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Modeling & Analysis

2003 NeuroImage  
in regional glucose metabolism), they do not simultaneously take into account information in both directions (e.g., both state-dependent increases and decreases in these measurements).  ...  Convergence rates will help to answer questions such as, "How many time points will give a reasonable estimate of the true Z-map?"  ...  To improve the classification rate, we use a p-value derived from a t-test on feature values to order features, and the first few features (with the smallest p-values) are the most significant.  ... 
doi:10.1016/s1053-8119(05)70006-9 fatcat:zff2suxcofbxvetfrwfwcxi3zm

Characterization of the image-derived carotid artery input function using independent component analysis for the quantitation of [18F] fluorodeoxyglucose positron emission tomography images

K Chen, X Chen, R Renaut, G E Alexander, D Bandy, H Guo, E M Reiman
2007 Physics in Medicine and Biology  
Positron emission tomography, Independent component analysis, Imagederived input function, quantitative measures of cerebral metabolic rates for glucose  ...  rate for glucose (CMRgl).  ...  Introduction In order to transform [18F] 2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) images into quantitative measurements of the cerebral metabolic rate for glucose (CMRgl, in  ... 
doi:10.1088/0031-9155/52/23/019 pmid:18029993 fatcat:humnjrfj5zbfneajaekndybsnu

A Curve-Fitting Approach to Estimate the Arterial Plasma Input Function for the Assessment of Glucose Metabolic Rate and Response to Treatment

D. Vriens, L.-F. de Geus-Oei, W. J.G. Oyen, E. P. Visser
2009 Journal of Nuclear Medicine  
This function was fitted to 80 oncologic patients and verified for 40 different oncologic patients by areaunder-the-curve (AUC) comparison, Patlak glucose metabolic rate (MR glc ) estimation, and therapy  ...  Arterial sampling is invasive and often not feasible in practice; IDIFs are biased because of partial-volume effects and cannot be used when no large arterial blood pool is in the field of view.  ...  All images were analyzed using the Inveon Research Workplace (version 2.2; Siemens). Comparison of Calibrated Plasma Time-Activity Curves and Glucose Metabolic Rates.  ... 
doi:10.2967/jnumed.109.065243 pmid:19910436 fatcat:fi2xd2rje5fpdf6htzwfvzgx44

Diagnostic techniques to detect the epileptogenic zone: Pathophysiological and presurgical analysis of epilepsy in dogs and cats

Daisuke Hasegawa
2016 The Veterinary Journal  
A B S T R A C T The use and availability of magnetic resonance imaging (MRI) and other neurosurgical devices is rapidly increasing in the field of veterinarian medicine.  ...  These zones can now be detected by suitable modalities including ictal video monitoring, interictal non-invasive or invasive electroencephalography (EEG), ictal video-EEG, magnetoencephalography, structural  ...  EEGtriggered fMRI uses interictal spikes, that are recorded from simultaneously recording EEG, as the task and have been studied as a non-invasive method for the detection of the epileptogenic (irritative  ... 
doi:10.1016/j.tvjl.2016.03.005 pmid:27052436 fatcat:pcnxcjkfrnfg3c4ua34c2u4hry

How Acute Total Sleep Loss Affects the Attending Brain: A Meta-Analysis of Neuroimaging Studies

Ning Ma, David F. Dinges, Mathias Basner, Hengyi Rao
2015 Sleep  
Methods: The current version of the activation likelihood estimation (ALE) approach was used for meta-analysis.  ...  total sleep loss affects the attending brain: a meta-analysis of neuroimaging studies.  ...  Dinges is Editor in Chief of SLEEP and Dr.  ... 
doi:10.5665/sleep.4404 pmid:25409102 pmcid:PMC4288604 fatcat:bhipolmufffylb5nywfqi6iona

An input function estimation method for FDG-PET human brain studies

Hongbin Guo, Rosemary A. Renaut, Kewei Chen
2007 Nuclear Medicine and Biology  
Conclusions: A reliable semi-automated alternative for input function estimation which uses image-derived data augmented with 3 plasma samples is presented and evaluated for FDG-PET human brain studies  ...  The estimates of K for real data by graphical Patlak analysis using the recovered input function are almost identical to those obtained using arterial plasma samples with correlation coefficients greater  ...  We are interested in dynamic [ 18 F]-2-Deoxy-2-fluoro-D-glucose fluoro (FDG) PET which permits the estimation of the cerebral metabolic rate for glucose (CMRglc), and has been used for analyses of brain  ... 
doi:10.1016/j.nucmedbio.2007.03.008 pmid:17591548 pmcid:PMC2041796 fatcat:tvpuhrjtsbfctn6zoiiba2evpa

Functional imaging and language: A critical guide to methodology and analysis

Sophie K. Scott, Richard J.S. Wise
2003 Speech Communication  
The strengths and weaknesses of PET and fMRI are addressed, with reference to language studies.  ...  Other imaging methods, reliant on the pattern of electrical discharges associated with neural activity, have also been used clinically and experimentally, and provide excellent temporal resolution but  ...  Acknowledgements SKS is a Wellcome Career Development fellow, and RJSW is a Wellcome Senior Clinical fellow.  ... 
doi:10.1016/s0167-6393(02)00089-4 fatcat:itlam2nov5g2dbco7ezmtdwvyq

Computer-Assisted Analysis of Biomedical Images [article]

Leonardo Rundo
2021 arXiv   pre-print
Therefore, the computational analysis of medical and biological images plays a key role in radiology and laboratory applications.  ...  In conclusion, the ultimate goal of these research studies is to gain clinically and biologically useful insights that can guide differential diagnosis and therapies, leading towards biomedical data integration  ...  Positron Emission Tomography (PET) is a non-invasive nuclear medical imaging technique for studying functional characteristics of the human body [656] .  ... 
arXiv:2106.04381v1 fatcat:osqiyd3sbja3zgrby7bf4eljfm

Neonatal brain resting-state functional connectivity imaging modalities

Ali-Reza Mohammadi-Nejad, Mahdi Mahmoudzadeh, Mahlega S. Hassanpour, Fabrice Wallois, Otto Muzik, Christos Papadelis, Anne Hansen, Hamid Soltanian-Zadeh, Juri Gelovani, Mohammadreza Nasiriavanaki
2018 Photoacoustics  
Sasan Bahrami, and Dr. Armin Iraji for their input. This study was supported by the WSU's Michigan Translational Research and Commercialization (MTRAC) program and Wayne State Startup fund.  ...  Some groups have shown that the magnitude of rs-FC can be used to infer the cerebral metabolic rate of glucose [38] , while others have shown that brain regions exhibiting a high number of functional  ...  Many PET tracers are now available for the study of various processes such as local cerebral metabolic rates for glucose utilization and protein synthesis, benzodiazepine receptor binding, serotonin synthesis  ... 
doi:10.1016/j.pacs.2018.01.003 pmid:29511627 pmcid:PMC5832677 fatcat:e4ywj37zhng6vbfjbbw2cdu7pu

Brain PET Poster Sessions PP01-M01 to PP02-N07

2019 Journal of Cerebral Blood Flow and Metabolism  
Highthroughput rat brain PET imaging and automatic spatial normalization of the dopamine D2/3 receptor ligand [F-18]fallypride.  ...  Acknowledgements The authors would like to thank A. Leukona, X. Rı´os, V. Salinas for technical support in radiosynthesis and technical assistance in the PET studies.  ...  This study was funded by MINECO SAF2014-54070-JIN. Acknowledgements Funding from ANR CYCLOPS (ANR-15-CE17-0020) and RHU MARVELOUS (ANR-16-RHUS-0009)  ... 
doi:10.1177/0271678x19851018 pmid:31265793 pmcid:PMC6610575 fatcat:auejdo6e3rb2pjtxgqq6rkm7ie

[F-18]-Fluoro-2-deoxy-d-glucose positron emission tomography as a tool for early detection of immunotherapy response in a murine B cell lymphoma model

Coralie Chaise, Emmanuel Itti, Yolande Petegnief, Evelyne Wirquin, Christiane Copie-Bergman, Jean-Pierre Farcet, Marie-Hélène Delfau-Larue, Michel Meignan, Jean-Noël Talbot, Valérie Molinier-Frenkel
2006 Cancer Immunology and Immunotherapy  
Estimation of tumour growth and metabolism using the calculated 14 tumour volumes and maximum standardized uptake values respectively, also demonstrated 15 delayed lymphoma development and lower activity  ...  [F-18]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) is a non-2 invasive imaging technique which has recently been validated for the assessment of therapy 3 response in patients with  ...  of local cerebral glucose utilization: theory, procedure, and normal 23 values in the conscious and anesthetized albino rat.  ... 
doi:10.1007/s00262-006-0265-0 pmid:17171356 pmcid:PMC1919400 fatcat:hhm553shkrcd5l5amufr7qrgze

Spreading Depolarization-Induced Adenosine Accumulation Reflects Metabolic Status In Vitro and In Vivo

Britta E Lindquist, C William Shuttleworth
2014 Journal of Cerebral Blood Flow and Metabolism  
Spreading depolarization (SD), a pathologic feature of migraine, stroke and traumatic brain injury, is a propagating depolarization of neurons and glia causing profound metabolic demand.  ...  These findings suggest that adenosine accumulation could serve as a biomarker of SD incidence and severity, in a range of clinical conditions.  ...  a respiratory rate of~2 Hz and burst-suppression firing.  ... 
doi:10.1038/jcbfm.2014.146 pmid:25160669 pmcid:PMC4269755 fatcat:qy25r4cy5zf4vom7hmqvo3k4na

Novel Quantitative Approach in Functional and Structural Imaging of Brain in Normal Ageing and Neurodegenerative Disorders: Part II. Clinical Applications of Positron Emission Tomography

2019 Journal of Experimental and Clinical Neurosciences  
In addition, most early studies on age-related glucose metabolism used region of interest (ROI) analysis.  ...  Several studies have now characterized the effect of aging on the distribution of glucose metabolism using FDG-PET.  ...  FDG Imaging FDG-PET functions as a non-invasive method for evaluating organ function using regional and global glucose metabolism., FDG-PET measures glucose metabolism, which reflects net brain metabolism  ... 
doi:10.13183/jecns.v6i1.95 fatcat:33xp6e53ivd4vaardq5eztrr7e

Poster Viewing Session II

2017 Journal of Cerebral Blood Flow and Metabolism  
We conducted a Phase I clinical trial, Superselective Administration of VErapamil During Recanalization in Acute Ischemic Stroke (SAVER-I) to study safety and feasibility.  ...  Abstract Objectives: The aim of the study is to develop a cellbased neuro-restorative therapy model for stroke using a multi-disciplinary approach combining systems biology tools and computational modelling  ...  Conclusions: Minimally invasive 15 O-water PET with very small radiation dose yielded expected values of global and regional CBF using a non-invasive IDIF.  ... 
doi:10.1177/0271678x17695989 pmid:28366134 pmcid:PMC5441166 fatcat:no54qir44jemni3wacaipk5wxa

Metabolic information on staging FDG-PET–CT as a prognostic tool in the evaluation of 97 patients with gastric cancer

Nicholas A. Coupe, Deme Karikios, Shanley Chong, June Yap, Weng Ng, Neil Merrett, Michael Lin
2013 Annals of Nuclear Medicine  
Lee University of Ulsan College of Medicine, Korea 28 9 874-879 Evaluation of regional cerebral glucose metabolism in patients with malignant lymphoma of the body using statistical image analysis  ...  tissue and breast attenuationPerformance characteristics of a novel clustered multipinhole technology for simultaneous high-resolution SPECT/PET Usefulness of the Chang attenuation correction method with  ... 
doi:10.1007/s12149-013-0791-8 pmid:24297388 fatcat:s2kzytrtjfbejpyws6r5u2jb6q
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