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Radioisotopes in Drug Research and Development: Focus on Positron Emission Tomography
[chapter]
2011
Radioisotopes - Applications in Bio-Medical Science
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Other applications of radiolabeled compounds are to investigate apoptosis (Glaser et al., 2003) , DNA replication and cell cycle progression (Hoy et al., 1990) in oncology. ...
These findings gave new insights in the metabolism, pharmacology and toxicology of the drug. ...
Currently, only two PET tracers have been described in a guidance by the FDA to assist applicants in preparing New Drug Applications (NDAs) (Guidance PET Drug Applications -Content and Format for NDAs ...
doi:10.5772/22728
fatcat:rowvddrarrhf3j5iwh3gkc2ale
Molecular imaging with SPECT as a tool for drug development
2011
Advanced Drug Delivery Reviews
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Radionuclide-based imaging modalities such as single-photon emission computed tomography (SPECT) and positron emission tomography (PET) have proven to be useful in phases ranging from preclinical development ...
The high sensitivity of these imaging modalities makes them particularly suited for exploratory investigational new drug (IND) studies as they have the potential to characterize in vivo pharmacokinetics ...
A variety of SPECT tracers exist for many important targets in oncology and neurology. An overview of the most important is given below. ...
doi:10.1016/j.addr.2010.09.015
pmid:20933557
fatcat:xeyfnkixhredflujzzns5ybixm
Interest and Limits of [18F]ML-10 PET Imaging for Early Detection of Response to Conventional Chemotherapy
2021
Frontiers in Oncology
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This review has pointed out the challenges of applying various apoptosis imaging strategies in clinical trials, the current methodologies available for image analysis and the future of molecular imaging ...
One of the current challenges in oncology is to develop imaging tools to early detect the response to conventional chemotherapy and adjust treatment strategies when necessary. ...
No Alternative Strategies to Overcome the Limited Applicability of [ 18 F]ML-10 PET Imaging Is Not the Right Candidate for Early Assessment of Therapeutic Response in Solid Tumors Applications
Frontiers ...
doi:10.3389/fonc.2021.789769
pmid:34988022
pmcid:PMC8722713
fatcat:owz2uomgmndsbnjf6oxaa4zazu
TSPO expression in brain tumours: is TSPO a target for brain tumour imaging?
2016
Clinical and translational imaging
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In this review, we will discuss the impact of preclinical PET studies and the application of TSPO imaging in human brain tumours, the advantages and disadvantages of TSPO imaging compared to other imaging ...
modalities and other PET tracers, and pathology studies on the extent and distribution of TSPO in gliomas. ...
Introduction PET imaging has increasingly been explored in the field of neuro-oncology for pre-operative prediction of tumour grade, monitoring of disease progression and response to treatment, and to ...
doi:10.1007/s40336-016-0168-9
pmid:27077069
pmcid:PMC4820497
fatcat:llvqgf35zffprjoxh77ibwzszq
PET Imaging of Inflammation Biomarkers
2013
Theranostics
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This review summarizes the potential inflammation imaging targets and corresponding PET tracers, and the applications of PET in major inflammatory diseases and tumor associated inflammation. ...
In addition to glucose metabolism, a variety of targets for inflammation imaging are being discovered and utilized, some of which are considered superior to FDG for imaging inflammation. ...
Acknowledgement This work was supported by the Intramural Research Program (IRP) of the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH). ...
doi:10.7150/thno.6592
pmid:23843893
pmcid:PMC3706689
fatcat:nj2t5la37bfohihsievanhf7iq
Molecular SPECT Imaging: An Overview
2011
International Journal of Molecular Imaging
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Moreover, the last section covers several application, of SPECT imaging in many areas of disease detection and diagnosis. ...
between SPECT and PET, and focusing on different SPECT designs and detection systems. ...
Tremoleda and Tamer B. Saleh contributed equally to the work. ...
doi:10.1155/2011/796025
pmid:21603240
pmcid:PMC3094893
fatcat:yfh6kqcdmnh53c5y6zh5dbzjpy
PET Imaging of the Human Nicotinic Cholinergic Pathway in Atherosclerosis
2015
Current Cardiology Reports
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that might be an option for vascular nAChR PET imaging in the future. ...
We also provide an overview of currently available nAChR positron emission tomography (PET) tracers and their performance in the noninvasive imaging of vascular nAChRs, as well as potential nAChR PET tracers ...
coronary arteries, and to develop new PET tracers for different nAChRs, with the goal of proving the feasibility of nAChR PET imaging in the clinical context. ...
doi:10.1007/s11886-015-0614-8
pmid:26183620
pmcid:PMC4504985
fatcat:6du4esxmcbclhc6ffw5oz2sizm
Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
2011
Insights into Imaging
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From medical imaging perspectives, this review focuses on the current concepts related to the TSPO, and discusses briefly on the status of its PET imaging related to neuroinflammation and neurodegenerative ...
TSPO expression may constitute a biomarker for brain inflammation that could be monitored by using TSPO tracers as neuroimaging agents. ...
affinity for the TSPO with better uptake and binding potential than [ 11 C]PK11195
Table 2 2 Examples of new potential PET tracers for TSPO imaging in clinical studies AD Alzheimer's disease, ALS amyotrophic ...
doi:10.1007/s13244-011-0128-x
pmid:22696004
pmcid:PMC3292648
fatcat:zktuxfhh6bfa7kzl2yfxpjcsne
Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging
2019
Pharmaceuticals
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Basic developments in medicinal chemistry, radiolabeling and translational PET imaging in multiple species including humans are highlighted. ...
Neurologic and oncologic studies of the spatiotemporal alterations in TrkA/B/C expression and density and the determination of target engagement of emerging antineoplastic clinical inhibitors in normal ...
Another potential application for Trk-targeted radioligands stems from the renewed and rapidly growing interest in anti-Trk therapy for cancer. ...
doi:10.3390/ph12010007
pmid:30609832
pmcid:PMC6469173
fatcat:6qfskwzu3jdbncbto2vztuhxce
Unparalleled contribution of 18F-FDG PET to medicine over 3 decades
2008
Journal of Nuclear Medicine
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F-FDG PET to Medicine Over 3 Decades 18 Unparalleled Contribution of http://jnm.snmjournals.org/content/49/10/17N.citation This article and updated information are available at: http://jnm.snmjournals.org ...
The success of 18 F-FDG has led the way for the development of new PET tracers with great promise for future expansion of the role of PET (2) (3) (4) (5) . ...
for thrombolysis treatment. 18 F-FDG PET provides important prognostic information in CNS malignancies. ...
pmid:18832112
fatcat:bupf6hlzmjgbjopkhgbtq7gdgi
CXCR4-directed theranostics in oncology and inflammation
2018
Annals of Nuclear Medicine
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suitable for positron emission tomography (PET) imaging, in both hematologic and solid malignancy as well as in inflammatory conditions. ...
Given its prominent role in inflammation and cancer biology, the C-X-C motif chemokine receptor 4 (CXCR4) has gained a lot of attention in the recent years. ...
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. ...
doi:10.1007/s12149-018-1290-8
pmid:30105558
fatcat:giggpqhpobdhjkrvrqhjrulidi
Recent Advances in the Development and Application of Radiolabeled Kinase Inhibitors for PET Imaging
2015
Molecules
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Given that inhibitor coverage of the kinome is continuously expanding, in vivo PET imaging will likely find increasing applications for therapy monitoring and receptor density studies both in-and outside ...
Novel radioligands for cancer and PET neuroimaging originating from novel but relevant target kinases are currently being explored in preclinical studies. ...
Both [ 11 C]GW441756 and [ 18 F]40 are lead tracers for Trk PET imaging. Single tracers for EphB4 and MET have also been reported for tumor imaging. ...
doi:10.3390/molecules201219816
pmid:26690113
fatcat:q6zrowx5rfg7xfr7xl2fopx5vi
Fluorine-18 patents (2009–2015). Part 1: novel radiotracers
2016
Pharmaceutical Patent Analyst
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In this review, we present the first analysis of patents issued for radiotracers labeled with fluorine-18 (between 2009 and 2015), and provide perspective on current trends and future directions in PET ...
The most commonly utilized PET radionuclide is fluorine-18 ( 18 F) because of its convenient half-life and excellent imaging properties. ...
New radiotracers for oncology imaging In oncology, PET imaging is a powerful diagnostic tool that allows for in vivo, noninvasive imaging for the improvement of diagnosis, management of therapy and improving ...
doi:10.4155/ppa.15.36
pmid:26670619
pmcid:PMC5561792
fatcat:ifg2j4ddirgr3gn5bc7eyql6pq
Molecular imaging in the development of a novel treatment paradigm for glioblastoma (GBM): an integrated multidisciplinary commentary
2013
Drug Discovery Today
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For the first time, using expertise from an integrated multidisciplinary group of authors, herein we present a comprehensive evaluation of state-of-the-art GBM imaging and explore how advances facilitate ...
The part played by molecular imaging (MI) in the development of novel therapies has gained increasing traction in recent years. ...
Acknowledgements Funding is acknowledged within the context of the Irish National Biophotonics and Imaging Platform and the European Commission Framework Programme 7 AngioTox and AngioPredict initiatives ...
doi:10.1016/j.drudis.2013.06.004
pmid:23792334
fatcat:lzpkvjdurrfxxjtskmbtk4epzy
Positron emission tomography imaging of coronary atherosclerosis
2016
Future Cardiology
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Using novel radiotracers targeted at specific cellular pathways, the potential exists to observe inflammation, apoptosis, cellular hypoxia, microcalcification and angiogenesis in vivo. ...
Several clinical studies are now underway assessing the ability of this hybrid imaging modality to inform about atherosclerotic disease activity and the prediction of future cardiovascular risk. ...
In addition, improvements in spatial resolution and techniques for correcting cardiac motion will be required if these new tracers are to prove of use in the small and highly mobile coronary arteries. ...
doi:10.2217/fca-2016-0017
pmid:27322032
pmcid:PMC4926532
fatcat:d3p7zfgj5zd5dfozzu42tzduum
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