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Neurophysiologically-informed markers of individual variability and pharmacological manipulation of human cortical gamma

A.D. Shaw, R.J. Moran, S.D. Muthukumaraswamy, J. Brealy, D.E. Linden, K.J. Friston, K.D. Singh
2017 NeuroImage  
Using variability in induced (spectral) responses over a large cohort of normal subjects, we find that the predominant determinants of gamma responses rest on recurrent and intrinsic connections between  ...  A B S T R A C T The ability to quantify synaptic function at the level of cortical microcircuits from non-invasive data would be enormously useful in the study of neuronal processing in humans and the  ...  Acknowledgements CUBRIC and the Schools of Psychology and Medicine at Cardiff University, together with the MRC/EPSRC funded UK MEG Partnership Grant (MR/K005464/1).  ... 
doi:10.1016/j.neuroimage.2017.08.034 pmid:28807873 pmcid:PMC5692925 fatcat:7wkgysie6bf6tfpwq3htzgker4

Neurophysiological biomarkers for drug development in schizophrenia

Daniel C. Javitt, Kevin M. Spencer, Gunvant K. Thaker, Georg Winterer, Mihály Hajós
2008 Nature reviews. Drug discovery  
db=OMIMSchizophrenia FURTHER INFORMATION Marker Effect in unaffected family members Effect in prodromes Effect at first-episode Effect in SPD EFfect in other disorders Response to clozapine Human challenge  ...  Moreover, many of these neurophysiological processes are phylogenetically conserved and can be modelled in preclinical studies, offering unique opportunities for use as translational biomarkers in schizophrenia  ...  to be closely similar in response to parametric manipulation and response to pharmacological agents 81 .  ... 
doi:10.1038/nrd2463 pmid:18064038 pmcid:PMC2753449 fatcat:qyvn67bi4ff7xmka4evbx75gbu

Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults

Claudio Del Percio, Philippe Derambure, Giuseppe Noce, Roberta Lizio, David Bartrés Faz, Olivier Blin, Pierre Payoux, Dominique Deplanque, Déborah Méligne, Nicolas Chauveau, Jean Louis Bourriez, Catherine Casse-Perrot (+8 others)
2019 Clinical Neurophysiology  
Here, we tested the following hypotheses in the PharmaCog project ( (i) sleep deprivation may alter posterior cortical delta and alpha sources of resting state eyes-closed electroencephalographic  ...  It has been reported that sleep deprivation affects the neurophysiological mechanisms underpinning the vigilance.  ...  cognitive properties of new drug candidates for neurodegenerative diseases in early clinical development, PharmaCog).  ... 
doi:10.1016/j.clinph.2019.06.007 pmid:31295717 fatcat:xpjv3pgmrfdfndqefimmvqj5ju

Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders

Jennifer H. Foss-Feig, Brendan D. Adkinson, Jie Lisa Ji, Genevieve Yang, Vinod H. Srihari, James C. McPartland, John H. Krystal, John D. Murray, Alan Anticevic
2017 Biological Psychiatry  
Here we take a clinical neuroscience perspective, highlighting emerging evidence from human neuroimaging studies testing markers of E/I imbalance in cortical microcircuits.  ...  Finally, we discuss how human non-invasive neuroimaging can benefit from pharmacological challenge studies to reveal mechanisms in ASD and SCZ.  ...  Acknowledgments The authors wish to acknowledge the following sources of funding support: NARSAD Young Investigator Award  ... 
doi:10.1016/j.biopsych.2017.03.005 pmid:28434615 pmcid:PMC5436134 fatcat:jukaaeopfbhg7hgyvi6nz5b2x4

Alpha oscillations and the control of voluntary saccadic behavior

Jordan P. Hamm, Dean Sabatinelli, Brett A. Clementz
2012 Experimental Brain Research  
The purpose of this review is to explore the dynamic properties of alpha oscillations as biological covariates of intra-and inter-individual variance in saccadic behavior.  ...  Here we discuss a growing body of research relating these measures to saccadic behavior, focusing also on how task related and spontaneous measures of alpha oscillations may serve as potential biomarkers  ...  Acknowledgments This work was supported by Grants from the National institutes of Health (R01s MH076998 and MH082514).  ... 
doi:10.1007/s00221-012-3167-8 pmid:22782481 pmcid:PMC3601791 fatcat:zfitjtlx7vefnarsxcsn2txqyi

Brain oscillations as biomarkers in neuropsychiatric disorders [chapter]

Görsev G. Yener, Erol Başar
2013 Supplements to Clinical Neurophysiology  
In an extension to conventional anatomical, biochemical and brain imaging biomarkers, the use of neurophysiologic markers may lead to new applications for functional interpretrations and also the possibility  ...  valproate; and for AD: (a) decreased alpha and beta, and increased theta and delta in spontaneous EEG, (b) hyperexcitability of motor cortices as shown by transcortical magnetic stimulation, (c) hyperexcitability  ...  This apparently simple state of the brain is very rich in information about, and the mechanisms of, neural synchronization and coordination within cortico-cortical and subcortical-cortical circuits modulating  ... 
doi:10.1016/b978-0-7020-5307-8.00016-8 pmid:24053048 fatcat:glo47bcw7bg7zhz6iaehhqi76a

Associations between a neurophysiological marker of central cholinergic activity and cognitive functions in young and older adults

Marielle Young-Bernier, Yael Kamil, François Tremblay, Patrick SR Davidson
2012 Behavioral and Brain Functions  
We also found clear age differences on several of the memory and one of the executive function measures. Individual differences in SAI levels predicted memory but not executive functions.  ...  Methods: We used short-latency afferent inhibition (SAI) with transcranial magnetic stimulation (TMS) as a putative marker of cholinergic activity in vivo in young (n = 24) and older adults (n = 31).  ...  from the Faculty of Social Sciences of the University of Ottawa to FT and PD, and a Discovery grant from the Natural Sciences and Engineering Research Council of Canada to PD.  ... 
doi:10.1186/1744-9081-8-17 pmid:22537877 pmcid:PMC3379946 fatcat:jwbpj55zvbblpos7jhwjszjcba

The translationally relevant mouse model of the 15q13.3 microdeletion syndrome reveals deficits in neuronal spike firing matching clinical neurophysiological biomarkers seen in schizophrenia

J. Thelin, P. Halje, J. Nielsen, M. Didriksen, P. Petersson, J. F. Bastlund
2016 Acta Physiologica  
Results: We find a decreased amplitude in the response to auditory stimuli and reduced recruitment of neurones to fast steady-state gamma oscillatory activity.  ...  For instance, it is unclear to what extent commonly used behavioural tests in animals can inform us on the mental and affective aspects of schizophrenia.  ...  and reduced capacity to generate cortical evoked gamma oscillations.  ... 
doi:10.1111/apha.12746 pmid:27364459 pmcid:PMC5412918 fatcat:vq3bgl55e5bc5nz4xczh4z5wye

Neurophysiological models for new treatment development in schizophrenia: early sensory approaches

Daniel C. Javitt
2015 Annals of the New York Academy of Sciences  
To date, several sensory-level ERP measures, including auditory mismatch negativity (MMN) and N1, and visual P1 and steadystate responses, have been validated in both human clinical investigations and  ...  This paper reviews the use of electroencephalography (EEG)-based neurophysiological measures, such as event-related potentials (ERP) or event-related spectral perturbations (ERSP), as novel translational  ...  Acknowledgments Manuscript preparation was supported by Grants R01 MH49334 and P50 MH086385 to D.C.J.  ... 
doi:10.1111/nyas.12689 pmid:25721890 pmcid:PMC4467888 fatcat:ordmcu2ucvbbfevfaj56urbnea

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L. Black, Arun L.W. Bokde, René S. Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman (+32 others)
2018 Journal of Alzheimer's Disease  
The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems  ...  different diseases and subgroups at different stages of pathophysiological progression.  ...  Walla and colleagues [381] used a recognition memory task in which they manipulated the depth of encoding of verbal information.  ... 
doi:10.3233/jad-179932 pmid:29562524 pmcid:PMC6008221 fatcat:j3u6gkzfqbg47kv4o2hpkjadn4

Dopamine Is Signaled by Mid-frequency Oscillations and Boosts Output Layers Visual Information in Visual Cortex

Daniel Zaldivar, Jozien Goense, Scott C. Lowe, Nikos K. Logothetis, Stefano Panzeri
2018 Current Biology  
The information increase due to dopamine was prominent in the 24 supragranular layers of cortex that project to higher cortical areas and in the gamma 25 [50-100 Hz] band that has been previously implicated  ...  this 21 band can be used as a robust marker of dopaminergic neuromodulation.  ...  ., and Goense, J. (2017). Pharmaco-Based 505 fMRI and Neurophysiology in Non-Human Primates. In In Vivo Neuropharmacology 506 and Neurophysiology, A. Philippu, ed.  ... 
doi:10.1016/j.cub.2017.12.006 pmid:29307559 fatcat:mgg6uaohb5heddej6bqrg5agzm

19th biennial IPEG Meeting

Igor Timofeev, Leon Kenemans, P. F. Fabene, A. Ahnaou, Sebastian Olbrich, Robert Oostenveld, Martijn Arns, Nash Boutros, Fernando Lopes da Silva, Igor Timofeev, Ole Jensen, Sandra K. Loo (+404 others)
2016 Neuropsychiatric Electrophysiology  
research program SGS (SGS15/229/OHK4/3 T/17), MH CZ -DRO ("National Institute of Mental Health -NIMH) project nr.: 00023752 and PRVOUK34.  ...  I declare no conflict of interests.  ...  We used neurophysiological state markers of qEEG.  ... 
doi:10.1186/s40810-016-0021-4 fatcat:iynffofbojdx3nspgskpizfwt4

Loss-of-function mutation in inositol monophosphatase 1 (IMPA1) results in abnormal synchrony in resting-state EEG

Christopher P. Walker, Andre L. S. Pessoa, Thalita Figueiredo, Megan Rafferty, Uirá S. Melo, Paulo R. Nóbrega, Nicholas Murphy, Fernando Kok, Mayana Zatz, Silvana Santos, Raymond Y. Cho
2019 Orphanet Journal of Rare Diseases  
Dysregulation of the inositol cycle is implicated in a wide variety of human diseases, including developmental defects and neurological diseases.  ...  However, the neurophysiologic mechanisms that mediate the IMPA1 mutation and associated ID phenotype have not been characterized.  ...  Acknowledgments We would like to thank the families who gave their time and energy and without whose support and hospitality this work would not be possible. Funding  ... 
doi:10.1186/s13023-018-0977-1 pmid:30616629 pmcid:PMC6322245 fatcat:u63frwncpfdfrbbzmpsvryequm

Methods for inferring neural circuit interactions and neuromodulation from local field potential and electroencephalogram measures

Pablo Martínez-Cañada, Shahryar Noei, Stefano Panzeri
2021 Brain Informatics  
This review article gives an overview of the main computational tools that we have developed and employed to invert LFPs and EEGs in terms of circuit-level neural phenomena, and outlines future challenges  ...  However, these aggregate signals lack cellular resolution and thus are not easy to be interpreted directly in terms of parameters of neural microcircuits.  ...  Acknowledgements We are most grateful to the organizers and participants of the 14th International Conference on Brain Informatics (BI 2021) for their feedback on the work presented here.  ... 
doi:10.1186/s40708-021-00148-y pmid:34910260 fatcat:qsrubfni5vglxexd2xac34xqha

Consciousness in humans and non-human animals: recent advances and future directions

Melanie Boly, Anil K. Seth, Melanie Wilke, Paul Ingmundson, Bernard Baars, Steven Laureys, David B. Edelman, Naotsugu Tsuchiya
2013 Frontiers in Psychology  
by pharmacological manipulations [e.g., psylocibin; (Carhart-Harris et al., 2012) ].  ...  , neurophysiological, and behavioral properties observed in non-human animals to the human case .  ...  Conflict of Interest Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest  ... 
doi:10.3389/fpsyg.2013.00625 pmid:24198791 pmcid:PMC3814086 fatcat:fq4o5x72ijcr5jsu2gxlh32eja
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