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Nick Hales: an appreciation of his life and work
2006
Diabetologia
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Nick was born in Stafford in 1935, into a medical familyhis father, Walter, was an oral surgeon. ...
There was of course no clinical medical course at Cambridge in those days, and Nick undertook his clinical training at University College Hospital, London. ...
Nick Hales, medical biochemist, was born on 25 April 1935 and died on 15 September 2005. ...
doi:10.1007/s00125-006-0223-6
fatcat:qvqs3h347rhy5hwmiy45z3dexq
Use of the canopy-scope for assessing canopy openness in plantation forests
2005
Forestry (London)
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See Hale (2003) for the approximate layout of measurement points at Aberfoyle and Kinlochard. ...
The stand was then thinned in fi ve interventions to 15 m 2 ha − 1 ( Hale, 2003 ) prior to clearfelling; measurements were repeated at each stand density, taken at the same nine points on each occasion ...
doi:10.1093/forestry/cpi043
fatcat:3caaaiaumjf6jpnqj4zc7wj6f4
Automatic Feedback Provision in Teaching Computational Science
[chapter]
2020
Lecture Notes in Computer Science
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We describe a method of automatic feedback provision for students learning computational science and data science methods in Python. We have implemented, used and refined this system since 2009 for growing student numbers, and summarise the design and experience of using it. The core idea is to use a unit testing framework: the teacher creates a set of unit tests, and the student code is tested by running these tests. With our implementation, students typically submit work for assessment, and
doi:10.1007/978-3-030-50436-6_45
fatcat:5d6ds3ms5fc4vbxhdf3vv3qnv4
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... ceive feedback by email within a few minutes after submission. The choice of tests and the reporting back to the student is chosen to optimise the educational value for the students. The system very significantly reduces the staff time required to establish whether a student's solution is correct, and shifts the emphasis of computing laboratory student contact time from assessing correctness to providing guidance. The self-paced nature of the automatic feedback provision supports a student-centred learning approach. Students can re-submit their work repeatedly and iteratively improve their solution, and enjoy using the system. We include an evaluation of the system from using it in a class of 425 students.
Preclinical development of monoclonal antibodies
2009
mAbs
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The global distribution of risk factors by poverty level
2005
Bulletin of the World Health Organization
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To estimate the individual-level association of income poverty with being underweight, using tobacco, drinking alcohol, having access only to unsafe water and sanitation, being exposed to indoor air pollution and being obese. Using survey data for as many countries as possible, we estimated the relative risk association between income or assets and risk factors at the individual level within 11 medium- and low-income subregions of WHO. WHO and The World Bank data on the prevalence of risk
pmid:15744404
pmcid:PMC2623808
fatcat:3d3tbij3kbcspdqyk3xdd7jzm4
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... s and income poverty (defined as living on < US$ 1.00 per day, US$ 1-2.00 per day and > US$ 2.00 per day) were analysed to impute the association between poverty and risk factors for each subregion. The possible effect of poverty reduction on the prevalence of risk factors was estimated using population-attributable risk percentages. There were strong associations between poverty and malnutrition among children, having access only to unsafe water and sanitation, and being exposed to indoor air pollution within each subregion (relative risks were twofold to threefold greater for those living on < US$ 1.00 per day compared with those living on > US$ 2.00 per day). Associations between poverty and obesity, tobacco use and alcohol use varied across subregions. If everyone living on < US$ 2.00 per day had the risk factor profile of those living on > US$ 2.00 per day, 51% of exposures to unimproved water and sanitation could be avoided as could 37% of malnutrition among children and 38% of exposure to indoor air pollution. The more realistic, but still challenging, Millennium Development Goal of halving the number of people living on < US$ 1.00 per day would achieve much smaller reductions. To achieve large gains in global health requires both poverty eradication and public health action. The methods used in this study may be useful for monitoring pro-equity progress towards Millennium Development Goals.
Interfacial pressure and shear sensor system for fingertip contact applications
2016
Healthcare technology letters
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This paper presents a capacitive-based sensor system for fingertip contact applications. It is capable of simultaneously measuring normal (pressure) and tangential (shear) stresses at the interface between a fingertip and external objects. This could be potentially exploitable for applications in the fields of upper limb prosthetics, robotics, hand rehabilitation, etc. The system was calibrated and its performance was tested using a test machine. To do so, specific test protocols reproducing
doi:10.1049/htl.2016.0062
pmid:28008364
pmcid:PMC5168806
fatcat:uwsjwmedlzevfbsp5zpqbvw24i
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... ical stress profiles in fingertip contact interactions were designed. Results show the system's capability to measure the applied pressure and stresses, respectively, with high linearity between the measured and applied stresses. Subsequently, as a case study, a "press-drag-lift "based fingertip contact test was conducted by using a finger of a healthy subject. This was to provide an initial evaluation for real life applications. The case study results indicate that both interface pressure and shear were indeed measured simultaneously, which aligns well with the designed finger test protocols. The potential applications for the sensor system and corresponding future works are also discussed.
Quantifying the nitrate levels in bottled water in New Zealand
2021
Australian and New Zealand Journal of Public Health
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Wilson, 1 Simon Hales, 1 Michael Baker 1 the laboratory reports from each bottled water manufacturer and searched the company websites for any publicly available information. ...
water brand from the same batch and took the median value as per one previous study. 1 We also requested
Quantifying the nitrate levels in bottled water in New Zealand Tim Chambers, 1 Mike Joy, 2 Nick ...
doi:10.1111/1753-6405.13196
pmid:34940997
fatcat:q5pwqmvwcjbtnjj3vhqwlfmo34
Ecological Conservation Through Aesthetic Landscape Planning: A Case Study of the Lower Wisconsin State Riverway
2005
Environmental Management
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Typical canopy species of the forest include silver maple, swamp white oak, green ash, and bitternut hickory (Hale 2004) . ...
doi:10.1007/s00267-003-3061-z
pmid:15920673
fatcat:3xtdkgdqnbhfvkult3yonbz5gy
Ontology-Based Interactive Information Extraction From Scientific Abstracts
2005
Comparative and Functional Genomics
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Over recent years, there has been a growing interest in extracting information automatically or semi-automatically from the scientific literature. This paper describes a novel ontology-based interactive information extraction (OBIIE) framework and a specific OBIIE system. We describe how this system enables life scientists to make ad hoc queries similar to using a standard search engine, but where the results are obtained in a database format similar to a pre-programmed information extraction
doi:10.1002/cfg.456
pmid:18629299
pmcid:PMC2448603
fatcat:l3gznxlcc5ewriixuqmnb2i2vi
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... gine. We present a case study in which the system was evaluated for extracting co-factors from EMBASE and MEDLINE.
Validation of the liver traffic light test as a predictive model for survival and development of liver‐related events
2021
JGH Open
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Liver disease mortality rates continue to rise due to late diagnosis. We need noninvasive tests to be made available in the community that can identify patients at risk from a serious liver-related event (SLE). We examine the performance of a blood test, the liver traffic light test (LTLT), with regard to its ability to predict survival and SLEs. Using routinely gathered clinical data, sequential LTLT test results from 4854 individuals with suspected liver disease were prospectively analyzed
doi:10.1002/jgh3.12460
pmid:34013053
pmcid:PMC8114996
fatcat:taxuuhjbb5c6do4tpstvoh25i4
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... dian follow-up 41 months). An SLE was defined as the development of cirrhosis, liver failure, ascites, or varices. Patients were graded as follows: red (high risk), amber (intermediate risk), and green (low risk). Overall, 565 individuals experienced an SLE (11.6%). The area under the curve (AUC) for the continuous LTLT variable was 0.87 (95% confidence interval 0.85-0.89) for prediction of an SLE and 0.81 (0.78-0.84) for mortality. When categorized into red/amber/green grades, a red LTLT result predicted an SLE with negative and positive predictive values of 0.97 and 0.29, respectively. A red LTLT score predicted mortality with negative and positive predictive values of 0.98 and 0.18, respectively. Kaplan-Meier plots demonstrated increased mortality and SLEs in the red group versus the green and amber groups (P < 0.001) and an increase in SLEs in the amber versus green group (P < 0.001). Here, the LTLT is further validated for the prediction of survival and SLE development. The LTLT could aid primary care risk management and referral pathways with the aim of detecting and treating liver disease earlier in the general population.
LAP-MALDI MS coupled with machine learning: an ambient mass spectrometry approach for high-throughput diagnostics
2022
Chemical Science
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Large-scale population screening for early and accurate detection of disease is a key objective for future diagnostics. Ideally, diagnostic tests that achieve this goal are also cost-effective, fast and easily...
doi:10.1039/d1sc05171g
pmid:35282613
pmcid:PMC8826629
fatcat:stk2foh62bakniinwxzm4mwnje
Speciation and milk adulteration analysis by rapid ambient liquid MALDI mass spectrometry profiling using machine learning
2021
Scientific Reports
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AbstractGrowing interest in food quality and traceability by regulators as well as consumers demands advances in more rapid, versatile and cost-effective analytical methods. Milk, as most food matrices, is a heterogeneous mixture composed of metabolites, lipids and proteins. One of the major challenges is to have simultaneous, quantitative detection (profiling) of this panel of biomolecules to gather valuable information for assessing food quality, traceability and safety. Here, for milk
doi:10.1038/s41598-021-82846-5
pmid:33558627
fatcat:j4w2bwwge5aqvefwvhrvhhtozm
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... s, atmospheric pressure matrix-assisted laser desorption/ionization employing homogenous liquid sample droplets was used on a Q-TOF mass analyzer. This method has the capability to produce multiply charged proteinaceous ions as well as highly informative profiles of singly charged lipids/metabolites. In two examples, this method is coupled with user-friendly machine-learning software. First, rapid speciation of milk (cow, goat, sheep and camel) is demonstrated with 100% classification accuracy. Second, the detection of cow milk as adulterant in goat milk is shown at concentrations as low as 5% with 92.5% sensitivity and 94.5% specificity.
A combined kinematic and kinetic analysis at the residuum/socket interface of a knee-disarticulation amputee
2017
Medical Engineering and Physics
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Particulate Air Pollution, Exceptional Aging, and Rates of Centenarians: A Nationwide Analysis of the United States, 1980–2010
2016
Environmental Health Perspectives
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Improvements in these determinants may contribute to increasing exceptional aging. citation: Baccarelli AA, Hales N, Burnett RT, Jerrett M, Mix C, Dockery DW, Pope CA III. 2016. ...
doi:10.1289/ehp197
pmid:27138440
pmcid:PMC5089884
fatcat:tllcn3pfc5ddxkylx6qqh42pqi
Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance
2015
International Journal of STD and AIDS
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In the UK, patients undergo HIV viral load and genotype testing before they are prescribed antiretroviral therapy. The genotype test guides clinicians in prescribing antiretroviral therapy with maximum efficacy against the patient's specific viral strain. HIV viral load escape under antiretroviral drug therapy, to which the virus was thought to be genotypically susceptible, is commonly observed in patients with poor adherence. We observed early viral escapes in two-newly diagnosed patients,
doi:10.1177/0956462415571671
pmid:25663247
pmcid:PMC4674743
fatcat:ruy47wokcrb75fjpmdjhvxfeqy
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... ng antiretroviral treatment, with different sequences compared to their original viral resistance test and who reported excellent adherence to and tolerance of their therapy. HIV superinfection with a new viral strain was identified in a patient with multiple risk factors and co-infections with sexually transmitted infections. The second patient was a case of the emergence of primary resistant virus under drug pressure. Both suppressed their virus promptly after treatment switch.
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