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No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers

Elsmarieke van de Giessen, Swen Hesse, Matthan W.A. Caan, Franziska Zientek, John C. Dickson, Livia Tossici-Bolt, Terez Sera, Susanne Asenbaum, Renaud Guignard, Umit O. Akdemir, Gitte M. Knudsen, Flavio Nobili (+7 others)
2013 NeuroImage  
In this study, we tested whether BMI and striatal DAT availability are associated. Methods: The study included 123 healthy individuals from a large European multi-center database.  ...  Conclusion: The lack of an association between BMI and striatal DAT availability suggests that the regulation of striatal synaptic dopamine levels by DAT plays no or a limited role in the pathophysiology  ...  Introduction Overweight and obesity are an increasing health problem worldwide and are defined as a body mass index (BMI) of 25-30 and >30 kg/m 2 , respectively.  ... 
doi:10.1016/j.neuroimage.2012.09.011 pmid:22982354 fatcat:b7ioh647sre6rp7uaxuw2el6gm

Applications of Radiotracer Imaging Poster Abstracts

2012 Journal of Cerebral Blood Flow and Metabolism  
The purpose of this study was to examine the relationships between age and both in vivo fibrillary amyloid deposition and glucose metabolism in AD.  ...  Linear regression analyses showed negative associations between visuo-spatial functioning and parietal [ 11 C]Pittsburgh compound-B binding for younger patients (standardized b: À0.37) and between visuo-spatial  ...  Methods: To examine whether morbid obesity is associated with changes in brain m-opioid receptor binding we recruited 17 morbidly obese women (mean body mass index [BMI] 41.9, mean age 43) and 9 normal-weight  ... 
doi:10.1038/jcbfm.2012.78 fatcat:2uvqdqlwsfgexhr5qno2gjfmqe

Food addiction A common neurobiological mechanism with drug abuse

Gene-Jack Wang
2018 Frontiers in Bioscience  
A select few studies have used PET imaging with radioligands binding to serotonin receptors and transporters in healthy volunteers to study the relationship of receptor or transporter binding to BMI, as  ...  Obesity, as defined by a body mass index (BMI) greater than 30 kg/m 2 , also proves to be simpler and more objective to measure than food addiction, and therefore it is more common to study obese populations  ... 
doi:10.2741/4618 pmid:28930574 fatcat:mjfhvuleyjcyra5lxdsbjheoba

Imaging in cell-based therapy for neurodegenerative diseases

Deniz Kirik, Nathalie Breysse, Tomas Björklund, Laurent Besret, Philippe Hantraye
2005 European Journal of Nuclear Medicine and Molecular Imaging  
A multi-center study that will allow the involvement of a number of patients large enough to carry out a valid group analysis, and therefore the comparison of a treated group with a matched control one  ...  Panel E and F: Diffusion weighted imaging (E) and fiber tracking (F) in a human volunteer.  ... 
doi:10.1007/s00259-005-1909-6 pmid:16267643 fatcat:hzywexbtsffyhg67gakr5oeo54

Neuro-Cognitive Effects of Acute Tyrosine Administration on Reactive and Proactive Response Inhibition in Healthy Older Adults

Mirjam Bloemendaal, Monja Isabel Froböse, Joost Wegman, Bram Bastiaan Zandbelt, Ondine van de Rest, Roshan Cools, Esther Aarts
2018 eNeuro  
However, no study has directly compared the effects of a catecholamine precursor on reactive and load-dependent proactive inhibition.  ...  In this study we explored the effects of tyrosine on reactive and proactive response inhibition and signal in dopaminergically innervated fronto-striatal regions.  ...  Acknowledgements: We thank Ilke van Loon and Ratigha Varatheeswaran for help with data collection and data processing.  ... 
doi:10.1523/eneuro.0035-17.2018 pmid:30094335 pmcid:PMC6084775 fatcat:cyeqvck27zdsbntgsfabeji6iu

Neuro-Cognitive Effects of Acute Tyrosine Administration on Reactive and Proactive Response Inhibition in Healthy Older Adults

Mirjam Bloemendaal, Monja Froboese, Bram Zandbelt, Ondine Rest, van de, Roshan Cools, Esther Aarts
2017 Social Science Research Network  
However, no study has directly compared the effects of a catecholamine precursor on reactive and load-dependent proactive inhibition.  ...  In this study we explored the effects of tyrosine on reactive and proactive response inhibition and signal in dopaminergically innervated fronto-striatal regions.  ...  Acknowledgements: We thank Ilke van Loon and Ratigha Varatheeswaran for help with data collection and data processing.  ... 
doi:10.2139/ssrn.3037114 fatcat:az6rviwvonbsjepjp2tfpyyg3u

Brain PET Poster Sessions PP01-M01 to PP02-N07

2019 Journal of Cerebral Blood Flow and Metabolism  
Highthroughput rat brain PET imaging and automatic spatial normalization of the dopamine D2/3 receptor ligand [F-18]fallypride.  ...  Acknowledgements The authors would like to thank A. Leukona, X. Rı´os, V. Salinas for technical support in radiosynthesis and technical assistance in the PET studies.  ...  This study was funded by MINECO SAF2014-54070-JIN. Acknowledgements Funding from ANR CYCLOPS (ANR-15-CE17-0020) and RHU MARVELOUS (ANR-16-RHUS-0009)  ... 
doi:10.1177/0271678x19851018 pmid:31265793 pmcid:PMC6610575 fatcat:auejdo6e3rb2pjtxgqq6rkm7ie

Progress in Genetic Polymorphisms Related to Lipid Disturbances Induced by Atypical Antipsychotic Drugs

Nana Li, Ting Cao, Xiangxin Wu, Mimi Tang, Daxiong Xiang, Hualin Cai
2020 Frontiers in Pharmacology  
Apart from clinical studies, in vitro and in vivo evidence is also analyzed to support related theories.  ...  Research on pharmacogenomics indicates that gene polymorphisms involved in the pathways controlling food intake and lipid metabolism may play a significant role.  ...  In a human study, the striatal dopamine transporter availability was negatively correlated with body mass index (BMI) in a group of healthy volunteers .  ... 
doi:10.3389/fphar.2019.01669 pmid:32116676 pmcid:PMC7011106 fatcat:twwzay3p65b6dhenyurzgcnlta

Panel and Study Groups

2013 Neuropsychopharmacology  
A second SNP in NKCC1, rs3087889, is also associated with increased risk for schizophrenia and a novel transcripts for NKCC1 (po.03).  ...  Moreover, both switches are associated with rs3749034, a SNP in the GAD1 promoter associated with increased risk for schizophrenia (po.05 for GAD25 and GAD67 and po.004)).  ...  There were no significant differences between the two groups in week 8 changes for body weight, body mass index, waist circumference, as well as various measures of lipid particles (p's40.100).  ... 
doi:10.1038/npp.2013.278 fatcat:expu2u3f3reypazj7tt7jhybfa

Poster Session I

2010 Neuropsychopharmacology  
In a subset of subjects, preliminary investigations show a significant correlation (r ¼ 0.56) between delayed discounting and cocaine place preference.  ...  While the underlying biochemistry of ADHD is poorly understood, reduced cortical dopamine levels have been implicated in a number of studies.  ...  There was a direct association between the magnitude of the reduction in viral load and the HDRS score (po0.03).  ... 
doi:10.1038/npp.2010.216 fatcat:v3q2xjxc45b2hckv33pzz7mtee

The 4th Schizophrenia International Research Society Conference, 5–9 April 2014, Florence, Italy: A summary of topics and trends

Olukayode Abayomi, Davide Amato, Candace Bailey, Byron Bitanihirwe, Lynneice Bowen, Shimon Burshtein, Alexis Cullen, Montserrat Fusté, Ana P. Herrmann, Babak Khodaie, Sanja Kilian, Qortni A. Lang (+19 others)
2014 Schizophrenia Research  
Anne O'Shea collected the reports and put them in to one manuscript in order and organized the references. Dr. DeLisi then edited the manuscript for accuracy, language and scholarship.  ...  Conflict of interest The authors declare that there are no conflicts of interest.  ...  Acknowledgments The information in this report and the accuracy of each statement were the sole responsibility of each rapporteur and based on personal interpretation of what was heard.  ... 
doi:10.1016/j.schres.2014.08.032 pmid:25306204 pmcid:PMC4394607 fatcat:lhwpf5jvd5g2hlsutb44qojrvi

Panel Session Co-Morbid Pain and Addiction: Novel Treatments

2006 Neuropsychopharmacology  
Interestingly, there was no difference in [I-123]5-IA uptake in the caudate, putamen and cerebellum between the schizophrenic and control smokers.  ...  Postmortem studies have showed higher nicotinic agonist binding in the frontal cortex and hippocampus in control smokers compared to nonsmokers, but not in schizophrenic smokers suggesting a dysfunction  ...  The Time Course of Antipsychotics Versus Placebo: On Overall Efficacy, Positive, Negative and Cognitive Symptoms John M. Davis*  ... 
doi:10.1038/sj.npp.1301265 fatcat:6odqjmshuncm5muxk5g5knprui

Abstracts of the 4th World Parkinson Congress, September 20–23, 2016, Portland, OR, USA

2016 Journal of Parkinson's Disease  
PD is a multi-system disorder and although dopaminergic replacement therapies are highly effective for ameliorating motor symptoms, other features of the disease require a more holistic approach.  ...  Another type of false sensation, called "presence hallucinations," are a feeling that someone or something is behind or nearby, when there is no one there.  ...  In addition, quantification of striatal dopamine transporter (DAT) expression was performed by western blot.  ... 
doi:10.3233/jpd-169900 pmid:27589541 fatcat:ld522ggsvvceriigc4fi7e5g7q

Poster Session III

2010 Neuropsychopharmacology  
Discussion: Our hypothesis is that given the opposite signaling between 5-HT6 receptors and dopamine D2 receptors in striatopallidal MSNs, selective over-expression of 5-HT6 receptors in these neurons  ...  Background: Schizophrenia is a severe neuropsychiatric disease that at present has no cure.  ...  Pretreatment with MCD eliminated cholesterol and flotillin from fractions 4-5 with no effect on transferrin receptor or total protein localization.  ... 
doi:10.1038/npp.2010.218 fatcat:i5knteqsgveybffza7g6b4iqei

Poster Session II

2005 Neuropsychopharmacology  
Within cocaine dependent subjects there was a significant positive correlation between years of cocaine use and λ2. There was no significant difference between groups for λ 1.  ...  All 7 segments of the corpus callosum were compared between cocaine users and controls for using a Mixed Model ANOVA for λ1 and λ2.  ...  Schizophrenia is Associated with Increased Synaptic Dopamine in Associative Rather than Limbic Regions of the Striatum Marc Laruelle*, Lawrence S Kegeles, Gordon W Frankle, Raj Narendran, Roberto Gil,  ... 
doi:10.1038/sj.npp.1300970 fatcat:ikayo4dkwrdrthgopr2hltn2hi
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