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Neuronal Calcium Wave Propagation Varies with Changes in Endoplasmic Reticulum Parameters: A Computer Model
2015
Neural Computation
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Our modeling suggests that pharmacological targeting of IP 3 Rs and SERCA could allow modulation of Ca 2+ wave propagation in diseases where Ca 2+ dysregulation has been implicated. ...
All three modes produced Ca 2+ waves with velocities similar to those measured in vitro (approximately 50-90 μm /sec). ...
Within the dendrite, we modeled cytosolic and endoplasmic reticulum (ER) compartments by using a fractional volume for each. ...
doi:10.1162/neco_a_00712
pmid:25734493
pmcid:PMC4386758
fatcat:dffp7mqamjdqbe272lykhpu4ky
A mathematical model for persistent post-CSD vasoconstriction
2020
PLoS Computational Biology
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Cortical spreading depression (CSD) is the propagation of a relatively slow wave in cortical brain tissue that is linked to a number of pathological conditions such as stroke and migraine. ...
We model the rate of calcium clearance as well as the dynamical implications on overall blood flow. ...
Chang, Kevin C. Brennan, Huaxiong Huang. ...
doi:10.1371/journal.pcbi.1007996
pmid:32667909
fatcat:n5hx5cv36vdmnjdhne3pkjrivm
A Neuron-Glial Model of Exosomal Release in the Onset and Progression of Alzheimer's Disease
2021
Frontiers in Computational Neuroscience
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Moreover, we exploit our model to assess how temperature dependence of exosome release could interact with Aβ neurotoxicity. ...
We propose a novel model for Alzheimer's Aβ accumulation based on Ca2+-dependent exosome release from astrocytes. ...
TRPM8 channel that colocalizes with the endoplasmic reticulum, is immunostained in the neurons. ...
doi:10.3389/fncom.2021.653097
pmid:34616283
pmcid:PMC8489198
fatcat:x7j35c5qlbcr5jxhvu3vp5zp6u
What Is Required for Neuronal Calcium Waves? A Numerical Parameter Study
2018
Journal of Mathematical Neuroscience
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Abstract Neuronal calcium signals propagating by simple diffusion and reaction with mobile and stationary buffers are limited to cellular microdomains. ...
We further observe that abortive regimes exist, which could be relevant for spike-timing dependent plasticity, as travel distances and wave velocities vary with changing intracellular architecture. ...
Acknowledgements We wish to thank Arne Nägel for the implementation of the LIMEX scheme in UG 4 and for his advice on how to use it. ...
doi:10.1186/s13408-018-0064-x
pmid:30006849
pmcid:PMC6045568
fatcat:omfrarva6bhajnwrp5fgqzv42a
A Computational Model of Motor Neuron Degeneration
2014
Neuron
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To explore the link between bioenergetics and motor neuron degeneration, we used a computational model in which detailed morphology and ion conductance are paired with intracellular ATP production and ...
A shortage of ATP also causes a rise in intracellular calcium. ...
ACKNOWLEDGMENTS We are thankful to Michael Hines for his help and advice concerning the development of the bioenergetics model in NEURON. ...
doi:10.1016/j.neuron.2014.07.001
pmid:25088365
pmcid:PMC4167823
fatcat:phxw7rl3dra4ddwupytnlzpo3q
Sparse short-distance connections enhance calcium wave propagation in a 3D model of astrocyte networks
2014
Frontiers in Computational Neuroscience
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Computer simulations of the model suggest that changing the topology of the network is indeed sufficient to reproduce the distinct ranges of ICW propagation reported experimentally. ...
Since this hypothesis is very difficult to investigate with current experimental approaches, we explore it here using a biophysically realistic model of three-dimensional astrocyte networks in which we ...
In such a situation, computer simulations are highly useful since one can easily vary intracellular signaling parameters while guarantying constant GJC-couplings and vice-versa. ...
doi:10.3389/fncom.2014.00045
pmid:24795613
pmcid:PMC3997029
fatcat:3x5wtutoqbhb7ixwo7sm4dzfdy
A Compartmental Model to Investigate Local and Global Ca2+ Dynamics in Astrocytes
2018
Frontiers in Computational Neuroscience
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Significantly, our model predicts that whether the endoplasmic reticulum is shared between soma and processes or not determines the relationship between the firing rate of somatic Ca2+ events and the rate ...
Intracellular Ca2+ dynamics in astrocytes can be triggered by neuronal activity and in turn regulate a variety of downstream processes that modulate neuronal function. ...
AUTHOR CONTRIBUTIONS All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication. ...
doi:10.3389/fncom.2018.00094
pmid:30555315
pmcid:PMC6284150
fatcat:2yvaizgfybcyvjay4xpr2hau5m
A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate
2020
Frontiers in Computational Neuroscience
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In this paper, we propose a computational model of interactions between an astrocyte network and a neuron network, starting from tripartite synapses and spanning to a joint network level. ...
Our model focuses on a two-dimensional setup emulating a mixed in vitro neuron-astrocyte cell culture. ...
from the endoplasmic reticulum. ...
doi:10.3389/fncom.2019.00092
pmid:32038210
pmcid:PMC6987305
fatcat:htx2te4mwbhjtpxdwlfqkqtvb4
Modulation of Spike-Timing Dependent Plasticity: Towards the Inclusion of a Third Factor in Computational Models
2018
Frontiers in Computational Neuroscience
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Modulation of spike-timing dependent plasticity: towards the inclusion of a third factor in computational models. ...
Recently, computational models of calcium dynamics and signaling pathway molecules have started to explore STDP emergence in ex and in vivo-like conditions. ...
reticulum calcium ATPase; Ca ER : calcium in the endoplasmic reticulum; (Ca) 4 CaM, fully bound calmodulin; CaN, calcineurin aka PP2B; PKA, protein kinase A; I1p/I1, phosphorylated/unphosphorylated protein ...
doi:10.3389/fncom.2018.00049
pmid:30018546
pmcid:PMC6037788
fatcat:4lhfzrw2i5dfdbj3mf3u3n6lui
Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling
2017
Translational Psychiatry
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We also show that the variants may crucially affect the propagation of the cardiac action potential in the sinus node. ...
A possible factor underlying this comorbidity are the common variants in the large set of genes that have recently been discovered in genome-wide association studies (GWASs) as risk genes of schizophrenia ...
There is a trend toward the development of increasingly detailed biophysical neuron models and hence a L5PC model incorporating the functions of the endoplasmic reticulum (ER), SERCA pump, and relevant ...
doi:10.1038/s41398-017-0007-4
pmid:30446648
pmcid:PMC5802468
fatcat:dzxrvti64nak3lmqdw7js33rgy
Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model
2019
eLife
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We re-examined these roles in a model of a synaptically connected population of excitatory neurons with ICAN and INaP. ...
Two intrinsic neuronal biophysical mechanisms—a persistent sodium current (INaP) and a calcium-activated non-selective cationic current (ICAN)—were proposed to individually or in combination generate cellular ...
vitro, and (3) in the dendrites calcium transients may be
triggered by excitatory synaptic inputs and travel in a wave propagated to the soma (Miro- ...
doi:10.7554/elife.41555
pmid:30907727
pmcid:PMC6433470
fatcat:g6xtkgbpzrapzavtma6mcvocva
Energetics based spike generation of a single neuron: simulation results and analysis
2012
Frontiers in Neuroenergetics
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It is imperative to develop a model that captures the spike train of a neuron as a function of its intracellular parameters for non-invasive diagnosis of diseased neurons. ...
The spectral analysis of the generated spike trains in a time-frequency domain will help identify abnormalities in the internals of a neuron. ...
Further, We are thankful to the Frontiers Foundation for providing us with a complete waiver for the publication of this paper. ...
doi:10.3389/fnene.2012.00002
pmid:22347180
pmcid:PMC3269776
fatcat:iowltdclofeubl5aaidkdugyyq
The Multi-Scale Impact of the Alzheimer's Disease in the Topology Diversity of Astrocytes Molecular Communications Nanonetworks
[article]
2018
arXiv
pre-print
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A proposed multi-scale stochastic computational model captures the relationship between the intracellular and intercellular scales. ...
Lastly, we designed and evaluated a single-hop communication system with frequency modulation using metrics such as propagation extend, molecular delay and channel gain. ...
Computational models are sufficient to accurately describe the same calcium wave propagation from the experiments with the topology variation [6] . ...
arXiv:1810.09294v1
fatcat:udbtdoipnrerfmyzbpzkoxvdna
Emergent dynamics in an astrocyte-neuronal network coupled via nitric oxide
[article]
2022
arXiv
pre-print
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The "glissandi" effect is one such phenomenon, associated with a decrease in infraslow fluctuations, in which synchronized calcium oscillations propagate as a wave in hundreds of astrocytes. ...
emergence of calcium waves in astrocytes. ...
astrocytes, calcium oscillations in almost all the astrocytes become synchronized and propagate as a wave. ...
arXiv:2203.07193v1
fatcat:tkmuatnzhfcnnhjbepk6f3npy4
A Neuromorphic Digital Circuit for Neuronal Information Encoding Using Astrocytic Calcium Oscillations
2019
Frontiers in Neuroscience
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It also can be employed as a subsystem for linking biological cells to artificial neuronal networks using astrocytic calcium oscillations in future research. ...
In this paper, astrocytic calcium oscillations and neuronal firing dynamics are presented by De Pittà and IF (Integrated & Fire) models, respectively. ...
This calcium store is called the endoplasmic reticulum (ER). ...
doi:10.3389/fnins.2019.00998
pmid:31649494
pmcid:PMC6794439
fatcat:lbrbukbna5bhdkr7tbeltwemaq
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