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A Brief History of Neuronal Reconstruction

Stephen L. Senft
2011 Neuroinformatics  
The new availability of acetate film in movie format provided another medium for assembling 3D material.  ...  These open questions helped to fuel the desire for additional and improved reconstruction of neurons in 3D.  ... 
doi:10.1007/s12021-011-9107-0 pmid:21347713 fatcat:u3ekkytcingshmippya7qbawe4

Structural and functional properties of a probabilistic model of neuronal connectivity in a simple locomotor network

Andrea Ferrario, Robert Merrison-Hort, Stephen R Soffe, Roman Borisyuk
2018 eLife  
We use the structural characteristics to study examples of neuronal dynamics, in the complete network and various sub-networks, and this allows us to explain the basis for key experimental findings, and  ...  We describe a probabilistic model of connectivity in the hatchling Xenopus tadpole spinal cord which, when combined with a spiking model, reliably produces rhythmic activity corresponding to swimming.  ...  Acknowledgements We thank Prof Alan Roberts for his valuable contribution to model development, discussion of results and many other useful comments.  ... 
doi:10.7554/elife.33281 pmid:29589828 pmcid:PMC5910024 fatcat:hnxopvfchbgbbc7xavkk52saiu

Modulation of flight and feeding behaviours requires presynaptic IP3Rs in dopaminergic neurons

Anamika Sharma, Gaiti Hasan
2020 eLife  
Expression of IP3RDN helped identify key flight-modulating dopaminergic neurons with axonal projections in the mushroom body.  ...  To address this, we generated an inducible dominant negative form of the IP3R (IP3RDN). Flies with neuronal expression of IP3RDN exhibit flight deficits.  ...  Source file two is provided with information for all the statistical tests performed. Model in Figure 7 was created using Biorender (  ... 
doi:10.7554/elife.62297 fatcat:ax76cyfzcveftfssqtka3v37xu

Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission

Matthew P McCabe, Erin R Cullen, Caitlynn M Barrows, Amy N Shore, Katherine I Tooke, Kathryn A Laprade, James M Stafford, Matthew C Weston
2020 eLife  
Although mTOR signaling is known as a broad regulator of cell growth and proliferation, in neurons it regulates synaptic transmission, which is thought to be a major mechanism through which altered mTOR  ...  Inactivation of either complex reduced neuron growth and evoked EPSCs (eEPSCs), however, the effects of mTORC1 on eEPSCs were postsynaptic and the effects of mTORC2 were presynaptic.  ...  Summary: mTOR kinase signaling is important for neuronal growth regulation and neuronal network integrity, as demonstrated by neurological disorders associated with disruption in proper mTOR signaling.  ... 
doi:10.7554/elife.51440 pmid:32125271 pmcid:PMC7080408 fatcat:nahwi2suqvawbfdcsuk4hphr74

Energetic Constraints Produce Self-sustained Oscillatory Dynamics in Neuronal Networks

Javier Burroni, P. Taylor, Cassian Corey, Tengiz Vachnadze, Hava T. Siegelmann
2017 Frontiers in Neuroscience  
Overview: We model energy constraints in a network of spiking neurons, while exploring general questions of resource limitation on network function abstractly.  ...  Yet, in computational models of glia-neuron cooperation, there have been no previous attempts to explore the effects of direct realistic energy costs on network activity in spiking neurons.  ...  Thomas McKenna, the Office of Naval Research, award: N00014-09-1-0069. This project was funded in-part by an NSF BRAIN initiative pilot.  ... 
doi:10.3389/fnins.2017.00080 pmid:28289370 pmcid:PMC5326782 fatcat:wekd2ed7u5brvi225ka75hkh3i

Beyond Neurons: Long Distance Communication in Development and Cancer

Patrick McMillen, Madeleine J. Oudin, Michael Levin, Samantha L. Payne
2021 Frontiers in Cell and Developmental Biology  
and tumor growth and invasion in cancer.  ...  Herein we discuss the growing body of evidence suggesting that communication methods known to be employed by neurons, also exist in other cell types.  ...  TNT formation has been linked to a stress response thought to be an attempt to reestablish homeostasis; for example, following brain injury, astrocytes will form TNTs with neurons in order to provide them  ... 
doi:10.3389/fcell.2021.739024 pmid:34621752 pmcid:PMC8491768 fatcat:nt26satuzrfwripku3hoy234wm

SimTracker tool and code template to design, manage and analyze neural network model simulations in parallel NEURON [article]

Marianne Bezaire, Ivan Raikov, Kelly Burk, Caren Armstrong, Ivan Soltesz
2016 bioRxiv   pre-print
It supports users at each step of the modeling process, including execution of large scale parallel models on supercomputers. SimTracker is suitable for users with a range of modeling experience.  ...  However, as network models grow in complexity and scale, the necessary tasks of development and organization become unwieldy.  ...  This growth makes more difficult the tasks associated with model development and organization of results.  ... 
doi:10.1101/081927 fatcat:zururgrl2ba35az2abb4fc6ksa

Light Sheet Illumination for 3D Single-Molecule Super-Resolution Imaging of Neuronal Synapses

Gabriella Gagliano, Tyler Nelson, Nahima Saliba, Sofía Vargas-Hernández, Anna-Karin Gustavsson
2021 Frontiers in Synaptic Neuroscience  
In this review, we first present a brief overview of light sheet illumination and previous super-resolution techniques used for imaging of neurons and synapses.  ...  The function of the neuronal synapse depends on the dynamics and interactions of individual molecules at the nanoscale.  ...  More recently, a Bessel light sheet together with astigmatism was used to obtain 3D super-resolved reconstructions of microtubule networks in the primary neurons of rat pups for large FOVs (Lu et al.,  ... 
doi:10.3389/fnsyn.2021.761530 pmid:34899261 pmcid:PMC8651567 fatcat:vrprqxgzgbfstknjdwdwc66f7u

TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus

Joaquin I. Hurtado-Zavala, Binu Ramachandran, Saheeb Ahmed, Rashi Halder, Christiane Bolleyer, Ankit Awasthi, Markus A. Stahlberg, Robin J. Wagener, Kristin Anderson, Ryan M. Drenan, Henry A. Lester, Julie M. Miwa (+3 others)
2017 Nature Communications  
Our results reveal a synaptogenic function of TRPV1 in a specific interneuron population in the hippocampus, where it is important for gating hippocampal plasticity.  ...  TRPV1 is an ion channel activated by heat and pungent agents including capsaicin, and has been extensively studied in nociception of sensory neurons.  ...  Acknowledgements We thank Rory McQuiston, Julie Kauer, Manuela Schmidt, and Nils Brose for insightful discussions and critical review of the manuscript.  ... 
doi:10.1038/ncomms15878 pmid:28722015 pmcid:PMC5524938 fatcat:smgannga5jehvjintrhx6njkci

Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons

E. Keimpema, G. Tortoriello, A. Alpar, S. Capsoni, I. Arisi, D. Calvigioni, S. S.-J. Hu, A. Cattaneo, P. Doherty, K. Mackie, T. Harkany
2013 Proceedings of the National Academy of Sciences of the United States of America  
Endocannabinoid, particularly 2-arachidonoyl glycerol (2-AG), signaling has recently emerged as a molecular determinant of neuronal migration and synapse formation during cortical development.  ...  By taking advantage of BRCA1's cisplatin sensitivity (15), we rescued MGL in cholinergic growth cones, introducing a "stop" signal for NGF-induced growth responses.  ...  Conclusions The contribution of endocannabinoid signaling to the formation of neuronal networks in the developing forebrain is increasingly appreciated (2, 4, 16) .  ... 
doi:10.1073/pnas.1212563110 pmid:23319656 pmcid:PMC3562802 fatcat:vt3l7czv7fcwlg5gqxpv4e6wxu

Brain aging-dependent glioma traits reversible by NAD+/BDNF-mediated neuronal reactivation [article]

Daisuke Yamashita, Victoria L Flanary, Rachel B Munk, Kazuhiro Sonomura, Saya Ozaki, Riki Kawaguchi, Satoshi Suehiro, Soniya Bastola, Marat S Pavlyukov, Shinobu Yamaguchi, Mayu A Nakano, Takeharu Kunieda (+8 others)
2020 bioRxiv   pre-print
We find that glioblastoma in older patients and older mice displayed reduced neuronal signaling, including a decline of NTRK-like family member 6 (SLITRK6), a receptor for neurotrophic factor BDNF.  ...  This reduction was linked to the systemic decline of nicotinamide adenine dinucleotide (NAD+) with aging, as old mice exposed to young blood via parabiosis or supplemented with the NAD+ precursor NMN (  ...  We acknowledge the contribution by all the members in the Nakano and Gorospe laboratories (past and present) for technical help. We also thank Oriental Yeast Co., Ltd. for supply of NMN, G.  ... 
doi:10.1101/2020.10.10.334748 fatcat:mwnspzlab5c75fdgc2ukdxakne

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1

Thomas Rathjen, Xin Yan, Natalia L Kononenko, Min-Chi Ku, Kun Song, Leiron Ferrarese, Valentina Tarallo, Dmytro Puchkov, Gaga Kochlamazashvili, Sebastian Brachs, Luis Varela, Klara Szigeti-Buck (+17 others)
2017 Nature Neuroscience  
Cadm1 functions in multiple neuronal circuits Cadm1 is present throughout the brain and has been shown to regulate synapse formation, morphology, plasticity, and network excitability20,24,21.  ...  We then quantified the number of synapses in contact with these neurons.  ... 
doi:10.1038/nn.4590 pmid:28628102 pmcid:PMC5533218 fatcat:ybhavopjebg2veg6inv3caebli

A dominant mutation in mec-7/β-tubulin affects axon development and regeneration in Caenorhabditis elegans neurons

Leonie Kirszenblat, Brent Neumann, Sean Coakley, Massimo A. Hilliard, David G. Drubin
2013 Molecular Biology of the Cell  
Together our results suggest that MEC-7/β-tubulin integrity is necessary for the correct number of neurites a neuron generates in vivo and for the capacity of an axon to regenerate. Monitoring Editor  ...  More recently, in vitro studies have implicated microtubules as signaling molecules that, through changes in their stability, have the potential to trigger growth of axons and dendrites in developing neurons  ...  Nematode strains used in this work were provided by the Caenorhabditis Genetics Center, which is funded by the National Institutes of Health (NIH) National Center for Research Resources, and the International  ... 
doi:10.1091/mbc.e12-06-0441 pmid:23223572 pmcid:PMC3564523 fatcat:utzyr2hz6ndmri23tvikqr7tdq

Single-Molecule Imaging Reveals Rapid Estradiol Action on the Surface Movement of AMPA Receptors in Live Neurons

Soma Godó, Klaudia Barabás, Ferenc Lengyel, Dávid Ernszt, Tamás Kovács, Miklós Kecskés, Csaba Varga, Tibor Z. Jánosi, Géza Makkai, Gergely Kovács, Barbara Orsolits, Takahiro Fujiwara (+2 others)
2021 Frontiers in Cell and Developmental Biology  
The cortical actin network played a pivotal role in the GPER1 mediated effects of E2 on the surface mobility of AMPAR.  ...  Our results provide evidence for understanding E2 action on neuronal plasticity and glutamatergic neurotransmission at the molecular level.  ...  The research was performed in collaboration with the Nano-Bio-Imaging core facility at the Szentágothai Research Centre of the University of Pécs.  ... 
doi:10.3389/fcell.2021.708715 pmid:34631701 pmcid:PMC8495425 fatcat:p54dnokomfe7na27ua5ttrc66q

Vav3-Deficient Astrocytes Enhance the Dendritic Development of Hippocampal Neurons in an Indirect Co-culture System

David Wegrzyn, Josephine Zokol, Andreas Faissner
2022 Frontiers in Cellular Neuroscience  
For this purpose, an indirect co-culture system of native hippocampal neurons and Vav3-deficient cortical astrocytes was used.  ...  Interestingly, neurons cultured in an indirect contact with Vav3-deficient astrocytes showed a significant increase in the dendritic complexity and length after 12 and 17 days in vitro (DIV).  ...  Deletion of the nucleotide exchange factor Vav3 enhances axonal complexity and synapse formation but tampers activity of hippocampal neuronal networks in vitro . Int. J. Mol.  ... 
doi:10.3389/fncel.2021.817277 pmid:35237130 pmcid:PMC8882586 fatcat:2fbf27sfhfcy5dd5owedi5qjke
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