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COURLIS (COURs en LIgne de Statistiques appliquées) Un MOOC francophone innovant

François Kohler, Nicolas Jay, Florence Ducreau, Gérard Casanova, Chantal Kohler, Albert-Claude Benhamou
2013 HEGEL - HEpato-GastroEntérologie Libérale  
doi:10.4267/2042/49205 fatcat:6zooqhppnjhhdlrtntxyshjzfm

COURLIS (COURs en LIgne de Statistiques appliquées). Un MOOC francophone innovant

François Kohler, Nicolas Jay, Florence Ducreau, Gérard Casanova, Chantal Kohler, Albert-Claude Benhamou
2013 HEGEL - HEpato-GastroEntérologie Libérale  
Distribution électronique pour ALN éditions. © ALN éditions. Tous droits réservés pour tous pays. La reproduction ou représentation de cet article, notamment par photocopie, n'est autorisée que dans les limites des conditions générales d'utilisation du site ou, le cas échéant, des conditions générales de la licence souscrite par votre établissement. Toute autre reproduction ou représentation, en tout ou partie, sous quelque forme et de quelque manière que ce soit, est interdite sauf
more » ... ccord préalable et écrit de l'éditeur, en dehors des cas prévus par la législation en vigueur en France. Il est précisé que son stockage dans une base de données est également interdit.
doi:10.3917/heg.031.0027 fatcat:laaldezfivhzvhuwab5xhdk27m

The anti-snoring bed - a pilot study

Elisabeth Wilhelm, Francesco Crivelli, Nicolas Gerig, Malcolm Kohler, Robert Riener
2020 Sleep Science and Practice  
Purpose Avoiding supine position can reduce snoring in most habitual snorers. However, devices that restrict the sleeping position cause discomfort or disrupt sleep resulting in low compliance. Therefore, mechanisms, which lift the trunk of the user without disturbing sleep, have been proposed. We present the first study, which investigates whether individual interventions provided by beds with lifting mechanisms are able to stop snoring (success rate) and whether they reduce the snoring index
more » ... number of total snores divided by total time in bed) using a repeated measures design. In addition, we investigated whether the intervention is interfering with the subjective sleep quality. Methods Twenty-two subjects were observed for four nights (adaptation, baseline, and two intervention nights). During intervention nights, the bed lifted the trunk of the user in closed-loop manner. Subjects were divided in three groups (non-snorer, snorer one, and snorer two). Non-snorers were lifted by the bed at random time points during the night. In group snorer one, a stepwise increase of the bed inclination was compared with going directly to a randomly selected angle. In group snorer two, the influence of a small inclination angle (10 ∘) and a big inclination angle (20 ∘) was compared. Results Snoring was stopped successfully in 22% (small angle) and 67% (big angle) of the interventions. This did not lead to a significant reduction in the snoring index. The subjective sleep quality was not reduced by the intervention. Conclusion The anti-snoring bed is able to stop individual episodes of habitual snoring without reducing the subjective sleep quality. Trial Registration, no. NCT04053738, registered 12 August 2019 - Retrospectively registered,
doi:10.1186/s41606-020-00050-2 fatcat:2p7vnqzphjbepoyzmamgxgagd4

Cancer patient flows discovery in DRG databases

Nicolas Jay, Amedeo Napoli, François Kohler
2006 Studies in Health Technology and Informatics  
In France, cancer care is evolving to the design of regional networks, so as to coordinate expertise, services and resources allocation. Existing information systems along with data-mining tools can provide better knowledge on the distribution of patient flows. We used one year data of the French Diagnosis Related Groups (DRGs) based system to perform our analysis. Formal Concept Analysis has been used to build Iceberg Lattices of cancer patient flows in the French region of Lorraine. This
more » ... ervised conceptual clustering method allowed us to describe patients flows with an easily understandable visual representation.
pmid:17108601 fatcat:mohtldc4qvgwxjnklhrijzz5ou

Functional role of Polymerase IV during pollen development in Capsella [article]

Zhenxing Wang, Nicolas Butel, Juan Santos-González, Filipe Borges, Jun Yi, Robert A Martienssen, German Martinez, Claudia Köhler
2019 bioRxiv   pre-print
author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors ( is: Claudia Kohler  ...  ., and Köhler, C. (2015). mediated transformation of Arabidopsis thaliana.  ...  ., Kohler, C., and mediate genome dosage response in Arabidopsis. Nat Genet 50: 186-192.  ... 
doi:10.1101/863522 fatcat:kml4z43lxjhpjhwrkzzyumy6ry

Evaluation of the Utility of in utero Treatment of Twin Anemia-Polycythemia Sequence

Nicolas Sananès, Marine Veujoz, Francois Severac, Maël Barthoulot, Nicolas Meyer, Anne-Sophie Weingertner, Monique Kohler, Fernando Guerra, Adrien Gaudineau, Israël Nisand, Romain Favre
2015 Fetal Diagnosis and Therapy  
diff >0) = 99.4%], and the neonatal transfusion rate was lower [diff = -30.5% (-60, 0), Pr (diff >0) = 2.6%] in the treated group. Conclusion: In utero treatment for TAPS is associated with a higher resolution rate of TAPS and a longer time between diagnosis and birth, but overall mortality is the same as with expectant management. Abstract Objective: The aim of this study is to evaluate the interest in the in utero treatment of twin anemia-polycythemia sequence (TAPS). Methods: The obstetrical
more » ... and neonatal data on all cases of TAPS followed up in our institution between 2006 and 2013 were reviewed. Statistical analyses were conducted using Bayesian methods. Results: Twenty cases of TAPS were included. Laser therapy or intrauterine transfusion (IUT) was performed on the donor twin in 9 cases. Eleven cases were included in the 'nontreated' group (managed expectantly or diagnosed at birth). The gestational age at diagnosis was lower in the group with treated TAPS [difference (diff) = -22.20 days (-57.13, 14.28), probability (Pr) (diff >0) = 10.6%]. The rate of preterm premature rupture of membranes was higher in the group with treated TAPS [diff = 22.5% (-14, 57), Pr (diff >0) = 89%], but overall mortality was similar. The interval between diagnosis and delivery was longer [diff = 44.37 days (9.41, 77.90), Pr (diff >0) = 99.2%], the TAPS resolution rate was higher [diff = 49.9% (12, 81), Pr
doi:10.1159/000380822 pmid:25790745 fatcat:42iiq5262zcsdo52dujanugylm

Digital Concrete: Opportunities and Challenges

Timothy Wangler, Ena Lloret, Lex Reiter, Norman Hack, Fabio Gramazio, Matthias Kohler, Mathias Bernhard, Benjamin Dillenburger, Jonas Buchli, Nicolas Roussel, Robert Flatt
2016 RILEM Technical Letters  
Digital fabrication has been termed the "third industrial revolution" in recent years, and promises to revolutionize the construction industry with the potential of freeform architecture, less material waste, reduced construction costs, and increased worker safety. Digital fabrication techniques and cementitious materials have only intersected in a significant way within recent years. In this letter, we review the methods of digital fabrication with concrete, including 3D printing, under the
more » ... ompassing term "digital concrete", identifying major challenges for concrete technology within this field. We additionally provide an analysis of layered extrusion, the most popular digital fabrication technique in concrete technology, identifying the importance of hydration control in its implementation.
doi:10.21809/rilemtechlett.2016.16 fatcat:3mxy5ta3jravpmhdikcfbta6ve

Transgenerational effect of mutants in the RNA-directed DNA methylation pathway on the triploid block [article]

Zhenxing Wang, Nicolas Butel, Juan Santos-González, Lauriane Simon, Cecilia Wärdig, Claudia Köhler
2020 bioRxiv   pre-print
, 629 Martinez, G., and Köhler, C. (2020).  ...  F., Parent, J.S., van Ex, F., Wolff, P., Martinez, G., Köhler, C., and485 Martienssen, R.A. (2018).  ... 
doi:10.1101/2020.09.08.288001 fatcat:kxwqilcs7zh2lmtd3m752ozkl4

Searches for direct pair production of third generation squarks with the ATLAS detector

Nicolas Köhler, Y. Aharonov, L. Bravina, S. Kabana
2018 EPJ Web of Conferences  
Naturalness arguments for weak-scale supersymmetry favour supersymmetric partners of the third generation quarks with masses not too far from those of their Standard Model counterparts. Top or bottom squarks with masses less than or around one TeV can also give rise to direct pair production rates at the Large Hadron Collider (LHC) that can be observed in the data sample recorded by the ATLAS detector. This document presents recent ATLAS results from searches for direct top and bottom squark
more » ... r production considering both R-parity conserving and R-parity violating scenarios, using the data collected during the LHC Run 2 at a centre-of-mass energy of √ s = 13 TeV. Summary of the searches R-parity conserving scenarios Assuming R-parity conservation, supersymmetric particles are produced in pairs and the LSP is stable. Since it escapes the detector without any interaction, signatures with large missing tranverse momena
doi:10.1051/epjconf/201818202065 fatcat:ri2ijqbpf5h7npsdq2mzcwebxq

Biodegradation of Microcystins during Gravity-Driven Membrane (GDM) Ultrafiltration

Esther Kohler, Jörg Villiger, Thomas Posch, Nicolas Derlon, Tanja Shabarova, Eberhard Morgenroth, Jakob Pernthaler, Judith F. Blom, Rajeev Misra
2014 PLoS ONE  
Gravity-driven membrane (GDM) ultrafiltration systems require little maintenance: they operate without electricity at ultralow pressure in dead-end mode and without control of the biofilm formation. These systems are already in use for water purification in some regions of the world where adequate treatment and distribution of drinking water is not readily available. However, many water bodies worldwide exhibit harmful blooms of cyanobacteria that severely lower the water quality due to the
more » ... uction of toxic microcystins (MCs). We studied the performance of a GDM system during an artificial Microcystis aeruginosa bloom in lake water and its simulated collapse (i.e., the massive release of microcystins) over a period of 21 days. Presence of live or destroyed cyanobacterial cells in the feed water decreased the permeate flux in the Microcystis treatments considerably. At the same time, the microbial biofilms on the filter membranes could successfully reduce the amount of microcystins in the filtrate below the critical threshold concentration of 1 mg L 21 MC for human consumption in three out of four replicates after 15 days. We found pronounced differences in the composition of bacterial communities of the biofilms on the filter membranes. Bacterial genera that could be related to microcystin degradation substantially enriched in the biofilms amended with microcystin-containing cyanobacteria. In addition to bacteria previously characterized as microcystin degraders, members of other bacterial clades potentially involved in MC degradation could be identified.
doi:10.1371/journal.pone.0111794 pmid:25369266 pmcid:PMC4219780 fatcat:mifyxtte6ndqpi6hzqohrw5uwm

Polymerase IV Plays a Crucial Role in Pollen Development in Capsella

Zhenxing Wang, Nicolas Butel, Juan Santos-González, Filipe Borges, Jun Yi, Robert Martienssen, German Martinez, Claudia Köhler
2020 The Plant Cell  
In Arabidopsis thaliana, the DNA-dependent RNA polymerase IV (Pol IV) is required for the formation of transposable element (TE)-derived small RNA (sRNA) transcripts. These transcripts are processed by DICER-LIKE 3 into 24-nt small interfering RNAs (siRNAs) that guide RNA-dependent DNA methylation. In the pollen grain, Pol IV is also required for the accumulation of 2½2-nt epigenetically-activated siRNAs (easiRNAs) that likely silence TEs by post-transcriptional mechanisms. Despite this
more » ... functional role, loss of Pol IV function in Arabidopsis does not cause a discernable pollen defect. Here, we show that loss of NRPD1, encoding the largest subunit of Pol IV in the Brassicaceae Capsella rubella, causes post-meiotic arrest of pollen development at the microspore stage. As in Arabidopsis, all TE-derived siRNAs were depleted in Capsella nrpd1 microspores. In wild-type background, we found that the same TEs produced 2½2-nt and 24-nt siRNAs and the formation of both types of siRNAs required Pol IV activity. Arrest of Capsella nrpd1 microspores was accompanied by deregulation of genes targeted by Pol IV-dependent siRNAs. The distance of TEs to genes was much closer in Capsella rubella compared to Arabidopsis thaliana, providing a possible explanation for the essential role of Pol IV for pollen development in Capsella. Our study in Capsella uncovers a functional requirement of Pol IV in microspores, emphasizing the relevance of investigating different plant models.
doi:10.1105/tpc.19.00938 pmid:31988265 pmcid:PMC7145478 fatcat:u6jhxxvs7ra6pmcpuwegyo7fia

A Framework for Assessing Import Costs of Medical Supplies and Results for a Tuberculosis Program in Karakalpakstan, Uzbekistan

Stefan Kohler, Norman Sitali, Nicolas Paul
2021 Health Data Science  
Background. Import of medical supplies is common, but limited knowledge about import costs and their structure introduces uncertainty to budget planning, cost management, and cost-effectiveness analysis of health programs. We aimed to estimate the import costs of a tuberculosis (TB) program in Uzbekistan, including the import costs of specific imported items. Methods. We developed a framework that applies costing and cost accounting to import costs. First, transport costs, customs-related
more » ... cargo weight, unit weights, and quantities ordered were gathered for a major shipment of medical supplies from the Médecins Sans Frontières (MSF) Procurement Unit in Amsterdam, the Netherlands, to a TB program in Karakalpakstan, Uzbekistan, in 2016. Second, air freight, land freight, and customs clearance cost totals were estimated. Third, total import costs were allocated to different cargos (standard, cool, and frozen), items (e.g., TB drugs), and units (e.g., one tablet) based on imported weight and quantity. Data sources were order invoices, waybills, the local MSF logistics department, and an MSF standard product list. Results. The shipment contained 1.8 million units of 85 medical items of standard, cool, and frozen cargo. The average import cost for the TB program was 9.0% of the shipment value. Import cost varied substantially between cargos (8.9–28% of the cargo value) and items (interquartile range 4.5–35% of the item value). The largest portion of the total import cost was caused by transport (82–99% of the cargo import cost) and allocated based on imported weight. Ten (14%) of the 69 items imported as standard cargo were associated with 85% of the standard cargo import cost. Standard cargo items could be grouped based on contributing to import costs predominantly through unit weight (e.g., fluids), imported quantity (e.g., tablets), or the combination of unit weight and imported quantity (e.g., items in powder form). Conclusion. The cost of importing medical supplies to a TB program in Karakalpakstan, Uzbekist [...]
doi:10.34133/2021/9813732 doaj:c37d71d28e864dfc8ab651a326e3cc95 fatcat:3qg3ixnejbchtbzgicacngox6e

Representing glycophenotypes: semantic unification of glycobiology resources for disease discovery

Jean-Philippe F Gourdine, Matthew H Brush, Nicole A Vasilevsky, Kent Shefchek, Sebastian Köhler, Nicolas Matentzoglu, Monica Munoz-Torres, July McMurry, Xingmin Aaron Zhang, Melissa A Haendel
2019 Zenodo  
While abnormalities related to carbohydrates (glycans) are frequent for patients with rare and undiagnosed diseases as well as in many common diseases, these glycan-related phenotypes (glycophenotypes) are not well represented in knowledge bases (KBs). If glycan related diseases were more robustly represented and curated with glycophenotypes, these could be used for molecular phenotyping to help realize the goals of precision medicine. Diagnosis of rare diseases by computational cross-species
more » ... mparison of genotype-phenotype data has been facilitated by leveraging ontological representations of clinical phenotypes, using Human Phenotype Ontology (HPO), and model organism ontologies such as Mammalian Phenotype Ontology (MP) in the context of the Monarch Initiative. In this article, we discuss the importance and complexity of glycobiology, and review the structure of glycan-related content from existing KBs and biological ontologies. We show how semantically structuring knowledge about annotation of glycophenotypes could enhance disease diagnosis, and propose a solution to integrate glycophenotypes and related diseases into the Unified Phenotype Ontology (uPheno), HPO, Monarch, and other KBs. We encourage the community to practice good identifier hygiene for glycans in support of semantic analysis, and clinicians to add glycomics to their diagnostic analyses of rare diseases.
doi:10.5281/zenodo.3234097 fatcat:kvhyw3o4l5epxkanw4fzpxlnkm

Long-term Associations of an Early Corrected Ventricular Septal Defect and Stress Systems of Child and Mother at Primary School Age

Valeska Stonawski, Laura Vollmer, Nicola Köhler-Jonas, Nicolas Rohleder, Yulia Golub, Ariawan Purbojo, Gunther H. Moll, Hartmut Heinrich, Robert A. Cesnjevar, Oliver Kratz, Anna Eichler
2018 Frontiers in Pediatrics  
Copyright © 2018 Stonawski, Vollmer, Köhler-Jonas, Rohleder, Golub, Purbojo, Moll, Heinrich, Cesnjevar, Kratz and Eichler.  ... 
doi:10.3389/fped.2017.00293 pmid:29379779 pmcid:PMC5775274 fatcat:sfinsle4zbgv7hrx5k76rvspiq

Revision of the phylogeny and chorology of the tribe Iphisini with the revalidation of Colobosaura kraepelini Werner, 1910 (Reptilia, Squamata, Gymnophthalmidae)

Pier Cacciali, Nicolás Martínez, Gunther Köhler
2017 ZooKeys  
In the color descriptions, the capitalized colors and the color codes (in parentheses) are those of Köhler (2012) .  ...  Thus, we herewith designate SMF 101370, a subadult male from 2.5 km E of Altos (25.2588°S, 57.2850°W, ca 280 masl), Cordillera Department, Paraguay, collected on 27 February 2012 by Gunther Köhler, as  ... 
doi:10.3897/zookeys.669.12245 pmid:28769654 pmcid:PMC5523374 fatcat:ztqe35wgmbcfdh5yyibvvnoylq
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