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White matter injury in ischemic stroke

Yuan Wang, Gang Liu, Dandan Hong, Fenghua Chen, Xunming Ji, Guodong Cao
2016 Progress in Neurobiology  
In this review, we discuss white matter injury after ischemic stroke, focusing on clinical features and tools, such as imaging, manifestation, and potential treatments.  ...  White matter injury can be noninvasively detected by MRI, which provides a three-dimensional assessment of its morphology, metabolism, and function.  ...  .), and Chinese 12th Five science and technology support program 2013BAI07B01 (to X. J).  ... 
doi:10.1016/j.pneurobio.2016.04.005 pmid:27090751 pmcid:PMC5677601 fatcat:chpgrjyxzzbujlwsmukptlzb3a

Emergent Prophylactic, Reparative and Restorative Brain Interventions for Infants Born Preterm With Cerebral Palsy

Megan Finch-Edmondson, Catherine Morgan, Rod W. Hunt, Iona Novak
2019 Frontiers in Physiology  
Current intensive care therapies aim to optimize cardiovascular and respiratory function to protect the brain from injury by preserving oxygenation and blood flow.  ...  Versus, waiting for a diagnosis before commencing targeted treatment for infants with a brain injury, and potentially missing the therapeutic window.  ...  MRI, diffusion tensor imaging, metabolic imaging (MR spectroscopy), functional ultrasound (Deffieux et al., 2018) and amplitude-integrated EEG, are transforming the neuroimaging field.  ... 
doi:10.3389/fphys.2019.00015 pmid:30745876 pmcid:PMC6360173 fatcat:d6ffcbcwjvahxnowyqpdcdugki

In vivo evaluation of retinal and callosal projections in early postnatal development and plasticity using manganese-enhanced MRI and diffusion tensor imaging

Kevin C. Chan, Joe S. Cheng, Shujuan Fan, Iris Y. Zhou, Jian Yang, Ed X. Wu
2012 NeuroImage  
In this study, we explored the feasibility of Mn-enhanced MRI (MEMRI) and diffusion tensor imaging (DTI) at 7 T for in vivo and longitudinal assessments of the retinal and callosal pathways in normal neonatal  ...  adult rats after neonatal monocular enucleation (ME) but not in normal adult rats or adult rats after monocular deprivation (MD).  ...  Acknowledgments This work was supported by the Hong Kong Research Grant Council (GRF HKU 7793/08M and GRF HKU 7808/09M).  ... 
doi:10.1016/j.neuroimage.2011.09.055 pmid:21985904 fatcat:wx5yifmquvf57fqbl7sgdfal5y

Poster Viewing Session III

2017 Journal of Cerebral Blood Flow and Metabolism  
pipeline for clinical fluid-attenuated inversion recovery (FLAIR) images.  ...  Objectives: The hypothesis is that the relationship between brain vascular and brain tissue mitochondrial oxygenation will differ with the severity of hypoxic-ischaemic injury that has been sustained by  ...  Acknowledgement: This research has been funded by Acknowledgements: T.Hollyer is grateful the financial and technical support for this project from SINAPSE, ReNeuron, and The University of Glasgow  ... 
doi:10.1177/0271678x17695987 pmid:28366135 pmcid:PMC5441165 fatcat:m4mfdovmpzasbh5brx26kp4ho4

Recent advances in the treatment of traumatic brain injury with autologous and non-autologous multipotent stem and progenitor cells: preclinical models and clinical trials

Mujahid Alizada, Shu Lin, Hongzhi Gao
2021 Folia Neuropathologica  
Traumatic brain injury (TBI) is a global health issue which causes millions of deaths and disabilities every year.  ...  This article reviews the research of autologous and non-autologous multipotent stem and progenitor cells for the treatment of TBI in both clinical and preclinical settings.  ...  Primary focal brain injury can be detected by computed tomography (CT) and magnetic resonance imaging (MRI), while diffuse brain injury requires diffusion tensor imaging (DTI) [46, 56, 68] .  ... 
doi:10.5114/fn.2021.108536 pmid:34628796 fatcat:j2ohcfxa2fe4fl5o2yv46xlmnu

Abstracts for the 24th Annual Meeting of the American Society for Neural Therapy and Repair

2017 Cell Transplantation  
These findings indicate that higher cognitive function may positively influence the neuroplasticity and stem cell mobilization after stroke.  ...  After training, rats were divided into fast learners and slow learners as a measure of high cognitive ability and poor cognitive ability, respectively, and then animals were subjected to ischemic stroke  ...  Serial MRI was conducted throughout the experiment, including diffusion tensor imaging (DTI), cerebral blood volume (CBV), and functional MRI (fMRI) based on electrical forepaw stimulation in the concluding  ... 
doi:10.3727/096368917x695146 pmid:28494821 pmcid:PMC5657807 fatcat:wpxmgozq2fgyxp6vvb7bk6i5au


2007 Neuroradiology  
Our experience confirm that neuroplasticity can be assessed on functional MRI in 1.5 tesla MRI, and can give important informations for location of eloquent areas and to evaluate the response to physiotherapy  ...  Neuroplasticity, consisting in cortical reorganization, is a well known phenomenon that explain how neurological functions can be preserved in cases of brain damage.  ...  help predicting conversion to AD DIFFUSION TENSOR IMAGING IN AMYOTROPHIC brain stimulation electrodes and MRI.  ... 
doi:10.1007/s00234-007-0285-2 fatcat:7tpmnyplxzbbdk23elrsfkoura

48th Annual Congress of the Canadian Neurological Sciences Federation

2013 Canadian Journal of Neurological Sciences  
J.03 MRI findings in infants with infantile spasms after neonatal hypoxic-ischemic encephalopathy D Gano (Vancouver)* MA Sargent (Vancouver) SP Miller (Toronto) MB Connolly (Vancouver) P Wong (Vancouver  ...  plasticity after traumatic spinal cord injury has been observed in animal models and human brain fMRI studies.  ...  Results: CIPN occurred in children at a frequency of 18.8% (29/154) for ALL; 9.4% (3/32) for lymphoma; 17.9% (5/28) for Wilms tumor; and 23.7% (9/38) for brain tumor.  ... 
doi:10.1017/s031716710001708x fatcat:m2kbjrxv2bh6xhyw3f45pvye5e

Abstracts From the 2008 International Stroke Conference

2008 Stroke  
However, in contrast to an earlier phase 2b trial, survival and functional outcome were not improved at 90 days.  ...  intracerebral hemorrhage (ICH) patients diagnosed by computed tomography (CT) scan Յ3 hours after symptom onset and treated with placebo, 20 or 80 g/kg rFVIIa Յ1 hour after CT.  ...  OBJECTIVES: To evaluate the healthcare costs and clinical outcomes (i.e., stroke, MI, death) in patients with ischemic stroke or TIA excluding those at risk for cardioembolism.  ... 
doi:10.1161/strokeaha.107.100001 fatcat:77qgaaljhbdvdia4xmfzhuv6ie

2013 Canadian Stroke Congress Abstracts

2013 Stroke  
Background: A guiding maxim in acute ischemic stroke (AIS) treatment is 'time is brain'. Rapid imaging and prompt diagnosis are essential.  ...  Critical hypoperfusion was well depicted by relative pCT in acute and subacute ischemic stroke.  ...  Reasons for the relatively low response rate have yet to be explored. Transition to the BCOS was supported by the psychometric properties of the scale and feedback from clinicians.  ... 
doi:10.1161/01.str.0000438095.11293.72 fatcat:wuapkkr73zcvbga266lrkjwdwy

Skin-derived precursor cells enhance peripheral nerve regeneration following chronic denervation

Sarah K. Walsh, Tessa Gordon, Bassam M.J. Addas, Stephen W.P. Kemp, Rajiv Midha
2010 Experimental Neurology  
Severe injuries to peripheral nerves are common and often followed by poor functional recovery due to their chronic nature.  ...  Recovery after peripheral nerve lesions with loss of axonal continuity and Wallerian degeneration is determined by the number of axons that regenerate, the specificity of reinnervation of targets, and  ...  , and functional recovery in rats.  ... 
doi:10.1016/j.expneurol.2009.05.025 pmid:19477174 fatcat:mnzj7u6sl5btdjchpofp7jnrqa

Are Ventriculostomy Infections Reduced by Standardized Protocols or by Antibiotic-Impregnated Catheters?

James S. Harrop, Mitchell G. Maltenfort, John K. Ratliff, Ashwini D. Sharan
2009 Neurosurgery  
CONCLUSION: The use of drain with burr hole drainage reduces the recurrence rate for CSDH and is associated with better functional status at discharge and lower rates of mortality at 6 months.  ...  Although the use of drains after burr hole evacuation may lower recurrence, they are not used routinely because of a lack of evidence showing efficacy and a concern for increasing surgical morbidity.  ...  Diffusion tensor imaging (DTI) is a powerful imaging analysis tool for reconstruction of white matter tracts.  ... 
doi:10.1227/01.neu.0000358684.48551.01 fatcat:ezsekagiwre5xiwddnkxoqdb4a

Abstracts: 6th World Congress of the international society of Physical and Rehabilitation Medicine in June 12-16, 2011, San Juan, Puerto Rico

2011 Journal of Rehabilitation Medicine  
ACTION OBSERVATION IN STROKE PATIENTS: INVESTIGATING THE NEUROPHySIOLOGICAL EFFECTS USING EEG  ...  brain injury in neonatal rats.  ...  Implications/Impact on Rehabilitation: Puerarin may reduce brain injury and improve learning and memory in hypoxic-ischemic brain injury rats.  ... 
doi:10.2340/16501977-0842 fatcat:kagqucdnuncvljk535slbn3wve

Abstracts of the 12th Annual Meeting of Israel Society for Neuroscience

2003 Neural Plasticity  
Step-do"aa PA was conditioned at 4 months using 0.5 mA footshock for 5 sec and tested after 24 hr and 72 hr.  ...  The models were: (i) the tail-flick in mice for noxious pain; (ii) carrageenan-induced thermal and mechanical hyperalgesia in the rat hind paw for inflammatory pain; (iii) IP acetic acid induced visceral  ...  Hutzel Hospital Prenatal hypoxic-ischemic .brain injury is believed to cause permanent neurological deficits in neonates.  ... 
doi:10.1155/np.2003.179 pmid:14712829 pmcid:PMC2565426 fatcat:4midzhgcurdejakjjwizqvpguq

Monday July 3, 2006 15:00-17:00 Hall 3A Discussion Group Session Cognitive dysfunction in children with temporal lobe epilepsy

2006 Epilepsia  
Conclusion: LTG and CBZ showed comparable effectiveness, with a trend for higher seizure-free rates for CBZ and better tolerability for LTG. Acknowledgment: Supported by GlaxoSmithKline.  ...  There were no significant changes in mean (±SEM) serum concentrations of testosterone (p = 0.225), SHBG (p = 0.201), or androstenedione (p = 0.394) in either patient group at 6 months after initiation  ...  and severity of perinatal hypoxic ischemic brain injury.  ... 
doi:10.1111/j.1528-1167.2006.00715_55.x fatcat:as6vr3saobh2noqiutoquvfmni
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