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No-boundary thinking in bioinformatics research

Xiuzhen Huang, Barry Bruce, Alison Buchan, Clare Bates Congdon, Carole L Cramer, Steven F Jennings, Hongmei Jiang, Zenglu Li, Gail McClure, Rick McMullen, Jason H Moore, Bindu Nanduri (+10 others)
2013 BioData Mining  
We would like to promote the idea of supporting human-infrastructure (HI) with no-boundary thinking (NT) in bioinformatics (HINT).  ...  Should this be the bioinformatics research focus? We will discuss this issue in this review article.  ...  A new scientific thinking was presented and discussed at the workshop: No-boundary thinking in bioinformatics research.  ... 
doi:10.1186/1756-0381-6-19 pmid:24192339 pmcid:PMC3827872 fatcat:jevbg3cjufaz7nppiwoynvn7gu


2016 Biocomputing 2017  
We have previously defined this evolution and its impact as No-Boundary Thinking (NBT) in Bioinformatics 2,3 .  ...  No-Boundary Thinking in Bioinformatics The purpose of this workshop is to introduce and discuss the future of bioinformatics as a mature discipline.  ... 
doi:10.1142/9789813207813_0060 pmid:27897015 fatcat:tru7wdtknnbv3nmhhslru52ome

Inscribing a discipline: tensions in the field of bioinformatics

Jamie Lewis, Andrew Bartlett
2013 New genetics and society (Print)  
With bioinformatics positioned as service, it cannot determine its own boundaries but has them imposed from the outside.  ...  In order to render these mass inscriptions comprehensible, bioinformatic techniques are employed, with bioinformaticians producing what we call 'secondary inscriptions'.  ...  This work is part of the research programme of the ESRC Genomics Network at Cesagen.  ... 
doi:10.1080/14636778.2013.773172 fatcat:ovo6s5iwanc6dmuidhtf5fbkfu

Team building without boundaries

Andy Perkins, Joan Peckham, Tayo Obafemi-Ajayi, Xiuzhen Huang
2022 Proceedings of the 13th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics  
Essential to No Boundary Thinking (NBT) teams is proper formulation of the problem to be solved, and a basic tenant is that the NBT team must come together with diverse perspectives to decide the problem  ...  At this workshop we will discuss principles that scholars who have worked in NBT teams have discovered as effective.  ...  We will examine some of those in this workshop and see how No Boundary Thinking techniques can contribute to building effective teams to address large-scale scientific challenges.  ... 
doi:10.1145/3535508.3545596 fatcat:upzznwmh5rd2xjoj3as3eiov4e

Systems Biology: The Next Frontier for Bioinformatics

Vladimir A. Likić, Malcolm J. McConville, Trevor Lithgow, Antony Bacic
2010 Advances in Bioinformatics  
The inevitable role bioinformatics plays in modern systems biology puts mathematical and computational sciences as an equal partner to analytical and experimental biology.  ...  the analysis of biochemical systems; and in the past decade increasingly (iii) the use of near-comprehensive data sets derived from 'omics platform technologies, in particular "downstream" technologies  ...  However, that is only a matter of a degree, with often no clear boundary between bioinformatics and systems biology.  ... 
doi:10.1155/2010/268925 pmid:21331364 pmcid:PMC3038413 fatcat:swth66ao4fffnbcjdjkqu3xxgy

Choices and challenges

Potter Wickware
1997 Nature  
Given the boundaries that someone in bioinformatics must cross, perhaps the premium is justified.  ...  Saccone has already started a project in bioinformatics, but Italy's national research council (CNR), although admitting that the subject is important, says that there is no money to support it.  ... 
doi:10.1038/38806 fatcat:uwajyyvipjarnogf3wsinizgiu

Hidden in the Middle: Culture, Value and Reward in Bioinformatics

Jamie Lewis, Andrew Bartlett, Paul Atkinson
2016 Minerva  
In bioinformatics, the 'parent' disciplines have different value systems; for example, what is considered worthwhile research by computer scientists can be thought of as trivial by biologists, and vice  ...  The trend in big, interdisciplinary science is towards multiple authors on a single paper; in bioinformatics this has created hybrid or fractional  ...  As Gieryn (1983) writes, ''science is no single thing: its boundaries are drawn and redrawn in flexible, historically changing and sometimes ambiguous ways'' (p. 781).  ... 
doi:10.1007/s11024-016-9304-y pmid:27942075 pmcid:PMC5124041 fatcat:mfz2zk6n25gv7dyphubohoukmi

Walking the Line between Lab and Computation: The "Moist" Zone

Bart Penders, Klasien Horstman, Rein Vos
2008 BioScience  
(project no. 050-32-011, "Nutrigenomics and Society in the Making"), and we would like to thank all the nutrition scientists for their participation and cooperation.  ...  Acknowledgments We would like to acknowledge support from the Societal Component of Genomics Research Program of the Netherlands Organization for Scientific Research to B. P.  ...  I think about that too, but [I think] about what is missing as well.  ... 
doi:10.1641/b580811 fatcat:4y5smqpdvvdu7ee2bg3566fehi

Teaching Bioinformatics in Concert

Anya L. Goodman, Alex Dekhtyar, Joanne A. Fox
2014 PLoS Computational Biology  
The goal of the in-concert teaching approach is to introduce biology students to computational thinking by engaging them in collaborative projects structured around the software development process.  ...  Supporting Information Text S1 Syllabi from the courses taught in 2013. (PDF)  ...  Acknowledgments We thank Sally Elgin, Wilson Leung, and the members of the GEP community for discussions, support, and research opportunities for us and our students.  ... 
doi:10.1371/journal.pcbi.1003896 pmid:25411792 pmcid:PMC4238947 fatcat:5juwo4e7tbe6tlgx4vd53ft3tm

Bioinformatics: indispensable, yet hidden in plain sight?

Andrew Bartlett, Bart Penders, Jamie Lewis
2017 BMC Bioinformatics  
This variety allows bioinformaticians and bioinformatic work to contribute to much (if not most) of life science research in profound ways.  ...  We describe, in sociological terms, the character, power and future of bioinformatic work.  ...  In this commentary, which draws on our previously published research in sociology of science journals, we suggest some ways in which the sociology of the life sciences, and of bioinformatics in particular  ... 
doi:10.1186/s12859-017-1730-9 pmid:28637426 pmcid:PMC5480157 fatcat:cou2olokk5gmze7mtdqbd63bkq

Industrial Doctoral Students as Brokers between Industry and Academia

Lillemor Wallgren, Lars Owe Dahlgren
2007 Industry & higher education  
The students are located in three different industrial research schools -Management, Medical Bioinformatics and Building and Indoor Climate.  ...  The authors look at the learning context for 23 industrial doctoral students and assess the prerequisites for the development of their identity as researchers.  ...  The doctoral students in the Medical Bioinformatics research school participate in the work of the company but, above all, they participate in boundary processes between several university departments  ... 
doi:10.5367/000000007781236871 fatcat:ldiuorv5tffuvoa5xzl2omazfm

Proceedings of the 2018 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) conference

Jonathan D. Wren, Robert J. Doerkson, Inimary T. Toby, Bindu Nanduri, Ramin Homayouni, Prashanti Manda, Shraddha Thakkar
2019 BMC Bioinformatics  
Funding Funding for the publication of this editorial was authorized by and obtained from the Mid-South Computational Biology and Bioinformatics Society.  ...  Workshop III: "MCBIOS and No-Boundary Thinking Joint Bioinformatics Research workshop". Session chair -Steve Jennings, Ph.D., UALR.  ...  "Evolution as a metaphor for No Boundary Thinking", Scott M. Williams, Ph.D., Case Western Reserve University, Cleveland, Ohio.  ... 
doi:10.1186/s12859-019-2618-7 fatcat:ye2ku5xo4zgx7fpdvzpoacfu3i

Voronoi Diagram and Delaunay Triangulation: Applications and Challenges in Bioinformatics

Binhai Zhu
2006 2006 3rd International Symposium on Voronoi Diagrams in Science and Engineering  
I think that Voronoi Diagram and Delaunay Triangulation can play important roles in handling these problems.  ...  bioinformatics.  ... 
doi:10.1109/isvd.2006.38 dblp:conf/isvd/Zhu06 fatcat:l2xc56syzbelzdzarbzizbl564

Big data - a 21st century science Maginot Line? No-boundary thinking: shifting from the big data paradigm

Xiuzhen Huang, Steven F Jennings, Barry Bruce, Alison Buchan, Liming Cai, Pengyin Chen, Carole L Cramer, Weihua Guan, Uwe KK Hilgert, Hongmei Jiang, Zenglu Li, Gail McClure (+13 others)
2015 BioData Mining  
This work was also partially supported by the National Institute of Health grants from the National Center for Research Resources (P20RR016460) and the National Institute of General Medical Sciences (P20GM103429  ...  No-boundary thinking We are proposing No-Boundary Thinking (NBT) to address real scientific challenges and to help science advance. Last year, we introduced the NBT concept [11] .  ...  Currently the core of NBT is applying no-boundary thinking in problem defining. NBT is not just adjusting the starting point from problem solving to problem defining, either.  ... 
doi:10.1186/s13040-015-0037-5 pmid:25670967 pmcid:PMC4323225 fatcat:xtrojiy4zrbrzj22kq2fqoey5i
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