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Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive–compulsive disorder

Joseph O'Neill, Eda Gorbis, Jamie D. Feusner, Jenny C. Yip, Susanna Chang, Karron M. Maidment, Jennifer G. Levitt, Noriko Salamon, John M. Ringman, Sanjaya Saxena
2013 Journal of Psychiatric Research  
The neurophysiological bases of cognitive-behavioral therapy (CBT) for obsessive-compulsive disorder (OCD) are incompletely understood.  ...  The goal of this pilot study was to determine the relationship between levels of the neurochemically interlinked metabolites glutamate + glutamine (Glx) and N-acetyl-aspartate + N-acetyl-aspartyl-glutamate  ...  London, and James T. McCracken for life support in a near terminal stage.  ... 
doi:10.1016/j.jpsychires.2012.11.010 pmid:23290560 pmcid:PMC3672238 fatcat:rkvvxglnhbbmbinguieh6vmllm

A Critical Review of Magnetic Resonance Spectroscopy Studies of Obsessive-Compulsive Disorder

Brian P. Brennan, Scott L. Rauch, J. Eric Jensen, Harrison G. Pope
2013 Biological Psychiatry  
Functional neuroimaging studies have converged to suggest that cortico-striatal-thalamo-cortical (CSTC) circuit dysfunction is a core pathophysiolologic feature of obsessive-compulsive disorder (OCD).  ...  We conclude with suggestions for possible future 1 H-MRS studies in OCD.  ...  Acknowledgments This work was funded in part by Grant 1K23-MH092397 from the National Institute of Mental Health (BPB) and the David Judah Fund at Massachusetts General Hospital (BPB).  ... 
doi:10.1016/j.biopsych.2012.06.023 pmid:22831979 pmcid:PMC3504626 fatcat:d2iy7ue2hfbhxdjjqpg663tlki

Brain-behavior relationships in obsessive-compulsive disorder

Sanjaya Saxena, Robert G. Bota, Arthur L. Brody
2001 Seminars in Clinical Neuropsychiatry  
Advances in neuroimaging have led to a greater understanding of brain-behavior relationships in obsessive-compulsive disorder (OCD).  ...  This article provides an updated review and analysis of the structural and functional neuroimaging studies in OCD published to date and discusses how evidence from various types of neuroimaging studies  ...  Acknowledgment The authors thank several colleagues, especially Lewis R Baxter,Jr, MD, who contributed greatty to the concepts and theofies pfesented here.  ... 
doi:10.1053/scnp.2001.21833 pmid:11296309 fatcat:zjyaybvvzrcvfbdvbpc63dwskq

Nuclear Neuroimaging in Social Anxiety Disorder: A Review

Alexander G. Doruyter, Patrick Dupont, Dan J. Stein, Christine Lochner, James M. Warwick
2018 Journal of Nuclear Medicine  
A recent neuroimaging review of social anxiety disorder focused predominantly on MRI, omitting the contribution of nuclear imaging methods.  ...  Evidence for disturbances in neurotransmitter systems in social anxiety disorder is limited but suggestive of both serotonergic and dopaminergic dysfunction.  ...  A study that used 123 I-iodobenzamide SPECT to investigate dopaminergic function in SAD patients with comorbid obsessive-compulsive disorder reported dopaminergic deficits in patients with comorbidity,  ... 
doi:10.2967/jnumed.118.212795 fatcat:nyemt22vrbcbzpktcxiqprmmom

Neurobiology of Posttraumatic Stress Disorder: The Role of Nuclear Neuroimaging [chapter]

Alex G. G. Doruyter, Dan J. Stein, James M. Warwick
2014 PET and SPECT in Psychiatry  
A recent neuroimaging review of social anxiety disorder focused predominantly on MRI, omitting the contribution of nuclear imaging methods.  ...  Evidence for disturbances in neurotransmitter systems in social anxiety disorder is limited but suggestive of both serotonergic and dopaminergic dysfunction.  ...  A study that used 123 I-iodobenzamide SPECT to investigate dopaminergic function in SAD patients with comorbid obsessive-compulsive disorder reported dopaminergic deficits in patients with comorbidity,  ... 
doi:10.1007/978-3-642-40384-2_14 fatcat:bdwwlidln5ctblseb2e4hrgyfq

Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline

Jennifer I. Lissemore, Debbie Sookman, Paul Gravel, Alexandre Berney, Amir Barsoum, Mirko Diksic, Thomas E. Nordahl, Gilbert Pinard, Igor Sibon, Jean Cottraux, Marco Leyton, Chawki Benkelfat
2018 Translational Psychiatry  
Nordahl may more directly participate in mathematical activity now that he is Professor Emeritus of the Department of Psychiatry and Behavioral Sciences.  ...  Acknowledgements This study was supported by funding from Fonds de la Recherche du Quebec -Sante (FRQS).  ...  Introduction Obsessive-compulsive disorder (OCD) is a chronic mental illness involving intrusive, unwanted thoughts (obsessions) and persistent mental or behavioral rituals (compulsions) that cause significant  ... 
doi:10.1038/s41398-018-0128-4 pmid:29666372 pmcid:PMC5904107 fatcat:246b5yt6wvcnheryyeuk23uhfa

Neuroimaging Studies in Eating Disorders

Guido K. Frank, Ursula F. Bailer, Shannan Henry, Angela Wagner, Walter H. Kaye
2004 CNS Spectrums  
AbstractThe understanding of the eating disorders (EDs) anorexia (AN) and bulimia nervosa (BN) has undergone remarkable advancements in the past decade.  ...  While fewer studies have been done in BN or binge eating disorder, there may be disturbances of serotonin metabolism in similar brain regions.  ...  A restricting type (AN-R) has been distinguished from a binge eating/purging type (AN-B/P). 4 Comorbid obsessive-compulsive disorder (OCD), depression, and anxiety are common. 5 Computed Tomography  ... 
doi:10.1017/s1092852900009639 fatcat:za2b36gbwjeuzptzfiwveq4wxy

The neurobiological link between OCD and ADHD

Silvia Brem, Edna Grünblatt, Renate Drechsler, Peter Riederer, Susanne Walitza
2014 ADHD Attention Deficit and Hyperactivity Disorders  
Obsessive compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD) are two of the most common neuropsychiatric diseases in paediatric populations.  ...  The high comorbidity of ADHD and OCD with each other, especially of ADHD in paediatric OCD, is well described. OCD and ADHD often follow a chronic course with persistent rates of at least 40-50 %.  ...  MRS Introduction Obsessive compulsive disorders (OCD) are typically characterized by the presence of recurrent, intrusive, and disturbing thoughts (obsessions) which often elicit anxiety or emotional  ... 
doi:10.1007/s12402-014-0146-x pmid:25017045 pmcid:PMC4148591 fatcat:vc3t2qjovfenlltyji6ht3aly4

Obsessive compulsive disorder: a practical guide

C Bench
2003 Journal of Neurology, Neurosurgery and Psychiatry  
the diagnosis, assessment, and management of obsessive compulsive disorder (OCD).  ...  Intuitively depression units are appealing, but it is disappointing that no Obsessive compulsive disorder: a practical guide The stated aim of this book is to provide a practical and accessible guide to  ... 
doi:10.1136/jnnp.74.11.1602-b fatcat:usikkbsrfrbx7j3xqdqxuvllr4

Eating Disorders: An Evolutionary Psychoneuroimmunological Approach

Markus J. Rantala, Severi Luoto, Tatjana Krama, Indrikis Krams
2019 Frontiers in Psychology  
We present the mismatch hypothesis as a necessary extension to the current theoretical framework of eating disorders.  ...  Eating disorders are evolutionarily novel conditions. They lead to some of the highest mortality rates of all psychiatric disorders.  ...  Eating Disorders and Obsessive Compulsive Disorder According to diagnostic criteria, obsession with physical exercise, appearance and food are common in eating disorders (American Psychiatric Association  ... 
doi:10.3389/fpsyg.2019.02200 pmid:31749720 pmcid:PMC6842941 fatcat:bicujoillvd7fc456ajw3xgjyi

Perspectives in affective disorders, Vol 21

C Bench
2003 Journal of Neurology, Neurosurgery and Psychiatry  
the diagnosis, assessment, and management of obsessive compulsive disorder (OCD).  ...  Intuitively depression units are appealing, but it is disappointing that no Obsessive compulsive disorder: a practical guide The stated aim of this book is to provide a practical and accessible guide to  ... 
doi:10.1136/jnnp.74.11.1602-a fatcat:wpfuzxqpofcqngteecvscvctxy

Differential Effects of Electroconvulsive Therapy in the Treatment of Major Depressive Disorder

Anna Stippl, Fatma Nur Kirkgöze, Malek Bajbouj, Simone Grimm
2020 Neuropsychobiology  
However, as current data is not consistent, future longitudinal investigations should combine modalities such as MRI, MR spectroscopy, and peripheral physiological measures to gain a deeper insight into  ...  The present review aims to describe differential antidepressant and cognitive effects of ECT as well as effects on markers of neural activity and connectivity, neurochemistry, and inflammation that might  ...  Statement of Ethics The authors have no ethical conflicts to declare. Disclosure Statement The authors have no conflicts of interests to declare.  ... 
doi:10.1159/000505553 pmid:32344410 fatcat:pt4ibep3znhuzpsxiqfwdd7y2e

Psychiatric and cognitive disorders in Parkinson's disease

I Hegeman Richard
2003 Journal of Neurology, Neurosurgery and Psychiatry  
the diagnosis, assessment, and management of obsessive compulsive disorder (OCD).  ...  Intuitively depression units are appealing, but it is disappointing that no Obsessive compulsive disorder: a practical guide The stated aim of this book is to provide a practical and accessible guide to  ... 
doi:10.1136/jnnp.74.11.1601 pmcid:PMC1738210 fatcat:td5tygcbfre4hoy7n75qvxgz2e

Neuromodulation in the Age of Modern Neuroimaging Technologies [chapter]

Mohammad Hossein Khosravi, Meysam Hoseinyazdi, Reza Jahankhah, Sara Haseli
2020 Neurostimulation and Neuromodulation in Contemporary Therapeutic Practice [Working Title]  
Neuroimaging has a variety of main roles in DBS including evaluating the final electrode contact position, localizing the target nucleus, and detecting complications.  ...  Most commonly used for the treatment of Parkinson's disease (PD), the deep brain stimulation (DBS) is a new neurosurgical method whose other applications are still under development.  ...  Combination of fMRI and PET modalities has provided a terrific opportunity in research to understand the neurochemistry of brain and underlying biochemical nature of brain function.  ... 
doi:10.5772/intechopen.92737 fatcat:sqggbrbcpjalnnx7pxvor4divq

An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials

Mallory E. Bowers, Kerry J. Ressler
2015 Biological Psychiatry  
Pre-clinical studies reveal a number of neurotransmitter systems and circuits critical for aversive learning and memory, which have informed the development of therapies used in human clinical trials.  ...  Posttraumatic stress disorder (PTSD) manifests after exposure to a traumatic event and is characterized by avoidance/numbing, intrusive symptoms and flashbacks, mood and cognitive disruptions, and hyperarousal  ...  Acknowledgments Support was provided by NIH (T32-GM08605, 1F31MH097397, and R01MH096764), the Burroughs Wellcome Fund, and by an NIH/NCRR base grant (P51RR000165) to Yerkes National Primate Research Center  ... 
doi:10.1016/j.biopsych.2015.06.008 pmid:26238379 pmcid:PMC4527085 fatcat:cvmkrjhweff63beevb4wtswhdq
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