnq
Brain-wide functional networks associated with anatomically- and functionally-defined hippocampal subfields using ultrahigh-resolution fMRI
[article]
2020
bioRxiv
pre-print
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Using a spatially restricted hippocampal Independent Component Analysis (ICA) approach, this study showed that fHPSFs were arranged along the longitudinal axis of the hippocampus that were not comparable ...
functional segmentation with ultrahigh-resolution data demonstrate similar anatomical, lamellar structures in the hippocampus, and 2) define and compare the brain-wide FC associated with fine-grained ...
Hence, ν ranges from 0 to 1 where 0 represents complete uniformity and 1 represents the highest non-uniformity, i.e. highest specificity. ...
doi:10.1101/2020.12.01.407049
fatcat:hbb2brxfeff3nojisz5ct4otry
Decoding the Traumatic Memory among Women with PTSD: Implications for Neurocircuitry Models of PTSD and Real-Time fMRI Neurofeedback
2015
PLoS ONE
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is reliably predictive of (i.e., discriminates) whether an individual is engaging in trauma or non-trauma memory recall. ...
While numerous studies have investigated the neural processing mechanisms engaged during trauma memory recall in PTSD, these analyses have only focused on group-level contrasts that reveal little about ...
In regards to the methodological parameters that optimize classification accuracy, we observed that spatial smoothing had a marked advantage over non-spatial smoothing. ...
doi:10.1371/journal.pone.0134717
pmid:26241958
pmcid:PMC4524593
fatcat:jst3g46trbdj7c74lf436ecl3i
Modality-Dependent Impact of Hallucinations on Low-Frequency Fluctuations in Schizophrenia
2016
Schizophrenia Bulletin
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These patients also had elevated ALFF in the left hippocampus in comparison to patients that endorsed auditory (but not visual) hallucinations. ...
In this study, we performed an analysis of the mean amplitude of low-frequency fluctuations (ALFF) to compare resting state spontaneous low-frequency fluctuations in patients with Sz who report experiencing ...
Acknowledgments The authors have declared that there are no conflicts of interest in relation to the subject of this study. ...
doi:10.1093/schbul/sbw093
pmid:27421792
pmcid:PMC5605256
fatcat:q7iybdbls5gblcy2y2yebygbvu
Cognitive network reorganization following surgical control of seizures in Lennox-Gastaut syndrome
2017
Epilepsia
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Acknowledgements We thank the patients and their families for participating in this research. We also thank Michael
Disclosure of conflicts of interest ...
Additionally, we explored the specificity of the patient's postsurgical network changes by anesthetized fMRI in a comparison group of non-operated children with LGS. ...
On visual inspection, pre-surgical seeded connectivity showed broad similarity to the average pattern in the comparison group of nonoperated LGS children as well as our prior observations in non-anesthetized ...
doi:10.1111/epi.13720
pmid:28295228
fatcat:tcxiarzxwzhrtkbsakho4kp7oy
Amygdala and hippocampus fail to habituate to faces in individuals with an inhibited temperament
2012
Social Cognitive and Affective Neuroscience
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Habituation to neutral faces in the amygdala and hippocampus differed significantly by temperament group. ...
In contrast, in individuals with an inhibited temperament, the amygdala and hippocampus failed to habituate across repeated presentations of faces. ...
and hippocampus that would also be evident with non-social stimuli. ...
doi:10.1093/scan/nsr078
pmid:22260816
pmcid:PMC3575717
fatcat:3of7bczhizbvbofosjedgcywb4
Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy
2018
NeuroImage: Clinical
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Different patterns of lateralization of the salience network involving the abnormal hippocampus were found in right versus left mTLE. ...
Studies suggested the reorganization of hubs in epilepsy. The patterns of connector hub abnormalities specific to mesial temporal lobe epilepsy (mTLE) are unclear. ...
Non-uniformity correction (Sled et al., 1998) and brain extraction (Park and Lee, 2009) were applied twice first in native space and then in the MNI template after nonlinear coregistration. ...
doi:10.1016/j.nicl.2018.06.029
pmid:30094158
pmcid:PMC6070692
fatcat:wv6wvigfvjf73nheajlvqeak7q
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