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Hippocampus-specific fMRI group activation analysis using the continuous medial representation

Paul A. Yushkevich, John A. Detre, Dawn Mechanic-Hamilton, María A. Fernández-Seara, Kathy Z. Tang, Angela Hoang, Marc Korczykowski, Hui Zhang, James C. Gee
2007 NeuroImage  
We present a new shape-based approach for regional group activation analysis in fMRI studies.  ...  We apply the technique to the hippocampus evaluate it using data from a visual scene encoding fMRI study, where activation in the hippocampus is expected.  ...  Results Hippocampus-Specific Analysis If we think of non-uniform smoothing as a way of increasing specificity, it is encouraging to find that it does not necessarily lower sensitivity.  ... 
doi:10.1016/j.neuroimage.2007.01.029 pmid:17383900 pmcid:PMC2262289 fatcat:xqhjj37tkzhv3imazjboo4t7lm

Aberrant Hippocampal Subregion Networks Associated with the Classifications of aMCI Subjects: A Longitudinal Resting-State Study

Feng Bai, Chunming Xie, David R. Watson, Yongmei Shi, Yonggui Yuan, Yi Wang, Chunxian Yue, Yuhuan Teng, Di Wu, Zhijun Zhang, Yong He
2011 PLoS ONE  
samples of aMCI converters from non-converters (sensitivity was 83.3%, specificity was 83.3%) and controls (sensitivity was 83.3%, specificity was 91.7%).  ...  However, little is known about the disrupted functional connectivity of hippocampus subregional networks in aMCI subjects.  ...  analysis using three unrelated groups (i.e. these subjects were not included in aMCI group-1 and controls group-1) who only underwent the baseline fMRI scan, such as aMCI group-2 (n = 12), control group  ... 
doi:10.1371/journal.pone.0029288 pmid:22216234 pmcid:PMC3246487 fatcat:sm2imgpbebekri7w26ac6ke4fm

Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding

Reinder Vos de Wael, Sara Larivière, Benoît Caldairou, Seok-Jun Hong, Daniel S. Margulies, Elizabeth Jefferies, Andrea Bernasconi, Jonathan Smallwood, Neda Bernasconi, Boris C. Bernhardt
2018 Proceedings of the National Academy of Sciences of the United States of America  
Participants Among the initial 898 participants provided in the HCP S900 release, we selected only those 816 that completed all four rs-fMRI scans and in whom structural MRI data (i.e., T2w, T1w, 1.25mm  ...  We combined one group of monozygotic twins with one group of unrelated individuals as discovery dataset and used the remaining group of unrelated participants for validation.  ...  Data analysis Analysis was carried out using SurfStat for MATLAB (22) , available at a) Subfield-specific connectivity analysis.  ... 
doi:10.1073/pnas.1803667115 pmid:30249658 pmcid:PMC6176604 fatcat:s3nhca577rctnfc2jiem2txgsa

Altered regional connectivity reflecting effects of different anaesthesia protocols in the mouse brain

Tong Wu, Joanes Grandjean, Simone C. Bosshard, Markus Rudin, David Reutens, Tianzi Jiang
2017 NeuroImage  
Regional homogeneity (ReHo) was used to map local synchronization in the brain, followed by analysis of several brain areas based on ReHo maps.  ...  The results revealed high local coherence in most brain areas. The primary somatosensory cortex and caudate-putamen showed agent-specific properties.  ...  Under the common observation of non-uniform local connectivity across the brain, regions yielding high ReHo were not the same between groups, suggesting the possibly drug-specific responses in some areas  ... 
doi:10.1016/j.neuroimage.2017.01.074 pmid:28159688 fatcat:v2dc5flqe5dudho5hpz4y7ryau

Head Motion and Correction Methods in Resting-state Functional MRI

Masami GOTO, Osamu ABE, Tosiaki MIYATI, Hidenori YAMASUE, Tsutomu GOMI, Tohoru TAKEDA
2016 Magnetic Resonance in Medical Sciences  
Following the unexpected previous result that group differences in head motion between control and patient groups caused group differences in the resting-state network with RS-fMRI, we reviewed the effects  ...  Development of a more effective correction method would improve the accuracy of RS-fMRI analysis.  ...  Acknowledgments This study was supported by a Grant-in-Aid for Scientific Research on Innovative Areas (Comprehensive Brain Science Network) from the Ministry of Education, Science, Sports and Culture  ... 
doi:10.2463/mrms.rev.2015-0060 pmid:26701695 pmcid:PMC5600054 fatcat:zw5roy3ywfestjoio2igdby52u

Altered Effective Connectivity in Schizophrenic Patients With Auditory Verbal Hallucinations: A Resting-State fMRI Study With Granger Causality Analysis

Jie Gao, Dongsheng Zhang, Lei Wang, Wei Wang, Yajuan Fan, Min Tang, Xin Zhang, Xiaoyan Lei, Yarong Wang, Jian Yang, Xiaoling Zhang
2020 Frontiers in Psychiatry  
in the AVH group compared with the non-AVH group.  ...  Eighteen patients with schizophrenia with AVH and eighteen matched patients without AVH who received resting-state fMRI scans were enrolled in the study.  ...  lower in the AVH group than in the non-AVH group.  ... 
doi:10.3389/fpsyt.2020.00575 pmid:32670108 pmcid:PMC7327618 fatcat:p34gz6vmgbfwxkq3iflrxcdvfq

Topographic profiling of memory-related pattern separation processes in humans [article]

Qiongling Li, Shahin Tavakol, Jessica Royer, Sara Lariviere, Reinder Vos de Wael, Bo-yong Park, Casey Paquola, Benoit Caldairou, Danielle S Bassett, Andrea Bernasconi, Neda Bernasconi, Birgit Frauscher (+4 others)
2020 bioRxiv   pre-print
Administering a pattern separation fMRI paradigm to a group of healthy adults, we detected task-related activation in bilateral hippocampal and distributed neocortical areas.  ...  Converging evidence suggests a pivotal role of the hippocampus, in concert with neocortical areas, in this process.  ...  To account for spatial autocorrelations, we used non-parametric spin tests ( c) Single subject analysis. In addition to group-wise analysis, we verified results at the single subject level.  ... 
doi:10.1101/2020.06.22.165290 fatcat:x4lvlnyw6bdlvflfkmih2hhxca

Healthy versus Entorhinal Cortical Atrophy Identification in Asymptomatic APOE4 Carriers at Risk for Alzheimer's Disease

Kyoko Konishi, Ridha Joober, Judes Poirier, Kathleen MacDonald, Mallar Chakravarty, Raihaan Patel, John Breitner, Véronique D. Bohbot, Jan Laczó
2018 Journal of Alzheimer's Disease  
APOE 4 allele carriers that predominantly use nonspatial strategies have decreased fMRI activity in the hippocampus and increased atrophy in the hippocampus, entorhinal cortex, and fimbria compared to  ...  Using a virtual navigation task developed in-house, specifically designed to assess spatial versus non-spatial strategies, the current study is the first to differentiate functional and structural differences  ...  Importantly, response learners in the non-4 groups showed no early fMRI activity in the hippocampus, as per our earlier findings.  ... 
doi:10.3233/jad-170540 pmid:29278888 pmcid:PMC5798531 fatcat:ewcgauaukrgm3f36iv2qnoisde

Heterogeneity of functional activation during memory encoding across hippocampal subfields in temporal lobe epilepsy

Sandhitsu R. Das, Dawn Mechanic-Hamilton, John Pluta, Marc Korczykowski, John A. Detre, Paul A. Yushkevich
2011 NeuroImage  
patients and between epileptogenic and non-epeileptogenic sides in patients. • The disease effects vary in severity between subfields.  ...  hippocampus region showing the greatest effects.  ...  Acknowledgments This work was supported in part by the following grants: NIH R21 NS061111, NIH K25 AG02778, NIH K24 NS058386, NIH P30 NS045839, NIH T32 EB000814.  ... 
doi:10.1016/j.neuroimage.2011.06.085 pmid:21763431 pmcid:PMC3285462 fatcat:2uzj3no5a5c4hbseuuurprmlnq

Brain-wide functional networks associated with anatomically- and functionally-defined hippocampal subfields using ultrahigh-resolution fMRI [article]

Wei-Tang Chang, Stephanie Kristina Langella, Yichuan Tang, Han c Zhang, Pew-Thian Yap, Kelly Sullivan Giovanello, Weili Lin
2020 bioRxiv   pre-print
Using a spatially restricted hippocampal Independent Component Analysis (ICA) approach, this study showed that fHPSFs were arranged along the longitudinal axis of the hippocampus that were not comparable  ...  functional segmentation with ultrahigh-resolution data demonstrate similar anatomical, lamellar structures in the hippocampus, and 2) define and compare the brain-wide FC associated with fine-grained  ...  Hence, ν ranges from 0 to 1 where 0 represents complete uniformity and 1 represents the highest non-uniformity, i.e. highest specificity.  ... 
doi:10.1101/2020.12.01.407049 fatcat:hbb2brxfeff3nojisz5ct4otry

Decoding the Traumatic Memory among Women with PTSD: Implications for Neurocircuitry Models of PTSD and Real-Time fMRI Neurofeedback

Josh M. Cisler, Keith Bush, G. Andrew James, Sonet Smitherman, Clinton D. Kilts, Jon D. Elhai
2015 PLoS ONE  
is reliably predictive of (i.e., discriminates) whether an individual is engaging in trauma or non-trauma memory recall.  ...  While numerous studies have investigated the neural processing mechanisms engaged during trauma memory recall in PTSD, these analyses have only focused on group-level contrasts that reveal little about  ...  In regards to the methodological parameters that optimize classification accuracy, we observed that spatial smoothing had a marked advantage over non-spatial smoothing.  ... 
doi:10.1371/journal.pone.0134717 pmid:26241958 pmcid:PMC4524593 fatcat:jst3g46trbdj7c74lf436ecl3i

Modality-Dependent Impact of Hallucinations on Low-Frequency Fluctuations in Schizophrenia

Stephanie M. Hare, Judith M. Ford, Aral Ahmadi, Eswar Damaraju, Aysenil Belger, Juan Bustillo, Hyo Jong Lee, Daniel H. Mathalon, Bryon A. Mueller, Adrian Preda, Theo G. M. van Erp, Steven G. Potkin (+2 others)
2016 Schizophrenia Bulletin  
These patients also had elevated ALFF in the left hippocampus in comparison to patients that endorsed auditory (but not visual) hallucinations.  ...  In this study, we performed an analysis of the mean amplitude of low-frequency fluctuations (ALFF) to compare resting state spontaneous low-frequency fluctuations in patients with Sz who report experiencing  ...  Acknowledgments The authors have declared that there are no conflicts of interest in relation to the subject of this study.  ... 
doi:10.1093/schbul/sbw093 pmid:27421792 pmcid:PMC5605256 fatcat:q7iybdbls5gblcy2y2yebygbvu

Cognitive network reorganization following surgical control of seizures in Lennox-Gastaut syndrome

Aaron E. L. Warren, A. Simon Harvey, David F. Abbott, Simon J. Vogrin, Catherine Bailey, Andrew Davidson, Graeme D. Jackson, John S. Archer
2017 Epilepsia  
Acknowledgements We thank the patients and their families for participating in this research. We also thank Michael Disclosure of conflicts of interest  ...  Additionally, we explored the specificity of the patient's postsurgical network changes by anesthetized fMRI in a comparison group of non-operated children with LGS.  ...  On visual inspection, pre-surgical seeded connectivity showed broad similarity to the average pattern in the comparison group of nonoperated LGS children as well as our prior observations in non-anesthetized  ... 
doi:10.1111/epi.13720 pmid:28295228 fatcat:tcxiarzxwzhrtkbsakho4kp7oy

Amygdala and hippocampus fail to habituate to faces in individuals with an inhibited temperament

Jennifer Urbano Blackford, Amil H. Allen, Ronald L. Cowan, Suzanne N. Avery
2012 Social Cognitive and Affective Neuroscience  
Habituation to neutral faces in the amygdala and hippocampus differed significantly by temperament group.  ...  In contrast, in individuals with an inhibited temperament, the amygdala and hippocampus failed to habituate across repeated presentations of faces.  ...  and hippocampus that would also be evident with non-social stimuli.  ... 
doi:10.1093/scan/nsr078 pmid:22260816 pmcid:PMC3575717 fatcat:3of7bczhizbvbofosjedgcywb4

Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy

Kangjoo Lee, Hui Ming Khoo, Jean-Marc Lina, François Dubeau, Jean Gotman, Christophe Grova
2018 NeuroImage: Clinical  
Different patterns of lateralization of the salience network involving the abnormal hippocampus were found in right versus left mTLE.  ...  Studies suggested the reorganization of hubs in epilepsy. The patterns of connector hub abnormalities specific to mesial temporal lobe epilepsy (mTLE) are unclear.  ...  Non-uniformity correction (Sled et al., 1998) and brain extraction (Park and Lee, 2009) were applied twice first in native space and then in the MNI template after nonlinear coregistration.  ... 
doi:10.1016/j.nicl.2018.06.029 pmid:30094158 pmcid:PMC6070692 fatcat:wv6wvigfvjf73nheajlvqeak7q
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