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Task-irrelevant financial losses inhibit the removal of information from working memory

Sean James Fallon, Nina Dolfen, Francesca Parolo, Nahid Zokaei, Masud Husain
2019 Scientific Reports  
The receipt of financial rewards or penalties - though task-irrelevant - may exert an obligatory effect on manipulating items in working memory (WM) by constraining a forthcoming shift in attention or reinforcing attentional shifts that have previously occurred. Here, we adjudicate between these two hypotheses by varying - after encoding- the order in which task-irrelevant financial outcomes and cues indicating which items need to be retained in memory are presented (so called retrocues). We
more » ... loyed a "what-is-where" design that allowed for the fractionation of WM recall into separate components: identification, precision and binding (between location and identity). Principally, valence-dependent effects were observed only for precision and binding, but only when outcomes were presented before, rather than after, the retrocue. Specifically, task-irrelevant financial losses presented before the retrocue caused a systematic breakdown in binding (misbinding), whereby the features of cued and non-cued memoranda became confused, i.e., the features that made up relevant memoranda were displaced by those of non-cued (irrelevant) items. A control experiment, in which outcomes but no cues were presented, failed to produce the same effects, indicating that the inclusion of retrocues were necessary for generating this effect. These results show that the receipt of financial penalties - even when uncoupled to performance - can prevent irrelevant information from being effectively pruned from WM. These results illustrate the importance of reward-related processing to controlling the contents of WM.
doi:10.1038/s41598-018-36826-x pmid:30737421 pmcid:PMC6368543 fatcat:hn7wf733szbllncobvkhlv6lfm

Ignoring versus updating in working memory reveal differential roles of attention and feature binding

Sean J. Fallon, Rozemarijn M. Mattiesing, Nina Dolfen, Sanjay G. Manohar, Masud Husain
2018 Cortex  
Binding Irrelevant information a b s t r a c t Ignoring distracting information and updating current contents are essential components of working memory (WM). Yet, although both require controlling irrelevant information, it is unclear whether they have the same effects on recall and produce the same level of misbinding errors (incorrectly joining the features of different memoranda). Moreover, the likelihood of misbinding may be affected by the feature similarity between the items already
more » ... ed into memory and the information that has to be filtered out (ignored) or updated into memory. Here, we investigate these questions. Participants were sequentially presented with two pairs of arrows. The first pair of arrows always had to be encoded into memory, but the second pair either had to be ignored (ignore condition) or allowed to displace the previously encoded items (update condition). To investigate the effect of similarity on recall, we also varied, in a factorial manner, whether the items that had to be ignored or updated were presented in the same or different colours and/or same or different spatial locations to the original memoranda. By applying a computational model, we were able to quantify the levels of misbinding. Ignoring, but not updating, increased overall recall error as well as misbinding rates, even when accounting for the retention period. This indicates that not all manipulations of attention in WM are equal in terms of their effects on recall and misbinding. Misbinding rates in the ignore condition were affected by the colour and spatial congruence of relevant and irrelevant information to a greater extent than in the update condition. This finding suggests that attentional templates are used to evaluate relevant and irrelevant information in different ways during ignoring and updating. Together, the results suggest that differences between the two functions might occur due to higher levels of attentional compartmentalisation e or protection e during updating compared to ignoring.
doi:10.1016/j.cortex.2017.12.016 pmid:29402388 pmcid:PMC6181802 fatcat:g74f6xgkwfewvh6ntg76xwat4i

Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation [article]

Mareike A. Gann, Bradley R. King, Nina Dolfen, Menno P. Veldman, Kimberly L. Chan, Nicolaas A. J. Puts, Richard A. E. Edden, Marco Davare, Stephan P. Swinnen, Dante Mantini, Edwin M. Robertson, Geneviève Albouy
2020 bioRxiv   pre-print
While it is widely accepted that motor sequence learning (MSL) is supported by a prefrontal-mediated interaction between hippocampal and striatal networks, it remains unknown whether the functional responses of these networks can be modulated in humans with targeted experimental interventions. The present proof-of-concept study employed a comprehensive multimodal neuroimaging approach, including functional magnetic resonance (MR) imaging and MR spectroscopy, to investigate whether
more » ... ailored theta-burst stimulation of the dorsolateral prefrontal cortex can modulate responses in the hippocampus and striatum during motor learning. Our results indicate that stimulation influenced task-related connectivity patterns within hippocampo-frontal and striatal networks. Stimulation also altered the relationship between the levels of gamma-aminobutyric acid (GABA) in the stimulated prefrontal cortex and learning-related changes in both activity and connectivity in fronto-striato-hippocampal networks. This study provides the first experimental evidence that brain stimulation can alter motor learning-related functional responses in the striatum and hippocampus.
doi:10.1101/2020.06.05.136531 fatcat:nj52h2orkrg5logktmh77zgege

Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation

Mareike A. Gann, Bradley R. King, Nina Dolfen, Menno P. Veldman, Kimberly L. Chan, Nicolaas A.J. Puts, Richard A.E. Edden, Marco Davare, Stephan P. Swinnen, Dante Mantini, Edwin M. Robertson, Geneviève Albouy
2021 NeuroImage  
Dolfen : Investigation; Methodology; Writing -review and editing Menno Veldman : Investigation; Writing -review and editing Kimberly Chan : Resources; Software; Methodology; Writing -review and editing  ...  Investigation; Visualization; Writing -original draft; Writing -review and editing Bradley King : Conceptualization; Resources; Data curation; Software; Formal analysis; Validation; Writing -review and editing Nina  ... 
doi:10.1016/j.neuroimage.2021.118158 pmid:33991699 fatcat:s5nkw2s2lbbkjoqp2z3k5547fm

Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults

Bradley R. King, Jost‐Julian Rumpf, Elvire Verbaanderd, Kirstin F. Heise, Nina Dolfen, Stefan Sunaert, Julien Doyon, Joseph Classen, Dante Mantini, Nicolaas A. J. Puts, Richard A. E. Edden, Geneviève Albouy (+1 others)
2020 Human Brain Mapping  
., 2015; Dolfen, King, Schwabe, Swinnen, & Albouy, 2019) , the percentage of correct transitions was high in the current study (92% on average) and participants, on average, did not exhibit practice-dependent  ...  2019) and acquiring data from other ROIs, including motor learning-relevant deep structures such as the hippocampus and striatum (see Albouy, King, Maquet, & Doyon, 2013; King, Hoedlmoser, Hirschauer, Dolfen  ... 
doi:10.1002/hbm.25041 pmid:32583940 pmcid:PMC7416055 fatcat:affqfagp5ngxhmqjrg57mxdyhm

Connectivity in Large-Scale Resting-State Brain Networks Is Related to Motor Learning: A High-Density EEG Study

Simon Titone, Jessica Samogin, Philippe Peigneux, Stephan Swinnen, Dante Mantini, Genevieve Albouy
2022 Brain Sciences  
Acknowledgments: Gratitude to those who assisted with collection of overnight sleep data, including Chloe Van Massenhove, Emma Osaer, Marte Eelen, Larissa Naulaerts, Marieke Gann, Menno Veldman, Nina Dolfen  ... 
doi:10.3390/brainsci12050530 pmid:35624919 fatcat:h3rgzyz27rgepl3s3qax6ln3me