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Serotonin modulates learning content-specific neuroplasticity of functional brain networks [article]

Manfred Klöbl, René Seiger, Thomas Vanicek, Patricia Handschuh, Murray Bruce Reed, Benjamin Spurny, Vera Ritter, Godber Mathis Godbersen, Gregor Gryglewski, Christoph Kraus, Andreas Hahn, Rupert Lanzenberger
2021 bioRxiv   pre-print
During relearning, subjects received either a daily dose of the selective serotonin reuptake inhibitor escitalopram or placebo.  ...  Animal models emphasized the crucial role of serotonin in neuroplasticity particularly for emotional relearning, but comparable studies in humans are scarce.  ...  We also want to express our gratitude towards the diploma students of the Neuroimaging Labs, especially Hannah van Alebeek who was responsible for recruiting a large proportion of the volunteers for the  ... 
doi:10.1101/2021.01.15.426779 fatcat:urjlya2edvh3lawrnnuv2da524

How do antidepressants work? New perspectives for refining future treatment approaches

Catherine J Harmer, Ronald S Duman, Philip J Cowen
2017 Lancet psychiatry  
Novel approaches to understanding of antidepressant drug action include a focus on early changes in emotional and social processing and the role of neural plasticity.  ...  However, a purely neurotransmitter-based explanation for antidepressant drug action is challenged by the delayed clinical onset of most agents and the need to explain how neurochemical changes reverse  ...  Acknowledgments Declaration of interests: CJH reports receiving grants from Johnson & Johnson, UCB, and Sunovion; and personal fees from P1vital and Lundbeck outside the submitted work.  ... 
doi:10.1016/s2215-0366(17)30015-9 pmid:28153641 pmcid:PMC5410405 fatcat:pmy547ikezdkpbbih3sihe7lwe

Effects of learning and escitalopram administration on serum BDNF levels, a randomised placebo-controlled trial [article]

Jakob Unterholzner, Godber Mathis Godbersen, Manfred Klöbl, Vera Ritter, Daniel Pacher, René Seiger, Nimmy Varghese, Anne Eckert, Rupert Lanzenberger, Thomas Vanicek
2021 bioRxiv   pre-print
Learning and serotonin reuptake inhibitors (SSRI) foster neuronal reorganization, a mechanism potentially related to BDNF.  ...  Results: One-way LME resulted in a significant effect of time during the first learning period over both groups (p<0.01).  ...  Learning and serotonin reuptake inhibitors (SSRI) foster neuronal reorganization, a 37 mechanism potentially related to BDNF.  ... 
doi:10.1101/2021.04.09.439014 fatcat:tooauur2fvhzrdjb55cmfoyj2y

Strategies for stroke rehabilitation

Bruce H Dobkin
2004 Lancet Neurology  
Promising adjunct approaches include practice with robotic devices or in a virtual environment, electrical stimulation to increase cortical excitability during training, and drugs to optimise molecular  ...  The amount of practice probably best determines gains for a given level of residual movement ability.  ...  None of these funding sources had a role in the preparation of this review or in the decision to submit it for publication.  ... 
doi:10.1016/s1474-4422(04)00851-8 pmid:15324721 pmcid:PMC4164204 fatcat:kwwmyoqhwzeaxgzcmvu5t3x2au

Pathophysiology of Motor Dysfunction in Parkinson's Disease as the Rationale for Drug Treatment and Rehabilitation

Francesca Magrinelli, Alessandro Picelli, Pierluigi Tocco, Angela Federico, Laura Roncari, Nicola Smania, Giampietro Zanette, Stefano Tamburin
2016 Parkinson's Disease  
Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and rigidity, which appear in the early stages of the disease and largely depend on dopaminergic nigrostriatal denervation  ...  There are a number of symptomatic drugs for PD motor signs, but the pharmacological resources for nonmotor signs and symptoms are limited, and rehabilitation may contribute to their treatment.  ...  Pharmacologic treatment with antidepressant medications, specifically the selective serotonin reuptake inhibitors, and cognitive behavioral interventions may significantly improve depression in PD patients  ... 
doi:10.1155/2016/9832839 pmid:27366343 pmcid:PMC4913065 fatcat:xwcydsyudzeqdd546y6q2ayyeu

Neuropsychiatric diagnosis and management of chronic sequelae of war-related mild to moderate traumatic brain injury

Joshua D. Halbauer, J. Wesson Ashford, Jamie M. Zeitzer, Maheen M. Adamson, Henry L. Lew, Jerome A. Yesavage
2009 Journal of rehabilitation research and development  
, PTSD = posttraumatic stress disorder, QOL = quality of life, ROI = region of interest, RR = risk ratio, SSRI = selective serotonergic reuptake inhibitor, TBI = traumatic brain injury, VA = Department  ...  Soldiers with a traumatic brain injury (TBI) present with an array of neuropsychiatric symptoms that can be grouped into nosological clusters: (1) cognitive dysfunctions: difficulties in memory, attention  ...  For second-line treatment of ADHD, atomoxetine is a specific noradrenergic reuptake inhibitor with an effect size of 0.7.  ... 
doi:10.1682/jrrd.2008.08.0119 fatcat:qp2dz5nzxfe3lnmo543sgnusmq

Adjunctive Approaches to Aphasia Rehabilitation: A Review on Efficacy and Safety

Chiara Picano, Agnese Quadrini, Francesca Pisano, Paola Marangolo
2021 Brain Sciences  
Finally, we focused on the use of Transcranial Direct Current Stimulation (tDCS), both discussing its applications at the cortical level and highlighting a new perspective, which considers the possibility  ...  First, we examined the effectiveness of the pharmacological approach, principally used as an adjunct to language therapy, reporting the mechanism of action of each single drug for the recovery of aphasia  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/brainsci11010041 pmid:33401678 fatcat:ccolrkb2v5dnfcpgykp2mb35ni

REVIEW Effects of memantine treatment on language abilities and functional communication: A review of data [chapter]

2016 Pharmacology and Aphasia  
This book is essential reading for anyone interested in the rehabilitation of aphasia and related cognitive disorders. This book was originally published as a special issue of Aphasiology.  ...  This is nicely illustrated by studies on single cases and case series describing the beneficial effects of interventions combining drugs with evidence-based rehabilitation techniques.  ...  Motor Aphasia; PPA, Primary Progressive Aphasia; SLT, Speech-language Therapy; CIAT, Constraint-induced Aphasia Therapy; MMSE, Mini Mental State Exam; SSRI, Selective Serotonin Reuptake Inhibitor.  ... 
doi:10.4324/9781315755816-18 fatcat:pikwmmwmozcgtdxwyoqlwtdhly

Rehabilitation of Motor Function after Stroke: A Multiple Systematic Review Focused on Techniques to Stimulate Upper Extremity Recovery

Samar M. Hatem, Geoffroy Saussez, Margaux della Faille, Vincent Prist, Xue Zhang, Delphine Dispa, Yannick Bleyenheuft
2016 Frontiers in Human Neuroscience  
All of these factors contribute to a low overall quality of life. Rehabilitation training is the most effective way to reduce motor impairments in stroke patients.  ...  Finally, a decisional tree based on evidence from the literature and characteristics of stroke patients is proposed.  ...  Selective serotonin reuptake inhibitors (SSRI) and noradrenaline reuptake inhibitors (NARI) are the best studied drugs in stroke patients.  ... 
doi:10.3389/fnhum.2016.00442 pmid:27679565 pmcid:PMC5020059 fatcat:c7gvofew3jdb7lppbjvj5swp7y

Taking Sides: An Integrative Review of the Impact of Laterality and Polarity on Efficacy of Therapeutic Transcranial Direct Current Stimulation for Anomia in Chronic Poststroke Aphasia

Margaret Sandars, Lauren Cloutman, Anna M. Woollams
2016 Neural Plasticity  
Cortical neuroplasticity plays a significant role in language recovery following stroke and can be facilitated by behavioral speech and language therapy.  ...  Anomia is a frequent and persistent symptom of poststroke aphasia, resulting from damage to areas of the brain involved in language production.  ...  The authors are grateful to Emma Wells for her contribution to the early stages of this review.  ... 
doi:10.1155/2016/8428256 pmid:26819777 pmcid:PMC4706968 fatcat:zvvticce3bep3efrankkcdkfme

Abstracts of the 12th Annual Meeting of Israel Society for Neuroscience

2003 Neural Plasticity  
ACh plays a major role in encoding, attention and regulation of cortical development, and sex differences were found for behavioral effects of AChE-I's.  ...  These effects were blocked by the PKC inhibitor, GFI09203X. Moreover, propargylamine similarly and significantly increased p-PKC (pan) levels.  ...  serotonin reuptake inhibitors (SSRI).  ... 
doi:10.1155/np.2003.179 pmid:14712829 pmcid:PMC2565426 fatcat:4midzhgcurdejakjjwizqvpguq

5-HTT Deficiency Affects Neuroplasticity and Increases Stress Sensitivity Resulting in Altered Spatial Learning Performance in the Morris Water Maze but Not in the Barnes Maze

Margherita M. Karabeg, Sandra Grauthoff, Sina Y. Kollert, Magdalena Weidner, Rebecca S. Heiming, Friederike Jansen, Sandy Popp, Sylvia Kaiser, Klaus-Peter Lesch, Norbert Sachser, Angelika G. Schmitt, Lars Lewejohann (+1 others)
2013 PLoS ONE  
Corticosterone levels were highest in 5-HTT-/-mice tested in the WM indicating greater aversiveness of the WM and a greater stress sensitivity of 5-HTT deficient mice.  ...  The experience of a single trial of either the WM or the BM resulted in increased plasma corticosterone levels in all genotypes.  ...  Acknowledgements We wish to thank Sabine Kruse, Tanja Möllers, Marion Winnig and Katharina Zürrlein for skillful technical assistance. Author Contributions  ... 
doi:10.1371/journal.pone.0078238 pmid:24167611 pmcid:PMC3805519 fatcat:fsdvaw2gljf5jjeq3ftc7vgubm

Activity-Dependent Neural Plasticity from Bench to Bedside

Karunesh Ganguly, Mu-ming Poo
2013 Neuron  
Studies of physiological and molecular mechanisms underlying activity-dependent plasticity in animal models have suggested potential therapeutic approaches for a wide range of brain disorders in humans  ...  Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons. Neuron 54, 933-947. Kim, S.J., and Linden, D.J. (2007) .  ...  ACKNOWLEDGMENTS This work is supported by grants to K.G. from the Department of Veterans Affairs (B6674W), American Heart Association (0875016N), Doris Duke Charitable Foundation (2013101), and Burroughs  ... 
doi:10.1016/j.neuron.2013.10.028 pmid:24183023 fatcat:pqtu3bhs4nhbhfaafqngagaaxi

Nutrition Interventions [chapter]

2017 Encyclopedia of Feeding and Eating Disorders  
Medication effects have largely been ignored in the eating disorder field as psychoactive medications such as selective serotonin reuptake inhibitors (SSRIs) do not seem to be as effective in AN compared  ...  The overarching hypothesis regarding the mechanisms of neuromodulation treatments relates to changes in the "effectiveness" and functional remodeling of neuronal synapses, known as neuroplasticity.  ... 
doi:10.1007/978-981-287-104-6_100179 fatcat:ktkky55c4vcxhkyod3n3onm37q

Abstracts of the 4th World Congress for NeuroRehabilitation

2006 Neurorehabilitation and Neural Repair  
Methods: We review the current model of identification and management of Chinese children with DD in Hong Kong, a southern city in China.  ...  Results: Our model was developed in early 1960s and our system had been originally adopted from the Western culture because of political reasons, as Hong Kong was a British colony.  ...  Executive dysfunction on cognitive tests has been associated with failure to respond to selective serotonin reuptake inhibitor treatment.  ... 
doi:10.1177/1545968305284198 fatcat:v4iywckx4bdbhiyoxugkmpkbky
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