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A Brief History of Neuronal Reconstruction
2011
Neuroinformatics
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The new availability of acetate film in movie format provided another medium for assembling 3D material. ...
These open questions helped to fuel the desire for additional and improved reconstruction of neurons in 3D. ...
doi:10.1007/s12021-011-9107-0
pmid:21347713
fatcat:u3ekkytcingshmippya7qbawe4
Structural and functional properties of a probabilistic model of neuronal connectivity in a simple locomotor network
2018
eLife
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We use the structural characteristics to study examples of neuronal dynamics, in the complete network and various sub-networks, and this allows us to explain the basis for key experimental findings, and ...
We describe a probabilistic model of connectivity in the hatchling Xenopus tadpole spinal cord which, when combined with a spiking model, reliably produces rhythmic activity corresponding to swimming. ...
Acknowledgements We thank Prof Alan Roberts for his valuable contribution to model development, discussion of results and many other useful comments. ...
doi:10.7554/elife.33281
pmid:29589828
pmcid:PMC5910024
fatcat:hnxopvfchbgbbc7xavkk52saiu
Modulation of flight and feeding behaviours requires presynaptic IP3Rs in dopaminergic neurons
2020
eLife
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Expression of IP3RDN helped identify key flight-modulating dopaminergic neurons with axonal projections in the mushroom body. ...
To address this, we generated an inducible dominant negative form of the IP3R (IP3RDN). Flies with neuronal expression of IP3RDN exhibit flight deficits. ...
Source file two is provided with information for all the statistical tests performed. Model in Figure 7 was created using Biorender (BioRender.com). ...
doi:10.7554/elife.62297
fatcat:ax76cyfzcveftfssqtka3v37xu
Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
2020
eLife
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Although mTOR signaling is known as a broad regulator of cell growth and proliferation, in neurons it regulates synaptic transmission, which is thought to be a major mechanism through which altered mTOR ...
Inactivation of either complex reduced neuron growth and evoked EPSCs (eEPSCs), however, the effects of mTORC1 on eEPSCs were postsynaptic and the effects of mTORC2 were presynaptic. ...
Summary: mTOR kinase signaling is important for neuronal growth regulation and neuronal network integrity, as demonstrated by neurological disorders associated with disruption in proper mTOR signaling. ...
doi:10.7554/elife.51440
pmid:32125271
pmcid:PMC7080408
fatcat:nahwi2suqvawbfdcsuk4hphr74
Energetic Constraints Produce Self-sustained Oscillatory Dynamics in Neuronal Networks
2017
Frontiers in Neuroscience
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Overview: We model energy constraints in a network of spiking neurons, while exploring general questions of resource limitation on network function abstractly. ...
Yet, in computational models of glia-neuron cooperation, there have been no previous attempts to explore the effects of direct realistic energy costs on network activity in spiking neurons. ...
Thomas McKenna, the Office of Naval Research, award: N00014-09-1-0069. This project was funded in-part by an NSF BRAIN initiative pilot. ...
doi:10.3389/fnins.2017.00080
pmid:28289370
pmcid:PMC5326782
fatcat:wekd2ed7u5brvi225ka75hkh3i
Beyond Neurons: Long Distance Communication in Development and Cancer
2021
Frontiers in Cell and Developmental Biology
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and tumor growth and invasion in cancer. ...
Herein we discuss the growing body of evidence suggesting that communication methods known to be employed by neurons, also exist in other cell types. ...
TNT formation has been linked to a stress response thought to be an attempt to reestablish homeostasis; for example, following brain injury, astrocytes will form TNTs with neurons in order to provide them ...
doi:10.3389/fcell.2021.739024
pmid:34621752
pmcid:PMC8491768
fatcat:nt26satuzrfwripku3hoy234wm
SimTracker tool and code template to design, manage and analyze neural network model simulations in parallel NEURON
[article]
2016
bioRxiv
pre-print
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It supports users at each step of the modeling process, including execution of large scale parallel models on supercomputers. SimTracker is suitable for users with a range of modeling experience. ...
However, as network models grow in complexity and scale, the necessary tasks of development and organization become unwieldy. ...
This growth makes more difficult the tasks associated with model development and organization of results. ...
doi:10.1101/081927
fatcat:zururgrl2ba35az2abb4fc6ksa
Light Sheet Illumination for 3D Single-Molecule Super-Resolution Imaging of Neuronal Synapses
2021
Frontiers in Synaptic Neuroscience
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In this review, we first present a brief overview of light sheet illumination and previous super-resolution techniques used for imaging of neurons and synapses. ...
The function of the neuronal synapse depends on the dynamics and interactions of individual molecules at the nanoscale. ...
More recently, a Bessel light sheet together with astigmatism was used to obtain 3D super-resolved reconstructions of microtubule networks in the primary neurons of rat pups for large FOVs (Lu et al., ...
doi:10.3389/fnsyn.2021.761530
pmid:34899261
pmcid:PMC8651567
fatcat:vrprqxgzgbfstknjdwdwc66f7u
TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus
2017
Nature Communications
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Our results reveal a synaptogenic function of TRPV1 in a specific interneuron population in the hippocampus, where it is important for gating hippocampal plasticity. ...
TRPV1 is an ion channel activated by heat and pungent agents including capsaicin, and has been extensively studied in nociception of sensory neurons. ...
Acknowledgements We thank Rory McQuiston, Julie Kauer, Manuela Schmidt, and Nils Brose for insightful discussions and critical review of the manuscript. ...
doi:10.1038/ncomms15878
pmid:28722015
pmcid:PMC5524938
fatcat:smgannga5jehvjintrhx6njkci
Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons
2013
Proceedings of the National Academy of Sciences of the United States of America
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Endocannabinoid, particularly 2-arachidonoyl glycerol (2-AG), signaling has recently emerged as a molecular determinant of neuronal migration and synapse formation during cortical development. ...
By taking advantage of BRCA1's cisplatin sensitivity (15), we rescued MGL in cholinergic growth cones, introducing a "stop" signal for NGF-induced growth responses. ...
Conclusions The contribution of endocannabinoid signaling to the formation of neuronal networks in the developing forebrain is increasingly appreciated (2, 4, 16) . ...
doi:10.1073/pnas.1212563110
pmid:23319656
pmcid:PMC3562802
fatcat:vt3l7czv7fcwlg5gqxpv4e6wxu
Brain aging-dependent glioma traits reversible by NAD+/BDNF-mediated neuronal reactivation
[article]
2020
bioRxiv
pre-print
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We find that glioblastoma in older patients and older mice displayed reduced neuronal signaling, including a decline of NTRK-like family member 6 (SLITRK6), a receptor for neurotrophic factor BDNF. ...
This reduction was linked to the systemic decline of nicotinamide adenine dinucleotide (NAD+) with aging, as old mice exposed to young blood via parabiosis or supplemented with the NAD+ precursor NMN ( ...
We acknowledge the contribution by all the members in the Nakano and Gorospe laboratories (past and present) for technical help. We also thank Oriental Yeast Co., Ltd. for supply of NMN, G. ...
doi:10.1101/2020.10.10.334748
fatcat:mwnspzlab5c75fdgc2ukdxakne
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1
2017
Nature Neuroscience
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Cadm1 functions in multiple neuronal circuits Cadm1 is present throughout the brain and has been shown to regulate synapse formation, morphology, plasticity, and network excitability20,24,21. ...
We then quantified the number of synapses in contact with these neurons. ...
doi:10.1038/nn.4590
pmid:28628102
pmcid:PMC5533218
fatcat:ybhavopjebg2veg6inv3caebli
A dominant mutation in mec-7/β-tubulin affects axon development and regeneration in Caenorhabditis elegans neurons
2013
Molecular Biology of the Cell
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Together our results suggest that MEC-7/β-tubulin integrity is necessary for the correct number of neurites a neuron generates in vivo and for the capacity of an axon to regenerate. Monitoring Editor ...
More recently, in vitro studies have implicated microtubules as signaling molecules that, through changes in their stability, have the potential to trigger growth of axons and dendrites in developing neurons ...
Nematode strains used in this work were provided by the Caenorhabditis Genetics Center, which is funded by the National Institutes of Health (NIH) National Center for Research Resources, and the International ...
doi:10.1091/mbc.e12-06-0441
pmid:23223572
pmcid:PMC3564523
fatcat:utzyr2hz6ndmri23tvikqr7tdq
Single-Molecule Imaging Reveals Rapid Estradiol Action on the Surface Movement of AMPA Receptors in Live Neurons
2021
Frontiers in Cell and Developmental Biology
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The cortical actin network played a pivotal role in the GPER1 mediated effects of E2 on the surface mobility of AMPAR. ...
Our results provide evidence for understanding E2 action on neuronal plasticity and glutamatergic neurotransmission at the molecular level. ...
The research was performed in collaboration with the Nano-Bio-Imaging core facility at the Szentágothai Research Centre of the University of Pécs. ...
doi:10.3389/fcell.2021.708715
pmid:34631701
pmcid:PMC8495425
fatcat:p54dnokomfe7na27ua5ttrc66q
Vav3-Deficient Astrocytes Enhance the Dendritic Development of Hippocampal Neurons in an Indirect Co-culture System
2022
Frontiers in Cellular Neuroscience
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For this purpose, an indirect co-culture system of native hippocampal neurons and Vav3-deficient cortical astrocytes was used. ...
Interestingly, neurons cultured in an indirect contact with Vav3-deficient astrocytes showed a significant increase in the dendritic complexity and length after 12 and 17 days in vitro (DIV). ...
Deletion of the nucleotide exchange factor Vav3 enhances axonal complexity and synapse formation but tampers activity of hippocampal neuronal networks in vitro . Int. J. Mol. ...
doi:10.3389/fncel.2021.817277
pmid:35237130
pmcid:PMC8882586
fatcat:2fbf27sfhfcy5dd5owedi5qjke
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